Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWM9_LEIMU

TriTrypDb:

LmxM.24.0390

Length:

771

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9AWM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWM9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.411
CLV_NRD_NRD_1	114	116	PF00675	0.401
CLV_NRD_NRD_1	547	549	PF00675	0.712
CLV_NRD_NRD_1	626	628	PF00675	0.658
CLV_NRD_NRD_1	728	730	PF00675	0.611
CLV_PCSK_KEX2_1	114	116	PF00082	0.401
CLV_PCSK_KEX2_1	547	549	PF00082	0.639
CLV_PCSK_KEX2_1	728	730	PF00082	0.611
CLV_PCSK_SKI1_1	114	118	PF00082	0.404
CLV_PCSK_SKI1_1	303	307	PF00082	0.571
CLV_PCSK_SKI1_1	379	383	PF00082	0.733
CLV_PCSK_SKI1_1	567	571	PF00082	0.681
CLV_PCSK_SKI1_1	642	646	PF00082	0.669
DEG_APCC_DBOX_1	605	613	PF00400	0.421
DEG_Nend_UBRbox_4	1	3	PF02207	0.604
DEG_SPOP_SBC_1	523	527	PF00917	0.424
DOC_CDC14_PxL_1	307	315	PF14671	0.451
DOC_CKS1_1	282	287	PF01111	0.493
DOC_CKS1_1	93	98	PF01111	0.613
DOC_CYCLIN_RxL_1	216	228	PF00134	0.359
DOC_CYCLIN_RxL_1	514	525	PF00134	0.411
DOC_CYCLIN_RxL_1	637	648	PF00134	0.410
DOC_MAPK_gen_1	154	162	PF00069	0.399
DOC_MAPK_JIP1_4	432	438	PF00069	0.527
DOC_MAPK_MEF2A_6	154	162	PF00069	0.499
DOC_MAPK_RevD_3	100	115	PF00069	0.598
DOC_PP1_RVXF_1	716	722	PF00149	0.479
DOC_PP1_RVXF_1	759	765	PF00149	0.416
DOC_PP2B_LxvP_1	65	68	PF13499	0.595
DOC_PP2B_LxvP_1	678	681	PF13499	0.518
DOC_PP4_FxxP_1	640	643	PF00568	0.497
DOC_PP4_FxxP_1	676	679	PF00568	0.423
DOC_USP7_MATH_1	15	19	PF00917	0.672
DOC_USP7_MATH_1	258	262	PF00917	0.479
DOC_USP7_MATH_1	289	293	PF00917	0.416
DOC_USP7_MATH_1	380	384	PF00917	0.489
DOC_USP7_MATH_1	385	389	PF00917	0.503
DOC_USP7_MATH_1	569	573	PF00917	0.479
DOC_USP7_MATH_1	670	674	PF00917	0.544
DOC_USP7_MATH_1	707	711	PF00917	0.430
DOC_USP7_MATH_1	739	743	PF00917	0.445
DOC_WW_Pin1_4	120	125	PF00397	0.629
DOC_WW_Pin1_4	136	141	PF00397	0.636
DOC_WW_Pin1_4	254	259	PF00397	0.462
DOC_WW_Pin1_4	281	286	PF00397	0.450
DOC_WW_Pin1_4	451	456	PF00397	0.445
DOC_WW_Pin1_4	48	53	PF00397	0.620
DOC_WW_Pin1_4	60	65	PF00397	0.618
DOC_WW_Pin1_4	86	91	PF00397	0.652
DOC_WW_Pin1_4	92	97	PF00397	0.605
LIG_14-3-3_CanoR_1	114	124	PF00244	0.606
LIG_14-3-3_CanoR_1	30	37	PF00244	0.628
LIG_14-3-3_CanoR_1	379	385	PF00244	0.537
LIG_14-3-3_CanoR_1	477	481	PF00244	0.573
LIG_14-3-3_CanoR_1	571	576	PF00244	0.496
LIG_14-3-3_CanoR_1	718	722	PF00244	0.425
LIG_14-3-3_CanoR_1	761	765	PF00244	0.414
LIG_Actin_WH2_2	612	629	PF00022	0.470
LIG_BIR_III_2	269	273	PF00653	0.478
LIG_BRCT_BRCA1_1	672	676	PF00533	0.487
LIG_CSL_BTD_1	77	80	PF09270	0.667
LIG_deltaCOP1_diTrp_1	582	588	PF00928	0.464
LIG_EVH1_2	67	71	PF00568	0.592
LIG_FHA_1	162	168	PF00498	0.334
LIG_FHA_1	184	190	PF00498	0.536
LIG_FHA_1	195	201	PF00498	0.507
LIG_FHA_1	217	223	PF00498	0.460
LIG_FHA_1	352	358	PF00498	0.468
LIG_FHA_1	376	382	PF00498	0.525
LIG_FHA_1	44	50	PF00498	0.618
LIG_FHA_1	664	670	PF00498	0.474
LIG_FHA_1	696	702	PF00498	0.453
LIG_FHA_2	180	186	PF00498	0.498
LIG_FHA_2	241	247	PF00498	0.379
LIG_FHA_2	264	270	PF00498	0.503
LIG_FHA_2	481	487	PF00498	0.571
LIG_FHA_2	575	581	PF00498	0.483
LIG_IRF3_LxIS_1	66	73	PF10401	0.591
LIG_LIR_Apic_2	279	285	PF02991	0.426
LIG_LIR_Apic_2	346	351	PF02991	0.444
LIG_LIR_Apic_2	510	516	PF02991	0.447
LIG_LIR_Apic_2	673	679	PF02991	0.483
LIG_LIR_Gen_1	479	485	PF02991	0.568
LIG_LIR_Gen_1	720	727	PF02991	0.416
LIG_LIR_Gen_1	745	754	PF02991	0.465
LIG_LIR_Gen_1	763	770	PF02991	0.336
LIG_LIR_Gen_1	95	105	PF02991	0.609
LIG_LIR_Nem_3	693	697	PF02991	0.448
LIG_LIR_Nem_3	720	725	PF02991	0.420
LIG_LIR_Nem_3	745	750	PF02991	0.534
LIG_LIR_Nem_3	763	767	PF02991	0.330
LIG_LIR_Nem_3	95	100	PF02991	0.612
LIG_MYND_1	655	659	PF01753	0.510
LIG_NBox_RRM_1	267	277	PF00076	0.497
LIG_NRBOX	413	419	PF00104	0.473
LIG_PCNA_TLS_4	728	735	PF02747	0.405
LIG_PCNA_yPIPBox_3	287	297	PF02747	0.421
LIG_Pex14_1	730	734	PF04695	0.404
LIG_Pex14_2	721	725	PF04695	0.424
LIG_SH2_CRK	304	308	PF00017	0.389
LIG_SH2_GRB2like	724	727	PF00017	0.411
LIG_SH2_SRC	743	746	PF00017	0.418
LIG_SH2_STAP1	210	214	PF00017	0.510
LIG_SH2_STAP1	225	229	PF00017	0.375
LIG_SH2_STAP1	236	240	PF00017	0.407
LIG_SH2_STAP1	294	298	PF00017	0.370
LIG_SH2_STAT5	170	173	PF00017	0.315
LIG_SH2_STAT5	225	228	PF00017	0.413
LIG_SH2_STAT5	236	239	PF00017	0.505
LIG_SH2_STAT5	697	700	PF00017	0.452
LIG_SH2_STAT5	724	727	PF00017	0.420
LIG_SH3_1	138	144	PF00018	0.610
LIG_SH3_3	137	143	PF00018	0.611
LIG_SH3_3	250	256	PF00018	0.427
LIG_SH3_3	470	476	PF00018	0.534
LIG_SH3_3	529	535	PF00018	0.498
LIG_SH3_3	55	61	PF00018	0.628
LIG_SH3_3	640	646	PF00018	0.501
LIG_SH3_3	649	655	PF00018	0.527
LIG_SH3_3	674	680	PF00018	0.464
LIG_SH3_3	74	80	PF00018	0.650
LIG_SUMO_SIM_anti_2	164	170	PF11976	0.304
LIG_SUMO_SIM_anti_2	561	566	PF11976	0.496
LIG_SUMO_SIM_par_1	536	542	PF11976	0.415
LIG_TRFH_1	676	680	PF08558	0.427
LIG_UBA3_1	609	613	PF00899	0.425
LIG_WW_1	679	682	PF00397	0.457
MOD_CDK_SPK_2	120	125	PF00069	0.609
MOD_CDK_SPxxK_3	48	55	PF00069	0.621
MOD_CDK_SPxxK_3	92	99	PF00069	0.612
MOD_CK1_1	118	124	PF00069	0.609
MOD_CK1_1	136	142	PF00069	0.634
MOD_CK1_1	387	393	PF00069	0.567
MOD_CK1_1	409	415	PF00069	0.524
MOD_CK1_1	419	425	PF00069	0.519
MOD_CK1_1	454	460	PF00069	0.565
MOD_CK1_1	51	57	PF00069	0.622
MOD_CK1_1	525	531	PF00069	0.428
MOD_CK1_1	574	580	PF00069	0.500
MOD_CK2_1	240	246	PF00069	0.382
MOD_CK2_1	315	321	PF00069	0.398
MOD_CK2_1	340	346	PF00069	0.441
MOD_CK2_1	419	425	PF00069	0.411
MOD_CK2_1	574	580	PF00069	0.486
MOD_CMANNOS	585	588	PF00535	0.652
MOD_CMANNOS	730	733	PF00535	0.604
MOD_DYRK1A_RPxSP_1	451	455	PF00069	0.436
MOD_GlcNHglycan	117	120	PF01048	0.445
MOD_GlcNHglycan	135	138	PF01048	0.414
MOD_GlcNHglycan	17	20	PF01048	0.411
MOD_GlcNHglycan	260	263	PF01048	0.772
MOD_GlcNHglycan	307	310	PF01048	0.651
MOD_GlcNHglycan	315	318	PF01048	0.597
MOD_GlcNHglycan	418	421	PF01048	0.742
MOD_GlcNHglycan	451	454	PF01048	0.829
MOD_GlcNHglycan	509	512	PF01048	0.691
MOD_GlcNHglycan	573	576	PF01048	0.795
MOD_GlcNHglycan	659	662	PF01048	0.807
MOD_GlcNHglycan	686	689	PF01048	0.605
MOD_GSK3_1	10	17	PF00069	0.608
MOD_GSK3_1	127	134	PF00069	0.645
MOD_GSK3_1	179	186	PF00069	0.503
MOD_GSK3_1	254	261	PF00069	0.562
MOD_GSK3_1	277	284	PF00069	0.417
MOD_GSK3_1	28	35	PF00069	0.608
MOD_GSK3_1	313	320	PF00069	0.375
MOD_GSK3_1	380	387	PF00069	0.580
MOD_GSK3_1	396	403	PF00069	0.615
MOD_GSK3_1	405	412	PF00069	0.514
MOD_GSK3_1	419	426	PF00069	0.489
MOD_GSK3_1	476	483	PF00069	0.543
MOD_GSK3_1	567	574	PF00069	0.490
MOD_GSK3_1	748	755	PF00069	0.403
MOD_N-GLC_1	158	163	PF02516	0.395
MOD_N-GLC_1	234	239	PF02516	0.670
MOD_N-GLC_1	523	528	PF02516	0.664
MOD_N-GLC_1	695	700	PF02516	0.635
MOD_NEK2_1	127	132	PF00069	0.623
MOD_NEK2_1	158	163	PF00069	0.339
MOD_NEK2_1	179	184	PF00069	0.434
MOD_NEK2_1	240	245	PF00069	0.404
MOD_NEK2_1	313	318	PF00069	0.506
MOD_NEK2_1	359	364	PF00069	0.445
MOD_NEK2_1	405	410	PF00069	0.508
