Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWK5_LEIMU

TriTrypDb:

LmxM.24.0160

Length:

289

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWK5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	41	45	PF00656	0.600
CLV_NRD_NRD_1	80	82	PF00675	0.486
CLV_PCSK_KEX2_1	256	258	PF00082	0.708
CLV_PCSK_KEX2_1	278	280	PF00082	0.661
CLV_PCSK_KEX2_1	60	62	PF00082	0.698
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.708
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.661
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.698
CLV_PCSK_SKI1_1	128	132	PF00082	0.633
CLV_PCSK_SKI1_1	257	261	PF00082	0.460
CLV_PCSK_SKI1_1	275	279	PF00082	0.719
CLV_PCSK_SKI1_1	37	41	PF00082	0.580
CLV_PCSK_SKI1_1	64	68	PF00082	0.699
DEG_SPOP_SBC_1	8	12	PF00917	0.402
DOC_PP4_FxxP_1	245	248	PF00568	0.557
DOC_USP7_MATH_1	146	150	PF00917	0.496
DOC_USP7_MATH_1	240	244	PF00917	0.607
LIG_14-3-3_CanoR_1	116	121	PF00244	0.506
LIG_14-3-3_CanoR_1	239	249	PF00244	0.705
LIG_14-3-3_CanoR_1	257	262	PF00244	0.512
LIG_14-3-3_CanoR_1	64	72	PF00244	0.572
LIG_14-3-3_CanoR_1	92	99	PF00244	0.615
LIG_AP2alpha_2	120	122	PF02296	0.639
LIG_BIR_II_1	1	5	PF00653	0.524
LIG_BRCT_BRCA1_1	107	111	PF00533	0.577
LIG_BRCT_BRCA1_1	118	122	PF00533	0.483
LIG_FHA_2	179	185	PF00498	0.484
LIG_FHA_2	39	45	PF00498	0.602
LIG_LIR_Apic_2	117	121	PF02991	0.571
LIG_LIR_Apic_2	243	248	PF02991	0.552
LIG_LIR_Nem_3	170	175	PF02991	0.412
LIG_Pex14_1	118	122	PF04695	0.567
LIG_SH2_NCK_1	142	146	PF00017	0.437
LIG_SH2_SRC	142	145	PF00017	0.430
LIG_SH2_SRC	267	270	PF00017	0.531
LIG_SH2_STAP1	142	146	PF00017	0.455
LIG_SH2_STAT5	103	106	PF00017	0.538
LIG_SH2_STAT5	231	234	PF00017	0.664
LIG_SH2_STAT5	78	81	PF00017	0.493
LIG_SH3_3	227	233	PF00018	0.531
MOD_CK1_1	11	17	PF00069	0.576
MOD_CK1_1	49	55	PF00069	0.709
MOD_CK1_1	91	97	PF00069	0.501
MOD_CK2_1	146	152	PF00069	0.528
MOD_CK2_1	178	184	PF00069	0.493
MOD_GlcNHglycan	131	134	PF01048	0.609
MOD_GlcNHglycan	148	151	PF01048	0.650
MOD_GlcNHglycan	216	219	PF01048	0.681
MOD_GlcNHglycan	48	51	PF01048	0.675
MOD_GlcNHglycan	99	102	PF01048	0.576
MOD_GSK3_1	122	129	PF00069	0.595
MOD_GSK3_1	158	165	PF00069	0.493
MOD_GSK3_1	214	221	PF00069	0.591
MOD_GSK3_1	248	255	PF00069	0.591
MOD_GSK3_1	281	288	PF00069	0.630
MOD_GSK3_1	29	36	PF00069	0.501
MOD_GSK3_1	60	67	PF00069	0.588
MOD_GSK3_1	7	14	PF00069	0.554
MOD_GSK3_1	88	95	PF00069	0.464
MOD_N-GLC_1	126	131	PF02516	0.382
MOD_N-GLC_1	197	202	PF02516	0.430
MOD_N-GLC_1	263	268	PF02516	0.619
MOD_N-GLC_1	97	102	PF02516	0.537
MOD_NEK2_1	122	127	PF00069	0.592
MOD_NEK2_1	76	81	PF00069	0.650
MOD_NEK2_1	88	93	PF00069	0.470
MOD_NEK2_1	99	104	PF00069	0.500
MOD_PKA_1	37	43	PF00069	0.593
MOD_PKA_1	60	66	PF00069	0.504
MOD_PKA_2	122	128	PF00069	0.540
MOD_PKA_2	60	66	PF00069	0.630
MOD_PKA_2	91	97	PF00069	0.577
MOD_Plk_1	126	132	PF00069	0.452
MOD_Plk_1	158	164	PF00069	0.547
MOD_Plk_1	55	61	PF00069	0.618
MOD_Plk_4	281	287	PF00069	0.678
MOD_Plk_4	99	105	PF00069	0.529
MOD_SUMO_for_1	277	280	PF00179	0.573
TRG_DiLeu_BaEn_1	187	192	PF01217	0.520
TRG_DiLeu_BaLyEn_6	71	76	PF01217	0.387
TRG_Pf-PMV_PEXEL_1	275	280	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA94	Leptomonas seymouri	58%	100%
A0A0S4J4T0	Bodo saltans	32%	97%
A0A1X0NIP3	Trypanosomatidae	46%	100%
A0A3S7WY29	Leishmania donovani	90%	100%
A0A422P481	Trypanosoma rangeli	42%	100%
A4HD73	Leishmania braziliensis	80%	100%
D0A6Y5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AH27	Leishmania infantum	90%	100%
Q4QAW5	Leishmania major	91%	100%
V5DSP6	Trypanosoma cruzi	43%	100%