LeishMANIAdb
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Hypothetical predicted transmembrane protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical predicted transmembrane protein
Gene product:
Protein of unknown function (DUF3184), putative
Species:
Leishmania mexicana
UniProt:
E9AWN4_LEIMU
TriTrypDb:
LmxM.24.0440
Length:
1373

Annotations

LeishMANIAdb annotations

N-acetylglucosamine-1-phosphotransferase homologous protein. Assumed to be a type II TM protein like its distant relatives.. Signal-anchored glycan biogenesis protein essential for mannose 6-P generation (lysosomal signal for the Metazoan hosts). Family only expended in Leishmaniids.. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
TermNameLevelCount
GO:0005794 Golgi apparatus 5 3
GO:0016020 membrane 2 12
GO:0043226 organelle 2 3
GO:0043227 membrane-bounded organelle 3 3
GO:0043229 intracellular organelle 3 3
GO:0043231 intracellular membrane-bounded organelle 4 3
GO:0110165 cellular anatomical entity 1 12
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Expansion

Sequence features

E9AWN4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

No structure information available for this entry

Related structures:

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 114 118 PF00656 0.233
CLV_C14_Caspase3-7 1331 1335 PF00656 0.431
CLV_C14_Caspase3-7 463 467 PF00656 0.503
CLV_NRD_NRD_1 1035 1037 PF00675 0.592
CLV_NRD_NRD_1 1100 1102 PF00675 0.636
CLV_NRD_NRD_1 1155 1157 PF00675 0.629
CLV_NRD_NRD_1 1177 1179 PF00675 0.634
CLV_NRD_NRD_1 1198 1200 PF00675 0.649
CLV_NRD_NRD_1 1239 1241 PF00675 0.622
CLV_NRD_NRD_1 1313 1315 PF00675 0.632
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Homologs

ProteinTaxonomySequence identityCoverage
A0A3Q8IB67 Leishmania donovani 83% 94%
A0A3S7WY38 Leishmania donovani 91% 100%
A0A3S7WY59 Leishmania donovani 83% 100%
A4HDA4 Leishmania braziliensis 78% 100%
A4HZW0 Leishmania infantum 80% 100%
A4I0N4 Leishmania infantum 91% 100%
E9AVR8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
E9AWN5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4QAT6 Leishmania major 84% 100%
Q4QAT7 Leishmania major 89% 99%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS