LeishMANIAdb
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Putative UDP-galactose transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative UDP-galactose transporter
Gene product:
UDP-galactose transporter
Species:
Leishmania mexicana
UniProt:
E9AWM5_LEIMU
TriTrypDb:
LmxM.24.0360
Length:
470

Annotations

LeishMANIAdb annotations

Homologous to animal UDP-N-acetylglucosamine, UDP-galactose and CMP-sialic acid transporters. Only expanded in the Leptomonas lineage. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 2, no: 14
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0000139 Golgi membrane 5 17
GO:0016020 membrane 2 17
GO:0031090 organelle membrane 3 17
GO:0098588 bounding membrane of organelle 4 17
GO:0110165 cellular anatomical entity 1 17

Expansion

Sequence features

E9AWM5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWM5

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006811 monoatomic ion transport 4 1
GO:0006820 monoatomic anion transport 5 1
GO:0009987 cellular process 1 1
GO:0015711 organic anion transport 5 1
GO:0015780 nucleotide-sugar transmembrane transport 3 1
GO:0015931 nucleobase-containing compound transport 5 1
GO:0034220 monoatomic ion transmembrane transport 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0055085 transmembrane transport 2 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
GO:0072334 UDP-galactose transmembrane transport 5 1
GO:0090481 pyrimidine nucleotide-sugar transmembrane transport 4 1
GO:0098656 monoatomic anion transmembrane transport 4 1
GO:1901264 carbohydrate derivative transport 5 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 17
GO:0005338 nucleotide-sugar transmembrane transporter activity 4 17
GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 5 17
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 17
GO:0022857 transmembrane transporter activity 2 17
GO:1901505 carbohydrate derivative transmembrane transporter activity 3 17
GO:0005459 UDP-galactose transmembrane transporter activity 6 1
GO:0015136 sialic acid transmembrane transporter activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 11 13 PF00675 0.481
CLV_NRD_NRD_1 186 188 PF00675 0.336
CLV_PCSK_KEX2_1 11 13 PF00082 0.468
CLV_PCSK_KEX2_1 185 187 PF00082 0.318
CLV_PCSK_KEX2_1 344 346 PF00082 0.354
CLV_PCSK_PC1ET2_1 344 346 PF00082 0.354
CLV_PCSK_SKI1_1 109 113 PF00082 0.357
CLV_PCSK_SKI1_1 12 16 PF00082 0.463
CLV_PCSK_SKI1_1 156 160 PF00082 0.452
CLV_PCSK_SKI1_1 180 184 PF00082 0.411
CLV_PCSK_SKI1_1 245 249 PF00082 0.386
CLV_PCSK_SKI1_1 254 258 PF00082 0.338
CLV_PCSK_SKI1_1 56 60 PF00082 0.703
DOC_CKS1_1 444 449 PF01111 0.311
DOC_MAPK_gen_1 11 17 PF00069 0.604
DOC_MAPK_gen_1 156 166 PF00069 0.557
DOC_MAPK_gen_1 185 193 PF00069 0.545
DOC_MAPK_gen_1 195 202 PF00069 0.500
DOC_MAPK_gen_1 205 214 PF00069 0.338
DOC_MAPK_MEF2A_6 157 166 PF00069 0.522
DOC_MAPK_MEF2A_6 245 253 PF00069 0.353
