Ubiquitin carboxyl-terminal hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C12, putative

Species:

Leishmania mexicana

UniProt:

E9AWN2_LEIMU

TriTrypDb:

LmxM.24.0420

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AWN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWN2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0016579	protein deubiquitination	6	12
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043632	modification-dependent macromolecule catabolic process	5	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044265	obsolete cellular macromolecule catabolic process	4	12
GO:0051603	proteolysis involved in protein catabolic process	5	12
GO:0070646	protein modification by small protein removal	5	12
GO:0070647	protein modification by small protein conjugation or removal	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004843	cysteine-type deubiquitinase activity	5	12
GO:0008233	peptidase activity	3	12
GO:0008234	cysteine-type peptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0019783	ubiquitin-like protein peptidase activity	4	12
GO:0101005	deubiquitinase activity	5	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.502
CLV_C14_Caspase3-7	187	191	PF00656	0.361
CLV_NRD_NRD_1	203	205	PF00675	0.443
CLV_NRD_NRD_1	262	264	PF00675	0.407
CLV_NRD_NRD_1	273	275	PF00675	0.259
CLV_PCSK_KEX2_1	203	205	PF00082	0.389
CLV_PCSK_KEX2_1	272	274	PF00082	0.307
CLV_PCSK_SKI1_1	186	190	PF00082	0.425
CLV_PCSK_SKI1_1	194	198	PF00082	0.400
DEG_APCC_DBOX_1	193	201	PF00400	0.475
DEG_APCC_DBOX_1	290	298	PF00400	0.588
DOC_CYCLIN_RxL_1	108	118	PF00134	0.424
DOC_MAPK_RevD_3	222	238	PF00069	0.480
DOC_PP1_RVXF_1	109	116	PF00149	0.424
DOC_USP7_MATH_1	137	141	PF00917	0.370
DOC_USP7_MATH_1	303	307	PF00917	0.582
DOC_WW_Pin1_4	150	155	PF00397	0.463
LIG_Actin_WH2_2	120	137	PF00022	0.440
LIG_eIF4E_1	50	56	PF01652	0.370
LIG_FHA_1	22	28	PF00498	0.379
LIG_FHA_1	247	253	PF00498	0.460
LIG_FHA_1	87	93	PF00498	0.370
LIG_FHA_2	224	230	PF00498	0.524
LIG_FHA_2	231	237	PF00498	0.517
LIG_FHA_2	248	254	PF00498	0.395
LIG_HCF-1_HBM_1	47	50	PF13415	0.424
LIG_LIR_Gen_1	129	137	PF02991	0.477
LIG_LIR_Gen_1	276	285	PF02991	0.588
LIG_LIR_Gen_1	44	54	PF02991	0.486
LIG_LIR_Gen_1	5	16	PF02991	0.376
LIG_LIR_Nem_3	129	134	PF02991	0.451
LIG_LIR_Nem_3	44	49	PF02991	0.386
LIG_LIR_Nem_3	5	11	PF02991	0.360
LIG_PCNA_yPIPBox_3	272	285	PF02747	0.607
LIG_Rb_LxCxE_1	180	199	PF01857	0.475
LIG_REV1ctd_RIR_1	75	84	PF16727	0.475
LIG_SH2_CRK	50	54	PF00017	0.391
LIG_SH2_GRB2like	112	115	PF00017	0.210
LIG_SH2_NCK_1	46	50	PF00017	0.412
LIG_SH2_SRC	46	49	PF00017	0.502
LIG_SH2_STAP1	46	50	PF00017	0.412
LIG_SH2_STAT3	99	102	PF00017	0.475
LIG_SH2_STAT5	112	115	PF00017	0.446
LIG_SH3_3	225	231	PF00018	0.467
LIG_SUMO_SIM_anti_2	229	236	PF11976	0.471
LIG_SUMO_SIM_anti_2	89	95	PF11976	0.389
LIG_SUMO_SIM_par_1	229	236	PF11976	0.489
LIG_UBA3_1	259	265	PF00899	0.616
LIG_UBA3_1	280	286	PF00899	0.509
LIG_WRC_WIRS_1	128	133	PF05994	0.502
LIG_WRC_WIRS_1	162	167	PF05994	0.355
MOD_CDK_SPK_2	150	155	PF00069	0.424
MOD_CK1_1	145	151	PF00069	0.424
MOD_CK1_1	223	229	PF00069	0.536
MOD_CK1_1	3	9	PF00069	0.636
MOD_CK2_1	127	133	PF00069	0.453
MOD_CK2_1	230	236	PF00069	0.518
MOD_CK2_1	284	290	PF00069	0.588
MOD_CK2_1	38	44	PF00069	0.475
MOD_GlcNHglycan	144	147	PF01048	0.516
MOD_GSK3_1	123	130	PF00069	0.479
MOD_N-GLC_1	3	8	PF02516	0.386
MOD_N-GLC_2	114	116	PF02516	0.210
MOD_N-GLC_2	85	87	PF02516	0.355
MOD_NEK2_1	123	128	PF00069	0.367
MOD_NEK2_1	284	289	PF00069	0.587
MOD_PK_1	28	34	PF00069	0.475
MOD_PKA_2	123	129	PF00069	0.369
MOD_PKA_2	210	216	PF00069	0.389
MOD_Plk_1	3	9	PF00069	0.662
MOD_Plk_2-3	230	236	PF00069	0.556
MOD_Plk_4	123	129	PF00069	0.473
MOD_Plk_4	161	167	PF00069	0.344
MOD_Plk_4	223	229	PF00069	0.536
MOD_Plk_4	230	236	PF00069	0.536
MOD_Plk_4	38	44	PF00069	0.475
MOD_Plk_4	66	72	PF00069	0.463
MOD_ProDKin_1	150	156	PF00069	0.463
MOD_SUMO_rev_2	230	240	PF00179	0.472
TRG_DiLeu_BaEn_3	254	260	PF01217	0.618
TRG_ENDOCYTIC_2	112	115	PF00928	0.475
TRG_ENDOCYTIC_2	277	280	PF00928	0.502
TRG_ENDOCYTIC_2	46	49	PF00928	0.387
TRG_ENDOCYTIC_2	50	53	PF00928	0.345
TRG_ER_diArg_1	203	205	PF00400	0.443
TRG_ER_diArg_1	272	274	PF00400	0.500
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	286	290	PF00026	0.302

