Putative ATPase domain protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATPase domain protein, putative

Species:

Leishmania mexicana

UniProt:

E9AWK7_LEIMU

TriTrypDb:

LmxM.24.0180

Length:

535

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005778	peroxisomal membrane	6	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0031903	microbody membrane	5	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AWK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWK7

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006625	protein targeting to peroxisome	5	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006996	organelle organization	4	1
GO:0007031	peroxisome organization	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0043574	peroxisomal transport	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072662	protein localization to peroxisome	6	1
GO:0072663	establishment of protein localization to peroxisome	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	177	179	PF00675	0.490
CLV_NRD_NRD_1	242	244	PF00675	0.662
CLV_NRD_NRD_1	345	347	PF00675	0.302
CLV_NRD_NRD_1	390	392	PF00675	0.400
CLV_NRD_NRD_1	463	465	PF00675	0.537
CLV_NRD_NRD_1	486	488	PF00675	0.497
CLV_NRD_NRD_1	527	529	PF00675	0.598
CLV_PCSK_KEX2_1	177	179	PF00082	0.490
CLV_PCSK_KEX2_1	242	244	PF00082	0.687
CLV_PCSK_KEX2_1	345	347	PF00082	0.337
CLV_PCSK_KEX2_1	390	392	PF00082	0.330
CLV_PCSK_KEX2_1	463	465	PF00082	0.552
CLV_PCSK_KEX2_1	527	529	PF00082	0.526
CLV_PCSK_PC7_1	341	347	PF00082	0.387
CLV_PCSK_SKI1_1	169	173	PF00082	0.617
CLV_PCSK_SKI1_1	177	181	PF00082	0.556
CLV_PCSK_SKI1_1	205	209	PF00082	0.488
CLV_PCSK_SKI1_1	390	394	PF00082	0.281
CLV_PCSK_SKI1_1	487	491	PF00082	0.428
CLV_PCSK_SKI1_1	97	101	PF00082	0.351
DEG_APCC_DBOX_1	176	184	PF00400	0.584
DEG_APCC_DBOX_1	389	397	PF00400	0.395
DEG_SCF_FBW7_1	198	204	PF00400	0.395
DEG_SPOP_SBC_1	135	139	PF00917	0.542
DOC_CDC14_PxL_1	434	442	PF14671	0.325
DOC_CKS1_1	198	203	PF01111	0.396
DOC_CYCLIN_yCln2_LP_2	100	106	PF00134	0.398
DOC_CYCLIN_yCln2_LP_2	124	127	PF00134	0.327
DOC_CYCLIN_yCln2_LP_2	62	68	PF00134	0.542
DOC_MAPK_DCC_7	346	356	PF00069	0.216
DOC_MAPK_gen_1	189	198	PF00069	0.483
DOC_MAPK_gen_1	262	271	PF00069	0.492
DOC_MAPK_gen_1	348	357	PF00069	0.330
DOC_MAPK_gen_1	427	437	PF00069	0.300
DOC_MAPK_gen_1	463	470	PF00069	0.508
DOC_MAPK_MEF2A_6	189	198	PF00069	0.418
DOC_MAPK_MEF2A_6	348	356	PF00069	0.281
DOC_PP2B_LxvP_1	124	127	PF13499	0.327
DOC_PP2B_LxvP_1	507	510	PF13499	0.389
DOC_PP2B_LxvP_1	62	65	PF13499	0.552
DOC_USP7_MATH_1	135	139	PF00917	0.355
DOC_USP7_MATH_1	201	205	PF00917	0.612
