Nucleoside 2-deoxyribosyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoside 2-deoxyribosyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9AWJ0_LEIMU

TriTrypDb:

LmxM.23.1580

Length:

155

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9AWJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWJ0

PDB structure(s): 6qai_A , 6qai_B

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009123	nucleoside monophosphate metabolic process	5	1
GO:0009125	nucleoside monophosphate catabolic process	6	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016740	transferase activity	2	5
GO:0016757	glycosyltransferase activity	3	1
GO:0016763	pentosyltransferase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	1
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	4	1
GO:0050144	nucleoside deoxyribosyltransferase activity	5	1
GO:0070694	deoxyribonucleoside 5'-monophosphate N-glycosidase activity	5	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.424
CLV_PCSK_SKI1_1	94	98	PF00082	0.258
DOC_CYCLIN_RxL_1	91	101	PF00134	0.515
DOC_MAPK_gen_1	32	39	PF00069	0.515
DOC_PP4_FxxP_1	123	126	PF00568	0.472
DOC_USP7_MATH_1	72	76	PF00917	0.458
DOC_WW_Pin1_4	68	73	PF00397	0.448
LIG_FHA_1	4	10	PF00498	0.303
LIG_FHA_1	40	46	PF00498	0.377
LIG_FHA_2	80	86	PF00498	0.448

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ26	Leptomonas seymouri	75%	100%
A0A1X0NWK1	Trypanosomatidae	66%	99%
A0A3R7L3D6	Trypanosoma rangeli	70%	100%
A0A3R7MAG4	Trypanosoma rangeli	64%	79%
A0A3S7WY56	Leishmania donovani	93%	100%
A0A422N0V5	Trypanosoma rangeli	65%	100%
A4HD42	Leishmania braziliensis	79%	100%
C9ZNS0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9AH20	Leishmania infantum	93%	100%
Q4QAY0	Leishmania major	90%	100%

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