DUF3592 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWJ9_LEIMU

TriTrypDb:

LmxM.24.0090

Length:

247

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AWJ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWJ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	207	209	PF00675	0.430
CLV_NRD_NRD_1	214	216	PF00675	0.471
CLV_NRD_NRD_1	36	38	PF00675	0.464
CLV_NRD_NRD_1	92	94	PF00675	0.535
CLV_PCSK_KEX2_1	116	118	PF00082	0.548
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.548
CLV_PCSK_SKI1_1	33	37	PF00082	0.393
DEG_Nend_Nbox_1	1	3	PF02207	0.550
DOC_CDC14_PxL_1	147	155	PF14671	0.282
DOC_CYCLIN_RxL_1	30	39	PF00134	0.648
DOC_MAPK_gen_1	215	221	PF00069	0.687
DOC_PP1_RVXF_1	216	222	PF00149	0.661
DOC_USP7_UBL2_3	165	169	PF12436	0.297
DOC_USP7_UBL2_3	242	246	PF12436	0.578
DOC_WW_Pin1_4	124	129	PF00397	0.282
LIG_14-3-3_CanoR_1	10	20	PF00244	0.530
LIG_14-3-3_CanoR_1	158	162	PF00244	0.296
LIG_14-3-3_CanoR_1	81	90	PF00244	0.346
LIG_Actin_WH2_2	193	210	PF00022	0.546
LIG_APCC_ABBAyCdc20_2	158	164	PF00400	0.296
LIG_FHA_2	138	144	PF00498	0.278
LIG_LIR_Nem_3	182	188	PF02991	0.401
LIG_Pex14_2	181	185	PF04695	0.323
LIG_Pex14_2	188	192	PF04695	0.306
LIG_SH2_CRK	138	142	PF00017	0.340
LIG_SH2_CRK	32	36	PF00017	0.636
LIG_SH2_CRK	70	74	PF00017	0.273
LIG_SH2_CRK	97	101	PF00017	0.269
LIG_SH2_GRB2like	63	66	PF00017	0.335
LIG_SH2_NCK_1	138	142	PF00017	0.340
LIG_SH2_PTP2	99	102	PF00017	0.269
LIG_SH2_SRC	224	227	PF00017	0.741
LIG_SH2_SRC	99	102	PF00017	0.340
LIG_SH2_STAP1	105	109	PF00017	0.273
LIG_SH2_STAT5	118	121	PF00017	0.274
LIG_SH2_STAT5	146	149	PF00017	0.275
LIG_SH2_STAT5	2	5	PF00017	0.548
LIG_SH2_STAT5	63	66	PF00017	0.329
LIG_SH2_STAT5	99	102	PF00017	0.269
LIG_SH3_1	224	230	PF00018	0.713
LIG_SH3_2	230	235	PF14604	0.734
LIG_SH3_3	224	230	PF00018	0.672
LIG_SH3_3	231	237	PF00018	0.668
LIG_SH3_3	48	54	PF00018	0.447
LIG_TYR_ITIM	95	100	PF00017	0.282
LIG_UBA3_1	89	94	PF00899	0.296
MOD_CDC14_SPxK_1	127	130	PF00782	0.282
MOD_CDK_SPxK_1	124	130	PF00069	0.282
MOD_CK2_1	137	143	PF00069	0.284
MOD_Cter_Amidation	114	117	PF01082	0.491
MOD_GlcNHglycan	13	16	PF01048	0.428
MOD_GlcNHglycan	171	174	PF01048	0.482
MOD_GlcNHglycan	27	30	PF01048	0.391
MOD_GlcNHglycan	73	76	PF01048	0.502
MOD_GSK3_1	117	124	PF00069	0.286
MOD_GSK3_1	177	184	PF00069	0.282
MOD_NEK2_1	181	186	PF00069	0.282
MOD_NEK2_1	3	8	PF00069	0.544
MOD_PIKK_1	82	88	PF00454	0.362
MOD_PKA_1	24	30	PF00069	0.687
MOD_PKA_2	121	127	PF00069	0.275
MOD_PKA_2	157	163	PF00069	0.285
MOD_Plk_1	181	187	PF00069	0.282
MOD_Plk_2-3	139	145	PF00069	0.313
MOD_Plk_2-3	177	183	PF00069	0.282
MOD_Plk_4	157	163	PF00069	0.282
MOD_ProDKin_1	124	130	PF00069	0.282
MOD_SUMO_for_1	107	110	PF00179	0.334
MOD_SUMO_rev_2	160	168	PF00179	0.348
TRG_DiLeu_BaLyEn_6	190	195	PF01217	0.378
TRG_ENDOCYTIC_2	138	141	PF00928	0.340
TRG_ENDOCYTIC_2	32	35	PF00928	0.586
TRG_ENDOCYTIC_2	70	73	PF00928	0.259
TRG_ENDOCYTIC_2	97	100	PF00928	0.282
TRG_ER_diArg_1	217	220	PF00400	0.622
TRG_NLS_MonoExtN_4	213	219	PF00514	0.665

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P429	Leptomonas seymouri	86%	100%
A0A0S4J094	Bodo saltans	68%	100%
A0A1X0NJD4	Trypanosomatidae	76%	100%
A0A3R7KS59	Trypanosoma rangeli	73%	100%
A0A3S7WXZ8	Leishmania donovani	95%	100%
A4HD67	Leishmania braziliensis	91%	100%
D0A6Y0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9AH21	Leishmania infantum	94%	100%
Q4QAX1	Leishmania major	96%	100%