DOC_USP7_MATH_1	273	277	PF00917	0.444
DOC_USP7_MATH_1	37	41	PF00917	0.478
DOC_USP7_MATH_1	478	482	PF00917	0.361
DOC_USP7_MATH_1	85	89	PF00917	0.655
DOC_USP7_UBL2_3	30	34	PF12436	0.479
DOC_WW_Pin1_4	197	202	PF00397	0.689
DOC_WW_Pin1_4	274	279	PF00397	0.485
DOC_WW_Pin1_4	66	71	PF00397	0.634
LIG_14-3-3_CanoR_1	178	184	PF00244	0.591
LIG_14-3-3_CanoR_1	242	251	PF00244	0.443
LIG_14-3-3_CanoR_1	264	269	PF00244	0.431
LIG_14-3-3_CanoR_1	283	289	PF00244	0.678
LIG_14-3-3_CanoR_1	86	92	PF00244	0.552
LIG_Actin_WH2_2	326	343	PF00022	0.281
LIG_Actin_WH2_2	482	498	PF00022	0.425
LIG_Actin_WH2_2	512	529	PF00022	0.524
LIG_BIR_II_1	1	5	PF00653	0.513
LIG_BRCT_BRCA1_1	316	320	PF00533	0.414
LIG_deltaCOP1_diTrp_1	446	453	PF00928	0.372
LIG_EH1_1	262	270	PF00400	0.494
LIG_FHA_1	290	296	PF00498	0.367
LIG_FHA_1	409	415	PF00498	0.345
LIG_FHA_1	96	102	PF00498	0.419
LIG_FHA_2	509	515	PF00498	0.539
LIG_LIR_Apic_2	433	439	PF02991	0.325
LIG_LIR_Gen_1	21	27	PF02991	0.396
LIG_LIR_Gen_1	450	459	PF02991	0.426
LIG_LIR_Gen_1	78	85	PF02991	0.548
LIG_LIR_Nem_3	21	26	PF02991	0.424
LIG_LIR_Nem_3	314	318	PF02991	0.381
LIG_LIR_Nem_3	326	332	PF02991	0.297
LIG_LIR_Nem_3	450	456	PF02991	0.401
LIG_LIR_Nem_3	78	84	PF02991	0.568
LIG_MYND_1	163	167	PF01753	0.431
LIG_NRBOX	113	119	PF00104	0.427
LIG_NRBOX	392	398	PF00104	0.281
LIG_PCNA_yPIPBox_3	427	435	PF02747	0.331
LIG_PCNA_yPIPBox_3	483	496	PF02747	0.503
LIG_Pex14_1	448	452	PF04695	0.371
LIG_Pex14_1	77	81	PF04695	0.466
LIG_Pex14_2	452	456	PF04695	0.379
LIG_REV1ctd_RIR_1	450	459	PF16727	0.430
LIG_RPA_C_Fungi	237	249	PF08784	0.442
LIG_SH2_CRK	81	85	PF00017	0.575
LIG_SH2_NCK_1	81	85	PF00017	0.538
LIG_SH2_PTP2	436	439	PF00017	0.300
LIG_SH2_SRC	436	439	PF00017	0.325
LIG_SH2_STAP1	81	85	PF00017	0.538
LIG_SH2_STAT5	332	335	PF00017	0.281
LIG_SH2_STAT5	436	439	PF00017	0.281
LIG_SH2_STAT5	484	487	PF00017	0.470
LIG_SH3_3	180	186	PF00018	0.651
LIG_SH3_3	195	201	PF00018	0.410
LIG_SH3_3	313	319	PF00018	0.347
LIG_SH3_3	432	438	PF00018	0.325
LIG_SH3_3	526	532	PF00018	0.512
LIG_SUMO_SIM_anti_2	110	116	PF11976	0.403
LIG_SUMO_SIM_anti_2	358	364	PF11976	0.295
LIG_SUMO_SIM_par_1	193	200	PF11976	0.412
LIG_SUMO_SIM_par_1	353	359	PF11976	0.300
LIG_SUMO_SIM_par_1	465	472	PF11976	0.487
LIG_TYR_ITIM	79	84	PF00017	0.549
LIG_UBA3_1	22	30	PF00899	0.424
LIG_WRC_WIRS_1	38	43	PF05994	0.469
LIG_WW_3	251	255	PF00397	0.348
MOD_CK1_1	146	152	PF00069	0.546
MOD_CK1_1	197	203	PF00069	0.659
MOD_CK1_1	287	293	PF00069	0.509
MOD_CK1_1	40	46	PF00069	0.503
MOD_CK1_1	95	101	PF00069	0.496
MOD_CK2_1	187	193	PF00069	0.689
MOD_CK2_1	508	514	PF00069	0.521
