Guanine nucleotide-binding protein beta subunit-like protein (G-protein (Beta)-like protein) (Beta transducin-like protein)

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD40/YVTN repeat-like-containing protein

Species:

Leishmania mexicana

UniProt:

E9AWK2_LEIMU

TriTrypDb:

LmxM.24.0130

Length:

555

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AWK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWK2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	267	271	PF00656	0.370
CLV_C14_Caspase3-7	71	75	PF00656	0.405
CLV_NRD_NRD_1	130	132	PF00675	0.360
CLV_NRD_NRD_1	151	153	PF00675	0.453
CLV_NRD_NRD_1	239	241	PF00675	0.449
CLV_NRD_NRD_1	328	330	PF00675	0.638
CLV_PCSK_KEX2_1	130	132	PF00082	0.374
CLV_PCSK_KEX2_1	151	153	PF00082	0.409
CLV_PCSK_KEX2_1	239	241	PF00082	0.449
CLV_PCSK_KEX2_1	452	454	PF00082	0.384
CLV_PCSK_PC1ET2_1	452	454	PF00082	0.474
CLV_PCSK_SKI1_1	121	125	PF00082	0.284
CLV_PCSK_SKI1_1	152	156	PF00082	0.474
CLV_PCSK_SKI1_1	233	237	PF00082	0.479
CLV_PCSK_SKI1_1	351	355	PF00082	0.416
DEG_APCC_DBOX_1	150	158	PF00400	0.423
DEG_Nend_UBRbox_1	1	4	PF02207	0.431
DEG_SPOP_SBC_1	264	268	PF00917	0.323
DEG_SPOP_SBC_1	505	509	PF00917	0.515
DOC_CYCLIN_RxL_1	149	159	PF00134	0.457
DOC_CYCLIN_yCln2_LP_2	66	72	PF00134	0.431
DOC_MAPK_DCC_7	312	322	PF00069	0.443
DOC_MAPK_gen_1	151	157	PF00069	0.487
DOC_MAPK_MEF2A_6	2	9	PF00069	0.409
DOC_PP2B_LxvP_1	543	546	PF13499	0.406
DOC_USP7_MATH_1	202	206	PF00917	0.237
DOC_USP7_MATH_1	506	510	PF00917	0.534
DOC_USP7_UBL2_3	47	51	PF12436	0.431
DOC_WW_Pin1_4	227	232	PF00397	0.483
DOC_WW_Pin1_4	313	318	PF00397	0.509
DOC_WW_Pin1_4	461	466	PF00397	0.594
LIG_14-3-3_CanoR_1	121	126	PF00244	0.265
LIG_14-3-3_CanoR_1	239	248	PF00244	0.434
LIG_14-3-3_CanoR_1	290	298	PF00244	0.315
LIG_14-3-3_CanoR_1	301	306	PF00244	0.332
LIG_14-3-3_CanoR_1	34	42	PF00244	0.462
LIG_14-3-3_CanoR_1	65	69	PF00244	0.485
LIG_APCC_ABBA_1	96	101	PF00400	0.467
LIG_BRCT_BRCA1_1	80	84	PF00533	0.341
LIG_Clathr_ClatBox_1	373	377	PF01394	0.406
LIG_FHA_1	195	201	PF00498	0.374
LIG_FHA_1	2	8	PF00498	0.548
LIG_FHA_1	302	308	PF00498	0.475
LIG_FHA_1	37	43	PF00498	0.420
LIG_FHA_1	387	393	PF00498	0.501
LIG_FHA_1	430	436	PF00498	0.433
LIG_FHA_1	445	451	PF00498	0.231
LIG_FHA_1	538	544	PF00498	0.363
LIG_FHA_2	148	154	PF00498	0.357
LIG_FHA_2	21	27	PF00498	0.525
LIG_FHA_2	337	343	PF00498	0.471
LIG_FHA_2	437	443	PF00498	0.452
LIG_GBD_Chelix_1	58	66	PF00786	0.464
LIG_LIR_Gen_1	186	196	PF02991	0.432
LIG_LIR_Gen_1	518	528	PF02991	0.362
LIG_LIR_Nem_3	186	192	PF02991	0.424
LIG_LIR_Nem_3	246	250	PF02991	0.488
LIG_LIR_Nem_3	275	279	PF02991	0.411
LIG_LIR_Nem_3	457	462	PF02991	0.546
LIG_LIR_Nem_3	518	523	PF02991	0.361
LIG_LYPXL_yS_3	247	250	PF13949	0.279
LIG_PDZ_Class_2	550	555	PF00595	0.505
LIG_REV1ctd_RIR_1	82	91	PF16727	0.362
LIG_SH2_CRK	520	524	PF00017	0.316
LIG_SH2_CRK	55	59	PF00017	0.483
LIG_SH2_GRB2like	313	316	PF00017	0.506
LIG_SH2_STAP1	142	146	PF00017	0.310
LIG_SH2_STAP1	218	222	PF00017	0.354
LIG_SH2_STAP1	292	296	PF00017	0.307
LIG_SH2_STAP1	55	59	PF00017	0.513
LIG_SH2_STAT5	222	225	PF00017	0.351
LIG_SH2_STAT5	254	257	PF00017	0.464
LIG_SH2_STAT5	313	316	PF00017	0.565
LIG_SH2_STAT5	361	364	PF00017	0.314
LIG_SH2_STAT5	385	388	PF00017	0.431
LIG_SH2_STAT5	495	498	PF00017	0.456
