Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWP1_LEIMU

TriTrypDb:

LmxM.24.0510

Length:

776

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWP1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.542
CLV_C14_Caspase3-7	723	727	PF00656	0.552
CLV_NRD_NRD_1	462	464	PF00675	0.693
CLV_NRD_NRD_1	625	627	PF00675	0.420
CLV_PCSK_SKI1_1	139	143	PF00082	0.544
CLV_PCSK_SKI1_1	162	166	PF00082	0.526
CLV_PCSK_SKI1_1	49	53	PF00082	0.462
CLV_PCSK_SKI1_1	626	630	PF00082	0.530
DEG_APCC_DBOX_1	184	192	PF00400	0.597
DEG_Nend_UBRbox_2	1	3	PF02207	0.652
DEG_SCF_FBW7_1	665	671	PF00400	0.454
DEG_SPOP_SBC_1	211	215	PF00917	0.631
DEG_SPOP_SBC_1	309	313	PF00917	0.491
DOC_CDC14_PxL_1	730	738	PF14671	0.502
DOC_CKS1_1	665	670	PF01111	0.457
DOC_CYCLIN_RxL_1	623	633	PF00134	0.455
DOC_CYCLIN_yCln2_LP_2	365	371	PF00134	0.508
DOC_PP1_RVXF_1	405	412	PF00149	0.475
DOC_PP1_SILK_1	764	769	PF00149	0.495
DOC_PP2B_LxvP_1	365	368	PF13499	0.503
DOC_PP2B_LxvP_1	588	591	PF13499	0.617
DOC_PP2B_LxvP_1	713	716	PF13499	0.500
DOC_PP4_FxxP_1	304	307	PF00568	0.612
DOC_USP7_MATH_1	133	137	PF00917	0.368
DOC_USP7_MATH_1	160	164	PF00917	0.573
DOC_USP7_MATH_1	200	204	PF00917	0.614
DOC_USP7_MATH_1	216	220	PF00917	0.506
DOC_USP7_MATH_1	32	36	PF00917	0.502
DOC_USP7_MATH_1	502	506	PF00917	0.534
DOC_USP7_MATH_1	668	672	PF00917	0.556
DOC_USP7_MATH_1	686	690	PF00917	0.602
DOC_USP7_UBL2_3	45	49	PF12436	0.465
DOC_WW_Pin1_4	303	308	PF00397	0.614
DOC_WW_Pin1_4	633	638	PF00397	0.607
DOC_WW_Pin1_4	664	669	PF00397	0.488
LIG_14-3-3_CanoR_1	278	286	PF00244	0.625
LIG_14-3-3_CanoR_1	334	338	PF00244	0.621
LIG_14-3-3_CanoR_1	407	412	PF00244	0.453
LIG_14-3-3_CanoR_1	69	79	PF00244	0.480
LIG_14-3-3_CanoR_1	737	746	PF00244	0.527
LIG_14-3-3_CanoR_1	747	751	PF00244	0.474
LIG_Actin_WH2_2	191	209	PF00022	0.483
LIG_APCC_ABBA_1	290	295	PF00400	0.617
LIG_BRCT_BRCA1_1	310	314	PF00533	0.637
LIG_BRCT_BRCA1_1	670	674	PF00533	0.548
LIG_BRCT_BRCA1_1	716	720	PF00533	0.568
LIG_Clathr_ClatBox_1	110	114	PF01394	0.473
LIG_CSL_BTD_1	286	289	PF09270	0.558
LIG_deltaCOP1_diTrp_1	233	240	PF00928	0.590
LIG_deltaCOP1_diTrp_1	282	287	PF00928	0.619
LIG_EVH1_1	285	289	PF00568	0.571
LIG_FHA_1	133	139	PF00498	0.474
LIG_FHA_1	19	25	PF00498	0.600
LIG_FHA_1	213	219	PF00498	0.665
LIG_FHA_1	222	228	PF00498	0.531
LIG_FHA_1	334	340	PF00498	0.671
LIG_FHA_1	46	52	PF00498	0.462
LIG_FHA_1	583	589	PF00498	0.582
LIG_FHA_1	641	647	PF00498	0.734
LIG_FHA_1	665	671	PF00498	0.502
LIG_FHA_1	759	765	PF00498	0.531
LIG_FHA_2	140	146	PF00498	0.468
LIG_FHA_2	26	32	PF00498	0.533
LIG_FHA_2	53	59	PF00498	0.491
LIG_FHA_2	555	561	PF00498	0.401
LIG_FHA_2	639	645	PF00498	0.424
LIG_LIR_Apic_2	280	286	PF02991	0.665
LIG_LIR_Gen_1	30	41	PF02991	0.496
LIG_LIR_Gen_1	494	504	PF02991	0.468
LIG_LIR_Gen_1	671	678	PF02991	0.552
LIG_LIR_Nem_3	30	36	PF02991	0.508
LIG_LIR_Nem_3	671	677	PF02991	0.525
LIG_MLH1_MIPbox_1	670	674	PF16413	0.475
LIG_MYND_1	288	292	PF01753	0.607
LIG_NRBOX	147	153	PF00104	0.486
LIG_NRBOX	166	172	PF00104	0.481
LIG_PCNA_PIPBox_1	358	367	PF02747	0.448
LIG_PCNA_yPIPBox_3	69	79	PF02747	0.520
LIG_PCNA_yPIPBox_3	82	95	PF02747	0.385
LIG_Pex14_2	137	141	PF04695	0.474
LIG_Pex14_2	411	415	PF04695	0.465
LIG_SH2_STAP1	478	482	PF00017	0.488
LIG_SH3_3	283	289	PF00018	0.572
LIG_SH3_3	304	310	PF00018	0.760
LIG_SH3_3	650	656	PF00018	0.500
LIG_SUMO_SIM_anti_2	763	770	PF11976	0.543
LIG_SUMO_SIM_par_1	643	652	PF11976	0.638
LIG_TRAF2_1	266	269	PF00917	0.663
LIG_TRAF2_1	28	31	PF00917	0.495
LIG_TRAF2_1	414	417	PF00917	0.338
LIG_WRC_WIRS_1	138	143	PF05994	0.497
LIG_WRC_WIRS_1	191	196	PF05994	0.642
LIG_WW_2	288	291	PF00397	0.560
LIG_WW_3	590	594	PF00397	0.503
MOD_CK1_1	126	132	PF00069	0.367
MOD_CK1_1	156	162	PF00069	0.517
MOD_CK1_1	18	24	PF00069	0.606
MOD_CK1_1	308	314	PF00069	0.633
MOD_CK1_1	582	588	PF00069	0.623
MOD_CK1_1	664	670	PF00069	0.607
MOD_CK2_1	160	166	PF00069	0.550
MOD_CK2_1	24	30	PF00069	0.542
MOD_CK2_1	319	325	PF00069	0.599
MOD_CK2_1	502	508	PF00069	0.358
MOD_CK2_1	52	58	PF00069	0.443
MOD_CK2_1	554	560	PF00069	0.400
MOD_CK2_1	638	644	PF00069	0.492
MOD_CK2_1	688	694	PF00069	0.639
MOD_CK2_1	746	752	PF00069	0.458
MOD_CMANNOS	415	418	PF00535	0.516
MOD_GlcNHglycan	107	110	PF01048	0.633
MOD_GlcNHglycan	119	122	PF01048	0.462
MOD_GlcNHglycan	125	128	PF01048	0.406
MOD_GlcNHglycan	155	158	PF01048	0.549
MOD_GlcNHglycan	162	165	PF01048	0.520
MOD_GlcNHglycan	199	203	PF01048	0.598
MOD_GlcNHglycan	218	221	PF01048	0.487
MOD_GlcNHglycan	322	325	PF01048	0.645
MOD_GlcNHglycan	372	375	PF01048	0.389
MOD_GlcNHglycan	508	513	PF01048	0.494
MOD_GlcNHglycan	606	609	PF01048	0.581
MOD_GlcNHglycan	630	633	PF01048	0.516
MOD_GlcNHglycan	690	693	PF01048	0.554
MOD_GlcNHglycan	740	743	PF01048	0.456
MOD_GSK3_1	133	140	PF00069	0.369
MOD_GSK3_1	156	163	PF00069	0.563
MOD_GSK3_1	16	23	PF00069	0.639
MOD_GSK3_1	190	197	PF00069	0.587
MOD_GSK3_1	206	213	PF00069	0.554
MOD_GSK3_1	216	223	PF00069	0.550
MOD_GSK3_1	305	312	PF00069	0.676
MOD_GSK3_1	315	322	PF00069	0.588
MOD_GSK3_1	393	400	PF00069	0.489
MOD_GSK3_1	45	52	PF00069	0.463
MOD_GSK3_1	504	511	PF00069	0.609
MOD_GSK3_1	664	671	PF00069	0.672
MOD_GSK3_1	686	693	PF00069	0.572
MOD_GSK3_1	758	765	PF00069	0.586
MOD_GSK3_1	766	773	PF00069	0.479
MOD_N-GLC_1	604	609	PF02516	0.595
MOD_NEK2_1	137	142	PF00069	0.501
MOD_NEK2_1	206	211	PF00069	0.658
MOD_NEK2_1	397	402	PF00069	0.485
MOD_NEK2_1	542	547	PF00069	0.552
MOD_NEK2_1	628	633	PF00069	0.592
MOD_NEK2_2	32	37	PF00069	0.499
MOD_PIKK_1	422	428	PF00454	0.552
MOD_PIKK_1	486	492	PF00454	0.501
MOD_PIKK_1	52	58	PF00454	0.474
MOD_PIKK_1	668	674	PF00454	0.502
MOD_PIKK_1	73	79	PF00454	0.551
MOD_PK_1	666	672	PF00069	0.446
MOD_PKA_2	206	212	PF00069	0.639
MOD_PKA_2	25	31	PF00069	0.511
MOD_PKA_2	277	283	PF00069	0.632
MOD_PKA_2	333	339	PF00069	0.611
MOD_PKA_2	492	498	PF00069	0.470
MOD_PKA_2	52	58	PF00069	0.492
MOD_PKA_2	554	560	PF00069	0.400
MOD_PKA_2	746	752	PF00069	0.465
MOD_PKA_2	98	104	PF00069	0.462
MOD_Plk_1	473	479	PF00069	0.513
MOD_Plk_1	49	55	PF00069	0.463
MOD_Plk_1	508	514	PF00069	0.556
MOD_Plk_1	762	768	PF00069	0.537
MOD_Plk_4	133	139	PF00069	0.368
MOD_ProDKin_1	303	309	PF00069	0.608
MOD_ProDKin_1	633	639	PF00069	0.607
MOD_ProDKin_1	664	670	PF00069	0.481
MOD_SUMO_rev_2	261	266	PF00179	0.464
MOD_SUMO_rev_2	655	664	PF00179	0.518
TRG_DiLeu_BaEn_1	166	171	PF01217	0.563
TRG_DiLeu_BaEn_1	355	360	PF01217	0.495
TRG_DiLeu_BaEn_2	751	757	PF01217	0.444
TRG_DiLeu_BaEn_4	508	514	PF01217	0.374
TRG_DiLeu_LyEn_5	166	171	PF01217	0.563
TRG_ER_diArg_1	546	549	PF00400	0.509
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	610	614	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7L7	Leptomonas seymouri	35%	100%
A0A3Q8ICS5	Leishmania donovani	88%	100%
A4HDA8	Leishmania braziliensis	72%	100%
A4I0P1	Leishmania infantum	88%	100%
Q4QAT0	Leishmania major	86%	100%