Phosducin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWK6_LEIMU

TriTrypDb:

LmxM.24.0170

Length:

242

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AWK6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWK6

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	207	209	PF00675	0.147
CLV_NRD_NRD_1	98	100	PF00675	0.259
CLV_PCSK_FUR_1	96	100	PF00082	0.250
CLV_PCSK_KEX2_1	196	198	PF00082	0.279
CLV_PCSK_KEX2_1	96	98	PF00082	0.251
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.279
CLV_PCSK_SKI1_1	163	167	PF00082	0.240
CLV_PCSK_SKI1_1	193	197	PF00082	0.336
DEG_APCC_DBOX_1	96	104	PF00400	0.498
DEG_Nend_UBRbox_2	1	3	PF02207	0.574
DOC_CYCLIN_RxL_1	206	217	PF00134	0.347
DOC_MAPK_gen_1	27	35	PF00069	0.430
DOC_MAPK_gen_1	96	103	PF00069	0.536
DOC_PP1_RVXF_1	161	168	PF00149	0.415
DOC_SPAK_OSR1_1	111	115	PF12202	0.471
DOC_USP7_MATH_1	130	134	PF00917	0.541
DOC_USP7_MATH_1	143	147	PF00917	0.475
DOC_USP7_MATH_1	41	45	PF00917	0.329
DOC_USP7_UBL2_3	58	62	PF12436	0.504
LIG_14-3-3_CanoR_1	161	166	PF00244	0.512
LIG_14-3-3_CanoR_1	208	214	PF00244	0.460
LIG_14-3-3_CanoR_1	8	17	PF00244	0.435
LIG_BRCT_BRCA1_1	163	167	PF00533	0.508
LIG_FHA_1	171	177	PF00498	0.461
LIG_FHA_1	77	83	PF00498	0.676
LIG_FHA_2	10	16	PF00498	0.452
LIG_FHA_2	48	54	PF00498	0.534
LIG_LIR_Gen_1	11	21	PF02991	0.445
LIG_LIR_Gen_1	164	175	PF02991	0.415
LIG_LIR_Nem_3	11	17	PF02991	0.446
LIG_LIR_Nem_3	110	115	PF02991	0.451
LIG_SH2_STAP1	172	176	PF00017	0.499
LIG_SH2_STAT3	52	55	PF00017	0.539
LIG_SH2_STAT5	123	126	PF00017	0.475
LIG_SH2_STAT5	172	175	PF00017	0.521
LIG_SH3_3	174	180	PF00018	0.554
LIG_SH3_3	222	228	PF00018	0.499
LIG_SH3_5	119	123	PF00018	0.536
LIG_SUMO_SIM_anti_2	32	37	PF11976	0.465
LIG_UBA3_1	100	107	PF00899	0.509
MOD_CK1_1	212	218	PF00069	0.452
MOD_CK1_1	44	50	PF00069	0.329
MOD_CK2_1	143	149	PF00069	0.511
MOD_CK2_1	82	88	PF00069	0.442
MOD_CK2_1	9	15	PF00069	0.447
MOD_GSK3_1	125	132	PF00069	0.476
MOD_GSK3_1	150	157	PF00069	0.506
MOD_GSK3_1	166	173	PF00069	0.414
MOD_GSK3_1	40	47	PF00069	0.525
MOD_N-GLC_2	46	48	PF02516	0.485
MOD_PIKK_1	41	47	PF00454	0.496
MOD_PK_1	161	167	PF00069	0.513
MOD_PKA_1	209	215	PF00069	0.499
MOD_PKA_2	9	15	PF00069	0.433
MOD_Plk_4	150	156	PF00069	0.446
MOD_Plk_4	166	172	PF00069	0.459
MOD_Plk_4	77	83	PF00069	0.409
MOD_SUMO_for_1	61	64	PF00179	0.579
TRG_DiLeu_BaEn_2	76	82	PF01217	0.410
TRG_ER_diArg_1	95	98	PF00400	0.461
TRG_NLS_Bipartite_1	196	212	PF00514	0.347
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.262

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II20	Leptomonas seymouri	72%	100%
A0A0S4J2X1	Bodo saltans	48%	96%
A0A1X0NJ53	Trypanosomatidae	58%	99%
A0A3R7KUG1	Trypanosoma rangeli	26%	98%
A0A3R7KZ12	Trypanosoma rangeli	58%	92%
A0A3S7WY28	Leishmania donovani	90%	100%
A4HD74	Leishmania braziliensis	78%	100%
D0A6Y6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	99%
E9AH28	Leishmania infantum	90%	100%
Q4QAW4	Leishmania major	88%	100%
Q71A38	Dictyostelium discoideum	26%	100%
Q8MR62	Drosophila melanogaster	33%	100%
Q9QW08	Mus musculus	26%	99%
V5BAV9	Trypanosoma cruzi	55%	100%