Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWJ5_LEIMU

TriTrypDb:

LmxM.24.0050

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWJ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWJ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.498
CLV_NRD_NRD_1	224	226	PF00675	0.324
CLV_PCSK_KEX2_1	216	218	PF00082	0.330
CLV_PCSK_KEX2_1	224	226	PF00082	0.291
CLV_PCSK_KEX2_1	32	34	PF00082	0.530
CLV_PCSK_KEX2_1	398	400	PF00082	0.322
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.399
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.530
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.322
CLV_PCSK_PC7_1	220	226	PF00082	0.343
CLV_PCSK_SKI1_1	155	159	PF00082	0.585
CLV_PCSK_SKI1_1	170	174	PF00082	0.321
CLV_PCSK_SKI1_1	19	23	PF00082	0.623
CLV_PCSK_SKI1_1	216	220	PF00082	0.347
CLV_PCSK_SKI1_1	263	267	PF00082	0.357
CLV_PCSK_SKI1_1	398	402	PF00082	0.301
CLV_PCSK_SKI1_1	423	427	PF00082	0.385
DEG_APCC_DBOX_1	23	31	PF00400	0.514
DEG_COP1_1	410	417	PF00400	0.342
DEG_Nend_Nbox_1	1	3	PF02207	0.489
DEG_SCF_FBW7_1	71	76	PF00400	0.469
DOC_CKS1_1	266	271	PF01111	0.303
DOC_CKS1_1	37	42	PF01111	0.495
DOC_CYCLIN_RxL_1	134	144	PF00134	0.425
DOC_MAPK_DCC_7	225	235	PF00069	0.441
DOC_MAPK_gen_1	216	223	PF00069	0.427
DOC_MAPK_gen_1	420	428	PF00069	0.265
DOC_MAPK_MEF2A_6	292	300	PF00069	0.432
DOC_MAPK_MEF2A_6	42	51	PF00069	0.499
DOC_PP1_RVXF_1	135	142	PF00149	0.317
DOC_PP1_RVXF_1	156	162	PF00149	0.389
DOC_USP7_MATH_1	67	71	PF00917	0.442
DOC_USP7_UBL2_3	62	66	PF12436	0.516
DOC_WW_Pin1_4	265	270	PF00397	0.287
DOC_WW_Pin1_4	36	41	PF00397	0.478
DOC_WW_Pin1_4	69	74	PF00397	0.597
DOC_WW_Pin1_4	91	96	PF00397	0.535
LIG_14-3-3_CanoR_1	140	149	PF00244	0.502
LIG_14-3-3_CanoR_1	190	198	PF00244	0.490
LIG_14-3-3_CanoR_1	263	269	PF00244	0.300
LIG_14-3-3_CanoR_1	399	407	PF00244	0.352
LIG_14-3-3_CanoR_1	434	438	PF00244	0.426
LIG_BRCT_BRCA1_1	185	189	PF00533	0.549
LIG_BRCT_BRCA1_1	269	273	PF00533	0.425
LIG_Clathr_ClatBox_1	146	150	PF01394	0.291
LIG_FHA_1	122	128	PF00498	0.532
LIG_FHA_1	190	196	PF00498	0.436
LIG_FHA_1	276	282	PF00498	0.353
LIG_FHA_1	63	69	PF00498	0.719
LIG_FHA_2	266	272	PF00498	0.568
LIG_FHA_2	312	318	PF00498	0.502
LIG_FHA_2	346	352	PF00498	0.399
LIG_FHA_2	363	369	PF00498	0.365
LIG_FHA_2	74	80	PF00498	0.460
LIG_LIR_Apic_2	249	254	PF02991	0.337
LIG_LIR_Gen_1	252	261	PF02991	0.447
LIG_LIR_Gen_1	345	354	PF02991	0.330
LIG_LIR_Gen_1	84	90	PF02991	0.435
LIG_LIR_Nem_3	252	258	PF02991	0.359
LIG_LIR_Nem_3	270	276	PF02991	0.272
LIG_LIR_Nem_3	345	349	PF02991	0.340
LIG_LIR_Nem_3	351	357	PF02991	0.287
LIG_MYND_1	460	464	PF01753	0.356
LIG_NRBOX	194	200	PF00104	0.439
LIG_OCRL_FandH_1	288	300	PF00620	0.432
LIG_Pex14_2	354	358	PF04695	0.389
LIG_SH2_CRK	435	439	PF00017	0.397
LIG_SH2_NCK_1	251	255	PF00017	0.328
LIG_SH2_PTP2	242	245	PF00017	0.286
LIG_SH2_STAT5	228	231	PF00017	0.512
LIG_SH2_STAT5	242	245	PF00017	0.348
LIG_SH2_STAT5	435	438	PF00017	0.387
