Protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein kinase

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9AWL2_LEIMU

TriTrypDb:

LmxM.24.0230

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AWL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWL2

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016310	phosphorylation	5	8
GO:0019538	protein metabolic process	3	8
GO:0036211	protein modification process	4	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:0000075	cell cycle checkpoint signaling	4	1
GO:0000077	DNA damage checkpoint signaling	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0007093	mitotic cell cycle checkpoint signaling	4	1
GO:0007165	signal transduction	2	1
GO:0007346	regulation of mitotic cell cycle	5	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010948	negative regulation of cell cycle process	6	1
GO:0022402	cell cycle process	2	1
GO:0031570	DNA integrity checkpoint signaling	5	1
GO:0033554	cellular response to stress	3	1
GO:0035556	intracellular signal transduction	3	1
GO:0042770	signal transduction in response to DNA damage	4	1
GO:0044773	mitotic DNA damage checkpoint signaling	6	1
GO:0044774	mitotic DNA integrity checkpoint signaling	5	1
GO:0045786	negative regulation of cell cycle	5	1
GO:0045930	negative regulation of mitotic cell cycle	6	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0051726	regulation of cell cycle	4	1
GO:0065007	biological regulation	1	1
GO:1901987	regulation of cell cycle phase transition	6	1
GO:1901988	negative regulation of cell cycle phase transition	7	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0004672	protein kinase activity	3	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0016301	kinase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140096	catalytic activity, acting on a protein	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	361	365	PF00656	0.476
CLV_NRD_NRD_1	143	145	PF00675	0.476
CLV_NRD_NRD_1	38	40	PF00675	0.741
CLV_NRD_NRD_1	493	495	PF00675	0.185
CLV_PCSK_KEX2_1	143	145	PF00082	0.405
CLV_PCSK_KEX2_1	18	20	PF00082	0.675
CLV_PCSK_KEX2_1	38	40	PF00082	0.488
CLV_PCSK_KEX2_1	493	495	PF00082	0.185
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.675
CLV_PCSK_SKI1_1	299	303	PF00082	0.351
CLV_PCSK_SKI1_1	315	319	PF00082	0.351
CLV_PCSK_SKI1_1	470	474	PF00082	0.391
CLV_PCSK_SKI1_1	485	489	PF00082	0.368
CLV_PCSK_SKI1_1	517	521	PF00082	0.621
CLV_PCSK_SKI1_1	523	527	PF00082	0.407
CLV_Separin_Metazoa	246	250	PF03568	0.328
DEG_APCC_DBOX_1	155	163	PF00400	0.476
DEG_APCC_DBOX_1	194	202	PF00400	0.405
DEG_APCC_DBOX_1	493	501	PF00400	0.351
DEG_Nend_UBRbox_2	1	3	PF02207	0.725
DEG_SPOP_SBC_1	340	344	PF00917	0.399
