J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWJ7_LEIMU

TriTrypDb:

LmxM.24.0070

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AWJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWJ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.442
CLV_C14_Caspase3-7	396	400	PF00656	0.620
CLV_C14_Caspase3-7	76	80	PF00656	0.405
CLV_NRD_NRD_1	31	33	PF00675	0.595
CLV_NRD_NRD_1	384	386	PF00675	0.393
CLV_NRD_NRD_1	392	394	PF00675	0.410
CLV_NRD_NRD_1	74	76	PF00675	0.543
CLV_PCSK_FUR_1	342	346	PF00082	0.452
CLV_PCSK_KEX2_1	344	346	PF00082	0.427
CLV_PCSK_KEX2_1	377	379	PF00082	0.382
CLV_PCSK_KEX2_1	392	394	PF00082	0.426
CLV_PCSK_KEX2_1	411	413	PF00082	0.443
CLV_PCSK_KEX2_1	74	76	PF00082	0.556
CLV_PCSK_PC1ET2_1	344	346	PF00082	0.427
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.382
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.443
CLV_PCSK_PC7_1	388	394	PF00082	0.407
CLV_PCSK_SKI1_1	188	192	PF00082	0.672
CLV_PCSK_SKI1_1	214	218	PF00082	0.721
CLV_PCSK_SKI1_1	300	304	PF00082	0.594
CLV_PCSK_SKI1_1	313	317	PF00082	0.642
CLV_PCSK_SKI1_1	377	381	PF00082	0.382
CLV_PCSK_SKI1_1	38	42	PF00082	0.636
CLV_PCSK_SKI1_1	417	421	PF00082	0.419
CLV_PCSK_SKI1_1	68	72	PF00082	0.513
DEG_Nend_UBRbox_1	1	4	PF02207	0.500
DEG_SPOP_SBC_1	230	234	PF00917	0.447
DOC_CYCLIN_RxL_1	211	222	PF00134	0.473
DOC_MAPK_gen_1	411	418	PF00069	0.569
DOC_MAPK_MEF2A_6	411	418	PF00069	0.572
DOC_MAPK_MEF2A_6	57	64	PF00069	0.324
DOC_MAPK_NFAT4_5	411	419	PF00069	0.587
DOC_MAPK_RevD_3	60	75	PF00069	0.336
DOC_USP7_MATH_1	129	133	PF00917	0.473
DOC_USP7_MATH_1	254	258	PF00917	0.545
DOC_USP7_MATH_1	262	266	PF00917	0.511
DOC_USP7_MATH_1	272	276	PF00917	0.422
DOC_USP7_MATH_1	387	391	PF00917	0.601
DOC_USP7_MATH_1	402	406	PF00917	0.599
DOC_USP7_UBL2_3	23	27	PF12436	0.406
LIG_14-3-3_CanoR_1	201	208	PF00244	0.515
LIG_14-3-3_CanoR_1	228	238	PF00244	0.530
LIG_14-3-3_CanoR_1	345	354	PF00244	0.662
LIG_14-3-3_CanoR_1	392	398	PF00244	0.646
LIG_14-3-3_CanoR_1	74	78	PF00244	0.353
LIG_14-3-3_CanoR_1	89	93	PF00244	0.283
LIG_Actin_WH2_2	174	190	PF00022	0.398
LIG_AP_GAE_1	246	252	PF02883	0.394
LIG_APCC_ABBA_1	333	338	PF00400	0.322
LIG_BIR_III_4	79	83	PF00653	0.418
LIG_FHA_1	187	193	PF00498	0.427
LIG_FHA_1	307	313	PF00498	0.408
LIG_FHA_2	139	145	PF00498	0.386
LIG_FHA_2	232	238	PF00498	0.574
LIG_FHA_2	266	272	PF00498	0.568
LIG_FHA_2	285	291	PF00498	0.488
LIG_FHA_2	299	305	PF00498	0.333
LIG_FHA_2	394	400	PF00498	0.620
LIG_FHA_2	408	414	PF00498	0.518
LIG_FHA_2	74	80	PF00498	0.364
LIG_LIR_Gen_1	24	30	PF02991	0.428
LIG_LIR_Gen_1	320	330	PF02991	0.331
LIG_LIR_Gen_1	331	341	PF02991	0.366
LIG_LIR_Gen_1	85	94	PF02991	0.335
LIG_LIR_Nem_3	135	139	PF02991	0.430
LIG_LIR_Nem_3	24	28	PF02991	0.387
LIG_LIR_Nem_3	320	326	PF02991	0.333
LIG_LIR_Nem_3	331	337	PF02991	0.362
LIG_LIR_Nem_3	43	47	PF02991	0.243
LIG_LIR_Nem_3	85	90	PF02991	0.350
LIG_LIR_Nem_3	91	97	PF02991	0.330
LIG_NRBOX	66	72	PF00104	0.318
LIG_Pex14_2	380	384	PF04695	0.580
LIG_SH2_PTP2	136	139	PF00017	0.450
LIG_SH2_PTP2	323	326	PF00017	0.287
LIG_SH2_PTP2	334	337	PF00017	0.306
LIG_SH2_SRC	126	129	PF00017	0.395
LIG_SH2_SRC	136	139	PF00017	0.394
LIG_SH2_SRC	334	337	PF00017	0.261
LIG_SH2_SRC	94	97	PF00017	0.308
LIG_SH2_STAP1	372	376	PF00017	0.577
LIG_SH2_STAT3	372	375	PF00017	0.577
LIG_SH2_STAT5	126	129	PF00017	0.395
LIG_SH2_STAT5	136	139	PF00017	0.394
LIG_SH2_STAT5	323	326	PF00017	0.330
LIG_SH2_STAT5	334	337	PF00017	0.292
LIG_SH2_STAT5	69	72	PF00017	0.315
LIG_SH3_3	224	230	PF00018	0.441
LIG_SH3_3	55	61	PF00018	0.326
LIG_SUMO_SIM_anti_2	277	284	PF11976	0.440
LIG_SUMO_SIM_par_1	325	331	PF11976	0.234
LIG_SUMO_SIM_par_1	60	65	PF11976	0.350
LIG_TRAF2_1	257	260	PF00917	0.446
LIG_TYR_ITIM	321	326	PF00017	0.287
LIG_TYR_ITIM	332	337	PF00017	0.306
LIG_TYR_ITIM	49	54	PF00017	0.309
LIG_TYR_ITIM	92	97	PF00017	0.311
MOD_CK1_1	132	138	PF00069	0.460
MOD_CK1_1	247	253	PF00069	0.482
MOD_CK1_1	265	271	PF00069	0.522
MOD_CK1_1	328	334	PF00069	0.306
MOD_CK2_1	137	143	PF00069	0.421
MOD_CK2_1	231	237	PF00069	0.575
MOD_CK2_1	254	260	PF00069	0.540
MOD_CK2_1	265	271	PF00069	0.533
MOD_CK2_1	272	278	PF00069	0.490
MOD_CK2_1	298	304	PF00069	0.387
MOD_CK2_1	346	352	PF00069	0.658
MOD_CK2_1	402	408	PF00069	0.594
MOD_GlcNHglycan	246	249	PF01048	0.710
MOD_GlcNHglycan	256	259	PF01048	0.635
MOD_GSK3_1	158	165	PF00069	0.479
MOD_GSK3_1	182	189	PF00069	0.462
MOD_GSK3_1	250	257	PF00069	0.522
MOD_GSK3_1	261	268	PF00069	0.496
MOD_GSK3_1	346	353	PF00069	0.683
MOD_NEK2_1	1	6	PF00069	0.431
MOD_NEK2_1	182	187	PF00069	0.485
MOD_NEK2_1	317	322	PF00069	0.364
MOD_NEK2_1	325	330	PF00069	0.367
MOD_NEK2_1	62	67	PF00069	0.337
MOD_NEK2_1	88	93	PF00069	0.344
MOD_NEK2_2	129	134	PF00069	0.322
MOD_NEK2_2	186	191	PF00069	0.411
MOD_PIKK_1	371	377	PF00454	0.590
MOD_PKA_2	1	7	PF00069	0.456
MOD_PKA_2	129	135	PF00069	0.456
MOD_PKA_2	200	206	PF00069	0.509
MOD_PKA_2	387	393	PF00069	0.616
MOD_PKA_2	402	408	PF00069	0.655
MOD_PKA_2	73	79	PF00069	0.353
MOD_PKA_2	88	94	PF00069	0.284
MOD_Plk_1	265	271	PF00069	0.568
MOD_Plk_1	317	323	PF00069	0.255
MOD_Plk_2-3	284	290	PF00069	0.419
MOD_Plk_4	317	323	PF00069	0.255
MOD_Plk_4	328	334	PF00069	0.297
MOD_Plk_4	358	364	PF00069	0.621
MOD_Plk_4	83	89	PF00069	0.446
MOD_SUMO_for_1	315	318	PF00179	0.434
MOD_SUMO_for_1	40	43	PF00179	0.409
MOD_SUMO_rev_2	104	111	PF00179	0.385
MOD_SUMO_rev_2	196	200	PF00179	0.460
MOD_SUMO_rev_2	310	315	PF00179	0.423
MOD_SUMO_rev_2	413	419	PF00179	0.629
TRG_DiLeu_BaEn_1	170	175	PF01217	0.392
TRG_DiLeu_BaEn_2	212	218	PF01217	0.540
TRG_ENDOCYTIC_2	136	139	PF00928	0.450
TRG_ENDOCYTIC_2	25	28	PF00928	0.380
TRG_ENDOCYTIC_2	323	326	PF00928	0.349
TRG_ENDOCYTIC_2	334	337	PF00928	0.301
TRG_ENDOCYTIC_2	51	54	PF00928	0.310
TRG_ENDOCYTIC_2	94	97	PF00928	0.337
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.645
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.603
TRG_Pf-PMV_PEXEL_1	267	271	PF00026	0.700
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N9	Leptomonas seymouri	78%	99%
A0A0S4IV95	Bodo saltans	53%	100%
A0A1X0NKJ2	Trypanosomatidae	64%	99%
A0A3Q8ICV4	Leishmania donovani	91%	100%
A4HD65	Leishmania braziliensis	82%	100%
A4I0N0	Leishmania infantum	91%	100%
D0A6X8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	99%
Q4QAX3	Leishmania major	92%	100%
V5BW05	Trypanosoma cruzi	64%	94%