LIG_SH3_1	228	234	PF00018	0.326
LIG_SH3_1	457	463	PF00018	0.309
LIG_SH3_3	202	208	PF00018	0.347
LIG_SH3_3	228	234	PF00018	0.326
LIG_SH3_3	457	463	PF00018	0.347
LIG_SUMO_SIM_anti_2	126	132	PF11976	0.542
LIG_SUMO_SIM_anti_2	143	150	PF11976	0.242
LIG_SUMO_SIM_anti_2	236	242	PF11976	0.202
LIG_SUMO_SIM_anti_2	450	456	PF11976	0.349
LIG_SUMO_SIM_par_1	147	154	PF11976	0.420
LIG_SUMO_SIM_par_1	208	213	PF11976	0.537
LIG_SUMO_SIM_par_1	450	456	PF11976	0.319
LIG_TRAF2_1	314	317	PF00917	0.354
LIG_TYR_ITIM	240	245	PF00017	0.413
LIG_UBA3_1	392	398	PF00899	0.315
LIG_UBA3_1	56	62	PF00899	0.604
MOD_CDK_SPxK_1	36	42	PF00069	0.536
MOD_CK1_1	267	273	PF00069	0.250
MOD_CK1_1	308	314	PF00069	0.367
MOD_CK1_1	333	339	PF00069	0.386
MOD_CK1_1	402	408	PF00069	0.282
MOD_CK1_1	94	100	PF00069	0.619
MOD_CK2_1	311	317	PF00069	0.427
MOD_CK2_1	73	79	PF00069	0.472
MOD_Cter_Amidation	214	217	PF01082	0.437
MOD_GlcNHglycan	112	115	PF01048	0.517
MOD_GlcNHglycan	116	119	PF01048	0.480
MOD_GlcNHglycan	143	146	PF01048	0.521
MOD_GlcNHglycan	205	208	PF01048	0.476
MOD_GlcNHglycan	212	215	PF01048	0.394
MOD_GlcNHglycan	332	335	PF01048	0.423
MOD_GlcNHglycan	381	384	PF01048	0.479
MOD_GlcNHglycan	52	55	PF01048	0.486
MOD_GSK3_1	110	117	PF00069	0.419
MOD_GSK3_1	119	126	PF00069	0.396
MOD_GSK3_1	267	274	PF00069	0.425
MOD_GSK3_1	433	440	PF00069	0.533
MOD_GSK3_1	67	74	PF00069	0.515
MOD_GSK3_1	90	97	PF00069	0.520
MOD_LATS_1	138	144	PF00433	0.314
MOD_N-GLC_1	379	384	PF02516	0.455
MOD_NEK2_1	151	156	PF00069	0.359
MOD_NEK2_1	189	194	PF00069	0.468
MOD_NEK2_1	264	269	PF00069	0.496
MOD_NEK2_1	50	55	PF00069	0.452
MOD_NEK2_1	60	65	PF00069	0.485
MOD_NEK2_1	90	95	PF00069	0.456
MOD_OFUCOSY	120	125	PF10250	0.312
MOD_PIKK_1	200	206	PF00454	0.441
MOD_PKA_2	189	195	PF00069	0.523
MOD_PKA_2	308	314	PF00069	0.588
MOD_PKA_2	433	439	PF00069	0.435
MOD_Plk_1	183	189	PF00069	0.526
MOD_Plk_1	402	408	PF00069	0.373
MOD_Plk_1	78	84	PF00069	0.477
MOD_Plk_2-3	345	351	PF00069	0.276
MOD_Plk_4	194	200	PF00069	0.430
MOD_Plk_4	433	439	PF00069	0.486
MOD_ProDKin_1	265	271	PF00069	0.293
MOD_ProDKin_1	36	42	PF00069	0.478
MOD_ProDKin_1	69	75	PF00069	0.585
MOD_ProDKin_1	91	97	PF00069	0.538
TRG_DiLeu_BaEn_1	236	241	PF01217	0.254
TRG_DiLeu_BaEn_1	260	265	PF01217	0.285
TRG_DiLeu_BaEn_1	450	455	PF01217	0.346
TRG_DiLeu_BaLyEn_6	417	422	PF01217	0.509
TRG_ENDOCYTIC_2	242	245	PF00928	0.413
TRG_ENDOCYTIC_2	435	438	PF00928	0.387
TRG_ER_diArg_1	223	225	PF00400	0.311
TRG_NLS_MonoExtN_4	395	401	PF00514	0.300
TRG_Pf-PMV_PEXEL_1	399	403	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBX3	Leptomonas seymouri	52%	100%
A0A1X0NIQ1	Trypanosomatidae	27%	100%
A0A3R7MWR0	Trypanosoma rangeli	27%	98%
A0A3S7WY18	Leishmania donovani	89%	100%
A4HD63	Leishmania braziliensis	78%	100%
A4I0M8	Leishmania infantum	89%	100%
D0A6X6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	99%
Q4QAX5	Leishmania major	89%	100%
V5BRC9	Trypanosoma cruzi	29%	99%