DEG_SPOP_SBC_1	44	48	PF00917	0.787
DOC_ANK_TNKS_1	89	96	PF00023	0.599
DOC_CYCLIN_yCln2_LP_2	9	15	PF00134	0.663
DOC_MAPK_gen_1	458	468	PF00069	0.399
DOC_MAPK_MEF2A_6	323	331	PF00069	0.405
DOC_PP2B_LxvP_1	107	110	PF13499	0.476
DOC_PP4_FxxP_1	161	164	PF00568	0.484
DOC_SPAK_OSR1_1	90	94	PF12202	0.615
DOC_USP7_MATH_1	180	184	PF00917	0.540
DOC_USP7_MATH_1	237	241	PF00917	0.405
DOC_USP7_MATH_1	44	48	PF00917	0.770
DOC_USP7_MATH_1	519	523	PF00917	0.689
DOC_WW_Pin1_4	31	36	PF00397	0.697
DOC_WW_Pin1_4	378	383	PF00397	0.380
DOC_WW_Pin1_4	411	416	PF00397	0.328
DOC_WW_Pin1_4	530	535	PF00397	0.586
DOC_WW_Pin1_4	73	78	PF00397	0.552
LIG_14-3-3_CanoR_1	147	153	PF00244	0.405
LIG_14-3-3_CanoR_1	21	26	PF00244	0.721
LIG_14-3-3_CanoR_1	29	35	PF00244	0.786
LIG_14-3-3_CanoR_1	315	324	PF00244	0.185
LIG_14-3-3_CanoR_1	470	478	PF00244	0.462
LIG_14-3-3_CanoR_1	485	490	PF00244	0.338
LIG_BRCT_BRCA1_1	183	187	PF00533	0.659
LIG_BRCT_BRCA1_1	532	536	PF00533	0.733
LIG_EH_1	290	294	PF12763	0.351
LIG_FHA_1	434	440	PF00498	0.379
LIG_FHA_1	527	533	PF00498	0.650
LIG_FHA_2	163	169	PF00498	0.538
LIG_FHA_2	186	192	PF00498	0.655
LIG_FHA_2	241	247	PF00498	0.375
LIG_FHA_2	292	298	PF00498	0.351
LIG_FHA_2	316	322	PF00498	0.194
LIG_FHA_2	359	365	PF00498	0.395
LIG_Integrin_isoDGR_2	141	143	PF01839	0.476
LIG_LIR_Apic_2	158	164	PF02991	0.387
LIG_LIR_Apic_2	414	420	PF02991	0.351
LIG_LIR_Gen_1	184	193	PF02991	0.581
LIG_LIR_Gen_1	280	286	PF02991	0.351
LIG_LIR_Nem_3	175	179	PF02991	0.450
LIG_LIR_Nem_3	184	190	PF02991	0.562
LIG_LIR_Nem_3	280	285	PF02991	0.351
LIG_NRBOX	443	449	PF00104	0.405
LIG_Pex14_2	135	139	PF04695	0.405
LIG_SH2_NCK_1	417	421	PF00017	0.405
LIG_SH2_SRC	311	314	PF00017	0.385
LIG_SH2_STAP1	383	387	PF00017	0.405
LIG_SH2_STAT3	63	66	PF00017	0.490
LIG_SH2_STAT5	275	278	PF00017	0.375
LIG_SH2_STAT5	284	287	PF00017	0.272
LIG_SH2_STAT5	311	314	PF00017	0.405
LIG_SH2_STAT5	449	452	PF00017	0.405
LIG_SH3_1	531	537	PF00018	0.656
LIG_SH3_3	149	155	PF00018	0.352
LIG_SH3_3	453	459	PF00018	0.352
LIG_SH3_3	531	537	PF00018	0.646
LIG_SUMO_SIM_anti_2	473	479	PF11976	0.399
LIG_SUMO_SIM_par_1	524	529	PF11976	0.643
LIG_TRAF2_1	165	168	PF00917	0.627
LIG_TRAF2_1	233	236	PF00917	0.373
LIG_TRAF2_1	431	434	PF00917	0.282
LIG_TRFH_1	196	200	PF08558	0.405
LIG_TRFH_1	73	77	PF08558	0.510
LIG_WW_3	458	462	PF00397	0.399
MOD_CDK_SPxxK_3	31	38	PF00069	0.724
MOD_CDK_SPxxK_3	73	80	PF00069	0.317
MOD_CK1_1	185	191	PF00069	0.597
MOD_CK1_1	23	29	PF00069	0.720
MOD_CK1_1	240	246	PF00069	0.357
MOD_CK1_1	31	37	PF00069	0.735
MOD_CK2_1	162	168	PF00069	0.608
MOD_CK2_1	185	191	PF00069	0.604
MOD_CK2_1	230	236	PF00069	0.473
MOD_CK2_1	240	246	PF00069	0.321
MOD_CK2_1	291	297	PF00069	0.405
MOD_CK2_1	333	339	PF00069	0.399
