Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWN7_LEIMU

TriTrypDb:

LmxM.24.0470

Length:

421

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWN7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.688
CLV_NRD_NRD_1	230	232	PF00675	0.684
CLV_NRD_NRD_1	372	374	PF00675	0.739
CLV_PCSK_KEX2_1	230	232	PF00082	0.688
CLV_PCSK_KEX2_1	372	374	PF00082	0.634
CLV_PCSK_SKI1_1	234	238	PF00082	0.681
CLV_PCSK_SKI1_1	277	281	PF00082	0.495
CLV_PCSK_SKI1_1	385	389	PF00082	0.726
CLV_PCSK_SKI1_1	66	70	PF00082	0.487
DEG_APCC_DBOX_1	233	241	PF00400	0.492
DOC_CDC14_PxL_1	258	266	PF14671	0.571
DOC_CKS1_1	284	289	PF01111	0.716
DOC_MAPK_gen_1	230	239	PF00069	0.716
DOC_MAPK_gen_1	64	71	PF00069	0.506
DOC_MAPK_MEF2A_6	64	71	PF00069	0.524
DOC_PP4_FxxP_1	246	249	PF00568	0.743
DOC_USP7_MATH_1	271	275	PF00917	0.745
DOC_USP7_MATH_1	310	314	PF00917	0.790
DOC_USP7_MATH_1	359	363	PF00917	0.814
DOC_USP7_MATH_1	400	404	PF00917	0.747
DOC_USP7_MATH_1	417	421	PF00917	0.656
DOC_WW_Pin1_4	105	110	PF00397	0.657
DOC_WW_Pin1_4	269	274	PF00397	0.618
DOC_WW_Pin1_4	280	285	PF00397	0.683
DOC_WW_Pin1_4	294	299	PF00397	0.703
DOC_WW_Pin1_4	327	332	PF00397	0.751
DOC_WW_Pin1_4	360	365	PF00397	0.762
DOC_WW_Pin1_4	388	393	PF00397	0.633
DOC_WW_Pin1_4	394	399	PF00397	0.635
DOC_WW_Pin1_4	7	12	PF00397	0.709
LIG_14-3-3_CanoR_1	234	240	PF00244	0.741
LIG_14-3-3_CanoR_1	312	317	PF00244	0.711
LIG_14-3-3_CanoR_1	385	394	PF00244	0.783
LIG_14-3-3_CanoR_1	401	405	PF00244	0.629
LIG_Actin_WH2_2	249	267	PF00022	0.464
LIG_Actin_WH2_2	54	72	PF00022	0.496
LIG_APCC_ABBA_1	97	102	PF00400	0.525
LIG_BRCT_BRCA1_1	215	219	PF00533	0.518
LIG_BRCT_BRCA1_1	249	253	PF00533	0.694
LIG_BRCT_BRCA1_1	271	275	PF00533	0.634
LIG_BRCT_BRCA1_1	334	338	PF00533	0.496
LIG_Clathr_ClatBox_1	43	47	PF01394	0.443
LIG_DLG_GKlike_1	312	320	PF00625	0.518
LIG_DLG_GKlike_1	373	381	PF00625	0.719
LIG_FHA_1	123	129	PF00498	0.508
LIG_FHA_1	150	156	PF00498	0.595
LIG_FHA_1	324	330	PF00498	0.566
LIG_FHA_2	212	218	PF00498	0.567
LIG_LIR_Apic_2	199	205	PF02991	0.652
LIG_LIR_Apic_2	294	299	PF02991	0.689
LIG_LIR_Gen_1	118	128	PF02991	0.539
LIG_LIR_Gen_1	250	261	PF02991	0.481
LIG_LIR_Gen_1	38	48	PF02991	0.487
LIG_LIR_Nem_3	250	256	PF02991	0.485
LIG_LIR_Nem_3	272	278	PF02991	0.652
LIG_LIR_Nem_3	38	43	PF02991	0.493
LIG_LIR_Nem_3	47	53	PF02991	0.499
LIG_MLH1_MIPbox_1	334	338	PF16413	0.496
LIG_SH2_CRK	202	206	PF00017	0.672
LIG_SH2_NCK_1	175	179	PF00017	0.619
LIG_SH2_PTP2	268	271	PF00017	0.736
LIG_SH2_STAT5	268	271	PF00017	0.634
LIG_SH3_1	328	334	PF00018	0.717
LIG_SH3_2	225	230	PF14604	0.500
LIG_SH3_3	222	228	PF00018	0.590
LIG_SH3_3	267	273	PF00018	0.680
LIG_SH3_3	281	287	PF00018	0.554
LIG_SH3_3	328	334	PF00018	0.711
LIG_SH3_3	98	104	PF00018	0.529
LIG_SUMO_SIM_anti_2	42	47	PF11976	0.455
LIG_SUMO_SIM_par_1	42	47	PF11976	0.455
LIG_SUMO_SIM_par_1	57	63	PF11976	0.449
LIG_TRAF2_1	162	165	PF00917	0.680
LIG_WW_3	297	301	PF00397	0.580
MOD_CDK_SPxK_1	294	300	PF00069	0.761
MOD_CDK_SPxxK_3	394	401	PF00069	0.578
MOD_CK1_1	105	111	PF00069	0.661
MOD_CK1_1	163	169	PF00069	0.664
MOD_CK1_1	209	215	PF00069	0.670
MOD_CK1_1	282	288	PF00069	0.782
MOD_CK1_1	31	37	PF00069	0.629
MOD_CK1_1	315	321	PF00069	0.724
MOD_CK1_1	333	339	PF00069	0.501
MOD_CK1_1	396	402	PF00069	0.732
MOD_CK2_1	211	217	PF00069	0.566
MOD_Cter_Amidation	370	373	PF01082	0.537
MOD_GlcNHglycan	141	144	PF01048	0.542
MOD_GlcNHglycan	209	212	PF01048	0.631
MOD_GlcNHglycan	305	308	PF01048	0.741
MOD_GlcNHglycan	31	34	PF01048	0.620
MOD_GlcNHglycan	312	315	PF01048	0.695
MOD_GlcNHglycan	398	401	PF01048	0.728
MOD_GSK3_1	196	203	PF00069	0.560
MOD_GSK3_1	205	212	PF00069	0.700
MOD_GSK3_1	235	242	PF00069	0.788
MOD_GSK3_1	279	286	PF00069	0.667
MOD_GSK3_1	308	315	PF00069	0.759
MOD_GSK3_1	31	38	PF00069	0.621
MOD_GSK3_1	323	330	PF00069	0.762
MOD_GSK3_1	396	403	PF00069	0.744
MOD_GSK3_1	7	14	PF00069	0.749
MOD_N-GLC_1	303	308	PF02516	0.506
MOD_NEK2_1	150	155	PF00069	0.479
MOD_NEK2_1	207	212	PF00069	0.738
MOD_NEK2_1	235	240	PF00069	0.725
MOD_NEK2_1	279	284	PF00069	0.493
MOD_NEK2_1	316	321	PF00069	0.535
MOD_NEK2_1	60	65	PF00069	0.487
MOD_NEK2_2	380	385	PF00069	0.530
MOD_PKA_2	137	143	PF00069	0.593
MOD_PKA_2	400	406	PF00069	0.693
MOD_PKB_1	136	144	PF00069	0.497
MOD_Plk_4	150	156	PF00069	0.472
MOD_Plk_4	179	185	PF00069	0.539
MOD_Plk_4	235	241	PF00069	0.490
MOD_Plk_4	271	277	PF00069	0.670
MOD_Plk_4	333	339	PF00069	0.788
MOD_Plk_4	35	41	PF00069	0.529
MOD_ProDKin_1	105	111	PF00069	0.658
MOD_ProDKin_1	269	275	PF00069	0.620
MOD_ProDKin_1	280	286	PF00069	0.684
MOD_ProDKin_1	294	300	PF00069	0.704
MOD_ProDKin_1	327	333	PF00069	0.748
MOD_ProDKin_1	360	366	PF00069	0.762
MOD_ProDKin_1	388	394	PF00069	0.636
MOD_ProDKin_1	7	13	PF00069	0.705
TRG_DiLeu_BaLyEn_6	274	279	PF01217	0.478
TRG_ENDOCYTIC_2	175	178	PF00928	0.616
TRG_ER_diArg_1	6	9	PF00400	0.678

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEP2	Leptomonas seymouri	37%	100%
A0A3S7WY45	Leishmania donovani	86%	100%
A4HDU6	Leishmania braziliensis	62%	100%
A4I0N7	Leishmania infantum	87%	100%
Q4QAT4	Leishmania major	85%	100%