Putative DNAJ domain protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNAJ domain protein, putative

Species:

Leishmania mexicana

UniProt:

E9AWP2_LEIMU

TriTrypDb:

LmxM.24.0520

Length:

792

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 2
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9AWP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWP2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	773	777	PF00656	0.553
CLV_MEL_PAP_1	342	348	PF00089	0.608
CLV_NRD_NRD_1	151	153	PF00675	0.554
CLV_NRD_NRD_1	219	221	PF00675	0.602
CLV_NRD_NRD_1	583	585	PF00675	0.547
CLV_NRD_NRD_1	631	633	PF00675	0.570
CLV_NRD_NRD_1	657	659	PF00675	0.555
CLV_NRD_NRD_1	751	753	PF00675	0.320
CLV_PCSK_FUR_1	632	636	PF00082	0.544
CLV_PCSK_KEX2_1	151	153	PF00082	0.554
CLV_PCSK_KEX2_1	634	636	PF00082	0.579
CLV_PCSK_KEX2_1	656	658	PF00082	0.557
CLV_PCSK_PC1ET2_1	634	636	PF00082	0.532
CLV_PCSK_SKI1_1	145	149	PF00082	0.583
CLV_PCSK_SKI1_1	160	164	PF00082	0.458
CLV_PCSK_SKI1_1	2	6	PF00082	0.665
CLV_PCSK_SKI1_1	289	293	PF00082	0.539
CLV_PCSK_SKI1_1	296	300	PF00082	0.470
CLV_PCSK_SKI1_1	325	329	PF00082	0.499
CLV_PCSK_SKI1_1	368	372	PF00082	0.732
CLV_PCSK_SKI1_1	59	63	PF00082	0.468
CLV_PCSK_SKI1_1	617	621	PF00082	0.498
CLV_PCSK_SKI1_1	681	685	PF00082	0.283
CLV_PCSK_SKI1_1	701	705	PF00082	0.235
CLV_PCSK_SKI1_1	772	776	PF00082	0.404
DEG_APCC_DBOX_1	159	167	PF00400	0.264
DEG_APCC_DBOX_1	295	303	PF00400	0.317
DEG_Nend_UBRbox_1	1	4	PF02207	0.503
DEG_SPOP_SBC_1	34	38	PF00917	0.386
DOC_CYCLIN_RxL_1	292	301	PF00134	0.338
DOC_CYCLIN_yCln2_LP_2	704	710	PF00134	0.575
DOC_MAPK_gen_1	157	166	PF00069	0.275
DOC_MAPK_gen_1	218	228	PF00069	0.380
DOC_MAPK_gen_1	584	590	PF00069	0.458
DOC_MAPK_gen_1	678	688	PF00069	0.508
DOC_MAPK_MEF2A_6	681	688	PF00069	0.497
DOC_MAPK_NFAT4_5	681	689	PF00069	0.502
DOC_PP2B_LxvP_1	285	288	PF13499	0.390
DOC_PP2B_LxvP_1	363	366	PF13499	0.447
DOC_PP2B_LxvP_1	697	700	PF13499	0.614
DOC_PP4_FxxP_1	598	601	PF00568	0.357
DOC_USP7_MATH_1	383	387	PF00917	0.462
DOC_USP7_MATH_1	388	392	PF00917	0.388
DOC_USP7_MATH_1	501	505	PF00917	0.431
DOC_USP7_MATH_1	51	55	PF00917	0.337
DOC_USP7_MATH_1	562	566	PF00917	0.436
DOC_USP7_MATH_1	570	574	PF00917	0.446
DOC_USP7_MATH_1	601	605	PF00917	0.355
DOC_USP7_MATH_1	640	644	PF00917	0.627
DOC_USP7_UBL2_3	484	488	PF12436	0.277
DOC_USP7_UBL2_3	55	59	PF12436	0.265
DOC_USP7_UBL2_3	753	757	PF12436	0.532
DOC_USP7_UBL2_3	80	84	PF12436	0.257
DOC_WW_Pin1_4	120	125	PF00397	0.385
DOC_WW_Pin1_4	132	137	PF00397	0.422
DOC_WW_Pin1_4	138	143	PF00397	0.363
DOC_WW_Pin1_4	206	211	PF00397	0.276
DOC_WW_Pin1_4	384	389	PF00397	0.464
DOC_WW_Pin1_4	499	504	PF00397	0.457
LIG_14-3-3_CanoR_1	176	185	PF00244	0.342
LIG_14-3-3_CanoR_1	286	295	PF00244	0.354
LIG_14-3-3_CanoR_1	39	47	PF00244	0.262
LIG_14-3-3_CanoR_1	744	749	PF00244	0.613
LIG_Actin_WH2_2	58	76	PF00022	0.175
LIG_AP2alpha_1	263	267	PF02296	0.326
LIG_APCC_ABBA_1	164	169	PF00400	0.270
LIG_BRCT_BRCA1_1	124	128	PF00533	0.422
LIG_BRCT_BRCA1_1	134	138	PF00533	0.464
LIG_BRCT_BRCA1_2	134	140	PF00533	0.460
LIG_Clathr_ClatBox_1	685	689	PF01394	0.537
LIG_CtBP_PxDLS_1	528	532	PF00389	0.383
LIG_deltaCOP1_diTrp_1	673	683	PF00928	0.611
LIG_EVH1_1	363	367	PF00568	0.449
LIG_FHA_1	231	237	PF00498	0.305
LIG_FHA_1	268	274	PF00498	0.378
LIG_FHA_1	358	364	PF00498	0.365
LIG_FHA_1	374	380	PF00498	0.491
LIG_FHA_1	430	436	PF00498	0.382
LIG_FHA_1	707	713	PF00498	0.560
LIG_FHA_2	121	127	PF00498	0.418
LIG_FHA_2	274	280	PF00498	0.401
LIG_FHA_2	530	536	PF00498	0.414
LIG_FHA_2	74	80	PF00498	0.352
LIG_GBD_Chelix_1	10	18	PF00786	0.577
LIG_LIR_Apic_2	597	601	PF02991	0.410
LIG_LIR_Gen_1	179	190	PF02991	0.336
LIG_LIR_Gen_1	333	342	PF02991	0.403
LIG_LIR_Gen_1	354	363	PF02991	0.306
LIG_LIR_Gen_1	432	440	PF02991	0.385
LIG_LIR_Gen_1	465	473	PF02991	0.362
LIG_LIR_Gen_1	515	525	PF02991	0.466
LIG_LIR_Gen_1	535	544	PF02991	0.215
LIG_LIR_Gen_1	680	688	PF02991	0.582
LIG_LIR_Nem_3	125	131	PF02991	0.439
LIG_LIR_Nem_3	232	237	PF02991	0.377
LIG_LIR_Nem_3	261	267	PF02991	0.305
LIG_LIR_Nem_3	354	358	PF02991	0.290
LIG_LIR_Nem_3	41	47	PF02991	0.258
LIG_LIR_Nem_3	432	437	PF02991	0.340
LIG_LIR_Nem_3	465	469	PF02991	0.315
LIG_LIR_Nem_3	515	521	PF02991	0.386
LIG_LIR_Nem_3	535	540	PF02991	0.207
LIG_LIR_Nem_3	604	610	PF02991	0.348
LIG_LIR_Nem_3	680	686	PF02991	0.586
LIG_NRBOX	13	19	PF00104	0.461
LIG_NRBOX	770	776	PF00104	0.546
LIG_Pex14_1	182	186	PF04695	0.371
LIG_Pex14_2	258	262	PF04695	0.262
LIG_Pex14_2	263	267	PF04695	0.272
LIG_Pex14_2	327	331	PF04695	0.293
LIG_SH2_CRK	518	522	PF00017	0.470
LIG_SH2_CRK	537	541	PF00017	0.247
LIG_SH2_NCK_1	167	171	PF00017	0.335