LIG_SH3_3	228	234	PF00018	0.553
LIG_SUMO_SIM_anti_2	74	81	PF11976	0.323
LIG_SUMO_SIM_par_1	153	159	PF11976	0.432
LIG_TYR_ITIM	187	192	PF00017	0.419
LIG_WRC_WIRS_1	550	555	PF05994	0.555
MOD_CDC14_SPxK_1	230	233	PF00782	0.517
MOD_CDK_SPxK_1	227	233	PF00069	0.482
MOD_CK1_1	156	162	PF00069	0.460
MOD_CK1_1	266	272	PF00069	0.493
MOD_CK1_1	356	362	PF00069	0.423
MOD_CK1_1	426	432	PF00069	0.464
MOD_CK1_1	436	442	PF00069	0.359
MOD_CK1_1	500	506	PF00069	0.501
MOD_CK1_1	508	514	PF00069	0.577
MOD_CK1_1	92	98	PF00069	0.400
MOD_CK2_1	147	153	PF00069	0.357
MOD_CK2_1	20	26	PF00069	0.448
MOD_CK2_1	396	402	PF00069	0.506
MOD_GlcNHglycan	200	203	PF01048	0.422
MOD_GlcNHglycan	204	207	PF01048	0.407
MOD_GlcNHglycan	355	359	PF01048	0.505
MOD_GlcNHglycan	425	428	PF01048	0.463
MOD_GlcNHglycan	472	475	PF01048	0.360
MOD_GlcNHglycan	91	94	PF01048	0.553
MOD_GSK3_1	156	163	PF00069	0.480
MOD_GSK3_1	172	179	PF00069	0.237
MOD_GSK3_1	194	201	PF00069	0.347
MOD_GSK3_1	234	241	PF00069	0.456
MOD_GSK3_1	265	272	PF00069	0.341
MOD_GSK3_1	365	372	PF00069	0.494
MOD_GSK3_1	386	393	PF00069	0.442
MOD_GSK3_1	406	413	PF00069	0.330
MOD_GSK3_1	429	436	PF00069	0.395
MOD_GSK3_1	470	477	PF00069	0.375
MOD_GSK3_1	497	504	PF00069	0.535
MOD_GSK3_1	64	71	PF00069	0.489
MOD_N-GLC_1	169	174	PF02516	0.389
MOD_N-GLC_1	212	217	PF02516	0.441
MOD_N-GLC_1	423	428	PF02516	0.438
MOD_N-GLC_1	497	502	PF02516	0.536
MOD_NEK2_1	1	6	PF00069	0.558
MOD_NEK2_1	132	137	PF00069	0.367
MOD_NEK2_1	20	25	PF00069	0.529
MOD_NEK2_1	212	217	PF00069	0.409
MOD_NEK2_1	238	243	PF00069	0.442
MOD_NEK2_1	296	301	PF00069	0.428
MOD_NEK2_1	346	351	PF00069	0.366
MOD_NEK2_1	353	358	PF00069	0.385
MOD_NEK2_1	404	409	PF00069	0.453
MOD_NEK2_1	476	481	PF00069	0.332
MOD_NEK2_1	499	504	PF00069	0.445
MOD_NEK2_2	234	239	PF00069	0.516
MOD_PIKK_1	379	385	PF00454	0.376
MOD_PKA_1	239	245	PF00069	0.436
MOD_PKA_2	238	244	PF00069	0.371
MOD_PKA_2	311	317	PF00069	0.498
MOD_PKA_2	64	70	PF00069	0.495
MOD_Plk_1	185	191	PF00069	0.250
MOD_Plk_1	212	218	PF00069	0.417
MOD_Plk_1	37	43	PF00069	0.382
MOD_Plk_1	410	416	PF00069	0.375
MOD_Plk_2-3	537	543	PF00069	0.327
MOD_Plk_2-3	549	555	PF00069	0.475
MOD_Plk_2-3	68	74	PF00069	0.256
MOD_Plk_4	121	127	PF00069	0.268
MOD_Plk_4	160	166	PF00069	0.411
MOD_Plk_4	212	218	PF00069	0.402
MOD_Plk_4	301	307	PF00069	0.401
MOD_Plk_4	369	375	PF00069	0.360
MOD_Plk_4	37	43	PF00069	0.526
MOD_Plk_4	411	417	PF00069	0.372
MOD_Plk_4	527	533	PF00069	0.413
MOD_Plk_4	54	60	PF00069	0.282
MOD_ProDKin_1	227	233	PF00069	0.493
MOD_ProDKin_1	313	319	PF00069	0.502
MOD_ProDKin_1	461	467	PF00069	0.587
MOD_SUMO_rev_2	104	112	PF00179	0.493
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.401
TRG_ENDOCYTIC_2	189	192	PF00928	0.431
TRG_ENDOCYTIC_2	247	250	PF00928	0.279
TRG_ENDOCYTIC_2	520	523	PF00928	0.317
TRG_ENDOCYTIC_2	55	58	PF00928	0.493
TRG_ER_diArg_1	129	131	PF00400	0.376
TRG_ER_diArg_1	238	240	PF00400	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1S8	Leptomonas seymouri	73%	100%
A0A1X0NIQ5	Trypanosomatidae	47%	99%
A0A3R7NVJ1	Trypanosoma rangeli	47%	99%
A0A3S7WY01	Leishmania donovani	97%	100%
A4HD70	Leishmania braziliensis	90%	100%
D0A6Y3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	99%
E9AH24	Leishmania infantum	97%	100%
Q4QAW8	Leishmania major	96%	100%
V5C0S8	Trypanosoma cruzi	47%	99%