Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWP0_LEIMU

TriTrypDb:

LmxM.24.0500

Length:

238

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AWP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWP0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.704
CLV_NRD_NRD_1	17	19	PF00675	0.501
CLV_NRD_NRD_1	175	177	PF00675	0.740
CLV_NRD_NRD_1	212	214	PF00675	0.603
CLV_NRD_NRD_1	223	225	PF00675	0.531
CLV_NRD_NRD_1	24	26	PF00675	0.482
CLV_NRD_NRD_1	90	92	PF00675	0.592
CLV_PCSK_FUR_1	224	228	PF00082	0.428
CLV_PCSK_KEX2_1	174	176	PF00082	0.745
CLV_PCSK_KEX2_1	212	214	PF00082	0.611
CLV_PCSK_KEX2_1	222	224	PF00082	0.546
CLV_PCSK_KEX2_1	226	228	PF00082	0.528
CLV_PCSK_KEX2_1	23	25	PF00082	0.483
CLV_PCSK_KEX2_1	90	92	PF00082	0.592
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.581
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.582
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.483
CLV_PCSK_SKI1_1	11	15	PF00082	0.562
CLV_PCSK_SKI1_1	124	128	PF00082	0.496
CLV_PCSK_SKI1_1	25	29	PF00082	0.571
CLV_PCSK_SKI1_1	38	42	PF00082	0.610
CLV_PCSK_SKI1_1	91	95	PF00082	0.598
CLV_Separin_Metazoa	8	12	PF03568	0.558
DEG_APCC_DBOX_1	123	131	PF00400	0.704
DEG_Nend_UBRbox_2	1	3	PF02207	0.531
DOC_CYCLIN_RxL_1	33	45	PF00134	0.681
DOC_PP2B_LxvP_1	205	208	PF13499	0.544
DOC_SPAK_OSR1_1	198	202	PF12202	0.655
DOC_USP7_MATH_1	120	124	PF00917	0.722
DOC_USP7_UBL2_3	19	23	PF12436	0.502
DOC_USP7_UBL2_3	222	226	PF12436	0.648
LIG_14-3-3_CanoR_1	72	76	PF00244	0.589
LIG_14-3-3_CanoR_1	90	94	PF00244	0.588
LIG_BIR_III_2	101	105	PF00653	0.587
LIG_FHA_1	4	10	PF00498	0.438
LIG_FHA_1	92	98	PF00498	0.647
LIG_FHA_2	133	139	PF00498	0.706
LIG_Integrin_isoDGR_2	196	198	PF01839	0.456
LIG_Integrin_RGD_1	186	188	PF01839	0.799
LIG_SH2_SRC	77	80	PF00017	0.654
LIG_SH2_STAP1	77	81	PF00017	0.649
LIG_SH3_2	208	213	PF14604	0.632
LIG_SH3_3	162	168	PF00018	0.674
LIG_SH3_3	205	211	PF00018	0.553
LIG_SUMO_SIM_anti_2	6	11	PF11976	0.520
LIG_TRAF2_1	148	151	PF00917	0.737
LIG_TRAF2_1	230	233	PF00917	0.696
LIG_UBA3_1	9	14	PF00899	0.500
MOD_CK1_1	48	54	PF00069	0.627
MOD_CK1_1	80	86	PF00069	0.622
MOD_CK1_1	89	95	PF00069	0.672
MOD_CK2_1	145	151	PF00069	0.634
MOD_CK2_1	214	220	PF00069	0.677
MOD_CK2_1	89	95	PF00069	0.662
MOD_GlcNHglycan	135	138	PF01048	0.717
MOD_GlcNHglycan	48	51	PF01048	0.662
MOD_GlcNHglycan	59	62	PF01048	0.670
MOD_GSK3_1	141	148	PF00069	0.796
MOD_GSK3_1	42	49	PF00069	0.601
MOD_GSK3_1	52	59	PF00069	0.595
MOD_GSK3_1	80	87	PF00069	0.620
MOD_GSK3_1	89	96	PF00069	0.684
MOD_NEK2_1	214	219	PF00069	0.484
MOD_NEK2_1	93	98	PF00069	0.647
MOD_PKA_2	71	77	PF00069	0.619
MOD_PKA_2	89	95	PF00069	0.646
MOD_Plk_1	77	83	PF00069	0.713
MOD_Plk_2-3	145	151	PF00069	0.674
MOD_Plk_4	71	77	PF00069	0.566
TRG_DiLeu_BaEn_1	122	127	PF01217	0.572
TRG_DiLeu_BaEn_4	150	156	PF01217	0.686
TRG_ER_diArg_1	174	176	PF00400	0.589
TRG_ER_diArg_1	211	213	PF00400	0.614
TRG_NLS_Bipartite_1	212	230	PF00514	0.625
TRG_NLS_MonoExtC_3	221	226	PF00514	0.576
TRG_NLS_MonoExtN_4	223	230	PF00514	0.495
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	124	129	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.678
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZZ3	Leptomonas seymouri	46%	100%
A0A3S7WYA2	Leishmania donovani	85%	100%
A4HDA7	Leishmania braziliensis	72%	100%
A4I0P0	Leishmania infantum	85%	100%
Q4QAT1	Leishmania major	87%	98%
V5C0P2	Trypanosoma cruzi	32%	100%