GPI ethanolamine phosphate transferase 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPI ethanolamine phosphate transferase 3, putative

Species:

Leishmania mexicana

UniProt:

E9AWM3_LEIMU

TriTrypDb:

LmxM.24.0340

Length:

975

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	8
GO:0016020	membrane	2	8
GO:0031090	organelle membrane	3	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AWM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWM3

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	8
GO:0006505	GPI anchor metabolic process	6	8
GO:0006506	GPI anchor biosynthetic process	6	8
GO:0006629	lipid metabolic process	3	8
GO:0006643	membrane lipid metabolic process	4	8
GO:0006644	phospholipid metabolic process	4	8
GO:0006650	glycerophospholipid metabolic process	5	8
GO:0006661	phosphatidylinositol biosynthetic process	6	8
GO:0006664	glycolipid metabolic process	5	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0008610	lipid biosynthetic process	4	8
GO:0008654	phospholipid biosynthetic process	5	8
GO:0009058	biosynthetic process	2	8
GO:0009247	glycolipid biosynthetic process	5	8
GO:0009987	cellular process	1	8
GO:0019538	protein metabolic process	3	8
GO:0019637	organophosphate metabolic process	3	8
GO:0036211	protein modification process	4	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044249	cellular biosynthetic process	3	8
GO:0044255	cellular lipid metabolic process	3	8
GO:0045017	glycerolipid biosynthetic process	4	8
GO:0046467	membrane lipid biosynthetic process	4	8
GO:0046474	glycerophospholipid biosynthetic process	5	8
GO:0046486	glycerolipid metabolic process	4	8
GO:0046488	phosphatidylinositol metabolic process	6	8
GO:0071704	organic substance metabolic process	2	8
GO:0090407	organophosphate biosynthetic process	4	8
GO:1901135	carbohydrate derivative metabolic process	3	8
GO:1901137	carbohydrate derivative biosynthetic process	4	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:1901576	organic substance biosynthetic process	3	8
GO:1903509	liposaccharide metabolic process	4	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	8
GO:0051377	mannose-ethanolamine phosphotransferase activity	5	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	207	211	PF00656	0.415
CLV_C14_Caspase3-7	364	368	PF00656	0.433
CLV_C14_Caspase3-7	867	871	PF00656	0.747
CLV_MEL_PAP_1	560	566	PF00089	0.335
CLV_NRD_NRD_1	189	191	PF00675	0.668
CLV_NRD_NRD_1	476	478	PF00675	0.586
CLV_NRD_NRD_1	571	573	PF00675	0.454
CLV_NRD_NRD_1	728	730	PF00675	0.554
CLV_NRD_NRD_1	877	879	PF00675	0.532
CLV_PCSK_KEX2_1	189	191	PF00082	0.604
CLV_PCSK_KEX2_1	476	478	PF00082	0.596
CLV_PCSK_KEX2_1	571	573	PF00082	0.453
