Helitron_like_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AWP9_LEIMU

TriTrypDb:

LmxM.24.0590

Length:

687

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWP9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.566
CLV_NRD_NRD_1	173	175	PF00675	0.646
CLV_NRD_NRD_1	230	232	PF00675	0.452
CLV_NRD_NRD_1	356	358	PF00675	0.469
CLV_NRD_NRD_1	381	383	PF00675	0.647
CLV_NRD_NRD_1	437	439	PF00675	0.587
CLV_NRD_NRD_1	442	444	PF00675	0.585
CLV_NRD_NRD_1	623	625	PF00675	0.504
CLV_NRD_NRD_1	679	681	PF00675	0.674
CLV_PCSK_KEX2_1	173	175	PF00082	0.646
CLV_PCSK_KEX2_1	201	203	PF00082	0.674
CLV_PCSK_KEX2_1	381	383	PF00082	0.647
CLV_PCSK_KEX2_1	437	439	PF00082	0.587
CLV_PCSK_KEX2_1	442	444	PF00082	0.585
CLV_PCSK_KEX2_1	679	681	PF00082	0.674
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.674
CLV_PCSK_PC7_1	377	383	PF00082	0.657
CLV_PCSK_PC7_1	438	444	PF00082	0.481
CLV_PCSK_SKI1_1	176	180	PF00082	0.657
CLV_PCSK_SKI1_1	225	229	PF00082	0.546
CLV_PCSK_SKI1_1	56	60	PF00082	0.432
CLV_Separin_Metazoa	386	390	PF03568	0.619
DEG_APCC_DBOX_1	155	163	PF00400	0.382
DEG_COP1_1	344	354	PF00400	0.554
DEG_SCF_FBW7_1	162	169	PF00400	0.445
DEG_SCF_FBW7_1	216	222	PF00400	0.616
DOC_CDC14_PxL_1	611	619	PF14671	0.527
DOC_CKS1_1	216	221	PF01111	0.549
DOC_CKS1_1	28	33	PF01111	0.700
DOC_CKS1_1	485	490	PF01111	0.442
DOC_CKS1_1	631	636	PF01111	0.542
DOC_CYCLIN_RxL_1	621	629	PF00134	0.439
DOC_MAPK_gen_1	231	238	PF00069	0.523
DOC_MAPK_gen_1	357	363	PF00069	0.592
DOC_MAPK_gen_1	501	509	PF00069	0.501
DOC_MAPK_gen_1	679	685	PF00069	0.707
DOC_MAPK_MEF2A_6	304	313	PF00069	0.599
DOC_MAPK_MEF2A_6	366	373	PF00069	0.593
DOC_MAPK_MEF2A_6	429	436	PF00069	0.652
DOC_PP1_RVXF_1	260	266	PF00149	0.603
DOC_PP1_RVXF_1	622	629	PF00149	0.621
DOC_PP2B_LxvP_1	519	522	PF13499	0.601
DOC_PP2B_LxvP_1	565	568	PF13499	0.805
DOC_USP7_MATH_1	166	170	PF00917	0.647
DOC_USP7_MATH_1	284	288	PF00917	0.744
DOC_USP7_MATH_1	80	84	PF00917	0.578
DOC_USP7_MATH_1	97	101	PF00917	0.502
DOC_WW_Pin1_4	162	167	PF00397	0.437
DOC_WW_Pin1_4	205	210	PF00397	0.686
DOC_WW_Pin1_4	215	220	PF00397	0.560
DOC_WW_Pin1_4	22	27	PF00397	0.675
DOC_WW_Pin1_4	396	401	PF00397	0.633
DOC_WW_Pin1_4	484	489	PF00397	0.447
DOC_WW_Pin1_4	630	635	PF00397	0.528
LIG_14-3-3_CanoR_1	176	185	PF00244	0.665
LIG_14-3-3_CanoR_1	202	211	PF00244	0.649
LIG_14-3-3_CanoR_1	231	238	PF00244	0.449
LIG_14-3-3_CanoR_1	262	270	PF00244	0.584
LIG_14-3-3_CanoR_1	343	352	PF00244	0.607
LIG_14-3-3_CanoR_1	357	363	PF00244	0.500
LIG_14-3-3_CanoR_1	679	684	PF00244	0.581
LIG_Actin_WH2_2	456	473	PF00022	0.583
LIG_Actin_WH2_2	631	646	PF00022	0.559
LIG_APCC_ABBA_1	416	421	PF00400	0.603
LIG_APCC_ABBAyCdc20_2	415	421	PF00400	0.610
LIG_BIR_III_4	472	476	PF00653	0.626
LIG_FHA_1	107	113	PF00498	0.702
LIG_FHA_1	118	124	PF00498	0.534
LIG_FHA_1	23	29	PF00498	0.644
LIG_FHA_1	345	351	PF00498	0.658
LIG_FHA_1	53	59	PF00498	0.571
LIG_FHA_2	109	115	PF00498	0.643
LIG_FHA_2	273	279	PF00498	0.640
LIG_FHA_2	42	48	PF00498	0.453
LIG_LIR_Gen_1	148	157	PF02991	0.520
LIG_LIR_Gen_1	208	219	PF02991	0.501
LIG_LIR_Gen_1	303	313	PF02991	0.601
LIG_LIR_Gen_1	444	453	PF02991	0.587
LIG_LIR_Gen_1	458	468	PF02991	0.434
LIG_LIR_Gen_1	492	503	PF02991	0.644
LIG_LIR_LC3C_4	151	155	PF02991	0.555
LIG_LIR_Nem_3	139	144	PF02991	0.598
LIG_LIR_Nem_3	148	153	PF02991	0.487
LIG_LIR_Nem_3	188	194	PF02991	0.503
LIG_LIR_Nem_3	303	308	PF02991	0.614
LIG_LIR_Nem_3	401	406	PF02991	0.596
LIG_LIR_Nem_3	444	448	PF02991	0.586
LIG_LIR_Nem_3	458	463	PF02991	0.419
LIG_LIR_Nem_3	47	53	PF02991	0.501
LIG_LIR_Nem_3	480	486	PF02991	0.654
LIG_LIR_Nem_3	492	498	PF02991	0.515
LIG_LIR_Nem_3	505	509	PF02991	0.496
LIG_LYPXL_S_1	430	434	PF13949	0.612
LIG_LYPXL_yS_3	431	434	PF13949	0.612
LIG_PCNA_yPIPBox_3	500	513	PF02747	0.498
LIG_PDZ_Class_2	682	687	PF00595	0.671
LIG_Pex14_2	211	215	PF04695	0.504
LIG_RPA_C_Fungi	377	389	PF08784	0.641
LIG_SH2_CRK	305	309	PF00017	0.608
LIG_SH2_GRB2like	161	164	PF00017	0.421
LIG_SH2_GRB2like	539	542	PF00017	0.604
LIG_SH2_PTP2	403	406	PF00017	0.594
LIG_SH2_PTP2	506	509	PF00017	0.447
LIG_SH2_SRC	113	116	PF00017	0.516
LIG_SH2_SRC	403	406	PF00017	0.544
LIG_SH2_SRC	453	456	PF00017	0.634
LIG_SH2_STAP1	254	258	PF00017	0.634
LIG_SH2_STAT5	161	164	PF00017	0.421
LIG_SH2_STAT5	217	220	PF00017	0.662
LIG_SH2_STAT5	264	267	PF00017	0.594
LIG_SH2_STAT5	312	315	PF00017	0.546
LIG_SH2_STAT5	403	406	PF00017	0.594
LIG_SH2_STAT5	483	486	PF00017	0.648
LIG_SH2_STAT5	494	497	PF00017	0.525
LIG_SH2_STAT5	50	53	PF00017	0.634
LIG_SH2_STAT5	506	509	PF00017	0.502
LIG_SH2_STAT5	618	621	PF00017	0.485
LIG_SH2_STAT5	630	633	PF00017	0.579
LIG_SH3_3	213	219	PF00018	0.549
LIG_SH3_3	240	246	PF00018	0.592
LIG_SH3_3	333	339	PF00018	0.656
LIG_SH3_3	346	352	PF00018	0.514
LIG_SH3_3	463	469	PF00018	0.635
LIG_SH3_3	482	488	PF00018	0.441
LIG_SH3_3	609	615	PF00018	0.592
LIG_SH3_3	628	634	PF00018	0.627
LIG_SH3_3	71	77	PF00018	0.656
LIG_SH3_5	502	506	PF00018	0.639
MOD_CDK_SPK_2	215	220	PF00069	0.617
MOD_CDK_SPxK_1	396	402	PF00069	0.575
MOD_CDK_SPxK_1	630	636	PF00069	0.458
MOD_CK1_1	205	211	PF00069	0.688
MOD_CK1_1	344	350	PF00069	0.583
MOD_CK1_1	356	362	PF00069	0.501
MOD_CK1_1	41	47	PF00069	0.455
MOD_CK2_1	145	151	PF00069	0.556
MOD_CK2_1	272	278	PF00069	0.641
MOD_CK2_1	438	444	PF00069	0.556
MOD_CK2_1	80	86	PF00069	0.642
MOD_Cter_Amidation	229	232	PF01082	0.450
MOD_Cter_Amidation	622	625	PF01082	0.446
MOD_Cter_Amidation	677	680	PF01082	0.531
MOD_GlcNHglycan	147	150	PF01048	0.562
MOD_GlcNHglycan	204	207	PF01048	0.540
MOD_GlcNHglycan	559	562	PF01048	0.684
MOD_GSK3_1	102	109	PF00069	0.499
MOD_GSK3_1	162	169	PF00069	0.445
MOD_GSK3_1	201	208	PF00069	0.628
MOD_GSK3_1	215	222	PF00069	0.530
MOD_GSK3_1	34	41	PF00069	0.484
MOD_GSK3_1	455	462	PF00069	0.407
MOD_GSK3_1	626	633	PF00069	0.534
MOD_N-GLC_1	117	122	PF02516	0.461
MOD_N-GLC_1	162	167	PF02516	0.437
MOD_N-GLC_1	22	27	PF02516	0.578
MOD_N-GLC_1	318	323	PF02516	0.460
MOD_N-GLC_1	38	43	PF02516	0.510
MOD_N-GLC_1	626	631	PF02516	0.429
MOD_N-GLC_1	97	102	PF02516	0.497
MOD_NEK2_1	341	346	PF00069	0.665
MOD_NEK2_1	373	378	PF00069	0.566
MOD_NEK2_1	38	43	PF00069	0.450
MOD_NEK2_1	448	453	PF00069	0.584
MOD_NEK2_1	459	464	PF00069	0.455
MOD_NEK2_1	626	631	PF00069	0.643
MOD_PIKK_1	176	182	PF00454	0.631
MOD_PIKK_1	320	326	PF00454	0.621
MOD_PIKK_1	356	362	PF00454	0.623
MOD_PK_1	422	428	PF00069	0.371
MOD_PK_1	679	685	PF00069	0.534
MOD_PKA_1	201	207	PF00069	0.627
MOD_PKA_1	231	237	PF00069	0.387
MOD_PKA_1	437	443	PF00069	0.560
MOD_PKA_1	679	685	PF00069	0.534
MOD_PKA_2	201	207	PF00069	0.645
MOD_PKA_2	356	362	PF00069	0.588
MOD_PKA_2	437	443	PF00069	0.560
MOD_PKA_2	678	684	PF00069	0.531
MOD_PKB_1	174	182	PF00069	0.658
MOD_Plk_1	117	123	PF00069	0.588
MOD_Plk_1	38	44	PF00069	0.520
MOD_Plk_1	626	632	PF00069	0.442
MOD_Plk_1	80	86	PF00069	0.642
MOD_Plk_1	97	103	PF00069	0.503
MOD_Plk_4	108	114	PF00069	0.625
MOD_Plk_4	210	216	PF00069	0.690
MOD_Plk_4	237	243	PF00069	0.573
MOD_Plk_4	24	30	PF00069	0.698
MOD_Plk_4	422	428	PF00069	0.394
MOD_ProDKin_1	162	168	PF00069	0.444
MOD_ProDKin_1	205	211	PF00069	0.688
MOD_ProDKin_1	215	221	PF00069	0.563
MOD_ProDKin_1	22	28	PF00069	0.678
MOD_ProDKin_1	396	402	PF00069	0.637
MOD_ProDKin_1	484	490	PF00069	0.443
MOD_ProDKin_1	630	636	PF00069	0.533
MOD_SUMO_for_1	546	549	PF00179	0.622
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.547
TRG_ENDOCYTIC_2	194	197	PF00928	0.670
TRG_ENDOCYTIC_2	305	308	PF00928	0.608
TRG_ENDOCYTIC_2	403	406	PF00928	0.594
TRG_ENDOCYTIC_2	431	434	PF00928	0.612
TRG_ENDOCYTIC_2	494	497	PF00928	0.640
TRG_ENDOCYTIC_2	506	509	PF00928	0.507
TRG_ER_diArg_1	173	176	PF00400	0.646
TRG_ER_diArg_1	380	382	PF00400	0.623
TRG_ER_diArg_1	388	391	PF00400	0.654
TRG_ER_diArg_1	436	438	PF00400	0.573
TRG_Pf-PMV_PEXEL_1	366	370	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	450	454	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	501	505	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	513	517	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBT9	Leishmania donovani	86%	100%
A4HDB7	Leishmania braziliensis	71%	100%
A4I0P7	Leishmania infantum	86%	100%
Q4QAS4	Leishmania major	86%	100%