Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWM0_LEIMU

TriTrypDb:

LmxM.24.0310

Length:

319

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AWM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWM0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	129	131	PF00675	0.641
CLV_NRD_NRD_1	18	20	PF00675	0.627
CLV_NRD_NRD_1	236	238	PF00675	0.595
CLV_NRD_NRD_1	84	86	PF00675	0.598
CLV_PCSK_KEX2_1	129	131	PF00082	0.677
CLV_PCSK_KEX2_1	18	20	PF00082	0.627
CLV_PCSK_KEX2_1	196	198	PF00082	0.474
CLV_PCSK_KEX2_1	236	238	PF00082	0.595
CLV_PCSK_KEX2_1	84	86	PF00082	0.598
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.531
CLV_PCSK_SKI1_1	146	150	PF00082	0.484
CLV_PCSK_SKI1_1	23	27	PF00082	0.509
CLV_PCSK_SKI1_1	236	240	PF00082	0.560
CLV_PCSK_SKI1_1	60	64	PF00082	0.780
DEG_APCC_DBOX_1	171	179	PF00400	0.635
DEG_APCC_DBOX_1	244	252	PF00400	0.415
DEG_SPOP_SBC_1	216	220	PF00917	0.647
DEG_SPOP_SBC_1	51	55	PF00917	0.477
DOC_CYCLIN_RxL_1	234	242	PF00134	0.455
DOC_MAPK_gen_1	243	251	PF00069	0.440
DOC_PP2B_LxvP_1	163	166	PF13499	0.577
DOC_USP7_MATH_1	137	141	PF00917	0.717
DOC_USP7_MATH_1	37	41	PF00917	0.488
DOC_USP7_MATH_1	50	54	PF00917	0.786
DOC_USP7_MATH_1	89	93	PF00917	0.714
DOC_WW_Pin1_4	217	222	PF00397	0.610
DOC_WW_Pin1_4	33	38	PF00397	0.685
DOC_WW_Pin1_4	91	96	PF00397	0.594
LIG_14-3-3_CanoR_1	146	152	PF00244	0.547
LIG_14-3-3_CanoR_1	155	163	PF00244	0.681
LIG_14-3-3_CanoR_1	18	22	PF00244	0.685
LIG_14-3-3_CanoR_1	236	242	PF00244	0.548
LIG_14-3-3_CanoR_1	84	89	PF00244	0.706
LIG_BIR_III_4	103	107	PF00653	0.565
LIG_CtBP_PxDLS_1	255	259	PF00389	0.519
LIG_FHA_1	196	202	PF00498	0.393
LIG_FHA_1	233	239	PF00498	0.511
LIG_FHA_1	29	35	PF00498	0.608
LIG_FHA_2	6	12	PF00498	0.750
LIG_LIR_Apic_2	117	123	PF02991	0.512
LIG_LIR_Gen_1	203	213	PF02991	0.413
LIG_LIR_Nem_3	203	208	PF02991	0.400
LIG_NRBOX	260	266	PF00104	0.456
LIG_Pex14_2	21	25	PF04695	0.712
LIG_Pex14_2	301	305	PF04695	0.381
LIG_SH2_PTP2	205	208	PF00017	0.399
LIG_SH2_PTP2	4	7	PF00017	0.713
LIG_SH2_STAT3	180	183	PF00017	0.429
LIG_SH2_STAT5	205	208	PF00017	0.399
LIG_SH2_STAT5	4	7	PF00017	0.717
LIG_SH3_3	164	170	PF00018	0.664
LIG_SH3_3	221	227	PF00018	0.452
LIG_SH3_3	83	89	PF00018	0.579
LIG_SUMO_SIM_par_1	237	242	PF11976	0.427
LIG_SUMO_SIM_par_1	246	252	PF11976	0.399
LIG_SUMO_SIM_par_1	254	260	PF11976	0.419
LIG_TRAF2_1	181	184	PF00917	0.410
MOD_CDK_SPK_2	217	222	PF00069	0.643
MOD_CK1_1	171	177	PF00069	0.636
MOD_CK1_1	217	223	PF00069	0.477
MOD_CK1_1	54	60	PF00069	0.593
MOD_CK1_1	72	78	PF00069	0.562
MOD_CK2_1	178	184	PF00069	0.443
MOD_CK2_1	278	284	PF00069	0.584
MOD_CK2_1	5	11	PF00069	0.706
MOD_Cter_Amidation	16	19	PF01082	0.646
MOD_DYRK1A_RPxSP_1	91	95	PF00069	0.702
MOD_GlcNHglycan	139	142	PF01048	0.622
MOD_GlcNHglycan	15	18	PF01048	0.682
MOD_GlcNHglycan	158	161	PF01048	0.582
MOD_GSK3_1	13	20	PF00069	0.673
MOD_GSK3_1	147	154	PF00069	0.537
MOD_GSK3_1	191	198	PF00069	0.585
MOD_GSK3_1	33	40	PF00069	0.504
MOD_GSK3_1	50	57	PF00069	0.592
MOD_LATS_1	68	74	PF00433	0.704
MOD_N-GLC_1	114	119	PF02516	0.644
MOD_N-GLC_1	307	312	PF02516	0.612
MOD_NEK2_1	151	156	PF00069	0.630
MOD_PIKK_1	191	197	PF00454	0.386
MOD_PIKK_1	39	45	PF00454	0.598
MOD_PKA_1	84	90	PF00069	0.671
MOD_PKA_2	128	134	PF00069	0.634
MOD_PKA_2	17	23	PF00069	0.650
MOD_PKA_2	171	177	PF00069	0.648
MOD_PKA_2	209	215	PF00069	0.608
MOD_PKA_2	84	90	PF00069	0.770
MOD_Plk_4	171	177	PF00069	0.596
MOD_ProDKin_1	217	223	PF00069	0.607
MOD_ProDKin_1	33	39	PF00069	0.686
MOD_ProDKin_1	91	97	PF00069	0.589
TRG_ENDOCYTIC_2	205	208	PF00928	0.399
TRG_ER_diArg_1	128	130	PF00400	0.624
TRG_ER_diArg_1	236	238	PF00400	0.598
TRG_ER_diArg_1	83	85	PF00400	0.603
TRG_NES_CRM1_1	246	260	PF08389	0.417
TRG_Pf-PMV_PEXEL_1	237	242	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.679

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1G9	Leptomonas seymouri	62%	100%
A0A1X0NJB4	Trypanosomatidae	36%	100%
A0A3Q8IB82	Leishmania donovani	89%	100%
A0A3R7RTA5	Trypanosoma rangeli	37%	100%
A4HD87	Leishmania braziliensis	81%	100%
D0A6Z9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AH42	Leishmania infantum	90%	100%
Q4QAV0	Leishmania major	91%	100%
V5C0R1	Trypanosoma cruzi	39%	100%