CLV_PCSK_KEX2_1	728	730	PF00082	0.554
CLV_PCSK_SKI1_1	442	446	PF00082	0.681
CLV_PCSK_SKI1_1	604	608	PF00082	0.429
CLV_PCSK_SKI1_1	938	942	PF00082	0.429
DEG_APCC_DBOX_1	433	441	PF00400	0.450
DEG_SCF_FBW7_1	737	744	PF00400	0.212
DEG_SPOP_SBC_1	127	131	PF00917	0.421
DOC_CKS1_1	184	189	PF01111	0.449
DOC_CKS1_1	889	894	PF01111	0.580
DOC_CYCLIN_RxL_1	935	942	PF00134	0.355
DOC_CYCLIN_yCln2_LP_2	403	409	PF00134	0.355
DOC_CYCLIN_yCln2_LP_2	625	631	PF00134	0.611
DOC_CYCLIN_yCln2_LP_2	845	851	PF00134	0.402
DOC_MAPK_gen_1	112	121	PF00069	0.409
DOC_MAPK_gen_1	189	198	PF00069	0.412
DOC_MAPK_gen_1	442	451	PF00069	0.480
DOC_MAPK_gen_1	659	667	PF00069	0.620
DOC_MAPK_HePTP_8	608	620	PF00069	0.456
DOC_MAPK_MEF2A_6	522	530	PF00069	0.429
DOC_MAPK_MEF2A_6	6	15	PF00069	0.514
DOC_MAPK_MEF2A_6	611	620	PF00069	0.594
DOC_MAPK_MEF2A_6	762	771	PF00069	0.509
DOC_MAPK_NFAT4_5	611	619	PF00069	0.657
DOC_PP1_RVXF_1	936	942	PF00149	0.355
DOC_PP1_SILK_1	161	166	PF00149	0.394
DOC_PP2B_LxvP_1	559	562	PF13499	0.335
DOC_PP2B_LxvP_1	625	628	PF13499	0.617
DOC_PP2B_LxvP_1	845	848	PF13499	0.402
DOC_PP2B_PxIxI_1	459	465	PF00149	0.491
DOC_USP7_MATH_1	41	45	PF00917	0.279
DOC_USP7_MATH_1	423	427	PF00917	0.471
DOC_USP7_MATH_1	469	473	PF00917	0.373
DOC_USP7_MATH_1	562	566	PF00917	0.235
DOC_USP7_MATH_1	576	580	PF00917	0.720
DOC_USP7_MATH_1	590	594	PF00917	0.628
DOC_USP7_MATH_1	721	725	PF00917	0.657
DOC_USP7_MATH_1	896	900	PF00917	0.575
DOC_WW_Pin1_4	183	188	PF00397	0.444
DOC_WW_Pin1_4	222	227	PF00397	0.406
DOC_WW_Pin1_4	343	348	PF00397	0.464
DOC_WW_Pin1_4	501	506	PF00397	0.429
DOC_WW_Pin1_4	737	742	PF00397	0.215
DOC_WW_Pin1_4	888	893	PF00397	0.653
DOC_WW_Pin1_4	958	963	PF00397	0.621
LIG_14-3-3_CanoR_1	112	122	PF00244	0.449
LIG_14-3-3_CanoR_1	292	297	PF00244	0.355
LIG_14-3-3_CanoR_1	38	46	PF00244	0.435
LIG_14-3-3_CanoR_1	386	392	PF00244	0.399
LIG_14-3-3_CanoR_1	459	465	PF00244	0.477
LIG_14-3-3_CanoR_1	476	485	PF00244	0.295
LIG_14-3-3_CanoR_1	522	530	PF00244	0.408
LIG_14-3-3_CanoR_1	531	536	PF00244	0.303
LIG_14-3-3_CanoR_1	571	578	PF00244	0.712
LIG_14-3-3_CanoR_1	6	10	PF00244	0.669
LIG_14-3-3_CanoR_1	649	655	PF00244	0.594
LIG_14-3-3_CanoR_1	682	686	PF00244	0.603
LIG_14-3-3_CanoR_1	878	887	PF00244	0.759
LIG_14-3-3_CanoR_1	895	904	PF00244	0.434
LIG_Actin_WH2_2	268	285	PF00022	0.317
LIG_BIR_II_1	1	5	PF00653	0.676
LIG_BIR_III_4	88	92	PF00653	0.576
LIG_BRCT_BRCA1_1	117	121	PF00533	0.323
LIG_BRCT_BRCA1_1	536	540	PF00533	0.434
LIG_BRCT_BRCA1_1	837	841	PF00533	0.429
LIG_Clathr_ClatBox_1	58	62	PF01394	0.327
LIG_Clathr_ClatBox_1	782	786	PF01394	0.604
LIG_CSL_BTD_1	502	505	PF09270	0.429
LIG_deltaCOP1_diTrp_1	176	183	PF00928	0.376
LIG_EH_1	267	271	PF12763	0.355
LIG_eIF4E_1	19	25	PF01652	0.500
LIG_eIF4E_1	830	836	PF01652	0.406
LIG_eIF4E_1	907	913	PF01652	0.212
LIG_FHA_1	18	24	PF00498	0.411
LIG_FHA_1	26	32	PF00498	0.466
LIG_FHA_1	388	394	PF00498	0.353
LIG_FHA_1	396	402	PF00498	0.296
LIG_FHA_1	463	469	PF00498	0.418
LIG_FHA_1	490	496	PF00498	0.376
LIG_FHA_1	525	531	PF00498	0.433
LIG_FHA_1	611	617	PF00498	0.634
LIG_FHA_1	636	642	PF00498	0.656
LIG_FHA_1	682	688	PF00498	0.611
LIG_FHA_1	763	769	PF00498	0.429
LIG_FHA_1	788	794	PF00498	0.500
LIG_FHA_1	884	890	PF00498	0.754
LIG_FHA_2	286	292	PF00498	0.406
LIG_FHA_2	476	482	PF00498	0.428
LIG_FHA_2	595	601	PF00498	0.713
LIG_FHA_2	82	88	PF00498	0.548
LIG_LIR_Apic_2	454	460	PF02991	0.444
LIG_LIR_Apic_2	96	102	PF02991	0.468
LIG_LIR_Gen_1	176	187	PF02991	0.387
LIG_LIR_Gen_1	216	226	PF02991	0.358
LIG_LIR_Gen_1	367	378	PF02991	0.434
LIG_LIR_Gen_1	744	753	PF02991	0.438
LIG_LIR_Gen_1	798	805	PF02991	0.499
LIG_LIR_Gen_1	838	849	PF02991	0.376
LIG_LIR_Gen_1	905	913	PF02991	0.500
LIG_LIR_Nem_3	118	124	PF02991	0.325
LIG_LIR_Nem_3	216	221	PF02991	0.358
LIG_LIR_Nem_3	324	330	PF02991	0.353
LIG_LIR_Nem_3	367	373	PF02991	0.404
LIG_LIR_Nem_3	612	618	PF02991	0.603
LIG_LIR_Nem_3	744	749	PF02991	0.438
LIG_LIR_Nem_3	798	803	PF02991	0.469
LIG_LIR_Nem_3	8	12	PF02991	0.537
LIG_LIR_Nem_3	838	844	PF02991	0.376
LIG_LIR_Nem_3	905	910	PF02991	0.451
LIG_LIR_Nem_3	918	923	PF02991	0.285
LIG_NRBOX	525	531	PF00104	0.500
LIG_NRBOX	551	557	PF00104	0.444
LIG_NRBOX	778	784	PF00104	0.486
LIG_Pex14_1	179	183	PF04695	0.380
LIG_Pex14_1	672	676	PF04695	0.598
LIG_Pex14_2	327	331	PF04695	0.392
LIG_Pex14_2	536	540	PF04695	0.388
LIG_Pex14_2	800	804	PF04695	0.423
LIG_SH2_CRK	218	222	PF00017	0.406
LIG_SH2_CRK	409	413	PF00017	0.271
LIG_SH2_CRK	696	700	PF00017	0.578
LIG_SH2_CRK	746	750	PF00017	0.429
LIG_SH2_CRK	907	911	PF00017	0.500
LIG_SH2_CRK	99	103	PF00017	0.433
LIG_SH2_GRB2like	409	412	PF00017	0.433
LIG_SH2_PTP2	909	912	PF00017	0.357
LIG_SH2_STAP1	218	222	PF00017	0.333
LIG_SH2_STAP1	746	750	PF00017	0.500
LIG_SH2_STAP1	907	911	PF00017	0.500
LIG_SH2_STAT5	19	22	PF00017	0.457
LIG_SH2_STAT5	330	333	PF00017	0.393
LIG_SH2_STAT5	443	446	PF00017	0.379
LIG_SH2_STAT5	748	751	PF00017	0.340
LIG_SH2_STAT5	907	910	PF00017	0.378
LIG_SH2_STAT5	923	926	PF00017	0.396
LIG_SH2_STAT5	99	102	PF00017	0.427
LIG_SH3_1	181	187	PF00018	0.435
LIG_SH3_2	184	189	PF14604	0.449
LIG_SH3_3	181	187	PF00018	0.406
LIG_SH3_3	193	199	PF00018	0.420
LIG_SH3_3	341	347	PF00018	0.407
LIG_SH3_3	964	970	PF00018	0.756
LIG_Sin3_3	843	850	PF02671	0.397
LIG_SUMO_SIM_anti_2	396	403	PF11976	0.331
LIG_SUMO_SIM_anti_2	524	530	PF11976	0.500
LIG_SUMO_SIM_anti_2	54	60	PF11976	0.333
LIG_SUMO_SIM_anti_2	553	560	PF11976	0.236
LIG_SUMO_SIM_anti_2	908	915	PF11976	0.212
