Putative transcription elongation factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transcription elongation factor, putative

Species:

Leishmania mexicana

UniProt:

E9AWL0_LEIMU

TriTrypDb:

LmxM.24.0210

Length:

337

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AWL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWL0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006351	DNA-templated transcription	7	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009059	macromolecule biosynthetic process	4	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0018130	heterocycle biosynthetic process	4	10
GO:0019438	aromatic compound biosynthetic process	4	10
GO:0032774	RNA biosynthetic process	5	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034654	nucleobase-containing compound biosynthetic process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044271	cellular nitrogen compound biosynthetic process	4	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:0097659	nucleic acid-templated transcription	6	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901362	organic cyclic compound biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003746	translation elongation factor activity	4	10
GO:0005488	binding	1	10
GO:0008135	translation factor activity, RNA binding	3	10
GO:0008270	zinc ion binding	6	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0045182	translation regulator activity	1	10
GO:0046872	metal ion binding	4	10
GO:0046914	transition metal ion binding	5	10
GO:0090079	translation regulator activity, nucleic acid binding	2	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.637
CLV_NRD_NRD_1	132	134	PF00675	0.623
CLV_NRD_NRD_1	239	241	PF00675	0.338
CLV_NRD_NRD_1	266	268	PF00675	0.273
CLV_NRD_NRD_1	285	287	PF00675	0.371
CLV_NRD_NRD_1	334	336	PF00675	0.326
CLV_PCSK_KEX2_1	173	175	PF00082	0.535
CLV_PCSK_KEX2_1	239	241	PF00082	0.338
CLV_PCSK_KEX2_1	266	268	PF00082	0.176
CLV_PCSK_KEX2_1	56	58	PF00082	0.603
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.535
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.603
CLV_PCSK_SKI1_1	174	178	PF00082	0.486
CLV_PCSK_SKI1_1	251	255	PF00082	0.340
DEG_SCF_FBW7_1	132	139	PF00400	0.693
DEG_SPOP_SBC_1	113	117	PF00917	0.497
DOC_CKS1_1	149	154	PF01111	0.631
DOC_CKS1_1	67	72	PF01111	0.670
DOC_MAPK_MEF2A_6	200	208	PF00069	0.482
DOC_PP2B_LxvP_1	16	19	PF13499	0.545
DOC_PP2B_LxvP_1	36	39	PF13499	0.650
DOC_PP4_FxxP_1	67	70	PF00568	0.669
DOC_USP7_MATH_1	140	144	PF00917	0.638
DOC_USP7_MATH_1	156	160	PF00917	0.572
DOC_USP7_MATH_1	164	168	PF00917	0.578
DOC_USP7_MATH_1	29	33	PF00917	0.697
DOC_USP7_MATH_1	304	308	PF00917	0.392
DOC_USP7_MATH_1	37	41	PF00917	0.612
DOC_USP7_MATH_1	47	51	PF00917	0.499
DOC_USP7_MATH_1	8	12	PF00917	0.694
DOC_USP7_UBL2_3	130	134	PF12436	0.723
DOC_WW_Pin1_4	104	109	PF00397	0.692
DOC_WW_Pin1_4	116	121	PF00397	0.475
DOC_WW_Pin1_4	132	137	PF00397	0.591
DOC_WW_Pin1_4	14	19	PF00397	0.733
DOC_WW_Pin1_4	148	153	PF00397	0.523
DOC_WW_Pin1_4	31	36	PF00397	0.788
DOC_WW_Pin1_4	50	55	PF00397	0.517
DOC_WW_Pin1_4	66	71	PF00397	0.767
DOC_WW_Pin1_4	81	86	PF00397	0.504
LIG_14-3-3_CanoR_1	251	256	PF00244	0.545
LIG_BIR_II_1	1	5	PF00653	0.700
LIG_BRCT_BRCA1_1	293	297	PF00533	0.424
LIG_Clathr_ClatBox_1	252	256	PF01394	0.552
LIG_FHA_1	101	107	PF00498	0.620
LIG_FHA_1	139	145	PF00498	0.706
LIG_FHA_1	28	34	PF00498	0.708
LIG_FHA_1	320	326	PF00498	0.420
LIG_FHA_1	63	69	PF00498	0.686
LIG_FHA_2	252	258	PF00498	0.525
LIG_LIR_Apic_2	65	70	PF02991	0.671
LIG_LIR_Gen_1	122	132	PF02991	0.700
