Glycosomal membrane like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycosomal membrane like protein

Species:

Leishmania mexicana

UniProt:

E9AWK4_LEIMU

TriTrypDb:

LmxM.24.0150

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AWK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWK4

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	9
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0016559	peroxisome fission	6	9
GO:0048285	organelle fission	5	9
GO:0071840	cellular component organization or biogenesis	2	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.513
CLV_C14_Caspase3-7	93	97	PF00656	0.412
CLV_PCSK_KEX2_1	146	148	PF00082	0.437
CLV_PCSK_KEX2_1	72	74	PF00082	0.339
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.485
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.339
CLV_PCSK_SKI1_1	19	23	PF00082	0.306
CLV_PCSK_SKI1_1	78	82	PF00082	0.294
CLV_PCSK_SKI1_1	85	89	PF00082	0.326
DEG_APCC_DBOX_1	77	85	PF00400	0.540
DOC_CYCLIN_RxL_1	82	89	PF00134	0.412
DOC_MAPK_gen_1	146	154	PF00069	0.640
DOC_PP1_RVXF_1	53	60	PF00149	0.500
DOC_PP1_RVXF_1	76	83	PF00149	0.511
DOC_PP4_FxxP_1	104	107	PF00568	0.264
DOC_USP7_MATH_1	198	202	PF00917	0.648
DOC_USP7_MATH_1	45	49	PF00917	0.540
DOC_WW_Pin1_4	106	111	PF00397	0.339
LIG_14-3-3_CanoR_1	120	124	PF00244	0.334
LIG_14-3-3_CanoR_1	55	60	PF00244	0.475
LIG_BIR_II_1	1	5	PF00653	0.656
LIG_FHA_2	197	203	PF00498	0.505
LIG_GBD_Chelix_1	3	11	PF00786	0.289
LIG_Integrin_RGD_1	147	149	PF01839	0.376
LIG_LIR_Gen_1	134	144	PF02991	0.288
LIG_LIR_Gen_1	8	15	PF02991	0.490
LIG_LIR_Gen_1	89	100	PF02991	0.392
LIG_LIR_Nem_3	122	127	PF02991	0.437
LIG_LIR_Nem_3	8	13	PF02991	0.490
LIG_LIR_Nem_3	89	95	PF02991	0.403
LIG_Pex14_2	100	104	PF04695	0.412
LIG_Pex14_2	88	92	PF04695	0.431
LIG_PTB_Apo_2	34	41	PF02174	0.464
LIG_PTB_Apo_2	94	101	PF02174	0.406
LIG_Rb_pABgroove_1	130	138	PF01858	0.245
LIG_Rb_pABgroove_1	82	90	PF01858	0.412
LIG_REV1ctd_RIR_1	25	33	PF16727	0.561
LIG_SH2_CRK	10	14	PF00017	0.376
LIG_SH2_CRK	35	39	PF00017	0.464
LIG_SH2_STAP1	127	131	PF00017	0.415
LIG_SH2_STAT5	117	120	PF00017	0.289
LIG_SH3_2	142	147	PF14604	0.637
LIG_SH3_3	104	110	PF00018	0.264
LIG_SH3_3	139	145	PF00018	0.535
LIG_Sin3_3	128	135	PF02671	0.182
LIG_UBA3_1	56	65	PF00899	0.535
MOD_CK1_1	113	119	PF00069	0.400
MOD_CK1_1	58	64	PF00069	0.496
MOD_GlcNHglycan	162	165	PF01048	0.379
MOD_GlcNHglycan	184	187	PF01048	0.360
MOD_GSK3_1	106	113	PF00069	0.293
MOD_GSK3_1	198	205	PF00069	0.630
MOD_N-GLC_2	157	159	PF02516	0.325
MOD_N-GLC_2	167	169	PF02516	0.351
MOD_NEK2_1	152	157	PF00069	0.584
MOD_NEK2_1	40	45	PF00069	0.439
MOD_PIKK_1	110	116	PF00454	0.331
MOD_PKA_2	119	125	PF00069	0.287
MOD_Plk_4	113	119	PF00069	0.316
MOD_Plk_4	55	61	PF00069	0.482
MOD_Plk_4	6	12	PF00069	0.540
MOD_ProDKin_1	106	112	PF00069	0.339
MOD_SUMO_rev_2	137	145	PF00179	0.514
TRG_ENDOCYTIC_2	10	13	PF00928	0.438
TRG_ENDOCYTIC_2	136	139	PF00928	0.283
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.332

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIQ6	Leptomonas seymouri	75%	100%
A0A1X0NJI5	Trypanosomatidae	33%	100%
A0A1X0NR15	Trypanosomatidae	27%	100%
A0A3Q8IB71	Leishmania donovani	94%	100%
A0A422P470	Trypanosoma rangeli	32%	100%
A4HD72	Leishmania braziliensis	84%	100%
A4HGT0	Leishmania braziliensis	26%	100%
E9AH26	Leishmania infantum	94%	100%
Q4QAW6	Leishmania major	93%	100%