Enkurin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Calmodulin-binding, putative

Species:

Leishmania mexicana

UniProt:

E9AWK0_LEIMU

TriTrypDb:

LmxM.24.0100

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AWK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWK0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0005516	calmodulin binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	60	64	PF00656	0.521
CLV_NRD_NRD_1	188	190	PF00675	0.371
CLV_NRD_NRD_1	224	226	PF00675	0.302
CLV_NRD_NRD_1	35	37	PF00675	0.652
CLV_NRD_NRD_1	69	71	PF00675	0.545
CLV_NRD_NRD_1	90	92	PF00675	0.637
CLV_PCSK_KEX2_1	224	226	PF00082	0.300
CLV_PCSK_KEX2_1	35	37	PF00082	0.605
CLV_PCSK_SKI1_1	190	194	PF00082	0.310
DOC_CKS1_1	241	246	PF01111	0.271
DOC_MAPK_gen_1	118	127	PF00069	0.613
DOC_MAPK_gen_1	128	136	PF00069	0.470
DOC_MAPK_gen_1	266	274	PF00069	0.300
DOC_MAPK_MEF2A_6	118	127	PF00069	0.613
DOC_MAPK_MEF2A_6	255	262	PF00069	0.404
DOC_PP2B_LxvP_1	152	155	PF13499	0.328
DOC_USP7_MATH_1	31	35	PF00917	0.703
DOC_USP7_MATH_1	40	44	PF00917	0.498
DOC_USP7_UBL2_3	183	187	PF12436	0.195
DOC_USP7_UBL2_3	236	240	PF12436	0.309
DOC_WW_Pin1_4	156	161	PF00397	0.611
DOC_WW_Pin1_4	208	213	PF00397	0.228
DOC_WW_Pin1_4	240	245	PF00397	0.271
DOC_WW_Pin1_4	82	87	PF00397	0.600
LIG_14-3-3_CanoR_1	165	172	PF00244	0.599
LIG_14-3-3_CanoR_1	206	212	PF00244	0.368
LIG_APCC_ABBA_1	272	277	PF00400	0.419
LIG_BIR_II_1	1	5	PF00653	0.473
LIG_Clathr_ClatBox_1	257	261	PF01394	0.397
LIG_FHA_1	149	155	PF00498	0.468
LIG_FHA_1	42	48	PF00498	0.513
LIG_FHA_2	165	171	PF00498	0.580
LIG_FHA_2	200	206	PF00498	0.165
LIG_FHA_2	9	15	PF00498	0.616
LIG_LIR_Gen_1	170	179	PF02991	0.416
LIG_LIR_Gen_1	205	215	PF02991	0.271
LIG_LIR_Gen_1	235	244	PF02991	0.258
LIG_LIR_Gen_1	4	15	PF02991	0.479
LIG_LIR_Nem_3	170	175	PF02991	0.420
LIG_LIR_Nem_3	205	210	PF02991	0.271
LIG_LIR_Nem_3	235	241	PF02991	0.291
LIG_LIR_Nem_3	4	10	PF02991	0.514
LIG_NRBOX	214	220	PF00104	0.296
LIG_PTB_Apo_2	105	112	PF02174	0.647
LIG_SH2_CRK	7	11	PF00017	0.574
LIG_SH2_NCK_1	7	11	PF00017	0.574
LIG_SH2_STAT5	178	181	PF00017	0.256
LIG_SH3_1	120	126	PF00018	0.603
LIG_SH3_2	123	128	PF14604	0.600
LIG_SH3_3	120	126	PF00018	0.603
LIG_SH3_CIN85_PxpxPR_1	160	165	PF14604	0.519
LIG_SUMO_SIM_par_1	149	156	PF11976	0.454
LIG_SUMO_SIM_par_1	256	261	PF11976	0.397
LIG_TRAF2_1	202	205	PF00917	0.403
LIG_TRAF2_1	248	251	PF00917	0.397
LIG_WRC_WIRS_1	73	78	PF05994	0.642
MOD_CDK_SPxxK_3	156	163	PF00069	0.448
MOD_CDK_SPxxK_3	240	247	PF00069	0.271
MOD_CK1_1	208	214	PF00069	0.291
MOD_CK2_1	164	170	PF00069	0.609
MOD_CK2_1	199	205	PF00069	0.376
MOD_CK2_1	208	214	PF00069	0.281
MOD_CK2_1	236	242	PF00069	0.389
MOD_GlcNHglycan	1	4	PF01048	0.511
MOD_GlcNHglycan	107	111	PF01048	0.642
MOD_GlcNHglycan	50	53	PF01048	0.482
MOD_GSK3_1	102	109	PF00069	0.572
MOD_GSK3_1	232	239	PF00069	0.229
MOD_GSK3_1	27	34	PF00069	0.669
MOD_GSK3_1	62	69	PF00069	0.603
MOD_NEK2_1	97	102	PF00069	0.545
MOD_PIKK_1	242	248	PF00454	0.271
MOD_PKA_2	164	170	PF00069	0.609
MOD_PKA_2	205	211	PF00069	0.256
MOD_Plk_1	106	112	PF00069	0.646
MOD_Plk_1	148	154	PF00069	0.510
MOD_Plk_1	62	68	PF00069	0.619
MOD_ProDKin_1	156	162	PF00069	0.610
MOD_ProDKin_1	208	214	PF00069	0.228
MOD_ProDKin_1	240	246	PF00069	0.271
MOD_ProDKin_1	82	88	PF00069	0.600
MOD_SUMO_rev_2	181	188	PF00179	0.321
MOD_SUMO_rev_2	194	199	PF00179	0.416
TRG_DiLeu_BaEn_1	214	219	PF01217	0.454
TRG_ENDOCYTIC_2	7	10	PF00928	0.539
TRG_ER_diArg_1	224	226	PF00400	0.298
TRG_NLS_MonoExtC_3	31	36	PF00514	0.667

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N8	Leptomonas seymouri	74%	100%
A0A0S4IY56	Bodo saltans	44%	100%
A0A1X0NJ07	Trypanosomatidae	59%	100%
A0A3R7RTB5	Trypanosoma rangeli	57%	100%
A0A3S7WY66	Leishmania donovani	95%	100%
A0A4X1TZW7	Sus scrofa	25%	100%
D0A6Y1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E1B836	Bos taurus	24%	100%
E9AH22	Leishmania infantum	95%	100%
E9AUG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
Q4QAX0	Leishmania major	93%	100%
V5BAW3	Trypanosoma cruzi	58%	100%