DOC_MAPK_MEF2A_6 265 274 PF00069 0.288
DOC_PP1_RVXF_1 178 184 PF00149 0.579
DOC_PP1_RVXF_1 243 249 PF00149 0.440
DOC_PP4_FxxP_1 4 7 PF00568 0.633
DOC_PP4_FxxP_1 444 447 PF00568 0.334
DOC_USP7_MATH_1 110 114 PF00917 0.774
DOC_USP7_MATH_1 126 130 PF00917 0.714
DOC_USP7_MATH_1 298 302 PF00917 0.342
DOC_USP7_MATH_1 80 84 PF00917 0.330
DOC_USP7_UBL2_3 156 160 PF12436 0.553
DOC_WW_Pin1_4 139 144 PF00397 0.759
DOC_WW_Pin1_4 259 264 PF00397 0.562
DOC_WW_Pin1_4 3 8 PF00397 0.633
DOC_WW_Pin1_4 443 448 PF00397 0.380
DOC_WW_Pin1_4 93 98 PF00397 0.711
LIG_14-3-3_CanoR_1 354 361 PF00244 0.548
LIG_AP2alpha_1 391 395 PF02296 0.354
LIG_BIR_II_1 1 5 PF00653 0.568
LIG_BRCT_BRCA1_1 333 337 PF00533 0.440
LIG_BRCT_BRCA1_1 388 392 PF00533 0.354
LIG_BRCT_BRCA1_1 427 431 PF00533 0.438
LIG_EH1_1 218 226 PF00400 0.440
LIG_EH1_1 451 459 PF00400 0.310
LIG_eIF4E_1 206 212 PF01652 0.554
LIG_eIF4E_1 219 225 PF01652 0.440
LIG_eIF4E_1 242 248 PF01652 0.428
LIG_FHA_1 157 163 PF00498 0.736
LIG_FHA_1 174 180 PF00498 0.530
LIG_FHA_1 394 400 PF00498 0.328
LIG_FHA_1 436 442 PF00498 0.379
LIG_FHA_1 67 73 PF00498 0.341
LIG_FHA_2 388 394 PF00498 0.348
LIG_GBD_Chelix_1 217 225 PF00786 0.380
LIG_HCF-1_HBM_1 203 206 PF13415 0.562
LIG_IRF3_LxIS_1 72 78 PF10401 0.211
LIG_LIR_Apic_2 3 7 PF02991 0.565
LIG_LIR_Gen_1 236 246 PF02991 0.309
LIG_LIR_Gen_1 334 342 PF02991 0.452
LIG_LIR_Gen_1 428 439 PF02991 0.393
LIG_LIR_Gen_1 78 88 PF02991 0.428
LIG_LIR_Nem_3 236 241 PF02991 0.298
LIG_LIR_Nem_3 331 336 PF02991 0.439
LIG_LIR_Nem_3 362 368 PF02991 0.344
LIG_LIR_Nem_3 389 395 PF02991 0.284
LIG_LIR_Nem_3 428 434 PF02991 0.404
LIG_LIR_Nem_3 78 84 PF02991 0.349
LIG_MLH1_MIPbox_1 388 392 PF16413 0.354
LIG_Pex14_1 9 13 PF04695 0.679
LIG_Pex14_2 188 192 PF04695 0.501
LIG_Pex14_2 329 333 PF04695 0.428
LIG_Pex14_2 366 370 PF04695 0.440
LIG_Pex14_2 387 391 PF04695 0.309
LIG_Pex14_2 427 431 PF04695 0.428
LIG_PTB_Apo_2 26 33 PF02174 0.435
LIG_SH2_STAP1 228 232 PF00017 0.360
LIG_SH2_STAT3 219 222 PF00017 0.333
LIG_SH2_STAT3 38 41 PF00017 0.359
LIG_SH2_STAT5 13 16 PF00017 0.652
LIG_SH2_STAT5 145 148 PF00017 0.641
LIG_SH2_STAT5 365 368 PF00017 0.376
LIG_SH2_STAT5 38 41 PF00017 0.304
LIG_SH2_STAT5 419 422 PF00017 0.554
LIG_SH2_STAT5 442 445 PF00017 0.223
LIG_SH2_STAT5 466 469 PF00017 0.419
LIG_Sin3_3 19 26 PF02671 0.416
LIG_SUMO_SIM_anti_2 208 215 PF11976 0.528
LIG_SUMO_SIM_anti_2 456 462 PF11976 0.310
LIG_SUMO_SIM_par_1 223 229 PF11976 0.380
LIG_SUMO_SIM_par_1 456 462 PF11976 0.186
LIG_TRFH_1 259 263 PF08558 0.562
LIG_TYR_ITIM 363 368 PF00017 0.452
LIG_UBA3_1 224 231 PF00899 0.380
LIG_UBA3_1 87 92 PF00899 0.642
LIG_WRC_WIRS_1 424 429 PF05994 0.489
MOD_CDC14_SPxK_1 262 265 PF00782 0.562
MOD_CDK_SPxK_1 259 265 PF00069 0.562
MOD_CK1_1 104 110 PF00069 0.777
MOD_CK1_1 114 120 PF00069 0.706
MOD_CK1_1 127 133 PF00069 0.728
MOD_CK1_1 3 9 PF00069 0.593
MOD_CK1_1 314 320 PF00069 0.339
MOD_CK1_1 331 337 PF00069 0.195
MOD_CK1_1 426 432 PF00069 0.409
MOD_CK2_1 127 133 PF00069 0.608
MOD_CK2_1 144 150 PF00069 0.573
MOD_CK2_1 298 304 PF00069 0.370
MOD_CK2_1 43 49 PF00069 0.249
MOD_CK2_1 464 470 PF00069 0.211
MOD_GlcNHglycan 146 149 PF01048 0.415
MOD_GlcNHglycan 284 287 PF01048 0.516
MOD_GlcNHglycan 330 333 PF01048 0.357
MOD_GlcNHglycan 351 354 PF01048 0.324
MOD_GlcNHglycan 435 438 PF01048 0.296
MOD_GSK3_1 100 107 PF00069 0.722
MOD_GSK3_1 110 117 PF00069 0.716
MOD_GSK3_1 124 131 PF00069 0.641
MOD_GSK3_1 135 142 PF00069 0.714
MOD_GSK3_1 144 151 PF00069 0.715
MOD_GSK3_1 152 159 PF00069 0.644
MOD_GSK3_1 306 313 PF00069 0.338
MOD_GSK3_1 314 321 PF00069 0.292
MOD_GSK3_1 349 356 PF00069 0.496
MOD_GSK3_1 433 440 PF00069 0.324
MOD_N-GLC_1 133 138 PF02516 0.457
MOD_N-GLC_1 448 453 PF02516 0.562
MOD_NEK2_1 152 157 PF00069 0.611
MOD_NEK2_1 226 231 PF00069 0.381
MOD_NEK2_1 274 279 PF00069 0.409
MOD_NEK2_1 318 323 PF00069 0.315
MOD_NEK2_1 349 354 PF00069 0.492
MOD_NEK2_1 387 392 PF00069 0.353
MOD_NEK2_1 435 440 PF00069 0.344
MOD_NEK2_1 448 453 PF00069 0.275
MOD_NEK2_1 458 463 PF00069 0.344
MOD_NEK2_1 61 66 PF00069 0.345
MOD_NEK2_1 75 80 PF00069 0.251
MOD_NEK2_2 437 442 PF00069 0.435
MOD_NEK2_2 80 85 PF00069 0.236
MOD_PIKK_1 135 141 PF00454 0.593
MOD_PIKK_1 344 350 PF00454 0.373
MOD_PKA_1 156 162 PF00069 0.518
MOD_PKA_1 344 350 PF00069 0.373
MOD_PKA_2 344 350 PF00069 0.461
MOD_PKA_2 353 359 PF00069 0.468
MOD_Plk_1 114 120 PF00069 0.605
MOD_Plk_1 124 130 PF00069 0.688
MOD_Plk_4 114 120 PF00069 0.700
MOD_Plk_4 206 212 PF00069 0.561
MOD_Plk_4 233 239 PF00069 0.277
MOD_Plk_4 387 393 PF00069 0.295
MOD_Plk_4 437 443 PF00069 0.345
MOD_Plk_4 448 454 PF00069 0.265
MOD_ProDKin_1 139 145 PF00069 0.759
MOD_ProDKin_1 259 265 PF00069 0.562
MOD_ProDKin_1 3 9 PF00069 0.631
MOD_ProDKin_1 443 449 PF00069 0.380
MOD_ProDKin_1 93 99 PF00069 0.718
TRG_DiLeu_BaEn_1 71 76 PF01217 0.310
TRG_DiLeu_BaEn_2 114 120 PF01217 0.585
TRG_DiLeu_LyEn_5 95 100 PF01217 0.533
TRG_ENDOCYTIC_2 365 368 PF00928 0.365
TRG_ER_diArg_1 10 12 PF00400 0.664
TRG_ER_diArg_1 185 187 PF00400 0.535
TRG_NES_CRM1_1 222 234 PF08389 0.368
TRG_NES_CRM1_1 406 421 PF08389 0.330

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7L9 Leptomonas seymouri 51% 100%
A0A0N1HVQ8 Leptomonas seymouri 24% 87%
A0A0S4JHP4 Bodo saltans 26% 98%
A0A1X0NTD6 Trypanosomatidae 31% 100%
A0A3Q8IES0 Leishmania donovani 73% 87%
A0A3S7WVZ3 Leishmania donovani 90% 100%
A0A3S7WY47 Leishmania donovani 84% 84%
A0A422P321 Trypanosoma rangeli 28% 100%
A4HD92 Leishmania braziliensis 59% 93%
A4HDA0 Leishmania braziliensis 58% 93%
A4I0N2 Leishmania infantum 85% 84%
D0AAP4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9AH47 Leishmania infantum 73% 87%
E9AWM6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 74% 100%
Q4QAU5 Leishmania major 70% 100%
Q6DCG9 Xenopus laevis 24% 100%
Q8LGE9 Arabidopsis thaliana 24% 100%
V5BLB8 Trypanosoma cruzi 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS