HEAT repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWK8_LEIMU

TriTrypDb:

LmxM.24.0190

Length:

813

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9AWK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWK8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.540
CLV_C14_Caspase3-7	494	498	PF00656	0.430
CLV_C14_Caspase3-7	576	580	PF00656	0.235
CLV_C14_Caspase3-7	711	715	PF00656	0.524
CLV_MEL_PAP_1	436	442	PF00089	0.419
CLV_NRD_NRD_1	337	339	PF00675	0.373
CLV_NRD_NRD_1	400	402	PF00675	0.450
CLV_NRD_NRD_1	657	659	PF00675	0.508
CLV_NRD_NRD_1	736	738	PF00675	0.337
CLV_NRD_NRD_1	761	763	PF00675	0.646
CLV_NRD_NRD_1	777	779	PF00675	0.601
CLV_NRD_NRD_1	809	811	PF00675	0.768
CLV_PCSK_KEX2_1	337	339	PF00082	0.373
CLV_PCSK_KEX2_1	400	402	PF00082	0.450
CLV_PCSK_KEX2_1	716	718	PF00082	0.528
CLV_PCSK_KEX2_1	736	738	PF00082	0.298
CLV_PCSK_KEX2_1	777	779	PF00082	0.729
CLV_PCSK_KEX2_1	811	813	PF00082	0.764
CLV_PCSK_PC1ET2_1	716	718	PF00082	0.472
CLV_PCSK_PC1ET2_1	811	813	PF00082	0.753
CLV_PCSK_SKI1_1	189	193	PF00082	0.447
CLV_PCSK_SKI1_1	319	323	PF00082	0.353
CLV_PCSK_SKI1_1	416	420	PF00082	0.490
CLV_PCSK_SKI1_1	425	429	PF00082	0.473
CLV_PCSK_SKI1_1	463	467	PF00082	0.379
CLV_PCSK_SKI1_1	477	481	PF00082	0.314
CLV_PCSK_SKI1_1	542	546	PF00082	0.520
CLV_PCSK_SKI1_1	643	647	PF00082	0.406
CLV_PCSK_SKI1_1	736	740	PF00082	0.507
CLV_PCSK_SKI1_1	741	745	PF00082	0.460
CLV_PCSK_SKI1_1	796	800	PF00082	0.707
DEG_APCC_DBOX_1	131	139	PF00400	0.528
DEG_APCC_DBOX_1	337	345	PF00400	0.366
DEG_APCC_DBOX_1	462	470	PF00400	0.477
DEG_APCC_DBOX_1	736	744	PF00400	0.458
DEG_Nend_UBRbox_2	1	3	PF02207	0.608
DEG_SPOP_SBC_1	766	770	PF00917	0.585
DEG_SPOP_SBC_1	787	791	PF00917	0.576
DOC_CKS1_1	194	199	PF01111	0.456
DOC_CYCLIN_RxL_1	263	274	PF00134	0.368
DOC_CYCLIN_RxL_1	422	432	PF00134	0.498
DOC_CYCLIN_RxL_1	643	656	PF00134	0.457
DOC_MAPK_FxFP_2	405	408	PF00069	0.470
DOC_MAPK_gen_1	745	755	PF00069	0.662
DOC_MAPK_gen_1	777	785	PF00069	0.589
DOC_PP1_RVXF_1	122	128	PF00149	0.484
DOC_PP1_RVXF_1	198	204	PF00149	0.357
DOC_PP1_RVXF_1	498	504	PF00149	0.468
DOC_PP2B_PxIxI_1	196	202	PF00149	0.520
DOC_PP4_FxxP_1	331	334	PF00568	0.332
DOC_PP4_FxxP_1	405	408	PF00568	0.470
DOC_USP7_MATH_1	117	121	PF00917	0.446
DOC_USP7_MATH_1	17	21	PF00917	0.667
DOC_USP7_MATH_1	438	442	PF00917	0.478
DOC_USP7_MATH_1	472	476	PF00917	0.432
DOC_USP7_MATH_1	704	708	PF00917	0.636
DOC_USP7_MATH_1	787	791	PF00917	0.609
DOC_USP7_UBL2_3	141	145	PF12436	0.507
DOC_USP7_UBL2_3	28	32	PF12436	0.749
DOC_USP7_UBL2_3	729	733	PF12436	0.462
DOC_WW_Pin1_4	193	198	PF00397	0.473
DOC_WW_Pin1_4	2	7	PF00397	0.618
DOC_WW_Pin1_4	452	457	PF00397	0.553
DOC_WW_Pin1_4	754	759	PF00397	0.694
DOC_WW_Pin1_4	800	805	PF00397	0.798
LIG_14-3-3_CanoR_1	124	128	PF00244	0.491
LIG_14-3-3_CanoR_1	18	25	PF00244	0.731
LIG_14-3-3_CanoR_1	319	329	PF00244	0.346
LIG_14-3-3_CanoR_1	439	446	PF00244	0.458
LIG_14-3-3_CanoR_1	500	504	PF00244	0.459
LIG_14-3-3_CanoR_1	542	550	PF00244	0.520
LIG_14-3-3_CanoR_1	604	608	PF00244	0.437
LIG_14-3-3_CanoR_1	616	621	PF00244	0.372
LIG_14-3-3_CanoR_1	796	804	PF00244	0.711
LIG_Actin_WH2_2	480	498	PF00022	0.516
LIG_AP2alpha_1	384	388	PF02296	0.407
LIG_APCC_ABBA_1	381	386	PF00400	0.449
LIG_BRCT_BRCA1_1	611	615	PF00533	0.388
LIG_eIF4E_1	336	342	PF01652	0.473
LIG_EVH1_1	755	759	PF00568	0.660
LIG_FHA_1	194	200	PF00498	0.396
LIG_FHA_1	455	461	PF00498	0.455
LIG_FHA_1	543	549	PF00498	0.510
LIG_FHA_1	668	674	PF00498	0.504
LIG_FHA_1	70	76	PF00498	0.617
LIG_FHA_1	766	772	PF00498	0.695
LIG_FHA_1	789	795	PF00498	0.716
LIG_FHA_2	147	153	PF00498	0.538
LIG_FHA_2	391	397	PF00498	0.497
LIG_FHA_2	541	547	PF00498	0.423
LIG_GBD_Chelix_1	480	488	PF00786	0.469
LIG_LIR_Apic_2	2	6	PF02991	0.640
LIG_LIR_Apic_2	330	334	PF02991	0.342
LIG_LIR_Gen_1	202	211	PF02991	0.243
LIG_LIR_Gen_1	305	314	PF02991	0.381
LIG_LIR_Gen_1	462	472	PF02991	0.478
LIG_LIR_Gen_1	502	512	PF02991	0.420
LIG_LIR_Gen_1	606	615	PF02991	0.386
LIG_LIR_Gen_1	666	676	PF02991	0.399
LIG_LIR_Nem_3	126	131	PF02991	0.395
LIG_LIR_Nem_3	202	206	PF02991	0.346
LIG_LIR_Nem_3	212	216	PF02991	0.414
LIG_LIR_Nem_3	305	310	PF02991	0.367
LIG_LIR_Nem_3	330	335	PF02991	0.419
LIG_LIR_Nem_3	339	345	PF02991	0.315
LIG_LIR_Nem_3	363	367	PF02991	0.346
LIG_LIR_Nem_3	462	468	PF02991	0.476
LIG_LIR_Nem_3	502	507	PF02991	0.425
LIG_LIR_Nem_3	606	610	PF02991	0.385
LIG_LIR_Nem_3	612	618	PF02991	0.380
LIG_NRBOX	146	152	PF00104	0.495
LIG_NRBOX	171	177	PF00104	0.533
LIG_NRBOX	305	311	PF00104	0.377
LIG_NRBOX	507	513	PF00104	0.488
LIG_NRBOX	739	745	PF00104	0.484
LIG_Pex14_2	384	388	PF04695	0.451
LIG_REV1ctd_RIR_1	615	625	PF16727	0.458
LIG_SH2_CRK	3	7	PF00017	0.603
LIG_SH2_SRC	213	216	PF00017	0.447
LIG_SH2_SRC	535	538	PF00017	0.427
LIG_SH2_STAT3	602	605	PF00017	0.472
LIG_SH2_STAT5	100	103	PF00017	0.472
LIG_SH2_STAT5	114	117	PF00017	0.405
LIG_SH2_STAT5	213	216	PF00017	0.393
LIG_SH2_STAT5	490	493	PF00017	0.478
LIG_SH2_STAT5	535	538	PF00017	0.396
LIG_SH2_STAT5	607	610	PF00017	0.335
LIG_SH2_STAT5	691	694	PF00017	0.490
LIG_SH3_3	133	139	PF00018	0.568
LIG_SH3_3	191	197	PF00018	0.536
LIG_SH3_3	512	518	PF00018	0.505
LIG_SH3_3	65	71	PF00018	0.681
LIG_SH3_3	753	759	PF00018	0.743
LIG_SH3_3	761	767	PF00018	0.690
LIG_SH3_3	768	774	PF00018	0.543
LIG_SH3_3	789	795	PF00018	0.746
LIG_SUMO_SIM_anti_2	781	787	PF11976	0.586
LIG_SUMO_SIM_par_1	133	140	PF11976	0.526
LIG_SUMO_SIM_par_1	190	196	PF11976	0.435
LIG_SUMO_SIM_par_1	323	330	PF11976	0.353
LIG_SUMO_SIM_par_1	426	434	PF11976	0.456
LIG_SUMO_SIM_par_1	751	757	PF11976	0.497
LIG_TRAF2_1	107	110	PF00917	0.460
LIG_TRAF2_1	311	314	PF00917	0.512
LIG_TRAF2_1	538	541	PF00917	0.440
LIG_TRAF2_1	664	667	PF00917	0.521
LIG_TYR_ITIM	211	216	PF00017	0.444
LIG_UBA3_1	223	230	PF00899	0.482
LIG_UBA3_1	341	346	PF00899	0.473
LIG_UBA3_1	752	760	PF00899	0.653
LIG_WRC_WIRS_1	536	541	PF05994	0.440
MOD_CDC14_SPxK_1	757	760	PF00782	0.721
MOD_CDC14_SPxK_1	803	806	PF00782	0.499
MOD_CDK_SPxK_1	754	760	PF00069	0.700
MOD_CDK_SPxK_1	800	806	PF00069	0.791
MOD_CDK_SPxxK_3	193	200	PF00069	0.455
MOD_CK1_1	20	26	PF00069	0.648
MOD_CK1_1	429	435	PF00069	0.494
MOD_CK1_1	499	505	PF00069	0.506
MOD_CK1_1	513	519	PF00069	0.339
MOD_CK1_1	781	787	PF00069	0.697
MOD_CK1_1	790	796	PF00069	0.631
MOD_CK2_1	104	110	PF00069	0.479
MOD_CK2_1	2	8	PF00069	0.561
MOD_CK2_1	308	314	PF00069	0.500
MOD_CK2_1	390	396	PF00069	0.496
MOD_CK2_1	535	541	PF00069	0.427
MOD_CK2_1	712	718	PF00069	0.544
MOD_CK2_1	743	749	PF00069	0.499
MOD_GlcNHglycan	109	113	PF01048	0.522
MOD_GlcNHglycan	440	443	PF01048	0.405
MOD_GlcNHglycan	504	507	PF01048	0.470
MOD_GlcNHglycan	52	55	PF01048	0.667
MOD_GlcNHglycan	57	61	PF01048	0.707
MOD_GlcNHglycan	611	614	PF01048	0.442
MOD_GSK3_1	104	111	PF00069	0.472
MOD_GSK3_1	137	144	PF00069	0.557
MOD_GSK3_1	146	153	PF00069	0.384
MOD_GSK3_1	30	37	PF00069	0.704
MOD_GSK3_1	347	354	PF00069	0.466
MOD_GSK3_1	370	377	PF00069	0.481
MOD_GSK3_1	410	417	PF00069	0.380
MOD_GSK3_1	495	502	PF00069	0.461
MOD_GSK3_1	586	593	PF00069	0.458
MOD_GSK3_1	653	660	PF00069	0.496
MOD_GSK3_1	700	707	PF00069	0.620
MOD_GSK3_1	786	793	PF00069	0.713
MOD_GSK3_1	796	803	PF00069	0.741
MOD_N-GLC_1	117	122	PF02516	0.467
MOD_N-GLC_1	228	233	PF02516	0.546
MOD_N-GLC_2	599	601	PF02516	0.344
MOD_NEK2_1	150	155	PF00069	0.502
MOD_NEK2_1	187	192	PF00069	0.414
MOD_NEK2_1	262	267	PF00069	0.318
MOD_NEK2_1	495	500	PF00069	0.512