LIG_SH2_NCK_1	237	241	PF00017	0.452
LIG_SH2_NCK_1	315	319	PF00017	0.385
LIG_SH2_NCK_1	405	409	PF00017	0.240
LIG_SH2_SRC	106	109	PF00017	0.401
LIG_SH2_SRC	167	170	PF00017	0.326
LIG_SH2_SRC	613	616	PF00017	0.381
LIG_SH2_STAP1	178	182	PF00017	0.373
LIG_SH2_STAP1	596	600	PF00017	0.410
LIG_SH2_STAT3	130	133	PF00017	0.395
LIG_SH2_STAT5	224	227	PF00017	0.370
LIG_SH2_STAT5	335	338	PF00017	0.307
LIG_SH2_STAT5	466	469	PF00017	0.311
LIG_SH2_STAT5	589	592	PF00017	0.325
LIG_SH2_STAT5	596	599	PF00017	0.320
LIG_SH2_STAT5	613	616	PF00017	0.318
LIG_SH3_1	665	671	PF00018	0.658
LIG_SH3_3	361	367	PF00018	0.398
LIG_SH3_3	556	562	PF00018	0.536
LIG_SH3_3	665	671	PF00018	0.660
LIG_SH3_3	726	732	PF00018	0.625
LIG_SUMO_SIM_par_1	224	230	PF11976	0.318
LIG_SUMO_SIM_par_1	683	690	PF11976	0.543
LIG_TRAF2_1	527	530	PF00917	0.399
LIG_TRAF2_1	54	57	PF00917	0.301
LIG_TRAF2_1	627	630	PF00917	0.741
LIG_TRAF2_1	677	680	PF00917	0.605
LIG_TRAF2_1	76	79	PF00917	0.270
LIG_TYR_ITIM	516	521	PF00017	0.348
LIG_UBA3_1	748	753	PF00899	0.601
LIG_WRC_WIRS_1	259	264	PF05994	0.323
LIG_WRC_WIRS_1	281	286	PF05994	0.335
LIG_WRC_WIRS_1	466	471	PF05994	0.382
LIG_WRC_WIRS_1	595	600	PF05994	0.424
MOD_CDK_SPxK_1	384	390	PF00069	0.458
MOD_CDK_SPxxK_3	138	145	PF00069	0.348
MOD_CK1_1	406	412	PF00069	0.271
MOD_CK1_1	468	474	PF00069	0.316
MOD_CK1_1	643	649	PF00069	0.665
MOD_CK2_1	120	126	PF00069	0.392
MOD_CK2_1	143	149	PF00069	0.321
MOD_CK2_1	186	192	PF00069	0.350
MOD_CK2_1	235	241	PF00069	0.455
MOD_CK2_1	273	279	PF00069	0.372
MOD_CK2_1	51	57	PF00069	0.302
MOD_CK2_1	542	548	PF00069	0.380
MOD_CK2_1	73	79	PF00069	0.352
MOD_CMANNOS	720	723	PF00535	0.334
MOD_GlcNHglycan	107	111	PF01048	0.665
MOD_GlcNHglycan	178	181	PF01048	0.619
MOD_GlcNHglycan	289	292	PF01048	0.614
MOD_GlcNHglycan	503	506	PF01048	0.604
MOD_GlcNHglycan	636	640	PF01048	0.544
MOD_GlcNHglycan	642	645	PF01048	0.501
MOD_GlcNHglycan	650	653	PF01048	0.516
MOD_GSK3_1	132	139	PF00069	0.404
MOD_GSK3_1	202	209	PF00069	0.428
MOD_GSK3_1	269	276	PF00069	0.375
MOD_GSK3_1	34	41	PF00069	0.470
MOD_GSK3_1	384	391	PF00069	0.421
MOD_GSK3_1	538	545	PF00069	0.318
MOD_GSK3_1	570	577	PF00069	0.327
MOD_GSK3_1	759	766	PF00069	0.539
MOD_GSK3_1	775	782	PF00069	0.488
MOD_N-GLC_1	512	517	PF02516	0.572
MOD_NEK2_1	185	190	PF00069	0.295
MOD_NEK2_1	258	263	PF00069	0.309
MOD_NEK2_1	267	272	PF00069	0.315
MOD_NEK2_1	273	278	PF00069	0.292
MOD_NEK2_1	33	38	PF00069	0.526
MOD_NEK2_1	346	351	PF00069	0.437
MOD_NEK2_1	403	408	PF00069	0.368
MOD_NEK2_1	73	78	PF00069	0.262
MOD_NEK2_1	775	780	PF00069	0.627
MOD_NEK2_2	388	393	PF00069	0.412
MOD_PIKK_1	241	247	PF00454	0.281
MOD_PIKK_1	273	279	PF00454	0.403
MOD_PKA_2	38	44	PF00069	0.439
MOD_PKA_2	751	757	PF00069	0.583
MOD_Plk_1	273	279	PF00069	0.358
MOD_Plk_1	478	484	PF00069	0.391
MOD_Plk_1	512	518	PF00069	0.373
MOD_Plk_2-3	202	208	PF00069	0.312
MOD_Plk_2-3	763	769	PF00069	0.518
MOD_Plk_2-3	95	101	PF00069	0.322
MOD_Plk_4	186	192	PF00069	0.303
MOD_Plk_4	258	264	PF00069	0.347
MOD_Plk_4	280	286	PF00069	0.384
MOD_Plk_4	539	545	PF00069	0.380
MOD_Plk_4	570	576	PF00069	0.363
MOD_Plk_4	591	597	PF00069	0.271
MOD_ProDKin_1	120	126	PF00069	0.385
MOD_ProDKin_1	132	138	PF00069	0.424
MOD_ProDKin_1	206	212	PF00069	0.272
MOD_ProDKin_1	384	390	PF00069	0.458
MOD_ProDKin_1	499	505	PF00069	0.446
MOD_SUMO_for_1	677	680	PF00179	0.608
MOD_SUMO_rev_2	54	61	PF00179	0.262
MOD_SUMO_rev_2	673	683	PF00179	0.564
MOD_SUMO_rev_2	79	86	PF00179	0.255
MOD_SUMO_rev_2	95	104	PF00179	0.286
TRG_DiLeu_BaEn_1	680	685	PF01217	0.590
TRG_DiLeu_BaEn_2	678	684	PF01217	0.606
TRG_DiLeu_BaEn_4	477	483	PF01217	0.327
TRG_DiLeu_LyEn_5	207	212	PF01217	0.308
TRG_ENDOCYTIC_2	264	267	PF00928	0.306
TRG_ENDOCYTIC_2	315	318	PF00928	0.307
TRG_ENDOCYTIC_2	335	338	PF00928	0.387
TRG_ENDOCYTIC_2	44	47	PF00928	0.244
TRG_ENDOCYTIC_2	466	469	PF00928	0.292
TRG_ENDOCYTIC_2	473	476	PF00928	0.267
TRG_ENDOCYTIC_2	518	521	PF00928	0.398
TRG_ENDOCYTIC_2	537	540	PF00928	0.396
TRG_ENDOCYTIC_2	94	97	PF00928	0.242
TRG_ER_diArg_1	150	152	PF00400	0.355
TRG_ER_diArg_1	655	658	PF00400	0.756
TRG_NLS_MonoExtN_4	581	588	PF00514	0.332
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	410	414	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	772	776	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILW3	Leptomonas seymouri	65%	99%
A0A1X0NIM6	Trypanosomatidae	34%	100%
A0A3Q8IB91	Leishmania donovani	94%	100%
A0A422P3X6	Trypanosoma rangeli	38%	100%
A4HDA9	Leishmania braziliensis	82%	100%
A4I0P2	Leishmania infantum	94%	100%
D0A720	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4QAS9	Leishmania major	92%	100%
V5DSK9	Trypanosoma cruzi	37%	100%