LeishMANIAdb
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SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
SET domain-containing protein
Gene product:
TPR repeat, putative
Species:
Leishmania mexicana
UniProt:
E9AWN0_LEIMU
TriTrypDb:
LmxM.24.0400
Length:
660

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005576 extracellular region 2 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

E9AWN0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWN0

Function

Biological processes
Term Name Level Count
GO:0009892 negative regulation of metabolic process 4 1
GO:0010468 regulation of gene expression 5 1
GO:0010605 negative regulation of macromolecule metabolic process 5 1
GO:0010629 negative regulation of gene expression 6 1
GO:0019222 regulation of metabolic process 3 1
GO:0040029 epigenetic regulation of gene expression 6 1
GO:0045814 negative regulation of gene expression, epigenetic 7 1
GO:0048519 negative regulation of biological process 3 1
GO:0050789 regulation of biological process 2 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0006457 protein folding 2 1
GO:0009987 cellular process 1 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0008168 methyltransferase activity 4 1
GO:0008170 N-methyltransferase activity 5 1
GO:0008276 protein methyltransferase activity 3 1
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 5 1
GO:0016278 lysine N-methyltransferase activity 6 1
GO:0016279 protein-lysine N-methyltransferase activity 4 1
GO:0016740 transferase activity 2 1
GO:0016741 transferase activity, transferring one-carbon groups 3 1
GO:0018024 obsolete histone lysine N-methyltransferase activity 5 1
GO:0042054 histone methyltransferase activity 4 1
GO:0042799 histone H4K20 methyltransferase activity 6 1
GO:0140096 catalytic activity, acting on a protein 2 1
GO:0005102 signaling receptor binding 3 3
GO:0005179 hormone activity 5 3
GO:0005184 neuropeptide hormone activity 6 3
GO:0005488 binding 1 4
GO:0005515 protein binding 2 4
GO:0030545 signaling receptor regulator activity 2 3
GO:0030546 signaling receptor activator activity 3 3
GO:0048018 receptor ligand activity 4 3
GO:0098772 molecular function regulator activity 1 3
GO:0140677 molecular function activator activity 2 3
GO:0030544 Hsp70 protein binding 4 1
GO:0031072 heat shock protein binding 3 1
GO:0051879 Hsp90 protein binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 553 557 PF00656 0.506
CLV_C14_Caspase3-7 585 589 PF00656 0.442
CLV_NRD_NRD_1 112 114 PF00675 0.391
CLV_NRD_NRD_1 139 141 PF00675 0.528
CLV_NRD_NRD_1 164 166 PF00675 0.262
CLV_NRD_NRD_1 184 186 PF00675 0.433
CLV_NRD_NRD_1 237 239 PF00675 0.536
CLV_NRD_NRD_1 357 359 PF00675 0.344
CLV_NRD_NRD_1 617 619 PF00675 0.281
CLV_NRD_NRD_1 63 65 PF00675 0.455
CLV_PCSK_KEX2_1 111 113 PF00082 0.387
CLV_PCSK_KEX2_1 139 141 PF00082 0.506
CLV_PCSK_KEX2_1 164 166 PF00082 0.262
CLV_PCSK_KEX2_1 184 186 PF00082 0.430
CLV_PCSK_KEX2_1 237 239 PF00082 0.524
CLV_PCSK_KEX2_1 243 245 PF00082 0.454
CLV_PCSK_KEX2_1 356 358 PF00082 0.320
CLV_PCSK_KEX2_1 617 619 PF00082 0.281
CLV_PCSK_KEX2_1 63 65 PF00082 0.455
CLV_PCSK_PC1ET2_1 243 245 PF00082 0.486
CLV_PCSK_PC1ET2_1 356 358 PF00082 0.333
CLV_PCSK_SKI1_1 129 133 PF00082 0.383
CLV_PCSK_SKI1_1 139 143 PF00082 0.457
CLV_PCSK_SKI1_1 244 248 PF00082 0.380
CLV_PCSK_SKI1_1 282 286 PF00082 0.482
CLV_PCSK_SKI1_1 358 362 PF00082 0.469
CLV_PCSK_SKI1_1 430 434 PF00082 0.508
CLV_PCSK_SKI1_1 477 481 PF00082 0.325
CLV_PCSK_SKI1_1 512 516 PF00082 0.489
CLV_PCSK_SKI1_1 592 596 PF00082 0.374
CLV_PCSK_SKI1_1 654 658 PF00082 0.432
CLV_Separin_Metazoa 359 363 PF03568 0.493
DEG_Nend_UBRbox_2 1 3 PF02207 0.547
DEG_SCF_FBW7_1 599 606 PF00400 0.467
DEG_SPOP_SBC_1 53 57 PF00917 0.446
DEG_SPOP_SBC_1 551 555 PF00917 0.442
DOC_CKS1_1 600 605 PF01111 0.475
DOC_CYCLIN_RxL_1 123 135 PF00134 0.468
DOC_CYCLIN_RxL_1 355 363 PF00134 0.433
DOC_CYCLIN_yCln2_LP_2 573 579 PF00134 0.356
DOC_CYCLIN_yCln2_LP_2 607 613 PF00134 0.285
DOC_MAPK_gen_1 164 172 PF00069 0.235
DOC_MAPK_gen_1 63 69 PF00069 0.428
DOC_MAPK_MEF2A_6 164 172 PF00069 0.416
DOC_PP1_RVXF_1 188 195 PF00149 0.475
DOC_PP1_RVXF_1 199 205 PF00149 0.389
DOC_PP2B_LxvP_1 573 576 PF13499 0.462
DOC_PP2B_LxvP_1 607 610 PF13499 0.256
DOC_USP7_MATH_1 233 237 PF00917 0.546
DOC_USP7_MATH_1 307 311 PF00917 0.341
DOC_USP7_MATH_1 443 447 PF00917 0.287
DOC_USP7_MATH_1 53 57 PF00917 0.754
DOC_USP7_MATH_1 603 607 PF00917 0.425
DOC_USP7_UBL2_3 462 466 PF12436 0.251
DOC_USP7_UBL2_3 654 658 PF12436 0.433
DOC_WW_Pin1_4 164 169 PF00397 0.465
DOC_WW_Pin1_4 423 428 PF00397 0.480
DOC_WW_Pin1_4 599 604 PF00397 0.473
LIG_14-3-3_CanoR_1 493 501 PF00244 0.532
LIG_14-3-3_CanoR_1 502 508 PF00244 0.496
LIG_14-3-3_CanoR_1 639 643 PF00244 0.556
LIG_14-3-3_CanoR_1 84 88 PF00244 0.360
LIG_APCC_ABBA_1 467 472 PF00400 0.362
LIG_APCC_ABBAyCdc20_2 190 196 PF00400 0.465
LIG_APCC_ABBAyCdc20_2 430 436 PF00400 0.262
LIG_APCC_ABBAyCdc20_2 466 472 PF00400 0.472
LIG_BRCT_BRCA1_1 297 301 PF00533 0.379
LIG_BRCT_BRCA1_1 362 366 PF00533 0.365
LIG_CSL_BTD_1 424 427 PF09270 0.489
LIG_deltaCOP1_diTrp_1 472 480 PF00928 0.444
LIG_FHA_1 145 151 PF00498 0.509
LIG_FHA_1 215 221 PF00498 0.429
LIG_FHA_1 301 307 PF00498 0.451
LIG_FHA_1 462 468 PF00498 0.495
LIG_FHA_1 486 492 PF00498 0.331
LIG_FHA_1 520 526 PF00498 0.462
LIG_FHA_2 447 453 PF00498 0.466
LIG_FHA_2 55 61 PF00498 0.638
LIG_FHA_2 551 557 PF00498 0.495
LIG_FHA_2 92 98 PF00498 0.385
LIG_HCF-1_HBM_1 196 199 PF13415 0.492
LIG_LIR_Apic_2 124 130 PF02991 0.470
LIG_LIR_Apic_2 522 526 PF02991 0.436
LIG_LIR_Gen_1 196 204 PF02991 0.466
LIG_LIR_Gen_1 236 246 PF02991 0.348
LIG_LIR_Gen_1 74 85 PF02991 0.454
LIG_LIR_LC3C_4 504 508 PF02991 0.255
LIG_LIR_Nem_3 196 202 PF02991 0.475
LIG_LIR_Nem_3 236 242 PF02991 0.370
LIG_LIR_Nem_3 271 276 PF02991 0.526
LIG_LIR_Nem_3 278 284 PF02991 0.385
LIG_LIR_Nem_3 74 80 PF02991 0.443
LIG_MLH1_MIPbox_1 297 301 PF16413 0.379
LIG_NRBOX 569 575 PF00104 0.451
LIG_NRBOX 64 70 PF00104 0.496
LIG_Pex14_1 631 635 PF04695 0.374
LIG_Pex14_2 242 246 PF04695 0.381
LIG_Pex14_2 296 300 PF04695 0.425
LIG_Pex14_2 83 87 PF04695 0.455
LIG_PTB_Apo_2 338 345 PF02174 0.360
LIG_PTB_Phospho_1 338 344 PF10480 0.362
LIG_REV1ctd_RIR_1 298 306 PF16727 0.322
LIG_SH2_CRK 199 203 PF00017 0.528
LIG_SH2_CRK 476 480 PF00017 0.342
LIG_SH2_GRB2like 70 73 PF00017 0.357
LIG_SH2_NCK_1 199 203 PF00017 0.528
LIG_SH2_NCK_1 319 323 PF00017 0.529
LIG_SH2_STAT5 127 130 PF00017 0.434
LIG_SH2_STAT5 199 202 PF00017 0.542
LIG_SH2_STAT5 223 226 PF00017 0.428
LIG_SH2_STAT5 344 347 PF00017 0.365
LIG_SH2_STAT5 448 451 PF00017 0.525
LIG_SH2_STAT5 481 484 PF00017 0.337
LIG_SH2_STAT5 524 527 PF00017 0.473
LIG_SH2_STAT5 622 625 PF00017 0.395
LIG_SH2_STAT5 77 80 PF00017 0.445
LIG_SH3_3 421 427 PF00018 0.531
LIG_SH3_3 573 579 PF00018 0.340
LIG_SUMO_SIM_anti_2 169 174 PF11976 0.488
LIG_SUMO_SIM_anti_2 566 572 PF11976 0.427
LIG_SUMO_SIM_par_1 327 332 PF11976 0.454
LIG_SUMO_SIM_par_1 566 572 PF11976 0.453
LIG_TRAF2_1 321 324 PF00917 0.521
LIG_TRAF2_1 58 61 PF00917 0.582
LIG_WRC_WIRS_1 438 443 PF05994 0.419
LIG_WRPW_2 101 104 PF00400 0.491
MOD_CDK_SPxxK_3 423 430 PF00069 0.390
MOD_CK1_1 207 213 PF00069 0.603
MOD_CK1_1 377 383 PF00069 0.407
MOD_CK1_1 446 452 PF00069 0.423
MOD_CK1_1 52 58 PF00069 0.690
MOD_CK1_1 554 560 PF00069 0.546
MOD_CK1_1 71 77 PF00069 0.237
MOD_CK2_1 216 222 PF00069 0.265
MOD_CK2_1 317 323 PF00069 0.485
MOD_CK2_1 446 452 PF00069 0.476
MOD_CK2_1 54 60 PF00069 0.664
MOD_CMANNOS 101 104 PF00535 0.491
MOD_CMANNOS 364 367 PF00535 0.360
MOD_Cter_Amidation 354 357 PF01082 0.319
MOD_GlcNHglycan 17 20 PF01048 0.498
MOD_GlcNHglycan 205 209 PF01048 0.599
MOD_GlcNHglycan 297 300 PF01048 0.394
MOD_GlcNHglycan 387 391 PF01048 0.478
MOD_GlcNHglycan 396 399 PF01048 0.460
MOD_GlcNHglycan 419 422 PF01048 0.522
MOD_GlcNHglycan 494 497 PF01048 0.451
MOD_GlcNHglycan 51 54 PF01048 0.749
MOD_GlcNHglycan 556 559 PF01048 0.543
MOD_GSK3_1 204 211 PF00069 0.580
MOD_GSK3_1 264 271 PF00069 0.482
MOD_GSK3_1 318 325 PF00069 0.444
MOD_GSK3_1 386 393 PF00069 0.343
MOD_GSK3_1 437 444 PF00069 0.500
MOD_GSK3_1 48 55 PF00069 0.709
MOD_GSK3_1 550 557 PF00069 0.542
MOD_GSK3_1 599 606 PF00069 0.504
MOD_GSK3_1 633 640 PF00069 0.501
MOD_N-GLC_1 307 312 PF02516 0.341
MOD_N-GLC_1 71 76 PF02516 0.343
MOD_NEK2_1 121 126 PF00069 0.468
MOD_NEK2_1 204 209 PF00069 0.522
MOD_NEK2_1 284 289 PF00069 0.419
MOD_NEK2_1 300 305 PF00069 0.279
MOD_NEK2_1 317 322 PF00069 0.417
MOD_NEK2_1 360 365 PF00069 0.460
MOD_NEK2_1 394 399 PF00069 0.461
MOD_NEK2_1 437 442 PF00069 0.429
MOD_NEK2_1 563 568 PF00069 0.433
MOD_NEK2_1 637 642 PF00069 0.490
MOD_NEK2_1 68 73 PF00069 0.406
MOD_NEK2_2 307 312 PF00069 0.423
MOD_OFUCOSY 304 311 PF10250 0.329
MOD_PIKK_1 208 214 PF00454 0.573
MOD_PIKK_1 374 380 PF00454 0.481
MOD_PIKK_1 456 462 PF00454 0.481
MOD_PIKK_1 501 507 PF00454 0.526
MOD_PK_1 318 324 PF00069 0.518
MOD_PKA_1 139 145 PF00069 0.542
MOD_PKA_2 139 145 PF00069 0.477
MOD_PKA_2 261 267 PF00069 0.546
MOD_PKA_2 374 380 PF00069 0.443
MOD_PKA_2 492 498 PF00069 0.512
MOD_PKA_2 501 507 PF00069 0.514
MOD_PKA_2 638 644 PF00069 0.560
MOD_PKA_2 83 89 PF00069 0.406
MOD_Plk_1 322 328 PF00069 0.458
MOD_Plk_2-3 582 588 PF00069 0.477
MOD_Plk_4 216 222 PF00069 0.509
MOD_Plk_4 443 449 PF00069 0.462
MOD_Plk_4 519 525 PF00069 0.456
MOD_Plk_4 563 569 PF00069 0.497
MOD_Plk_4 618 624 PF00069 0.419
MOD_ProDKin_1 164 170 PF00069 0.457
MOD_ProDKin_1 423 429 PF00069 0.477
MOD_ProDKin_1 599 605 PF00069 0.467
MOD_SUMO_for_1 8 11 PF00179 0.447
MOD_SUMO_rev_2 191 200 PF00179 0.488
MOD_SUMO_rev_2 41 49 PF00179 0.501
MOD_SUMO_rev_2 504 514 PF00179 0.482
TRG_DiLeu_BaEn_1 428 433 PF01217 0.342
TRG_DiLeu_BaEn_3 323 329 PF01217 0.474
TRG_DiLeu_BaEn_4 60 66 PF01217 0.519
TRG_DiLeu_BaLyEn_6 127 132 PF01217 0.358
TRG_DiLeu_BaLyEn_6 30 35 PF01217 0.336
TRG_DiLeu_BaLyEn_6 405 410 PF01217 0.459
TRG_ENDOCYTIC_2 199 202 PF00928 0.514
TRG_ENDOCYTIC_2 319 322 PF00928 0.511
TRG_ENDOCYTIC_2 476 479 PF00928 0.312
TRG_ENDOCYTIC_2 70 73 PF00928 0.339
TRG_ENDOCYTIC_2 77 80 PF00928 0.369
TRG_ER_diArg_1 111 113 PF00400 0.412
TRG_ER_diArg_1 139 141 PF00400 0.515
TRG_ER_diArg_1 163 165 PF00400 0.391
TRG_ER_diArg_1 227 230 PF00400 0.520
TRG_ER_diArg_1 237 239 PF00400 0.491
TRG_ER_diArg_1 269 272 PF00400 0.510
TRG_ER_diArg_1 616 618 PF00400 0.280
TRG_ER_diArg_1 63 65 PF00400 0.455
TRG_NES_CRM1_1 452 465 PF08389 0.407
TRG_Pf-PMV_PEXEL_1 164 169 PF00026 0.252

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I9W0 Leptomonas seymouri 65% 100%
A0A0S4J867 Bodo saltans 32% 100%
A0A1X0NIX9 Trypanosomatidae 38% 98%
A0A3S5H7C8 Leishmania donovani 92% 100%
A0A422P403 Trypanosoma rangeli 38% 100%
A4HD96 Leishmania braziliensis 85% 100%
D0A710 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
E9AH51 Leishmania infantum 92% 100%
Q4QAU1 Leishmania major 90% 100%
V5BRA0 Trypanosoma cruzi 40% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS