LeishMANIAdb
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Putative CMP-sialic acid transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative CMP-sialic acid transporter
Gene product:
UDP-galactose transporter
Species:
Leishmania mexicana
UniProt:
E9AWM6_LEIMU
TriTrypDb:
LmxM.24.0365
Length:
451

Annotations

LeishMANIAdb annotations

Homologous to animal UDP-N-acetylglucosamine, UDP-galactose and CMP-sialic acid transporters. Only expanded in the Leptomonas lineage. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 2, no: 13
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0000139 Golgi membrane 5 16
GO:0016020 membrane 2 16
GO:0031090 organelle membrane 3 16
GO:0098588 bounding membrane of organelle 4 16
GO:0110165 cellular anatomical entity 1 16

Expansion

Sequence features

E9AWM6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWM6

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006811 monoatomic ion transport 4 1
GO:0006820 monoatomic anion transport 5 1
GO:0009987 cellular process 1 1
GO:0015711 organic anion transport 5 1
GO:0015780 nucleotide-sugar transmembrane transport 3 1
GO:0015931 nucleobase-containing compound transport 5 1
GO:0034220 monoatomic ion transmembrane transport 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0055085 transmembrane transport 2 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
GO:0072334 UDP-galactose transmembrane transport 5 1
GO:0090481 pyrimidine nucleotide-sugar transmembrane transport 4 1
GO:0098656 monoatomic anion transmembrane transport 4 1
GO:1901264 carbohydrate derivative transport 5 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 16
GO:0005338 nucleotide-sugar transmembrane transporter activity 4 16
GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 5 16
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 16
GO:0022857 transmembrane transporter activity 2 16
GO:1901505 carbohydrate derivative transmembrane transporter activity 3 16
GO:0005459 UDP-galactose transmembrane transporter activity 6 1
GO:0015136 sialic acid transmembrane transporter activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 130 134 PF00656 0.774
CLV_C14_Caspase3-7 147 151 PF00656 0.744
CLV_NRD_NRD_1 11 13 PF00675 0.466
CLV_NRD_NRD_1 167 169 PF00675 0.418
CLV_PCSK_KEX2_1 11 13 PF00082 0.451
CLV_PCSK_KEX2_1 166 168 PF00082 0.414
CLV_PCSK_KEX2_1 325 327 PF00082 0.353
CLV_PCSK_PC1ET2_1 325 327 PF00082 0.353
CLV_PCSK_SKI1_1 12 16 PF00082 0.403
CLV_PCSK_SKI1_1 161 165 PF00082 0.390
CLV_PCSK_SKI1_1 226 230 PF00082 0.379
CLV_PCSK_SKI1_1 235 239 PF00082 0.329
CLV_PCSK_SKI1_1 61 65 PF00082 0.653
CLV_PCSK_SKI1_1 78 82 PF00082 0.242
DEG_SPOP_SBC_1 440 444 PF00917 0.166
DOC_CKS1_1 104 109 PF01111 0.591
DOC_CKS1_1 425 430 PF01111 0.315
DOC_MAPK_gen_1 11 17 PF00069 0.599
DOC_MAPK_gen_1 166 174 PF00069 0.620
DOC_MAPK_gen_1 176 183 PF00069 0.571
DOC_MAPK_gen_1 186 195 PF00069 0.343
DOC_MAPK_MEF2A_6 226 234 PF00069 0.344
DOC_MAPK_MEF2A_6 246 255 PF00069 0.278
DOC_PP1_RVXF_1 159 165 PF00149 0.570
DOC_PP1_RVXF_1 224 230 PF00149 0.438
DOC_PP1_RVXF_1 59 66 PF00149 0.398
DOC_PP4_FxxP_1 4 7 PF00568 0.628
DOC_PP4_FxxP_1 425 428 PF00568 0.332
DOC_USP7_MATH_1 132 136 PF00917 0.725
DOC_USP7_MATH_1 279 283 PF00917 0.341
DOC_WW_Pin1_4 103 108 PF00397 0.701
DOC_WW_Pin1_4 124 129 PF00397 0.761
DOC_WW_Pin1_4 150 155 PF00397 0.562
DOC_WW_Pin1_4 240 245 PF00397 0.567
DOC_WW_Pin1_4 3 8 PF00397 0.629
DOC_WW_Pin1_4 424 429 PF00397 0.384
LIG_14-3-3_CanoR_1 335 342 PF00244 0.546
LIG_14-3-3_CanoR_1 61 66 PF00244 0.473
LIG_14-3-3_CanoR_1 98 104 PF00244 0.672
LIG_AP2alpha_1 372 376 PF02296 0.353
LIG_BIR_II_1 1 5 PF00653 0.575
LIG_BRCT_BRCA1_1 314 318 PF00533 0.438
LIG_BRCT_BRCA1_1 369 373 PF00533 0.353
LIG_BRCT_BRCA1_1 408 412 PF00533 0.436
LIG_EH1_1 199 207 PF00400 0.438
LIG_EH1_1 432 440 PF00400 0.301
LIG_eIF4E_1 187 193 PF01652 0.553
LIG_eIF4E_1 200 206 PF01652 0.438
LIG_eIF4E_1 223 229 PF01652 0.424
LIG_FHA_1 106 112 PF00498 0.709
LIG_FHA_1 375 381 PF00498 0.325
LIG_FHA_1 417 423 PF00498 0.372
LIG_FHA_1 71 77 PF00498 0.351
LIG_FHA_2 121 127 PF00498 0.553
LIG_FHA_2 369 375 PF00498 0.347
LIG_FHA_2 53 59 PF00498 0.497
LIG_GBD_Chelix_1 198 206 PF00786 0.384
LIG_HCF-1_HBM_1 184 187 PF13415 0.567
LIG_LIR_Apic_2 3 7 PF02991 0.562
LIG_LIR_Gen_1 217 227 PF02991 0.304
LIG_LIR_Gen_1 315 323 PF02991 0.456
LIG_LIR_Gen_1 409 420 PF02991 0.386
LIG_LIR_Gen_1 82 93 PF02991 0.407
LIG_LIR_Nem_3 217 222 PF02991 0.293
LIG_LIR_Nem_3 312 317 PF02991 0.436
LIG_LIR_Nem_3 343 349 PF02991 0.335
LIG_LIR_Nem_3 370 376 PF02991 0.279
LIG_LIR_Nem_3 409 415 PF02991 0.399
LIG_LIR_Nem_3 82 88 PF02991 0.340
LIG_MLH1_MIPbox_1 369 373 PF16413 0.353
LIG_Pex14_1 9 13 PF04695 0.697
LIG_Pex14_2 169 173 PF04695 0.556
LIG_Pex14_2 310 314 PF04695 0.424
LIG_Pex14_2 347 351 PF04695 0.438
LIG_Pex14_2 368 372 PF04695 0.305
LIG_Pex14_2 408 412 PF04695 0.424
LIG_PTB_Apo_2 26 33 PF02174 0.432
LIG_PTB_Phospho_1 26 32 PF10480 0.415
LIG_SH2_STAP1 209 213 PF00017 0.360
LIG_SH2_STAT3 200 203 PF00017 0.324
LIG_SH2_STAT3 38 41 PF00017 0.379
LIG_SH2_STAT5 13 16 PF00017 0.615
LIG_SH2_STAT5 32 35 PF00017 0.232
LIG_SH2_STAT5 346 349 PF00017 0.368
LIG_SH2_STAT5 400 403 PF00017 0.553
LIG_SH2_STAT5 423 426 PF00017 0.218
LIG_SH3_3 101 107 PF00018 0.578
LIG_Sin3_3 19 26 PF02671 0.420
LIG_SUMO_SIM_anti_2 189 196 PF11976 0.525
LIG_SUMO_SIM_anti_2 437 445 PF11976 0.301
LIG_SUMO_SIM_par_1 204 210 PF11976 0.384
LIG_SUMO_SIM_par_1 32 37 PF11976 0.408
LIG_SUMO_SIM_par_1 437 445 PF11976 0.191
LIG_TRAF2_1 55 58 PF00917 0.447
LIG_TRFH_1 240 244 PF08558 0.567
LIG_TYR_ITIM 344 349 PF00017 0.456
LIG_UBA3_1 205 212 PF00899 0.384
LIG_Vh1_VBS_1 131 149 PF01044 0.611
LIG_WRC_WIRS_1 121 126 PF05994 0.553