MOD_NEK2_1	646	651	PF00069	0.433
MOD_NEK2_1	653	658	PF00069	0.456
MOD_NEK2_2	472	477	PF00069	0.310
MOD_PIKK_1	17	23	PF00454	0.636
MOD_PIKK_1	651	657	PF00454	0.533
MOD_PKA_2	123	129	PF00069	0.497
MOD_PKA_2	17	23	PF00069	0.714
MOD_PKA_2	438	444	PF00069	0.365
MOD_PKA_2	499	505	PF00069	0.464
MOD_PKA_2	603	609	PF00069	0.460
MOD_PKA_2	635	641	PF00069	0.491
MOD_PKA_2	657	663	PF00069	0.610
MOD_Plk_1	472	478	PF00069	0.451
MOD_Plk_1	496	502	PF00069	0.338
MOD_Plk_1	540	546	PF00069	0.401
MOD_Plk_1	667	673	PF00069	0.493
MOD_Plk_2-3	104	110	PF00069	0.548
MOD_Plk_2-3	308	314	PF00069	0.500
MOD_Plk_2-3	374	380	PF00069	0.489
MOD_Plk_2-3	540	546	PF00069	0.526
MOD_Plk_4	146	152	PF00069	0.453
MOD_Plk_4	187	193	PF00069	0.400
MOD_Plk_4	499	505	PF00069	0.469
MOD_Plk_4	510	516	PF00069	0.470
MOD_Plk_4	558	564	PF00069	0.468
MOD_Plk_4	566	572	PF00069	0.448
MOD_Plk_4	603	609	PF00069	0.452
MOD_Plk_4	781	787	PF00069	0.586
MOD_ProDKin_1	193	199	PF00069	0.462
MOD_ProDKin_1	2	8	PF00069	0.612
MOD_ProDKin_1	452	458	PF00069	0.543
MOD_ProDKin_1	754	760	PF00069	0.700
MOD_ProDKin_1	800	806	PF00069	0.801
MOD_SUMO_for_1	744	747	PF00179	0.472
MOD_SUMO_rev_2	374	384	PF00179	0.434
MOD_SUMO_rev_2	489	498	PF00179	0.545
TRG_DiLeu_BaEn_1	202	207	PF01217	0.196
TRG_DiLeu_BaEn_1	355	360	PF01217	0.364
TRG_DiLeu_BaEn_2	362	368	PF01217	0.352
TRG_DiLeu_BaEn_3	667	673	PF01217	0.452
TRG_DiLeu_BaLyEn_6	464	469	PF01217	0.455
TRG_DiLeu_BaLyEn_6	648	653	PF01217	0.415
TRG_DiLeu_LyEn_5	448	453	PF01217	0.482
TRG_ENDOCYTIC_2	213	216	PF00928	0.447
TRG_ENDOCYTIC_2	607	610	PF00928	0.354
TRG_ER_diArg_1	278	281	PF00400	0.386
TRG_ER_diArg_1	336	338	PF00400	0.339
TRG_ER_diArg_1	810	813	PF00400	0.806
TRG_NES_CRM1_1	205	220	PF08389	0.505
TRG_NES_CRM1_1	284	296	PF08389	0.377
TRG_NLS_MonoExtN_4	25	31	PF00514	0.742
TRG_Pf-PMV_PEXEL_1	467	471	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	542	546	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	750	754	PF00026	0.686

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P426	Leptomonas seymouri	69%	99%
A0A1X0NKB5	Trypanosomatidae	47%	100%
A0A3Q8IBR9	Leishmania donovani	95%	100%
A0A3S5ISP0	Trypanosoma rangeli	45%	100%
A4HD76	Leishmania braziliensis	85%	100%
D0A6Y8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AH30	Leishmania infantum	95%	100%
Q4QAW2	Leishmania major	94%	100%
Q6NUP7	Homo sapiens	23%	93%
Q8C0Y0	Mus musculus	23%	93%
V5C0S3	Trypanosoma cruzi	47%	100%