LIG_LIR_Gen_1	221	230	PF02991	0.538
LIG_LIR_Nem_3	122	127	PF02991	0.686
LIG_LIR_Nem_3	221	226	PF02991	0.456
LIG_LIR_Nem_3	332	337	PF02991	0.299
LIG_MYND_1	14	18	PF01753	0.545
LIG_SH2_CRK	124	128	PF00017	0.696
LIG_SH2_GRB2like	124	127	PF00017	0.689
LIG_SH2_STAT5	66	69	PF00017	0.464
LIG_SH3_3	117	123	PF00018	0.587
LIG_SH3_3	12	18	PF00018	0.601
LIG_SH3_3	134	140	PF00018	0.597
LIG_SH3_3	147	153	PF00018	0.533
LIG_SH3_3	2	8	PF00018	0.639
LIG_SH3_3	57	63	PF00018	0.666
LIG_SUMO_SIM_par_1	321	326	PF11976	0.411
LIG_TRFH_1	66	70	PF08558	0.462
LIG_UBA3_1	226	234	PF00899	0.456
MOD_CDC14_SPxK_1	53	56	PF00782	0.649
MOD_CDK_SPK_2	104	109	PF00069	0.803
MOD_CDK_SPK_2	116	121	PF00069	0.468
MOD_CDK_SPxK_1	50	56	PF00069	0.719
MOD_CDK_SPxxK_3	50	57	PF00069	0.652
MOD_CK1_1	122	128	PF00069	0.628
MOD_CK1_1	138	144	PF00069	0.572
MOD_CK1_1	167	173	PF00069	0.632
MOD_CK1_1	195	201	PF00069	0.557
MOD_CK1_1	277	283	PF00069	0.604
MOD_CK1_1	292	298	PF00069	0.384
MOD_CK1_1	50	56	PF00069	0.776
MOD_CK1_1	74	80	PF00069	0.722
MOD_CK1_1	86	92	PF00069	0.709
MOD_CK2_1	304	310	PF00069	0.364
MOD_CK2_1	313	319	PF00069	0.254
MOD_GlcNHglycan	25	28	PF01048	0.640
MOD_GlcNHglycan	315	318	PF01048	0.296
MOD_GlcNHglycan	49	52	PF01048	0.776
MOD_GlcNHglycan	73	76	PF01048	0.522
MOD_GlcNHglycan	85	88	PF01048	0.693
MOD_GSK3_1	100	107	PF00069	0.769
MOD_GSK3_1	112	119	PF00069	0.659
MOD_GSK3_1	132	139	PF00069	0.628
MOD_GSK3_1	14	21	PF00069	0.517
MOD_GSK3_1	140	147	PF00069	0.629
MOD_GSK3_1	151	158	PF00069	0.450
MOD_GSK3_1	23	30	PF00069	0.557
MOD_GSK3_1	288	295	PF00069	0.512
MOD_GSK3_1	319	326	PF00069	0.375
MOD_GSK3_1	46	53	PF00069	0.729
MOD_GSK3_1	62	69	PF00069	0.573
MOD_GSK3_1	77	84	PF00069	0.632
MOD_LATS_1	110	116	PF00433	0.503
MOD_N-GLC_1	145	150	PF02516	0.602
MOD_N-GLC_1	195	200	PF02516	0.175
MOD_N-GLC_1	280	285	PF02516	0.628
MOD_N-GLC_1	292	297	PF02516	0.572
MOD_N-GLC_1	47	52	PF02516	0.735
MOD_N-GLC_2	328	330	PF02516	0.296
MOD_NEK2_1	1	6	PF00069	0.775
MOD_NEK2_1	144	149	PF00069	0.693
MOD_NEK2_1	289	294	PF00069	0.589
MOD_PIKK_1	329	335	PF00454	0.411
MOD_PIKK_1	74	80	PF00454	0.711
MOD_PKA_2	192	198	PF00069	0.527
MOD_PKA_2	289	295	PF00069	0.528
MOD_PKA_2	304	310	PF00069	0.356
MOD_PKA_2	311	317	PF00069	0.373
MOD_Plk_1	113	119	PF00069	0.508
MOD_Plk_1	145	151	PF00069	0.631
MOD_Plk_1	292	298	PF00069	0.504
MOD_Plk_1	305	311	PF00069	0.240
MOD_Plk_4	145	151	PF00069	0.686
MOD_Plk_4	222	228	PF00069	0.541
MOD_Plk_4	292	298	PF00069	0.432
MOD_Plk_4	319	325	PF00069	0.344
MOD_ProDKin_1	104	110	PF00069	0.693
MOD_ProDKin_1	116	122	PF00069	0.470
MOD_ProDKin_1	132	138	PF00069	0.589
MOD_ProDKin_1	14	20	PF00069	0.734
MOD_ProDKin_1	148	154	PF00069	0.525
MOD_ProDKin_1	31	37	PF00069	0.789
MOD_ProDKin_1	50	56	PF00069	0.519
MOD_ProDKin_1	66	72	PF00069	0.768
MOD_ProDKin_1	81	87	PF00069	0.505
MOD_SUMO_rev_2	264	273	PF00179	0.525
TRG_DiLeu_BaEn_1	244	249	PF01217	0.538
TRG_ENDOCYTIC_2	124	127	PF00928	0.689
TRG_ER_diArg_1	238	240	PF00400	0.547
TRG_ER_diArg_1	265	267	PF00400	0.422
TRG_ER_diArg_1	57	60	PF00400	0.651
TRG_NES_CRM1_1	250	264	PF08389	0.545
TRG_NLS_MonoCore_2	55	60	PF00514	0.624
TRG_NLS_MonoExtN_4	54	60	PF00514	0.695
TRG_Pf-PMV_PEXEL_1	267	271	PF00026	0.216

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFJ1	Leptomonas seymouri	62%	97%
A0A1X0NIZ8	Trypanosomatidae	44%	100%
A0A3Q8IER0	Leishmania donovani	90%	100%
A0A422P430	Trypanosoma rangeli	42%	100%
A4HD78	Leishmania braziliensis	70%	96%
E9AH32	Leishmania infantum	90%	100%
Q4QAW0	Leishmania major	89%	99%
V5DSP1	Trypanosoma cruzi	45%	100%