MOD_NEK2_1	423	428	PF00069	0.529
MOD_NEK2_1	633	638	PF00069	0.558
MOD_NEK2_1	70	75	PF00069	0.591
MOD_NEK2_1	734	739	PF00069	0.413
MOD_NEK2_2	289	294	PF00069	0.417
MOD_NEK2_2	476	481	PF00069	0.519
MOD_NEK2_2	717	722	PF00069	0.480
MOD_OFUCOSY	69	74	PF10250	0.392
MOD_PIKK_1	128	134	PF00454	0.627
MOD_PIKK_1	246	252	PF00454	0.505
MOD_PIKK_1	30	36	PF00454	0.702
MOD_PIKK_1	391	397	PF00454	0.564
MOD_PIKK_1	412	418	PF00454	0.540
MOD_PIKK_1	619	625	PF00454	0.495
MOD_PK_1	10	16	PF00069	0.608
MOD_PKA_2	359	365	PF00069	0.399
MOD_PKA_2	476	482	PF00069	0.576
MOD_PKA_2	570	576	PF00069	0.493
MOD_PKA_2	717	723	PF00069	0.420
MOD_PKA_2	760	766	PF00069	0.416
MOD_Plk_1	158	164	PF00069	0.395
MOD_Plk_1	263	269	PF00069	0.506
MOD_Plk_1	278	284	PF00069	0.381
MOD_Plk_1	320	326	PF00069	0.385
MOD_Plk_1	406	412	PF00069	0.458
MOD_Plk_1	492	498	PF00069	0.489
MOD_Plk_1	707	713	PF00069	0.427
MOD_Plk_2-3	492	498	PF00069	0.506
MOD_Plk_4	158	164	PF00069	0.305
MOD_Plk_4	278	284	PF00069	0.411
MOD_Plk_4	289	295	PF00069	0.391
MOD_Plk_4	340	346	PF00069	0.417
MOD_Plk_4	400	406	PF00069	0.471
MOD_Plk_4	476	482	PF00069	0.503
MOD_Plk_4	593	599	PF00069	0.419
MOD_Plk_4	717	723	PF00069	0.478
MOD_ProDKin_1	120	126	PF00069	0.628
MOD_ProDKin_1	136	142	PF00069	0.634
MOD_ProDKin_1	254	260	PF00069	0.462
MOD_ProDKin_1	281	287	PF00069	0.449
MOD_ProDKin_1	451	457	PF00069	0.447
MOD_ProDKin_1	48	54	PF00069	0.620
MOD_ProDKin_1	60	66	PF00069	0.615
MOD_ProDKin_1	86	92	PF00069	0.653
MOD_SUMO_for_1	690	693	PF00179	0.506
TRG_DiLeu_BaLyEn_6	294	299	PF01217	0.368
TRG_DiLeu_BaLyEn_6	327	332	PF01217	0.412
TRG_DiLeu_BaLyEn_6	640	645	PF01217	0.467
TRG_ENDOCYTIC_2	203	206	PF00928	0.433
TRG_ENDOCYTIC_2	304	307	PF00928	0.391
TRG_ENDOCYTIC_2	366	369	PF00928	0.394
TRG_ENDOCYTIC_2	481	484	PF00928	0.441
TRG_ENDOCYTIC_2	682	685	PF00928	0.464
TRG_ER_diArg_1	114	116	PF00400	0.601
TRG_ER_diArg_1	154	157	PF00400	0.436
TRG_ER_diArg_1	217	220	PF00400	0.366
TRG_ER_diArg_1	55	58	PF00400	0.627
TRG_ER_diArg_1	672	675	PF00400	0.488
TRG_ER_diArg_1	727	729	PF00400	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7L4	Leptomonas seymouri	46%	100%
A0A3Q8IMJ3	Leishmania donovani	89%	100%
A4HD95	Leishmania braziliensis	76%	96%
E9AH50	Leishmania infantum	89%	100%
Q4QAU2	Leishmania major	90%	100%