Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWN1_LEIMU

TriTrypDb:

LmxM.24.0410

Length:

748

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWN1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWN1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	476	480	PF00656	0.439
CLV_C14_Caspase3-7	79	83	PF00656	0.488
CLV_NRD_NRD_1	132	134	PF00675	0.767
CLV_NRD_NRD_1	201	203	PF00675	0.736
CLV_NRD_NRD_1	357	359	PF00675	0.452
CLV_NRD_NRD_1	692	694	PF00675	0.616
CLV_NRD_NRD_1	97	99	PF00675	0.649
CLV_PCSK_KEX2_1	201	203	PF00082	0.736
CLV_PCSK_KEX2_1	713	715	PF00082	0.427
CLV_PCSK_KEX2_1	97	99	PF00082	0.649
CLV_PCSK_PC1ET2_1	713	715	PF00082	0.427
CLV_PCSK_SKI1_1	320	324	PF00082	0.531
CLV_PCSK_SKI1_1	445	449	PF00082	0.460
CLV_PCSK_SKI1_1	485	489	PF00082	0.587
CLV_PCSK_SKI1_1	651	655	PF00082	0.677
CLV_PCSK_SKI1_1	714	718	PF00082	0.437
DEG_APCC_DBOX_1	208	216	PF00400	0.706
DEG_APCC_DBOX_1	419	427	PF00400	0.482
DEG_SCF_FBW7_1	114	121	PF00400	0.499
DEG_SCF_FBW7_1	292	298	PF00400	0.546
DEG_SPOP_SBC_1	166	170	PF00917	0.816
DEG_SPOP_SBC_1	295	299	PF00917	0.724
DEG_SPOP_SBC_1	99	103	PF00917	0.730
DOC_CKS1_1	292	297	PF01111	0.546
DOC_CKS1_1	509	514	PF01111	0.376
DOC_CYCLIN_RxL_1	482	490	PF00134	0.292
DOC_CYCLIN_yCln2_LP_2	726	732	PF00134	0.650
DOC_MAPK_gen_1	666	674	PF00069	0.521
DOC_MAPK_gen_1	690	698	PF00069	0.618
DOC_MAPK_MEF2A_6	557	565	PF00069	0.449
DOC_MAPK_MEF2A_6	668	676	PF00069	0.529
DOC_PP1_RVXF_1	422	429	PF00149	0.494
DOC_PP1_RVXF_1	443	449	PF00149	0.475
DOC_PP2B_LxvP_1	267	270	PF13499	0.746
DOC_PP2B_LxvP_1	696	699	PF13499	0.626
DOC_PP2B_LxvP_1	726	729	PF13499	0.584
DOC_PP2B_PxIxI_1	111	117	PF00149	0.577
DOC_USP7_MATH_1	118	122	PF00917	0.609
DOC_USP7_MATH_1	167	171	PF00917	0.770
DOC_USP7_MATH_1	196	200	PF00917	0.674
DOC_USP7_MATH_1	231	235	PF00917	0.702
DOC_USP7_MATH_1	249	253	PF00917	0.811
DOC_USP7_MATH_1	254	258	PF00917	0.730
DOC_USP7_MATH_1	325	329	PF00917	0.642
DOC_USP7_MATH_1	624	628	PF00917	0.581
DOC_USP7_MATH_1	641	645	PF00917	0.336
DOC_USP7_MATH_1	9	13	PF00917	0.391
DOC_USP7_MATH_1	99	103	PF00917	0.727
DOC_USP7_MATH_2	569	575	PF00917	0.539
DOC_USP7_UBL2_3	713	717	PF12436	0.440
DOC_WW_Pin1_4	114	119	PF00397	0.761
DOC_WW_Pin1_4	133	138	PF00397	0.751
DOC_WW_Pin1_4	213	218	PF00397	0.787
DOC_WW_Pin1_4	250	255	PF00397	0.785
DOC_WW_Pin1_4	270	275	PF00397	0.587
DOC_WW_Pin1_4	291	296	PF00397	0.560
DOC_WW_Pin1_4	508	513	PF00397	0.394
DOC_WW_Pin1_4	547	552	PF00397	0.517
DOC_WW_Pin1_4	627	632	PF00397	0.556
LIG_14-3-3_CanoR_1	29	33	PF00244	0.503
LIG_14-3-3_CanoR_1	365	371	PF00244	0.577
LIG_14-3-3_CanoR_1	408	418	PF00244	0.579
LIG_14-3-3_CanoR_1	49	53	PF00244	0.430
LIG_14-3-3_CanoR_1	693	697	PF00244	0.631
LIG_14-3-3_CanoR_1	97	107	PF00244	0.726
LIG_Actin_WH2_2	39	55	PF00022	0.638
LIG_Actin_WH2_2	474	491	PF00022	0.459
LIG_Actin_WH2_2	561	579	PF00022	0.545
LIG_APCC_ABBAyCdc20_2	305	311	PF00400	0.621
LIG_BRCT_BRCA1_1	574	578	PF00533	0.456
LIG_Clathr_ClatBox_1	439	443	PF01394	0.533
LIG_CSL_BTD_1	193	196	PF09270	0.754
LIG_FHA_1	264	270	PF00498	0.826
LIG_FHA_1	278	284	PF00498	0.588
LIG_FHA_1	305	311	PF00498	0.615
LIG_FHA_1	328	334	PF00498	0.692
LIG_FHA_1	45	51	PF00498	0.522
LIG_FHA_1	548	554	PF00498	0.527
LIG_FHA_1	571	577	PF00498	0.259
LIG_FHA_1	617	623	PF00498	0.444
LIG_FHA_1	638	644	PF00498	0.530
LIG_FHA_1	693	699	PF00498	0.730
LIG_FHA_1	83	89	PF00498	0.481
LIG_FHA_2	36	42	PF00498	0.512
LIG_LIR_Gen_1	256	267	PF02991	0.673
LIG_LIR_Gen_1	532	541	PF02991	0.564
LIG_LIR_Nem_3	256	262	PF02991	0.672
LIG_LIR_Nem_3	443	447	PF02991	0.486
LIG_LIR_Nem_3	522	527	PF02991	0.552
LIG_LIR_Nem_3	532	536	PF02991	0.480
LIG_LIR_Nem_3	538	544	PF02991	0.434
LIG_LIR_Nem_3	562	568	PF02991	0.437
LIG_LIR_Nem_3	575	581	PF02991	0.457
LIG_LIR_Nem_3	657	662	PF02991	0.489
LIG_LIR_Nem_3	700	706	PF02991	0.706
LIG_LYPXL_S_1	540	544	PF13949	0.562
LIG_LYPXL_yS_3	541	544	PF13949	0.566
LIG_NRBOX	351	357	PF00104	0.563
LIG_NRBOX	734	740	PF00104	0.533
LIG_PCNA_yPIPBox_3	471	485	PF02747	0.526
LIG_Pex14_2	444	448	PF04695	0.475
LIG_SH2_CRK	339	343	PF00017	0.346
LIG_SH2_CRK	363	367	PF00017	0.512
LIG_SH2_CRK	435	439	PF00017	0.476
LIG_SH2_CRK	470	474	PF00017	0.455
LIG_SH2_CRK	566	570	PF00017	0.431
LIG_SH2_CRK	63	67	PF00017	0.504
LIG_SH2_GRB2like	17	20	PF00017	0.486
LIG_SH2_NCK_1	566	570	PF00017	0.431
LIG_SH2_SRC	17	20	PF00017	0.486
LIG_SH2_SRC	566	569	PF00017	0.431
LIG_SH2_SRC	635	638	PF00017	0.623
LIG_SH2_STAP1	595	599	PF00017	0.602
LIG_SH2_STAP1	722	726	PF00017	0.575
LIG_SH2_STAT5	17	20	PF00017	0.486
LIG_SH2_STAT5	422	425	PF00017	0.593
LIG_SH2_STAT5	45	48	PF00017	0.611
LIG_SH2_STAT5	635	638	PF00017	0.623
LIG_SH2_STAT5	681	684	PF00017	0.525
LIG_SH3_1	313	319	PF00018	0.651
LIG_SH3_3	103	109	PF00018	0.675
LIG_SH3_3	192	198	PF00018	0.764
LIG_SH3_3	248	254	PF00018	0.735
LIG_SH3_3	289	295	PF00018	0.622
LIG_SH3_3	313	319	PF00018	0.522
LIG_SH3_3	400	406	PF00018	0.445
LIG_SH3_3	427	433	PF00018	0.625
LIG_SH3_3	480	486	PF00018	0.266
LIG_SH3_3	499	505	PF00018	0.438
LIG_SH3_3	506	512	PF00018	0.548
LIG_SH3_3	596	602	PF00018	0.583
LIG_SH3_3	631	637	PF00018	0.480
LIG_SH3_4	504	511	PF00018	0.704
LIG_SUMO_SIM_par_1	112	117	PF11976	0.653
LIG_SUMO_SIM_par_1	437	443	PF11976	0.432
LIG_SUMO_SIM_par_1	694	701	PF11976	0.634
LIG_SUMO_SIM_par_1	84	89	PF11976	0.475
LIG_UBA3_1	383	390	PF00899	0.695
LIG_WRC_WIRS_1	326	331	PF05994	0.439
LIG_WRC_WIRS_1	515	520	PF05994	0.546
LIG_WW_3	317	321	PF00397	0.522
LIG_WW_3	405	409	PF00397	0.538
LIG_WW_3	458	462	PF00397	0.720
MOD_CDK_SPxK_1	114	120	PF00069	0.682
MOD_CDK_SPxxK_3	137	144	PF00069	0.749
MOD_CK1_1	233	239	PF00069	0.642
MOD_CK1_1	257	263	PF00069	0.661
MOD_CK1_1	344	350	PF00069	0.516
MOD_CK1_1	35	41	PF00069	0.505
MOD_CK1_1	409	415	PF00069	0.526
MOD_CK1_1	627	633	PF00069	0.559
MOD_CK1_1	683	689	PF00069	0.646
MOD_CK1_1	697	703	PF00069	0.494
MOD_CK2_1	201	207	PF00069	0.835
MOD_CK2_1	249	255	PF00069	0.708
MOD_CK2_1	347	353	PF00069	0.483
MOD_CK2_1	35	41	PF00069	0.527
MOD_CK2_1	516	522	PF00069	0.325
MOD_Cter_Amidation	131	134	PF01082	0.779
MOD_GlcNHglycan	11	14	PF01048	0.340
MOD_GlcNHglycan	119	123	PF01048	0.626
MOD_GlcNHglycan	128	131	PF01048	0.840
MOD_GlcNHglycan	137	140	PF01048	0.713
MOD_GlcNHglycan	226	229	PF01048	0.719
MOD_GlcNHglycan	247	250	PF01048	0.821
MOD_GlcNHglycan	285	288	PF01048	0.739
MOD_GlcNHglycan	333	336	PF01048	0.576
MOD_GlcNHglycan	343	346	PF01048	0.515
MOD_GlcNHglycan	403	406	PF01048	0.449
MOD_GlcNHglycan	408	411	PF01048	0.463
MOD_GlcNHglycan	578	581	PF01048	0.452
MOD_GlcNHglycan	685	688	PF01048	0.556
MOD_GlcNHglycan	69	72	PF01048	0.544
MOD_GlcNHglycan	703	706	PF01048	0.506
MOD_GSK3_1	114	121	PF00069	0.499
MOD_GSK3_1	133	140	PF00069	0.702
MOD_GSK3_1	167	174	PF00069	0.822
MOD_GSK3_1	211	218	PF00069	0.607
MOD_GSK3_1	245	252	PF00069	0.752
MOD_GSK3_1	254	261	PF00069	0.654
MOD_GSK3_1	268	275	PF00069	0.601
MOD_GSK3_1	28	35	PF00069	0.503
MOD_GSK3_1	291	298	PF00069	0.725
MOD_GSK3_1	325	332	PF00069	0.635
MOD_GSK3_1	344	351	PF00069	0.409
MOD_GSK3_1	406	413	PF00069	0.572
MOD_GSK3_1	44	51	PF00069	0.504
MOD_GSK3_1	5	12	PF00069	0.540
MOD_GSK3_1	572	579	PF00069	0.453
MOD_GSK3_1	637	644	PF00069	0.584
MOD_GSK3_1	694	701	PF00069	0.627
MOD_GSK3_1	82	89	PF00069	0.490
MOD_N-GLC_1	513	518	PF02516	0.521
MOD_N-GLC_1	654	659	PF02516	0.612
MOD_NEK2_1	258	263	PF00069	0.833
MOD_NEK2_1	329	334	PF00069	0.697
MOD_NEK2_1	346	351	PF00069	0.379
MOD_NEK2_1	366	371	PF00069	0.570
MOD_NEK2_1	383	388	PF00069	0.459
MOD_NEK2_1	434	439	PF00069	0.515
MOD_NEK2_1	572	577	PF00069	0.450
MOD_NEK2_1	654	659	PF00069	0.540
MOD_NEK2_1	692	697	PF00069	0.725
MOD_NEK2_2	254	259	PF00069	0.622
MOD_NEK2_2	304	309	PF00069	0.631
MOD_NEK2_2	48	53	PF00069	0.365
MOD_OGLYCOS	284	289	PF02709	0.528
MOD_PIKK_1	201	207	PF00454	0.711
MOD_PIKK_1	231	237	PF00454	0.755
MOD_PIKK_1	516	522	PF00454	0.493
MOD_PK_1	211	217	PF00069	0.746
MOD_PK_1	694	700	PF00069	0.654
MOD_PKA_1	201	207	PF00069	0.660
MOD_PKA_1	97	103	PF00069	0.666
MOD_PKA_2	186	192	PF00069	0.729
MOD_PKA_2	201	207	PF00069	0.711
MOD_PKA_2	277	283	PF00069	0.723
MOD_PKA_2	28	34	PF00069	0.497
MOD_PKA_2	304	310	PF00069	0.625
MOD_PKA_2	48	54	PF00069	0.341
MOD_PKA_2	597	603	PF00069	0.583
MOD_PKA_2	692	698	PF00069	0.724
MOD_PKA_2	97	103	PF00069	0.666
MOD_PKB_1	209	217	PF00069	0.744
MOD_PKB_1	222	230	PF00069	0.762
MOD_Plk_1	254	260	PF00069	0.642
MOD_Plk_1	513	519	PF00069	0.500
MOD_Plk_1	654	660	PF00069	0.423
MOD_Plk_4	174	180	PF00069	0.546
MOD_Plk_4	254	260	PF00069	0.642
MOD_Plk_4	304	310	PF00069	0.625
MOD_Plk_4	413	419	PF00069	0.572
MOD_Plk_4	434	440	PF00069	0.451
MOD_Plk_4	680	686	PF00069	0.583
MOD_Plk_4	82	88	PF00069	0.579
MOD_ProDKin_1	114	120	PF00069	0.770
MOD_ProDKin_1	133	139	PF00069	0.752
MOD_ProDKin_1	213	219	PF00069	0.786
MOD_ProDKin_1	250	256	PF00069	0.786
MOD_ProDKin_1	270	276	PF00069	0.585
MOD_ProDKin_1	291	297	PF00069	0.560
MOD_ProDKin_1	508	514	PF00069	0.388
MOD_ProDKin_1	547	553	PF00069	0.518
MOD_ProDKin_1	627	633	PF00069	0.559
TRG_DiLeu_BaEn_1	490	495	PF01217	0.571
TRG_DiLeu_BaEn_1	734	739	PF01217	0.553
TRG_DiLeu_BaLyEn_6	442	447	PF01217	0.455
TRG_DiLeu_BaLyEn_6	458	463	PF01217	0.457
TRG_DiLeu_BaLyEn_6	483	488	PF01217	0.282
TRG_DiLeu_BaLyEn_6	605	610	PF01217	0.596
TRG_ENDOCYTIC_2	363	366	PF00928	0.522
TRG_ENDOCYTIC_2	435	438	PF00928	0.503
TRG_ENDOCYTIC_2	470	473	PF00928	0.460
TRG_ENDOCYTIC_2	541	544	PF00928	0.566
TRG_ENDOCYTIC_2	63	66	PF00928	0.512
TRG_ENDOCYTIC_2	681	684	PF00928	0.547
TRG_ER_diArg_1	200	202	PF00400	0.735
TRG_ER_diArg_1	221	224	PF00400	0.765
TRG_ER_diArg_1	663	666	PF00400	0.537
TRG_ER_diArg_1	97	99	PF00400	0.649
TRG_Pf-PMV_PEXEL_1	424	429	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	461	465	PF00026	0.662
TRG_Pf-PMV_PEXEL_1	485	490	PF00026	0.374

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I868	Leptomonas seymouri	53%	95%
A0A3S7WY82	Leishmania donovani	87%	99%
A4HD97	Leishmania braziliensis	75%	100%
E9AH52	Leishmania infantum	88%	99%
Q4QAU0	Leishmania major	86%	100%