Neutral sphingomyelinase activation associated factor-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

neutral sphingomyelinase activation associated factor-like protein

Species:

Leishmania mexicana

UniProt:

E9AWI9_LEIMU

TriTrypDb:

LmxM.23.1570

Length:

925

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWI9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWI9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0004620	phospholipase activity	5	4
GO:0004767	sphingomyelin phosphodiesterase activity	6	4
GO:0008081	phosphoric diester hydrolase activity	5	4
GO:0016298	lipase activity	4	4
GO:0016787	hydrolase activity	2	4
GO:0016788	hydrolase activity, acting on ester bonds	3	4
GO:0042578	phosphoric ester hydrolase activity	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	766	770	PF00656	0.465
CLV_NRD_NRD_1	147	149	PF00675	0.566
CLV_NRD_NRD_1	164	166	PF00675	0.481
CLV_NRD_NRD_1	201	203	PF00675	0.450
CLV_NRD_NRD_1	4	6	PF00675	0.609
CLV_NRD_NRD_1	835	837	PF00675	0.401
CLV_PCSK_FUR_1	2	6	PF00082	0.578
CLV_PCSK_KEX2_1	147	149	PF00082	0.566
CLV_PCSK_KEX2_1	164	166	PF00082	0.473
CLV_PCSK_KEX2_1	201	203	PF00082	0.450
CLV_PCSK_KEX2_1	4	6	PF00082	0.593
CLV_PCSK_KEX2_1	661	663	PF00082	0.509
CLV_PCSK_KEX2_1	835	837	PF00082	0.401
CLV_PCSK_PC1ET2_1	661	663	PF00082	0.509
CLV_PCSK_SKI1_1	133	137	PF00082	0.512
CLV_PCSK_SKI1_1	173	177	PF00082	0.413
CLV_PCSK_SKI1_1	33	37	PF00082	0.641
CLV_PCSK_SKI1_1	335	339	PF00082	0.327
CLV_PCSK_SKI1_1	463	467	PF00082	0.312
CLV_PCSK_SKI1_1	623	627	PF00082	0.480
CLV_PCSK_SKI1_1	650	654	PF00082	0.441
CLV_PCSK_SKI1_1	836	840	PF00082	0.393
CLV_PCSK_SKI1_1	87	91	PF00082	0.435
CLV_PCSK_SKI1_1	92	96	PF00082	0.458
DEG_APCC_DBOX_1	6	14	PF00400	0.480
DEG_Nend_UBRbox_1	1	4	PF02207	0.642
DEG_SPOP_SBC_1	611	615	PF00917	0.484
DEG_SPOP_SBC_1	799	803	PF00917	0.333
DOC_AGCK_PIF_1	499	504	PF00069	0.312
DOC_CDC14_PxL_1	393	401	PF14671	0.312
DOC_CKS1_1	94	99	PF01111	0.565
DOC_CYCLIN_yCln2_LP_2	324	330	PF00134	0.312
DOC_CYCLIN_yCln2_LP_2	498	504	PF00134	0.312
DOC_MAPK_DCC_7	509	518	PF00069	0.316
DOC_MAPK_DCC_7	849	859	PF00069	0.365
DOC_MAPK_FxFP_2	119	122	PF00069	0.427
DOC_MAPK_FxFP_2	296	299	PF00069	0.312
DOC_MAPK_FxFP_2	502	505	PF00069	0.388
DOC_MAPK_gen_1	170	178	PF00069	0.384
DOC_MAPK_gen_1	2	10	PF00069	0.583
DOC_MAPK_gen_1	812	820	PF00069	0.470
DOC_MAPK_MEF2A_6	509	518	PF00069	0.312
DOC_MAPK_MEF2A_6	525	534	PF00069	0.312
DOC_MAPK_MEF2A_6	75	84	PF00069	0.313
DOC_PP1_RVXF_1	208	215	PF00149	0.357
DOC_PP2B_LxvP_1	254	257	PF13499	0.341
DOC_PP2B_LxvP_1	386	389	PF13499	0.388
DOC_PP2B_LxvP_1	511	514	PF13499	0.388
DOC_PP2B_LxvP_1	538	541	PF13499	0.279
DOC_PP2B_LxvP_1	95	98	PF13499	0.562