LIG_SUMO_SIM_par_1	299	305	PF11976	0.396
LIG_SUMO_SIM_par_1	56	62	PF11976	0.327
LIG_SUMO_SIM_par_1	833	838	PF11976	0.339
LIG_SUMO_SIM_par_1	885	891	PF11976	0.700
LIG_SUMO_SIM_par_1	901	908	PF11976	0.382
LIG_SUMO_SIM_par_1	942	949	PF11976	0.429
LIG_SUMO_SIM_par_1	953	958	PF11976	0.429
LIG_TRAF2_1	318	321	PF00917	0.402
LIG_TRAF2_1	873	876	PF00917	0.827
LIG_TRFH_1	844	848	PF08558	0.376
LIG_TYR_ITIM	407	412	PF00017	0.270
LIG_TYR_ITSM	903	910	PF00017	0.397
LIG_UBA3_1	930	938	PF00899	0.307
LIG_WRC_WIRS_1	198	203	PF05994	0.453
MOD_CDC14_SPxK_1	961	964	PF00782	0.575
MOD_CDK_SPxK_1	183	189	PF00069	0.441
MOD_CDK_SPxK_1	958	964	PF00069	0.628
MOD_CDK_SPxxK_3	183	190	PF00069	0.440
MOD_CDK_SPxxK_3	501	508	PF00069	0.531
MOD_CDK_SPxxK_3	888	895	PF00069	0.578
MOD_CK1_1	110	116	PF00069	0.417
MOD_CK1_1	29	35	PF00069	0.398
MOD_CK1_1	534	540	PF00069	0.520
MOD_CK1_1	610	616	PF00069	0.469
MOD_CK1_1	642	648	PF00069	0.516
MOD_CK1_1	775	781	PF00069	0.397
MOD_CK1_1	883	889	PF00069	0.739
MOD_CK1_1	915	921	PF00069	0.465
MOD_CK2_1	233	239	PF00069	0.333
MOD_CK2_1	285	291	PF00069	0.412
MOD_CK2_1	315	321	PF00069	0.410
MOD_CK2_1	41	47	PF00069	0.350
MOD_CK2_1	81	87	PF00069	0.536
MOD_GlcNHglycan	115	118	PF01048	0.606
MOD_GlcNHglycan	169	172	PF01048	0.587
MOD_GlcNHglycan	310	313	PF01048	0.617
MOD_GlcNHglycan	317	320	PF01048	0.594
MOD_GlcNHglycan	425	428	PF01048	0.681
MOD_GlcNHglycan	514	517	PF01048	0.464
MOD_GlcNHglycan	579	582	PF01048	0.518
MOD_GlcNHglycan	644	647	PF01048	0.437
MOD_GlcNHglycan	672	675	PF01048	0.452
MOD_GlcNHglycan	797	800	PF01048	0.422
MOD_GlcNHglycan	898	901	PF01048	0.443
MOD_GlcNHglycan	914	917	PF01048	0.252
MOD_GlcNHglycan	920	923	PF01048	0.561
MOD_GSK3_1	107	114	PF00069	0.389
MOD_GSK3_1	148	155	PF00069	0.494
MOD_GSK3_1	25	32	PF00069	0.472
MOD_GSK3_1	315	322	PF00069	0.405
MOD_GSK3_1	41	48	PF00069	0.271
MOD_GSK3_1	497	504	PF00069	0.429
MOD_GSK3_1	562	569	PF00069	0.502
MOD_GSK3_1	586	593	PF00069	0.755
MOD_GSK3_1	635	642	PF00069	0.573
MOD_GSK3_1	681	688	PF00069	0.671
MOD_GSK3_1	729	736	PF00069	0.747
MOD_GSK3_1	737	744	PF00069	0.344
MOD_GSK3_1	771	778	PF00069	0.444
MOD_GSK3_1	879	886	PF00069	0.748
MOD_GSK3_1	898	905	PF00069	0.183
MOD_N-GLC_1	167	172	PF02516	0.594
MOD_N-GLC_1	283	288	PF02516	0.517
MOD_N-GLC_1	423	428	PF02516	0.623
MOD_N-GLC_1	817	822	PF02516	0.518
MOD_NEK2_1	107	112	PF00069	0.387
MOD_NEK2_1	24	29	PF00069	0.392
MOD_NEK2_1	30	35	PF00069	0.417
MOD_NEK2_1	387	392	PF00069	0.375
MOD_NEK2_1	422	427	PF00069	0.421
MOD_NEK2_1	488	493	PF00069	0.369
MOD_NEK2_1	521	526	PF00069	0.429
MOD_NEK2_1	536	541	PF00069	0.369
MOD_NEK2_1	551	556	PF00069	0.384
MOD_NEK2_1	68	73	PF00069	0.351
MOD_NEK2_1	753	758	PF00069	0.375
MOD_NEK2_1	76	81	PF00069	0.409
MOD_NEK2_1	771	776	PF00069	0.376
MOD_NEK2_1	795	800	PF00069	0.438
MOD_NEK2_1	835	840	PF00069	0.376
MOD_NEK2_1	912	917	PF00069	0.422
MOD_NEK2_1	955	960	PF00069	0.431
MOD_NEK2_2	41	46	PF00069	0.281
MOD_NEK2_2	469	474	PF00069	0.406
MOD_NEK2_2	681	686	PF00069	0.460
MOD_NEK2_2	81	86	PF00069	0.396
MOD_PIKK_1	462	468	PF00454	0.416
MOD_PIKK_1	566	572	PF00454	0.597
MOD_PIKK_1	787	793	PF00454	0.555
MOD_PK_1	115	121	PF00069	0.397
MOD_PK_1	531	537	PF00069	0.415
MOD_PKA_1	571	577	PF00069	0.709
MOD_PKA_2	111	117	PF00069	0.464
MOD_PKA_2	232	238	PF00069	0.352
MOD_PKA_2	291	297	PF00069	0.319
MOD_PKA_2	475	481	PF00069	0.387
MOD_PKA_2	5	11	PF00069	0.672
MOD_PKA_2	521	527	PF00069	0.451
MOD_PKA_2	562	568	PF00069	0.542
MOD_PKA_2	570	576	PF00069	0.665
MOD_PKA_2	594	600	PF00069	0.767
MOD_PKA_2	610	616	PF00069	0.555
MOD_PKA_2	681	687	PF00069	0.623
MOD_PKB_1	231	239	PF00069	0.200
MOD_PKB_1	290	298	PF00069	0.406
MOD_Plk_1	107	113	PF00069	0.377
MOD_Plk_1	175	181	PF00069	0.376
MOD_Plk_1	469	475	PF00069	0.341
MOD_Plk_1	480	486	PF00069	0.425
MOD_Plk_1	817	823	PF00069	0.316
MOD_Plk_4	159	165	PF00069	0.339
MOD_Plk_4	19	25	PF00069	0.423
MOD_Plk_4	216	222	PF00069	0.362
MOD_Plk_4	26	32	PF00069	0.435
MOD_Plk_4	321	327	PF00069	0.364
MOD_Plk_4	469	475	PF00069	0.449
MOD_Plk_4	497	503	PF00069	0.369
MOD_Plk_4	524	530	PF00069	0.397
MOD_Plk_4	531	537	PF00069	0.315
MOD_Plk_4	551	557	PF00069	0.384
MOD_Plk_4	604	610	PF00069	0.660
MOD_Plk_4	681	687	PF00069	0.637
MOD_Plk_4	721	727	PF00069	0.710
MOD_Plk_4	748	754	PF00069	0.500
MOD_Plk_4	817	823	PF00069	0.375
MOD_Plk_4	898	904	PF00069	0.461
MOD_Plk_4	905	911	PF00069	0.423
MOD_ProDKin_1	183	189	PF00069	0.441
MOD_ProDKin_1	222	228	PF00069	0.406
MOD_ProDKin_1	343	349	PF00069	0.458
MOD_ProDKin_1	501	507	PF00069	0.429
MOD_ProDKin_1	737	743	PF00069	0.215
MOD_ProDKin_1	888	894	PF00069	0.651
MOD_ProDKin_1	958	964	PF00069	0.628
MOD_SUMO_rev_2	43	51	PF00179	0.384
MOD_SUMO_rev_2	446	452	PF00179	0.446
TRG_DiLeu_BaEn_1	547	552	PF01217	0.440
TRG_DiLeu_BaEn_2	320	326	PF01217	0.370
TRG_DiLeu_BaLyEn_6	703	708	PF01217	0.644
TRG_ENDOCYTIC_2	218	221	PF00928	0.355
TRG_ENDOCYTIC_2	409	412	PF00928	0.382
TRG_ENDOCYTIC_2	746	749	PF00928	0.347
TRG_ENDOCYTIC_2	907	910	PF00928	0.380
TRG_ER_diArg_1	189	191	PF00400	0.262
TRG_ER_diArg_1	231	234	PF00400	0.274
TRG_ER_diArg_1	476	479	PF00400	0.418
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	414	418	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEK1	Leptomonas seymouri	61%	100%
A0A1X0NIL0	Trypanosomatidae	38%	100%
A0A3Q8IBS9	Leishmania donovani	90%	100%
A4HD90	Leishmania braziliensis	78%	100%
E9AH45	Leishmania infantum	90%	100%
Q4QAU7	Leishmania major	89%	100%