RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AWJ8_LEIMU

TriTrypDb:

LmxM.24.0080

Length:

512

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AWJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWJ8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	75	79	PF00656	0.352
CLV_NRD_NRD_1	4	6	PF00675	0.445
CLV_NRD_NRD_1	94	96	PF00675	0.401
CLV_PCSK_KEX2_1	94	96	PF00082	0.401
CLV_PCSK_SKI1_1	177	181	PF00082	0.430
CLV_PCSK_SKI1_1	370	374	PF00082	0.291
CLV_PCSK_SKI1_1	6	10	PF00082	0.416
DEG_Nend_UBRbox_4	1	3	PF02207	0.415
DOC_PP2B_LxvP_1	16	19	PF13499	0.418
DOC_PP2B_LxvP_1	84	87	PF13499	0.530
DOC_USP7_MATH_1	137	141	PF00917	0.391
DOC_USP7_MATH_1	230	234	PF00917	0.333
DOC_USP7_MATH_1	268	272	PF00917	0.589
DOC_USP7_MATH_1	507	511	PF00917	0.689
DOC_USP7_MATH_1	87	91	PF00917	0.258
DOC_USP7_UBL2_3	366	370	PF12436	0.328
DOC_WW_Pin1_4	253	258	PF00397	0.489
DOC_WW_Pin1_4	398	403	PF00397	0.508
DOC_WW_Pin1_4	85	90	PF00397	0.348
LIG_14-3-3_CanoR_1	110	117	PF00244	0.444
LIG_14-3-3_CanoR_1	5	11	PF00244	0.443
LIG_BRCT_BRCA1_1	13	17	PF00533	0.429
LIG_BRCT_BRCA1_1	466	470	PF00533	0.363
LIG_BRCT_BRCA1_1	493	497	PF00533	0.480
LIG_deltaCOP1_diTrp_1	302	311	PF00928	0.465
LIG_FHA_1	140	146	PF00498	0.332
LIG_FHA_1	187	193	PF00498	0.493
LIG_FHA_1	274	280	PF00498	0.313
LIG_FHA_1	319	325	PF00498	0.325
LIG_FHA_1	53	59	PF00498	0.271
LIG_FHA_2	230	236	PF00498	0.509
LIG_FHA_2	267	273	PF00498	0.511
LIG_FHA_2	363	369	PF00498	0.436
LIG_FHA_2	484	490	PF00498	0.505
LIG_LIR_Gen_1	158	166	PF02991	0.311
LIG_LIR_Gen_1	345	356	PF02991	0.423
LIG_LIR_Gen_1	494	504	PF02991	0.454
LIG_LIR_Nem_3	133	138	PF02991	0.424
LIG_LIR_Nem_3	146	152	PF02991	0.432
LIG_LIR_Nem_3	158	164	PF02991	0.247
LIG_LIR_Nem_3	345	351	PF02991	0.408
LIG_LIR_Nem_3	368	374	PF02991	0.409
LIG_LIR_Nem_3	494	500	PF02991	0.472
LIG_PCNA_yPIPBox_3	169	183	PF02747	0.382
LIG_Pex14_2	171	175	PF04695	0.370
LIG_Pex14_2	439	443	PF04695	0.529
LIG_REV1ctd_RIR_1	114	123	PF16727	0.441
LIG_SH2_CRK	135	139	PF00017	0.442
LIG_SH2_CRK	149	153	PF00017	0.477
LIG_SH2_NCK_1	348	352	PF00017	0.418
LIG_SH2_STAT5	295	298	PF00017	0.324
LIG_SH2_STAT5	348	351	PF00017	0.565
LIG_SH2_STAT5	374	377	PF00017	0.301
LIG_SH2_STAT5	429	432	PF00017	0.311
LIG_SH2_STAT5	83	86	PF00017	0.306
LIG_SH3_3	131	137	PF00018	0.317
LIG_SH3_3	224	230	PF00018	0.489
LIG_SH3_3	330	336	PF00018	0.466
LIG_SH3_3	47	53	PF00018	0.507
LIG_SUMO_SIM_par_1	218	223	PF11976	0.523
LIG_SxIP_EBH_1	63	72	PF03271	0.386
LIG_TRAF2_1	401	404	PF00917	0.383
LIG_TYR_ITIM	147	152	PF00017	0.363
LIG_WRC_WIRS_1	188	193	PF05994	0.375
MOD_CK1_1	126	132	PF00069	0.462
MOD_CK1_1	187	193	PF00069	0.449
MOD_CK1_1	253	259	PF00069	0.426
MOD_CK1_1	266	272	PF00069	0.512
MOD_CK1_1	438	444	PF00069	0.441
MOD_CK1_1	72	78	PF00069	0.397
MOD_CK2_1	137	143	PF00069	0.497
MOD_CK2_1	215	221	PF00069	0.559
MOD_CK2_1	266	272	PF00069	0.512
MOD_CK2_1	362	368	PF00069	0.445
MOD_CK2_1	398	404	PF00069	0.390
MOD_GlcNHglycan	125	128	PF01048	0.509
MOD_GlcNHglycan	21	24	PF01048	0.461
MOD_GlcNHglycan	252	255	PF01048	0.542
MOD_GlcNHglycan	43	46	PF01048	0.367
MOD_GlcNHglycan	509	512	PF01048	0.463
MOD_GlcNHglycan	71	74	PF01048	0.290
MOD_GlcNHglycan	98	101	PF01048	0.484
MOD_GSK3_1	126	133	PF00069	0.320
MOD_GSK3_1	139	146	PF00069	0.239
MOD_GSK3_1	211	218	PF00069	0.510
MOD_GSK3_1	246	253	PF00069	0.478
MOD_GSK3_1	262	269	PF00069	0.563
MOD_GSK3_1	338	345	PF00069	0.541
MOD_GSK3_1	6	13	PF00069	0.434
MOD_LATS_1	28	34	PF00433	0.431
MOD_NEK2_1	123	128	PF00069	0.275
MOD_NEK2_1	263	268	PF00069	0.524
MOD_NEK2_1	338	343	PF00069	0.363
MOD_NEK2_1	362	367	PF00069	0.552
MOD_OFUCOSY	462	468	PF10250	0.382
MOD_PIKK_1	110	116	PF00454	0.372
MOD_PIKK_1	263	269	PF00454	0.534
MOD_PIKK_1	336	342	PF00454	0.356
MOD_PIKK_1	432	438	PF00454	0.457
MOD_Plk_1	101	107	PF00069	0.462
MOD_Plk_1	130	136	PF00069	0.210
MOD_Plk_2-3	215	221	PF00069	0.410
MOD_Plk_2-3	286	292	PF00069	0.399
MOD_Plk_4	11	17	PF00069	0.419
MOD_Plk_4	130	136	PF00069	0.403
MOD_Plk_4	187	193	PF00069	0.383
MOD_Plk_4	215	221	PF00069	0.410
MOD_Plk_4	61	67	PF00069	0.570
MOD_Plk_4	87	93	PF00069	0.431
MOD_ProDKin_1	253	259	PF00069	0.491
MOD_ProDKin_1	398	404	PF00069	0.510
MOD_ProDKin_1	85	91	PF00069	0.349
MOD_SUMO_for_1	313	316	PF00179	0.428
MOD_SUMO_rev_2	363	372	PF00179	0.406
TRG_DiLeu_BaLyEn_6	147	152	PF01217	0.291
TRG_DiLeu_BaLyEn_6	333	338	PF01217	0.389
TRG_ENDOCYTIC_2	135	138	PF00928	0.478
TRG_ENDOCYTIC_2	149	152	PF00928	0.512
TRG_ENDOCYTIC_2	195	198	PF00928	0.233
TRG_ENDOCYTIC_2	348	351	PF00928	0.447
TRG_ENDOCYTIC_2	83	86	PF00928	0.387
TRG_Pf-PMV_PEXEL_1	150	155	PF00026	0.234
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9Y9	Leptomonas seymouri	56%	100%
A0A1X0NKC7	Trypanosomatidae	33%	100%
A0A3Q8ICQ4	Leishmania donovani	88%	95%
A0A3R7LDY0	Trypanosoma rangeli	33%	100%
A4HD66	Leishmania braziliensis	76%	100%
A4I0N1	Leishmania infantum	87%	94%
D0A6X9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4QAX2	Leishmania major	89%	100%
V5DSQ1	Trypanosoma cruzi	34%	100%