Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWJ6_LEIMU

TriTrypDb:

LmxM.24.0060

Length:

409

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AWJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWJ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	306	308	PF00082	0.448
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.481
CLV_PCSK_PC7_1	302	308	PF00082	0.452
CLV_PCSK_SKI1_1	178	182	PF00082	0.562
CLV_PCSK_SKI1_1	223	227	PF00082	0.564
DOC_CYCLIN_RxL_1	154	165	PF00134	0.403
DOC_CYCLIN_yCln2_LP_2	146	149	PF00134	0.439
DOC_MAPK_gen_1	314	322	PF00069	0.674
DOC_PP2B_LxvP_1	146	149	PF13499	0.439
DOC_USP7_MATH_1	173	177	PF00917	0.363
DOC_USP7_MATH_1	180	184	PF00917	0.358
DOC_WW_Pin1_4	358	363	PF00397	0.743
DOC_WW_Pin1_4	59	64	PF00397	0.445
LIG_14-3-3_CanoR_1	157	162	PF00244	0.404
LIG_14-3-3_CanoR_1	174	178	PF00244	0.292
LIG_BIR_II_1	1	5	PF00653	0.438
LIG_BRCT_BRCA1_1	159	163	PF00533	0.369
LIG_BRCT_BRCA1_1	24	28	PF00533	0.407
LIG_deltaCOP1_diTrp_1	153	163	PF00928	0.253
LIG_deltaCOP1_diTrp_1	275	283	PF00928	0.168
LIG_FHA_1	110	116	PF00498	0.454
LIG_FHA_1	48	54	PF00498	0.390
LIG_FHA_2	106	112	PF00498	0.353
LIG_FHA_2	185	191	PF00498	0.393
LIG_Integrin_RGD_1	258	260	PF01839	0.466
LIG_LIR_Gen_1	141	149	PF02991	0.496
LIG_LIR_Gen_1	2	11	PF02991	0.492
LIG_LIR_Gen_1	294	303	PF02991	0.427
LIG_LIR_Gen_1	344	351	PF02991	0.683
LIG_LIR_Nem_3	132	136	PF02991	0.411
LIG_LIR_Nem_3	141	146	PF02991	0.465
LIG_LIR_Nem_3	153	159	PF02991	0.256
LIG_LIR_Nem_3	162	167	PF02991	0.386
LIG_LIR_Nem_3	193	197	PF02991	0.454
LIG_LIR_Nem_3	2	6	PF02991	0.501
LIG_LIR_Nem_3	232	236	PF02991	0.421
LIG_LIR_Nem_3	275	281	PF02991	0.182
LIG_LIR_Nem_3	294	298	PF02991	0.586
LIG_LIR_Nem_3	344	349	PF02991	0.564
LIG_Pex14_1	278	282	PF04695	0.332
LIG_Pex14_2	10	14	PF04695	0.349
LIG_REV1ctd_RIR_1	254	260	PF16727	0.281
LIG_SH2_CRK	164	168	PF00017	0.341
LIG_SH2_CRK	236	240	PF00017	0.470
LIG_SH2_CRK	3	7	PF00017	0.507
LIG_SH2_CRK	336	340	PF00017	0.708
LIG_SH2_CRK	346	350	PF00017	0.720
LIG_SH2_CRK	359	363	PF00017	0.587
LIG_SH2_GRB2like	136	139	PF00017	0.431
LIG_SH2_NCK_1	164	168	PF00017	0.341
LIG_SH2_NCK_1	346	350	PF00017	0.597
LIG_SH2_NCK_1	359	363	PF00017	0.655
LIG_SH2_SRC	334	337	PF00017	0.708
LIG_SH2_STAP1	233	237	PF00017	0.396
LIG_SH2_STAP1	3	7	PF00017	0.426
LIG_SH2_STAP1	386	390	PF00017	0.682
LIG_SH2_STAT3	396	399	PF00017	0.618
LIG_SH2_STAT3	401	404	PF00017	0.595
LIG_SH2_STAT5	104	107	PF00017	0.220
LIG_SH2_STAT5	136	139	PF00017	0.424
LIG_SH2_STAT5	164	167	PF00017	0.394
LIG_SH2_STAT5	247	250	PF00017	0.351
LIG_SH2_STAT5	279	282	PF00017	0.311
LIG_SH2_STAT5	295	298	PF00017	0.576
LIG_SH2_STAT5	390	393	PF00017	0.685
LIG_SH2_STAT5	401	404	PF00017	0.595
LIG_SH2_STAT5	86	89	PF00017	0.399
LIG_SH3_2	63	68	PF14604	0.329
LIG_SH3_3	60	66	PF00018	0.494
LIG_SUMO_SIM_anti_2	226	232	PF11976	0.279
LIG_SUMO_SIM_par_1	226	232	PF11976	0.332
LIG_SUMO_SIM_par_1	78	83	PF11976	0.378
LIG_TYR_ITIM	192	197	PF00017	0.371
LIG_TYR_ITSM	160	167	PF00017	0.328
LIG_WRC_WIRS_1	181	186	PF05994	0.365