LIG_WRC_WIRS_1 405 410 PF05994 0.484
MOD_CDC14_SPxK_1 243 246 PF00782 0.567
MOD_CDK_SPK_2 124 129 PF00069 0.594
MOD_CDK_SPxK_1 240 246 PF00069 0.567
MOD_CK1_1 116 122 PF00069 0.708
MOD_CK1_1 295 301 PF00069 0.366
MOD_CK1_1 3 9 PF00069 0.581
MOD_CK1_1 312 318 PF00069 0.195
MOD_CK1_1 407 413 PF00069 0.403
MOD_CK2_1 120 126 PF00069 0.604
MOD_CK2_1 279 285 PF00069 0.372
MOD_CK2_1 52 58 PF00069 0.381
MOD_GlcNHglycan 114 118 PF01048 0.329
MOD_GlcNHglycan 265 268 PF01048 0.512
MOD_GlcNHglycan 311 314 PF01048 0.370
MOD_GlcNHglycan 332 335 PF01048 0.321
MOD_GlcNHglycan 416 419 PF01048 0.287
MOD_GlcNHglycan 99 102 PF01048 0.470
MOD_GSK3_1 116 123 PF00069 0.731
MOD_GSK3_1 132 139 PF00069 0.717
MOD_GSK3_1 287 294 PF00069 0.336
MOD_GSK3_1 295 302 PF00069 0.287
MOD_GSK3_1 330 337 PF00069 0.506
MOD_GSK3_1 414 421 PF00069 0.315
MOD_GSK3_1 61 68 PF00069 0.402
MOD_N-GLC_1 429 434 PF02516 0.567
MOD_NEK2_1 207 212 PF00069 0.374
MOD_NEK2_1 255 260 PF00069 0.403
MOD_NEK2_1 299 304 PF00069 0.311
MOD_NEK2_1 330 335 PF00069 0.487
MOD_NEK2_1 368 373 PF00069 0.352
MOD_NEK2_1 416 421 PF00069 0.335
MOD_NEK2_1 429 434 PF00069 0.270
MOD_NEK2_1 439 444 PF00069 0.335
MOD_NEK2_1 65 70 PF00069 0.354
MOD_NEK2_1 79 84 PF00069 0.258
MOD_NEK2_2 418 423 PF00069 0.432
MOD_PIKK_1 325 331 PF00454 0.377
MOD_PIKK_1 36 42 PF00454 0.311
MOD_PKA_1 325 331 PF00069 0.377
MOD_PKA_2 325 331 PF00069 0.456
MOD_PKA_2 334 340 PF00069 0.472
MOD_PKA_2 97 103 PF00069 0.646
MOD_Plk_4 187 193 PF00069 0.561
MOD_Plk_4 214 220 PF00069 0.272
MOD_Plk_4 368 374 PF00069 0.290
MOD_Plk_4 418 424 PF00069 0.336
MOD_Plk_4 429 435 PF00069 0.260
MOD_Plk_4 442 448 PF00069 0.302
MOD_Plk_4 79 85 PF00069 0.366
MOD_ProDKin_1 103 109 PF00069 0.705
MOD_ProDKin_1 124 130 PF00069 0.760
MOD_ProDKin_1 150 156 PF00069 0.559
MOD_ProDKin_1 240 246 PF00069 0.567
MOD_ProDKin_1 3 9 PF00069 0.628
MOD_ProDKin_1 424 430 PF00069 0.384
TRG_ENDOCYTIC_2 32 35 PF00928 0.412
TRG_ENDOCYTIC_2 346 349 PF00928 0.357
TRG_ER_diArg_1 10 12 PF00400 0.669
TRG_ER_diArg_1 166 168 PF00400 0.632
TRG_NES_CRM1_1 203 215 PF08389 0.372
TRG_NES_CRM1_1 387 402 PF08389 0.320

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7L9 Leptomonas seymouri 52% 100%
A0A0N1HVQ8 Leptomonas seymouri 23% 84%
A0A1X0NTD6 Trypanosomatidae 29% 100%
A0A3Q8IES0 Leishmania donovani 91% 84%
A0A3S7WVZ3 Leishmania donovani 91% 100%
A0A3S7WY47 Leishmania donovani 72% 81%
A0A422P321 Trypanosoma rangeli 30% 100%
A4HD92 Leishmania braziliensis 69% 100%
A4HDA0 Leishmania braziliensis 69% 100%
A4I0N2 Leishmania infantum 72% 81%
D0AAP4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9AH47 Leishmania infantum 91% 84%
E9AWM5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 74% 99%
Q4QAU5 Leishmania major 88% 100%
Q6DCG9 Xenopus laevis 23% 100%
V5BLB8 Trypanosoma cruzi 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS