Ubiquitin carboxyl-terminal hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin carboxyl-terminal hydrolase, putative

Species:

Leishmania mexicana

UniProt:

E9AWQ2_LEIMU

TriTrypDb:

LmxM.24.0620

Length:

807

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005730	nucleolus	5	1
GO:0005829	cytosol	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AWQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWQ2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	13
GO:0006511	ubiquitin-dependent protein catabolic process	7	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009056	catabolic process	2	13
GO:0009057	macromolecule catabolic process	4	13
GO:0009987	cellular process	1	13
GO:0016579	protein deubiquitination	6	13
GO:0019538	protein metabolic process	3	13
GO:0019941	modification-dependent protein catabolic process	6	13
GO:0036211	protein modification process	4	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043412	macromolecule modification	4	13
GO:0043632	modification-dependent macromolecule catabolic process	5	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044248	cellular catabolic process	3	13
GO:0044260	obsolete cellular macromolecule metabolic process	3	13
GO:0044265	obsolete cellular macromolecule catabolic process	4	13
GO:0051603	proteolysis involved in protein catabolic process	5	13
GO:0070646	protein modification by small protein removal	5	13
GO:0070647	protein modification by small protein conjugation or removal	5	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:1901575	organic substance catabolic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004843	cysteine-type deubiquitinase activity	5	13
GO:0008233	peptidase activity	3	13
GO:0008234	cysteine-type peptidase activity	4	13
GO:0016787	hydrolase activity	2	13
GO:0019783	ubiquitin-like protein peptidase activity	4	13
GO:0101005	deubiquitinase activity	5	13
GO:0140096	catalytic activity, acting on a protein	2	13
GO:0004175	endopeptidase activity	4	2
GO:0004197	cysteine-type endopeptidase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	338	342	PF00656	0.385
CLV_C14_Caspase3-7	465	469	PF00656	0.385
CLV_C14_Caspase3-7	541	545	PF00656	0.384
CLV_C14_Caspase3-7	621	625	PF00656	0.756
CLV_C14_Caspase3-7	63	67	PF00656	0.720
CLV_NRD_NRD_1	170	172	PF00675	0.327
CLV_NRD_NRD_1	18	20	PF00675	0.577
CLV_NRD_NRD_1	26	28	PF00675	0.519
CLV_NRD_NRD_1	490	492	PF00675	0.504
CLV_NRD_NRD_1	567	569	PF00675	0.741
CLV_NRD_NRD_1	638	640	PF00675	0.577
CLV_NRD_NRD_1	664	666	PF00675	0.818
CLV_NRD_NRD_1	734	736	PF00675	0.545
CLV_NRD_NRD_1	805	807	PF00675	0.636
CLV_NRD_NRD_1	87	89	PF00675	0.582
CLV_PCSK_FUR_1	801	805	PF00082	0.560
CLV_PCSK_KEX2_1	292	294	PF00082	0.439
CLV_PCSK_KEX2_1	373	375	PF00082	0.331
CLV_PCSK_KEX2_1	428	430	PF00082	0.433
CLV_PCSK_KEX2_1	553	555	PF00082	0.551
CLV_PCSK_KEX2_1	567	569	PF00082	0.693
CLV_PCSK_KEX2_1	613	615	PF00082	0.698
CLV_PCSK_KEX2_1	638	640	PF00082	0.577
CLV_PCSK_KEX2_1	664	666	PF00082	0.818
CLV_PCSK_KEX2_1	695	697	PF00082	0.604
CLV_PCSK_KEX2_1	803	805	PF00082	0.545
CLV_PCSK_KEX2_1	87	89	PF00082	0.582
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.439
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.331
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.355
CLV_PCSK_PC1ET2_1	553	555	PF00082	0.544
CLV_PCSK_PC1ET2_1	613	615	PF00082	0.745
CLV_PCSK_PC1ET2_1	695	697	PF00082	0.649
CLV_PCSK_PC7_1	634	640	PF00082	0.474
CLV_PCSK_PC7_1	801	807	PF00082	0.710
CLV_PCSK_SKI1_1	225	229	PF00082	0.307
CLV_PCSK_SKI1_1	36	40	PF00082	0.496
CLV_PCSK_SKI1_1	373	377	PF00082	0.464
CLV_PCSK_SKI1_1	638	642	PF00082	0.466
CLV_PCSK_SKI1_1	680	684	PF00082	0.696
CLV_PCSK_SKI1_1	692	696	PF00082	0.616
CLV_PCSK_SKI1_1	735	739	PF00082	0.704
CLV_PCSK_SKI1_1	772	776	PF00082	0.750
CLV_PCSK_SKI1_1	795	799	PF00082	0.634
DEG_APCC_DBOX_1	101	109	PF00400	0.249
DEG_Nend_UBRbox_2	1	3	PF02207	0.621
DOC_CKS1_1	738	743	PF01111	0.615
DOC_CYCLIN_RxL_1	4	15	PF00134	0.685
DOC_CYCLIN_RxL_1	634	642	PF00134	0.471
DOC_CYCLIN_yCln2_LP_2	156	162	PF00134	0.385
DOC_MAPK_DCC_7	384	392	PF00069	0.306
DOC_MAPK_gen_1	272	282	PF00069	0.397
DOC_MAPK_gen_1	354	363	PF00069	0.346
DOC_MAPK_HePTP_8	351	363	PF00069	0.415
DOC_MAPK_MEF2A_6	275	284	PF00069	0.431
DOC_MAPK_MEF2A_6	354	363	PF00069	0.302
DOC_MAPK_MEF2A_6	717	724	PF00069	0.494
DOC_MAPK_RevD_3	359	374	PF00069	0.345
DOC_PP1_RVXF_1	17	24	PF00149	0.493
DOC_PP1_RVXF_1	5	12	PF00149	0.622
DOC_PP2B_LxvP_1	156	159	PF13499	0.385
DOC_USP7_MATH_1	427	431	PF00917	0.173
DOC_USP7_MATH_1	516	520	PF00917	0.787
DOC_USP7_MATH_1	552	556	PF00917	0.375
DOC_USP7_MATH_1	620	624	PF00917	0.704
DOC_USP7_MATH_1	660	664	PF00917	0.642
DOC_USP7_MATH_1	671	675	PF00917	0.679
DOC_USP7_MATH_1	682	686	PF00917	0.711
DOC_USP7_UBL2_3	283	287	PF12436	0.431
DOC_USP7_UBL2_3	695	699	PF12436	0.717
DOC_USP7_UBL2_3	773	777	PF12436	0.701
DOC_WW_Pin1_4	110	115	PF00397	0.570
DOC_WW_Pin1_4	135	140	PF00397	0.263
DOC_WW_Pin1_4	344	349	PF00397	0.292
DOC_WW_Pin1_4	373	378	PF00397	0.374
DOC_WW_Pin1_4	400	405	PF00397	0.458
DOC_WW_Pin1_4	420	425	PF00397	0.464
DOC_WW_Pin1_4	499	504	PF00397	0.524
DOC_WW_Pin1_4	716	721	PF00397	0.821
DOC_WW_Pin1_4	737	742	PF00397	0.652
LIG_14-3-3_CanoR_1	102	106	PF00244	0.365
LIG_14-3-3_CanoR_1	208	215	PF00244	0.431
LIG_14-3-3_CanoR_1	240	250	PF00244	0.355
LIG_14-3-3_CanoR_1	308	313	PF00244	0.173
LIG_14-3-3_CanoR_1	36	41	PF00244	0.556
LIG_14-3-3_CanoR_1	473	479	PF00244	0.317
LIG_14-3-3_CanoR_1	608	613	PF00244	0.782
LIG_14-3-3_CanoR_1	746	751	PF00244	0.688
LIG_Actin_WH2_2	683	701	PF00022	0.590
LIG_AP2alpha_2	313	315	PF02296	0.292
LIG_AP2alpha_2	782	784	PF02296	0.648
LIG_APCC_ABBA_1	787	792	PF00400	0.648
LIG_BIR_III_4	584	588	PF00653	0.529
LIG_BRCT_BRCA1_1	200	204	PF00533	0.327
LIG_BRCT_BRCA1_1	7	11	PF00533	0.659
LIG_EH_1	787	791	PF12763	0.726
LIG_FHA_1	12	18	PF00498	0.444
LIG_FHA_1	136	142	PF00498	0.309
LIG_FHA_1	242	248	PF00498	0.292
LIG_FHA_1	44	50	PF00498	0.606
LIG_FHA_2	572	578	PF00498	0.751
LIG_FHA_2	619	625	PF00498	0.720
LIG_Integrin_isoDGR_2	565	567	PF01839	0.501
LIG_Integrin_RGD_1	665	667	PF01839	0.546
LIG_LIR_Apic_2	24	29	PF02991	0.564
LIG_LIR_Apic_2	344	348	PF02991	0.439
LIG_LIR_Gen_1	313	323	PF02991	0.316
LIG_LIR_Gen_1	332	340	PF02991	0.431
LIG_LIR_Gen_1	395	404	PF02991	0.436
LIG_LIR_Nem_3	15	21	PF02991	0.580
LIG_LIR_Nem_3	22	26	PF02991	0.561
LIG_LIR_Nem_3	309	315	PF02991	0.292
LIG_LIR_Nem_3	332	337	PF02991	0.431
LIG_LIR_Nem_3	395	400	PF02991	0.436
LIG_LIR_Nem_3	446	452	PF02991	0.351
LIG_LIR_Nem_3	685	690	PF02991	0.622
LIG_LIR_Nem_3	782	787	PF02991	0.755
LIG_PCNA_yPIPBox_3	263	271	PF02747	0.359
LIG_Pex14_2	145	149	PF04695	0.327
LIG_Pex14_2	160	164	PF04695	0.355
LIG_PTB_Apo_2	121	128	PF02174	0.331
LIG_SH2_CRK	26	30	PF00017	0.550
LIG_SH2_CRK	397	401	PF00017	0.355
LIG_SH2_CRK	687	691	PF00017	0.582
LIG_SH2_STAP1	434	438	PF00017	0.292
LIG_SH2_STAT5	144	147	PF00017	0.331
LIG_SH2_STAT5	254	257	PF00017	0.300
LIG_SH2_STAT5	345	348	PF00017	0.329
LIG_SH2_STAT5	397	400	PF00017	0.374
LIG_SH2_STAT5	453	456	PF00017	0.418
LIG_SH2_STAT5	636	639	PF00017	0.605
LIG_SH3_3	184	190	PF00018	0.232
LIG_SH3_3	29	35	PF00018	0.607
LIG_SH3_3	360	366	PF00018	0.431
LIG_SH3_3	37	43	PF00018	0.588
LIG_SH3_3	383	389	PF00018	0.375
LIG_SH3_3	405	411	PF00018	0.326
LIG_SH3_3	741	747	PF00018	0.555
LIG_SUMO_SIM_par_1	316	321	PF11976	0.307
LIG_SUMO_SIM_par_1	388	393	PF11976	0.431
LIG_TRAF2_1	262	265	PF00917	0.351
LIG_TRAF2_1	336	339	PF00917	0.306
LIG_TRAF2_1	789	792	PF00917	0.686
LIG_TYR_ITSM	393	400	PF00017	0.173
LIG_UBA3_1	193	202	PF00899	0.351
LIG_UBA3_1	227	236	PF00899	0.386
LIG_UBA3_1	690	699	PF00899	0.668
LIG_WRC_WIRS_1	146	151	PF05994	0.431
MOD_CDK_SPK_2	344	349	PF00069	0.292
MOD_CDK_SPK_2	499	504	PF00069	0.555
MOD_CDK_SPxxK_3	716	723	PF00069	0.633
MOD_CK1_1	151	157	PF00069	0.363
MOD_CK1_1	257	263	PF00069	0.346
MOD_CK1_1	344	350	PF00069	0.423
MOD_CK1_1	402	408	PF00069	0.446
MOD_CK1_1	423	429	PF00069	0.431
MOD_CK1_1	469	475	PF00069	0.391
MOD_CK1_1	517	523	PF00069	0.655
MOD_CK1_1	570	576	PF00069	0.782
MOD_CK1_1	583	589	PF00069	0.693
MOD_CK1_1	707	713	PF00069	0.813
MOD_CK2_1	259	265	PF00069	0.307
MOD_CK2_1	540	546	PF00069	0.448
MOD_CK2_1	571	577	PF00069	0.649
MOD_Cter_Amidation	290	293	PF01082	0.306
MOD_Cter_Amidation	565	568	PF01082	0.679
MOD_Cter_Amidation	801	804	PF01082	0.560
MOD_GlcNHglycan	150	153	PF01048	0.397
MOD_GlcNHglycan	182	185	PF01048	0.324
MOD_GlcNHglycan	36	39	PF01048	0.665
MOD_GlcNHglycan	512	515	PF01048	0.722
MOD_GlcNHglycan	516	519	PF01048	0.648
MOD_GlcNHglycan	520	523	PF01048	0.513
MOD_GlcNHglycan	554	557	PF01048	0.521
MOD_GlcNHglycan	570	573	PF01048	0.767
MOD_GlcNHglycan	584	588	PF01048	0.624
MOD_GlcNHglycan	673	676	PF01048	0.554
MOD_GlcNHglycan	706	709	PF01048	0.554
MOD_GlcNHglycan	748	751	PF01048	0.768
MOD_GSK3_1	198	205	PF00069	0.331
MOD_GSK3_1	219	226	PF00069	0.425
MOD_GSK3_1	392	399	PF00069	0.369
MOD_GSK3_1	400	407	PF00069	0.354
MOD_GSK3_1	419	426	PF00069	0.415
MOD_GSK3_1	487	494	PF00069	0.498
MOD_GSK3_1	510	517	PF00069	0.731
MOD_GSK3_1	566	573	PF00069	0.749
MOD_GSK3_1	599	606	PF00069	0.629
MOD_GSK3_1	618	625	PF00069	0.663
MOD_GSK3_1	704	711	PF00069	0.699
MOD_GSK3_1	90	97	PF00069	0.563
MOD_N-GLC_1	466	471	PF02516	0.374
MOD_N-GLC_1	5	10	PF02516	0.665
MOD_N-GLC_1	603	608	PF02516	0.620
MOD_N-GLC_2	124	126	PF02516	0.340
MOD_N-GLC_2	645	647	PF02516	0.641
MOD_NEK2_1	101	106	PF00069	0.552
MOD_NEK2_1	108	113	PF00069	0.511
MOD_NEK2_1	122	127	PF00069	0.293
MOD_NEK2_1	145	150	PF00069	0.298
MOD_NEK2_1	166	171	PF00069	0.303
MOD_NEK2_1	219	224	PF00069	0.408
MOD_NEK2_1	231	236	PF00069	0.231
MOD_NEK2_1	392	397	PF00069	0.401
MOD_NEK2_1	466	471	PF00069	0.431
MOD_NEK2_1	487	492	PF00069	0.354
MOD_NEK2_1	603	608	PF00069	0.735
MOD_NEK2_2	682	687	PF00069	0.625
MOD_PIKK_1	151	157	PF00454	0.469
MOD_PIKK_1	254	260	PF00454	0.385
MOD_PIKK_1	497	503	PF00454	0.638
MOD_PIKK_1	52	58	PF00454	0.748
MOD_PIKK_1	639	645	PF00454	0.689
MOD_PIKK_1	90	96	PF00454	0.518