MOD_CK2_1	43	49	PF00069	0.814
MOD_Cter_Amidation	141	144	PF01082	0.405
MOD_GlcNHglycan	184	187	PF01048	0.602
MOD_GlcNHglycan	264	268	PF01048	0.385
MOD_GlcNHglycan	343	346	PF01048	0.465
MOD_GlcNHglycan	356	359	PF01048	0.257
MOD_GlcNHglycan	393	396	PF01048	0.476
MOD_GlcNHglycan	452	455	PF01048	0.325
MOD_GlcNHglycan	511	514	PF01048	0.579
MOD_GSK3_1	108	115	PF00069	0.385
MOD_GSK3_1	131	138	PF00069	0.357
MOD_GSK3_1	181	188	PF00069	0.660
MOD_GSK3_1	19	26	PF00069	0.697
MOD_GSK3_1	335	342	PF00069	0.418
MOD_GSK3_1	343	350	PF00069	0.403
MOD_GSK3_1	354	361	PF00069	0.204
MOD_GSK3_1	407	414	PF00069	0.392
MOD_GSK3_1	485	492	PF00069	0.476
MOD_GSK3_1	526	533	PF00069	0.611
MOD_GSK3_1	76	83	PF00069	0.501
MOD_LATS_1	313	319	PF00433	0.185
MOD_N-GLC_1	135	140	PF02516	0.351
MOD_N-GLC_1	468	473	PF02516	0.476
MOD_N-GLC_2	103	105	PF02516	0.185
MOD_NEK2_1	135	140	PF00069	0.405
MOD_NEK2_1	263	268	PF00069	0.385
MOD_NEK2_1	354	359	PF00069	0.185
MOD_NEK2_1	407	412	PF00069	0.388
MOD_NEK2_1	468	473	PF00069	0.431
MOD_NEK2_1	526	531	PF00069	0.635
MOD_NEK2_1	78	83	PF00069	0.567
MOD_NEK2_2	237	242	PF00069	0.405
MOD_PKA_1	493	499	PF00069	0.185
MOD_PKA_2	148	154	PF00069	0.405
MOD_PKA_2	155	161	PF00069	0.405
MOD_PKA_2	20	26	PF00069	0.690
MOD_PKA_2	215	221	PF00069	0.387
MOD_PKA_2	230	236	PF00069	0.441
MOD_PKA_2	28	34	PF00069	0.646
MOD_PKA_2	333	339	PF00069	0.480
MOD_PKA_2	493	499	PF00069	0.405
MOD_PKA_2	86	92	PF00069	0.531
MOD_PKB_1	19	27	PF00069	0.697
MOD_PKB_1	229	237	PF00069	0.234
MOD_Plk_1	131	137	PF00069	0.405
MOD_Plk_1	468	474	PF00069	0.484
MOD_Plk_4	119	125	PF00069	0.395
MOD_Plk_4	135	141	PF00069	0.258
MOD_Plk_4	148	154	PF00069	0.351
MOD_Plk_4	157	163	PF00069	0.340
MOD_Plk_4	365	371	PF00069	0.395
MOD_Plk_4	473	479	PF00069	0.340
MOD_ProDKin_1	31	37	PF00069	0.699
MOD_ProDKin_1	378	384	PF00069	0.380
MOD_ProDKin_1	411	417	PF00069	0.328
MOD_ProDKin_1	530	536	PF00069	0.587
MOD_ProDKin_1	73	79	PF00069	0.555
MOD_SUMO_for_1	322	325	PF00179	0.351
MOD_SUMO_for_1	395	398	PF00179	0.399
MOD_SUMO_rev_2	316	324	PF00179	0.405
MOD_SUMO_rev_2	371	380	PF00179	0.405
MOD_SUMO_rev_2	46	53	PF00179	0.731
TRG_ER_diArg_1	143	145	PF00400	0.476
TRG_ER_diArg_1	229	232	PF00400	0.399
TRG_ER_diArg_1	37	39	PF00400	0.770
TRG_ER_diArg_1	493	495	PF00400	0.185
TRG_Pf-PMV_PEXEL_1	299	304	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.701

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P787	Leptomonas seymouri	23%	100%
A0A0N1HTF0	Leptomonas seymouri	25%	86%
A0A0N1HZY0	Leptomonas seymouri	58%	90%
A0A0S4IZ14	Bodo saltans	40%	91%
A0A0S4J1U0	Bodo saltans	24%	74%
A0A0S4JI27	Bodo saltans	26%	75%
A0A0S4JPZ7	Bodo saltans	25%	100%
A0A3Q8INQ4	Leishmania donovani	26%	100%
A0A3R7MPF2	Trypanosoma rangeli	25%	84%
A0A3S5H5U5	Leishmania donovani	23%	100%
A0A3S7WTN9	Leishmania donovani	22%	100%
A0A3S7WV74	Leishmania donovani	25%	86%
A0A3S7WVR6	Leishmania donovani	25%	87%
A0A3S7WY10	Leishmania donovani	93%	100%
A0A3S7X8Z8	Leishmania donovani	28%	100%
A0A3S7X9D1	Leishmania donovani	23%	94%
A0A5K1K8H0	Plasmodium falciparum (isolate 3D7)	26%	96%
A4H459	Leishmania braziliensis	25%	100%
A4H9X1	Leishmania braziliensis	25%	86%
A4HD79	Leishmania braziliensis	80%	100%
A4HEA1	Leishmania braziliensis	26%	96%
A4HHE4	Leishmania braziliensis	27%	92%
A4HMK7	Leishmania braziliensis	24%	94%
A4HWP5	Leishmania infantum	22%	100%
A4HYH7	Leishmania infantum	25%	87%
A4I1T4	Leishmania infantum	26%	100%
A4IB02	Leishmania infantum	28%	100%
A4IB86	Leishmania infantum	23%	94%
C9ZQP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AET0	Leishmania major	27%	100%
E9AF07	Leishmania major	23%	94%
E9AG71	Leishmania infantum	23%	100%
E9AGR6	Leishmania infantum	25%	86%
E9AH34	Leishmania infantum	93%	100%
E9AKB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9APX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	76%
E9AQF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9ASA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	87%
E9AXT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	95%
E9B5Y5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B663	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	94%
O08875	Rattus norvegicus	28%	100%
O15075	Homo sapiens	28%	73%
O61267	Drosophila melanogaster	28%	100%
O96017	Homo sapiens	29%	100%
P00518	Oryctolagus cuniculus	26%	100%
P07934	Mus musculus	26%	100%
P22216	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	66%
P34101	Dictyostelium discoideum	27%	91%
P39009	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
P93759	Arabidopsis thaliana	26%	100%
Q07250	Malus domestica	27%	100%
Q09170	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q10292	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q2QQR2	Oryza sativa subsp. japonica	26%	89%
Q4QAV8	Leishmania major	92%	99%
Q4QDK7	Leishmania major	25%	86%
Q4QF23	Leishmania major	23%	100%
Q4QFK4	Leishmania major	22%	87%
Q54BF0	Dictyostelium discoideum	25%	92%
Q54MH0	Dictyostelium discoideum	29%	72%
Q54VI1	Dictyostelium discoideum	27%	76%
Q5MPA9	Rattus norvegicus	28%	71%
Q6C3J2	Yarrowia lipolytica (strain CLIB 122 / E 150)	26%	100%
Q6F3A6	Oryza sativa subsp. japonica	27%	91%
Q6RET6	Pisum sativum	26%	100%
Q75H77	Oryza sativa subsp. japonica	29%	100%
Q8BW96	Mus musculus	28%	100%
Q8IU85	Homo sapiens	28%	100%
Q9JLM8	Mus musculus	27%	72%
Q9U1Y5	Caenorhabditis elegans	26%	100%
Q9Z265	Mus musculus	30%	99%
V5BL06	Trypanosoma cruzi	26%	84%
V5C224	Trypanosoma cruzi	22%	100%