Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWP3_LEIMU

TriTrypDb:

LmxM.24.0530

Length:

227

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AWP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWP3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.634
CLV_C14_Caspase3-7	150	154	PF00656	0.724
CLV_NRD_NRD_1	103	105	PF00675	0.602
CLV_NRD_NRD_1	111	113	PF00675	0.507
CLV_NRD_NRD_1	171	173	PF00675	0.688
CLV_PCSK_KEX2_1	111	113	PF00082	0.509
CLV_PCSK_KEX2_1	171	173	PF00082	0.688
CLV_PCSK_KEX2_1	213	215	PF00082	0.476
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.720
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.494
CLV_PCSK_SKI1_1	182	186	PF00082	0.540
CLV_PCSK_SKI1_1	192	196	PF00082	0.526
CLV_PCSK_SKI1_1	214	218	PF00082	0.496
CLV_PCSK_SKI1_1	55	59	PF00082	0.547
DEG_APCC_DBOX_1	213	221	PF00400	0.473
DEG_Nend_UBRbox_2	1	3	PF02207	0.762
DOC_CYCLIN_RxL_1	189	199	PF00134	0.550
DOC_MAPK_gen_1	213	220	PF00069	0.494
DOC_MAPK_MEF2A_6	213	220	PF00069	0.552
DOC_PP1_RVXF_1	53	59	PF00149	0.464
DOC_PP2B_LxvP_1	139	142	PF13499	0.646
DOC_USP7_MATH_1	178	182	PF00917	0.578
DOC_USP7_MATH_1	190	194	PF00917	0.485
DOC_WW_Pin1_4	3	8	PF00397	0.671
DOC_WW_Pin1_4	60	65	PF00397	0.585
LIG_14-3-3_CanoR_1	158	162	PF00244	0.689
LIG_FHA_1	114	120	PF00498	0.640
LIG_FHA_2	121	127	PF00498	0.678
LIG_Integrin_RGD_1	112	114	PF01839	0.615
LIG_LIR_Apic_2	2	7	PF02991	0.673
LIG_MYND_1	28	32	PF01753	0.652
LIG_PDZ_Class_1	222	227	PF00595	0.676
LIG_SH2_CRK	17	21	PF00017	0.651
LIG_SH2_CRK	4	8	PF00017	0.666
LIG_SH2_CRK	50	54	PF00017	0.400
LIG_SH2_NCK_1	4	8	PF00017	0.666
LIG_SH2_STAT5	127	130	PF00017	0.624
LIG_SUMO_SIM_par_1	215	223	PF11976	0.523
LIG_TRAF2_1	199	202	PF00917	0.525
LIG_TRAF2_1	42	45	PF00917	0.437
LIG_TYR_ITIM	15	20	PF00017	0.664
LIG_UBA3_1	206	213	PF00899	0.560
MOD_CDK_SPxxK_3	60	67	PF00069	0.593
MOD_CK1_1	154	160	PF00069	0.710
MOD_CK2_1	196	202	PF00069	0.627
MOD_Cter_Amidation	109	112	PF01082	0.335
MOD_GlcNHglycan	105	108	PF01048	0.494
MOD_GlcNHglycan	153	156	PF01048	0.664
MOD_GlcNHglycan	198	201	PF01048	0.595
MOD_GSK3_1	186	193	PF00069	0.590
MOD_PKA_2	103	109	PF00069	0.607
MOD_PKA_2	157	163	PF00069	0.751
MOD_Plk_1	120	126	PF00069	0.639
MOD_Plk_2-3	120	126	PF00069	0.629
MOD_Plk_4	157	163	PF00069	0.735
MOD_Plk_4	190	196	PF00069	0.580
MOD_ProDKin_1	3	9	PF00069	0.669
MOD_ProDKin_1	60	66	PF00069	0.587
TRG_DiLeu_BaEn_1	202	207	PF01217	0.561
TRG_ENDOCYTIC_2	17	20	PF00928	0.659
TRG_ENDOCYTIC_2	50	53	PF00928	0.407
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDI0	Leptomonas seymouri	69%	98%
A0A1X0NIJ7	Trypanosomatidae	34%	88%
A0A3S7WY43	Leishmania donovani	93%	100%
A0A422P3Y6	Trypanosoma rangeli	37%	94%
A4HDB0	Leishmania braziliensis	84%	100%
A4I0P3	Leishmania infantum	93%	100%
D0A721	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	97%
Q4QAS8	Leishmania major	94%	100%