MOD_GlcNHglycan	145	148	PF01048	0.410
MOD_GlcNHglycan	299	302	PF01048	0.305
MOD_GlcNHglycan	378	381	PF01048	0.318
MOD_GlcNHglycan	405	409	PF01048	0.388
MOD_GlcNHglycan	42	45	PF01048	0.503
MOD_GSK3_1	197	204	PF00069	0.467
MOD_GSK3_1	217	224	PF00069	0.476
MOD_GSK3_1	267	274	PF00069	0.397
MOD_GSK3_1	284	291	PF00069	0.517
MOD_GSK3_1	29	36	PF00069	0.526
MOD_GSK3_1	323	330	PF00069	0.400
MOD_GSK3_1	404	411	PF00069	0.411
MOD_LATS_1	240	246	PF00433	0.677
MOD_N-GLC_2	211	213	PF02516	0.588
MOD_NEK2_1	117	122	PF00069	0.474
MOD_NEK2_1	136	141	PF00069	0.399
MOD_NEK2_1	179	184	PF00069	0.573
MOD_NEK2_1	187	192	PF00069	0.595
MOD_NEK2_1	194	199	PF00069	0.552
MOD_NEK2_1	209	214	PF00069	0.441
MOD_NEK2_1	284	289	PF00069	0.548
MOD_NEK2_1	327	332	PF00069	0.397
MOD_NEK2_1	45	50	PF00069	0.356
MOD_NEK2_1	490	495	PF00069	0.531
MOD_NEK2_1	519	524	PF00069	0.430
MOD_NEK2_2	18	23	PF00069	0.448
MOD_PIKK_1	146	152	PF00454	0.429
MOD_PIKK_1	438	444	PF00454	0.373
MOD_PK_1	102	108	PF00069	0.541
MOD_PKA_1	242	248	PF00069	0.452
MOD_PKA_2	241	247	PF00069	0.451
MOD_PKA_2	85	91	PF00069	0.550
MOD_PKB_1	262	270	PF00069	0.494
MOD_Plk_1	323	329	PF00069	0.331
MOD_Plk_1	490	496	PF00069	0.365
MOD_Plk_1	72	78	PF00069	0.476
MOD_Plk_4	18	24	PF00069	0.439
MOD_Plk_4	267	273	PF00069	0.375
MOD_Plk_4	323	329	PF00069	0.373
MOD_Plk_4	37	43	PF00069	0.319
MOD_Plk_4	430	436	PF00069	0.332
MOD_Plk_4	490	496	PF00069	0.387
MOD_Plk_4	521	527	PF00069	0.454
MOD_ProDKin_1	197	203	PF00069	0.684
MOD_ProDKin_1	274	280	PF00069	0.492
MOD_ProDKin_1	66	72	PF00069	0.624
TRG_DiLeu_BaEn_2	233	239	PF01217	0.669
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.313
TRG_DiLeu_BaLyEn_6	175	180	PF01217	0.565
TRG_ENDOCYTIC_2	81	84	PF00928	0.574
TRG_ER_diArg_1	177	179	PF00400	0.490
TRG_ER_diArg_1	261	264	PF00400	0.498
TRG_ER_diArg_1	344	346	PF00400	0.364
TRG_ER_diArg_1	348	351	PF00400	0.356
TRG_ER_diArg_1	390	392	PF00400	0.402
TRG_ER_diArg_1	526	528	PF00400	0.600
TRG_NES_CRM1_1	206	217	PF08389	0.473
TRG_Pf-PMV_PEXEL_1	15	20	PF00026	0.590
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.630
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	331	335	PF00026	0.273

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTJ8	Leptomonas seymouri	63%	100%
A0A0S4IKL1	Bodo saltans	28%	80%
A0A1X0NKH8	Trypanosomatidae	35%	100%
A0A3Q8IG04	Leishmania donovani	91%	100%
A0A3R7MBQ6	Trypanosoma rangeli	38%	100%
A4HD75	Leishmania braziliensis	82%	100%
D0A6Y7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	99%
E9AH29	Leishmania infantum	91%	100%
Q4QAW3	Leishmania major	92%	100%
V5BRB9	Trypanosoma cruzi	40%	100%