MOD_PK_1	202	208	PF00069	0.415
MOD_PK_1	357	363	PF00069	0.355
MOD_PKA_1	357	363	PF00069	0.355
MOD_PKA_1	491	497	PF00069	0.598
MOD_PKA_1	567	573	PF00069	0.490
MOD_PKA_2	101	107	PF00069	0.429
MOD_PKA_2	180	186	PF00069	0.173
MOD_PKA_2	207	213	PF00069	0.431
MOD_PKA_2	295	301	PF00069	0.375
MOD_PKA_2	472	478	PF00069	0.361
MOD_PKA_2	510	516	PF00069	0.666
MOD_PKA_2	566	572	PF00069	0.588
MOD_Plk_1	392	398	PF00069	0.420
MOD_Plk_1	466	472	PF00069	0.398
MOD_Plk_1	5	11	PF00069	0.631
MOD_Plk_2-3	443	449	PF00069	0.475
MOD_Plk_2-3	622	628	PF00069	0.683
MOD_Plk_4	127	133	PF00069	0.347
MOD_Plk_4	223	229	PF00069	0.351
MOD_Plk_4	36	42	PF00069	0.571
MOD_Plk_4	396	402	PF00069	0.306
MOD_Plk_4	682	688	PF00069	0.707
MOD_ProDKin_1	110	116	PF00069	0.564
MOD_ProDKin_1	135	141	PF00069	0.263
MOD_ProDKin_1	344	350	PF00069	0.292
MOD_ProDKin_1	373	379	PF00069	0.374
MOD_ProDKin_1	400	406	PF00069	0.458
MOD_ProDKin_1	420	426	PF00069	0.464
MOD_ProDKin_1	499	505	PF00069	0.525
MOD_ProDKin_1	716	722	PF00069	0.820
MOD_ProDKin_1	737	743	PF00069	0.656
MOD_SUMO_for_1	282	285	PF00179	0.431
MOD_SUMO_rev_2	278	284	PF00179	0.363
MOD_SUMO_rev_2	285	294	PF00179	0.359
TRG_DiLeu_BaEn_1	266	271	PF01217	0.351
TRG_DiLeu_BaEn_1	546	551	PF01217	0.570
TRG_DiLeu_BaEn_1	577	582	PF01217	0.605
TRG_DiLeu_BaLyEn_6	195	200	PF01217	0.431
TRG_DiLeu_BaLyEn_6	636	641	PF01217	0.469
TRG_ENDOCYTIC_2	312	315	PF00928	0.280
TRG_ENDOCYTIC_2	397	400	PF00928	0.439
TRG_ENDOCYTIC_2	452	455	PF00928	0.292
TRG_ENDOCYTIC_2	485	488	PF00928	0.320
TRG_ENDOCYTIC_2	687	690	PF00928	0.580
TRG_ER_diArg_1	637	639	PF00400	0.574
TRG_ER_diArg_1	800	803	PF00400	0.560
TRG_ER_diArg_1	804	806	PF00400	0.542
TRG_ER_diArg_1	86	88	PF00400	0.569
TRG_NES_CRM1_1	155	168	PF08389	0.355
TRG_NES_CRM1_1	755	767	PF08389	0.709
TRG_NLS_MonoExtN_4	354	360	PF00514	0.431
TRG_NLS_MonoExtN_4	770	776	PF00514	0.607
TRG_Pf-PMV_PEXEL_1	540	544	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	638	643	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	696	700	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Z2	Leptomonas seymouri	61%	100%
A0A0S4JHR5	Bodo saltans	36%	99%
A0A1X0NIL8	Trypanosomatidae	38%	100%
A0A3S7WY54	Leishmania donovani	90%	100%
A0A422P3Z4	Trypanosoma rangeli	39%	100%
A4HDC0	Leishmania braziliensis	77%	99%
A4I0Q0	Leishmania infantum	90%	100%
D0A726	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
Q4QAS1	Leishmania major	88%	100%
Q4QCH5	Leishmania major	23%	100%
V5BR83	Trypanosoma cruzi	42%	100%