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0E1	Leptomonas seymouri	25%	100%
A0A0N1I1H5	Leptomonas seymouri	78%	100%
A0A0S4J7R4	Bodo saltans	47%	99%
A0A0S4JHD6	Bodo saltans	26%	100%
A0A1X0NIK0	Trypanosomatidae	49%	96%
A0A3Q8IGE5	Leishmania donovani	29%	100%
A0A3R7LDV5	Trypanosoma rangeli	54%	99%
A0A3S7WY30	Leishmania donovani	95%	100%
A4HD98	Leishmania braziliensis	91%	100%
A4HDW6	Leishmania braziliensis	28%	100%
A4I161	Leishmania infantum	29%	100%
B4JW98	Drosophila grimshawi	26%	66%
B4KT51	Drosophila mojavensis	27%	67%
B4LQ24	Drosophila virilis	27%	66%
D0A5E6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D0A712	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	99%
E9AH53	Leishmania infantum	95%	100%
E9AX95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
O01391	Aplysia californica	27%	100%
O04482	Arabidopsis thaliana	31%	93%
P15374	Homo sapiens	26%	100%
P35122	Drosophila melanogaster	26%	100%
P58321	Mus musculus	26%	100%
Q00981	Rattus norvegicus	26%	100%
Q06AB3	Sus scrofa	25%	100%
Q06AT3	Sus scrofa	38%	93%
Q09444	Caenorhabditis elegans	34%	96%
Q10171	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q2TBG8	Bos taurus	26%	100%
Q4QA77	Leishmania major	28%	100%
Q4QAT9	Leishmania major	94%	100%
Q54N38	Dictyostelium discoideum	31%	90%
Q54T48	Dictyostelium discoideum	25%	100%
Q8GWE1	Arabidopsis thaliana	24%	100%
Q8IIJ6	Plasmodium falciparum (isolate 3D7)	26%	66%
Q91Y78	Rattus norvegicus	26%	100%
Q9FFF2	Arabidopsis thaliana	32%	92%
Q9JKB1	Mus musculus	26%	100%
Q9R0P9	Mus musculus	26%	100%
Q9UUB6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
Q9WUP7	Mus musculus	39%	93%
Q9XSJ0	Bos taurus	38%	94%
Q9Y5K5	Homo sapiens	38%	93%
V5BN93	Trypanosoma cruzi	28%	100%
V5DSM1	Trypanosoma cruzi	54%	99%