Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AWL1_LEIMU

TriTrypDb:

LmxM.24.0220

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWL1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.484
CLV_MEL_PAP_1	36	42	PF00089	0.413
CLV_NRD_NRD_1	145	147	PF00675	0.679
CLV_NRD_NRD_1	194	196	PF00675	0.430
CLV_PCSK_SKI1_1	113	117	PF00082	0.405
CLV_PCSK_SKI1_1	138	142	PF00082	0.524
CLV_PCSK_SKI1_1	261	265	PF00082	0.398
CLV_PCSK_SKI1_1	317	321	PF00082	0.637
CLV_PCSK_SKI1_1	45	49	PF00082	0.299
DEG_APCC_DBOX_1	80	88	PF00400	0.418
DEG_Nend_UBRbox_1	1	4	PF02207	0.340
DOC_CKS1_1	219	224	PF01111	0.589
DOC_CKS1_1	272	277	PF01111	0.513
DOC_CYCLIN_yCln2_LP_2	272	278	PF00134	0.463
DOC_MAPK_gen_1	136	144	PF00069	0.448
DOC_MAPK_gen_1	271	278	PF00069	0.470
DOC_MAPK_JIP1_4	138	144	PF00069	0.450
DOC_MAPK_MEF2A_6	136	144	PF00069	0.448
DOC_MAPK_MEF2A_6	33	40	PF00069	0.430
DOC_PP2B_LxvP_1	132	135	PF13499	0.545
DOC_USP7_UBL2_3	114	118	PF12436	0.596
DOC_WW_Pin1_4	204	209	PF00397	0.457
DOC_WW_Pin1_4	21	26	PF00397	0.492
DOC_WW_Pin1_4	218	223	PF00397	0.559
DOC_WW_Pin1_4	271	276	PF00397	0.482
LIG_14-3-3_CanoR_1	12	16	PF00244	0.346
LIG_14-3-3_CanoR_1	2	6	PF00244	0.404
LIG_14-3-3_CanoR_1	39	49	PF00244	0.444
LIG_AP2alpha_2	223	225	PF02296	0.545
LIG_BIR_III_4	151	155	PF00653	0.643
LIG_Clathr_ClatBox_1	48	52	PF01394	0.477
LIG_FHA_1	56	62	PF00498	0.564
LIG_FHA_1	74	80	PF00498	0.293
LIG_FHA_2	26	32	PF00498	0.401
LIG_FHA_2	93	99	PF00498	0.593
LIG_FXI_DFP_1	244	248	PF00024	0.431
LIG_G3BP_FGDF_1	242	247	PF02136	0.381
LIG_LIR_Gen_1	10	21	PF02991	0.465
LIG_LIR_Gen_1	181	192	PF02991	0.481
LIG_LIR_Gen_1	246	254	PF02991	0.404
LIG_LIR_Gen_1	304	315	PF02991	0.429
LIG_LIR_Nem_3	10	16	PF02991	0.452
LIG_LIR_Nem_3	181	187	PF02991	0.408
LIG_LIR_Nem_3	223	228	PF02991	0.657
LIG_LIR_Nem_3	246	250	PF02991	0.397
LIG_LIR_Nem_3	304	310	PF02991	0.384
LIG_LYPXL_S_1	284	288	PF13949	0.389
LIG_LYPXL_yS_3	285	288	PF13949	0.371
LIG_NRBOX	50	56	PF00104	0.516
LIG_Pex14_2	141	145	PF04695	0.429
LIG_SH2_CRK	184	188	PF00017	0.474
LIG_SH2_NCK_1	13	17	PF00017	0.433
LIG_SH2_SRC	184	187	PF00017	0.506
LIG_SH2_STAT5	243	246	PF00017	0.387
LIG_SH3_3	117	123	PF00018	0.565
LIG_SH3_3	155	161	PF00018	0.666
LIG_SH3_3	207	213	PF00018	0.497
LIG_SUMO_SIM_anti_2	46	52	PF11976	0.378
LIG_SUMO_SIM_par_1	290	296	PF11976	0.354
LIG_SUMO_SIM_par_1	46	52	PF11976	0.471
LIG_TYR_ITSM	180	187	PF00017	0.289
MOD_CK1_1	24	30	PF00069	0.461
MOD_CK2_1	11	17	PF00069	0.450
MOD_CK2_1	25	31	PF00069	0.319
MOD_CK2_1	40	46	PF00069	0.404
MOD_CK2_1	80	86	PF00069	0.595
MOD_GlcNHglycan	330	333	PF01048	0.695
MOD_GSK3_1	21	28	PF00069	0.388
MOD_GSK3_1	7	14	PF00069	0.407
MOD_NEK2_1	1	6	PF00069	0.403
MOD_NEK2_1	40	45	PF00069	0.474
MOD_NEK2_1	55	60	PF00069	0.450
MOD_NEK2_1	85	90	PF00069	0.628
MOD_PKA_1	179	185	PF00069	0.294
MOD_PKA_2	1	7	PF00069	0.404
MOD_PKA_2	11	17	PF00069	0.356
MOD_PKA_2	80	86	PF00069	0.513
MOD_Plk_1	25	31	PF00069	0.548
MOD_Plk_2-3	172	178	PF00069	0.372
MOD_Plk_4	11	17	PF00069	0.385
MOD_Plk_4	179	185	PF00069	0.294
MOD_Plk_4	80	86	PF00069	0.425
MOD_ProDKin_1	204	210	PF00069	0.454
MOD_ProDKin_1	21	27	PF00069	0.485
MOD_ProDKin_1	218	224	PF00069	0.575
MOD_ProDKin_1	271	277	PF00069	0.487
MOD_SUMO_rev_2	172	181	PF00179	0.421
MOD_SUMO_rev_2	26	35	PF00179	0.465
TRG_DiLeu_BaEn_1	31	36	PF01217	0.390
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.499
TRG_ENDOCYTIC_2	13	16	PF00928	0.424
TRG_ENDOCYTIC_2	184	187	PF00928	0.412
TRG_ENDOCYTIC_2	285	288	PF00928	0.371
TRG_ER_diArg_1	135	138	PF00400	0.479
TRG_ER_diArg_1	270	273	PF00400	0.460
TRG_Pf-PMV_PEXEL_1	261	265	PF00026	0.255

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7K8	Leptomonas seymouri	65%	100%
A0A0S4JUQ7	Bodo saltans	38%	100%
A0A1X0NIQ0	Trypanosomatidae	46%	100%
A0A3Q8IBY8	Leishmania donovani	91%	100%
E9AH33	Leishmania infantum	91%	100%
Q4QAV9	Leishmania major	91%	100%