LIG_WW_3	147	151	PF00397	0.325
MOD_CDC14_SPxK_1	65	68	PF00782	0.322
MOD_CDK_SPxK_1	62	68	PF00069	0.332
MOD_CK1_1	109	115	PF00069	0.420
MOD_CK1_1	151	157	PF00069	0.418
MOD_CK1_1	176	182	PF00069	0.428
MOD_CK1_1	2	8	PF00069	0.668
MOD_CK1_1	403	409	PF00069	0.596
MOD_CK1_1	62	68	PF00069	0.327
MOD_CK2_1	184	190	PF00069	0.248
MOD_CK2_1	218	224	PF00069	0.235
MOD_Cter_Amidation	304	307	PF01082	0.386
MOD_GlcNHglycan	108	111	PF01048	0.627
MOD_GlcNHglycan	178	181	PF01048	0.516
MOD_GlcNHglycan	206	209	PF01048	0.483
MOD_GlcNHglycan	303	306	PF01048	0.370
MOD_GlcNHglycan	322	325	PF01048	0.451
MOD_GlcNHglycan	343	346	PF01048	0.470
MOD_GSK3_1	102	109	PF00069	0.431
MOD_GSK3_1	134	141	PF00069	0.439
MOD_GSK3_1	176	183	PF00069	0.346
MOD_GSK3_1	196	203	PF00069	0.349
MOD_GSK3_1	214	221	PF00069	0.243
MOD_GSK3_1	262	269	PF00069	0.434
MOD_GSK3_1	301	308	PF00069	0.550
MOD_GSK3_1	341	348	PF00069	0.576
MOD_GSK3_1	43	50	PF00069	0.349
MOD_GSK3_1	62	69	PF00069	0.362
MOD_GSK3_1	80	87	PF00069	0.286
MOD_N-GLC_1	100	105	PF02516	0.557
MOD_N-GLC_1	134	139	PF02516	0.617
MOD_N-GLC_1	151	156	PF02516	0.625
MOD_N-GLC_1	157	162	PF02516	0.516
MOD_N-GLC_1	168	173	PF02516	0.504
MOD_N-GLC_1	204	209	PF02516	0.563
MOD_N-GLC_1	266	271	PF02516	0.670
MOD_N-GLC_1	309	314	PF02516	0.299
MOD_N-GLC_1	35	40	PF02516	0.558
MOD_N-GLC_2	138	140	PF02516	0.656
MOD_NEK2_1	1	6	PF00069	0.601
MOD_NEK2_1	119	124	PF00069	0.327
MOD_NEK2_1	13	18	PF00069	0.523
MOD_NEK2_1	159	164	PF00069	0.297
MOD_NEK2_1	197	202	PF00069	0.433
MOD_NEK2_1	291	296	PF00069	0.393
MOD_NEK2_1	43	48	PF00069	0.403
MOD_NEK2_2	173	178	PF00069	0.222
MOD_PIKK_1	197	203	PF00454	0.415
MOD_PIKK_1	371	377	PF00454	0.638
MOD_PIKK_1	400	406	PF00454	0.593
MOD_PKA_2	173	179	PF00069	0.415
MOD_PKA_2	301	307	PF00069	0.615
MOD_Plk_1	151	157	PF00069	0.392
MOD_Plk_1	22	28	PF00069	0.454
MOD_Plk_1	223	229	PF00069	0.390
MOD_Plk_1	241	247	PF00069	0.308
MOD_Plk_1	35	41	PF00069	0.302
MOD_Plk_2-3	190	196	PF00069	0.269
MOD_Plk_4	129	135	PF00069	0.396
MOD_Plk_4	138	144	PF00069	0.432
MOD_Plk_4	159	165	PF00069	0.317
MOD_Plk_4	180	186	PF00069	0.383
MOD_Plk_4	2	8	PF00069	0.560
MOD_Plk_4	223	229	PF00069	0.323
MOD_Plk_4	235	241	PF00069	0.335
MOD_Plk_4	80	86	PF00069	0.360
MOD_ProDKin_1	358	364	PF00069	0.743
MOD_ProDKin_1	59	65	PF00069	0.443
MOD_SUMO_rev_2	383	391	PF00179	0.577
TRG_ENDOCYTIC_2	164	167	PF00928	0.338
TRG_ENDOCYTIC_2	194	197	PF00928	0.378
TRG_ENDOCYTIC_2	236	239	PF00928	0.409
TRG_ENDOCYTIC_2	279	282	PF00928	0.302
TRG_ENDOCYTIC_2	295	298	PF00928	0.605
TRG_ENDOCYTIC_2	3	6	PF00928	0.507
TRG_ENDOCYTIC_2	346	349	PF00928	0.669
TRG_Pf-PMV_PEXEL_1	368	372	PF00026	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0L6	Leptomonas seymouri	45%	97%
A0A0S4IYQ4	Bodo saltans	26%	100%
A0A3R7P473	Trypanosoma rangeli	28%	100%
A0A3S7WY17	Leishmania donovani	84%	100%
A4HD64	Leishmania braziliensis	62%	99%
A4I0M9	Leishmania infantum	84%	100%
D0A6X7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
Q4QAX4	Leishmania major	81%	100%
V5C0T3	Trypanosoma cruzi	27%	100%