DOC_PP4_FxxP_1	119	122	PF00568	0.379
DOC_PP4_FxxP_1	189	192	PF00568	0.385
DOC_PP4_FxxP_1	296	299	PF00568	0.312
DOC_PP4_FxxP_1	502	505	PF00568	0.388
DOC_PP4_FxxP_1	747	750	PF00568	0.545
DOC_SPAK_OSR1_1	815	819	PF12202	0.438
DOC_USP7_MATH_1	122	126	PF00917	0.473
DOC_USP7_MATH_1	151	155	PF00917	0.447
DOC_USP7_MATH_1	452	456	PF00917	0.388
DOC_USP7_MATH_1	465	469	PF00917	0.242
DOC_USP7_MATH_1	562	566	PF00917	0.519
DOC_USP7_MATH_1	799	803	PF00917	0.514
DOC_WW_Pin1_4	227	232	PF00397	0.528
DOC_WW_Pin1_4	329	334	PF00397	0.388
DOC_WW_Pin1_4	437	442	PF00397	0.388
DOC_WW_Pin1_4	634	639	PF00397	0.550
DOC_WW_Pin1_4	740	745	PF00397	0.520
DOC_WW_Pin1_4	746	751	PF00397	0.442
DOC_WW_Pin1_4	93	98	PF00397	0.568
LIG_14-3-3_CanoR_1	205	209	PF00244	0.506
LIG_14-3-3_CanoR_1	271	276	PF00244	0.250
LIG_14-3-3_CanoR_1	5	11	PF00244	0.487
LIG_14-3-3_CanoR_1	509	514	PF00244	0.388
LIG_14-3-3_CanoR_1	544	550	PF00244	0.613
LIG_14-3-3_CanoR_1	623	628	PF00244	0.486
LIG_14-3-3_CanoR_1	650	655	PF00244	0.461
LIG_14-3-3_CanoR_1	662	667	PF00244	0.433
LIG_14-3-3_CanoR_1	835	845	PF00244	0.504
LIG_14-3-3_CanoR_1	877	882	PF00244	0.445
LIG_Actin_WH2_2	332	349	PF00022	0.410
LIG_Actin_WH2_2	822	837	PF00022	0.461
LIG_APCC_ABBA_1	532	537	PF00400	0.312
LIG_APCC_ABBA_1	683	688	PF00400	0.373
LIG_BRCT_BRCA1_1	233	237	PF00533	0.362
LIG_BRCT_BRCA1_1	406	410	PF00533	0.388
LIG_BRCT_BRCA1_1	454	458	PF00533	0.388
LIG_BRCT_BRCA1_1	620	624	PF00533	0.549
LIG_BRCT_BRCA1_1	80	84	PF00533	0.412
LIG_deltaCOP1_diTrp_1	115	121	PF00928	0.424
LIG_EH1_1	138	146	PF00400	0.477
LIG_FHA_1	228	234	PF00498	0.462
LIG_FHA_1	383	389	PF00498	0.312
LIG_FHA_1	41	47	PF00498	0.426
LIG_FHA_1	583	589	PF00498	0.671
LIG_FHA_1	597	603	PF00498	0.625
LIG_FHA_1	612	618	PF00498	0.473
LIG_FHA_1	637	643	PF00498	0.567
LIG_FHA_1	649	655	PF00498	0.368
LIG_FHA_1	704	710	PF00498	0.446
LIG_FHA_1	740	746	PF00498	0.563
LIG_FHA_1	775	781	PF00498	0.446
LIG_FHA_1	901	907	PF00498	0.479
LIG_FHA_2	307	313	PF00498	0.362
LIG_FHA_2	318	324	PF00498	0.307
LIG_FHA_2	36	42	PF00498	0.605
LIG_FHA_2	651	657	PF00498	0.445
LIG_FHA_2	787	793	PF00498	0.450
LIG_FXI_DFP_1	666	670	PF00024	0.446
LIG_LIR_Apic_2	116	122	PF02991	0.472
LIG_LIR_Apic_2	186	192	PF02991	0.301
LIG_LIR_Apic_2	294	299	PF02991	0.312
LIG_LIR_Gen_1	621	632	PF02991	0.586
LIG_LIR_Gen_1	789	799	PF02991	0.291
LIG_LIR_Gen_1	814	825	PF02991	0.456
LIG_LIR_Gen_1	867	876	PF02991	0.485
LIG_LIR_LC3C_4	721	725	PF02991	0.456
LIG_LIR_Nem_3	182	188	PF02991	0.377
LIG_LIR_Nem_3	30	35	PF02991	0.577
LIG_LIR_Nem_3	319	324	PF02991	0.312
LIG_LIR_Nem_3	407	413	PF02991	0.312
LIG_LIR_Nem_3	496	502	PF02991	0.312
LIG_LIR_Nem_3	526	530	PF02991	0.312
LIG_LIR_Nem_3	621	627	PF02991	0.548
LIG_LIR_Nem_3	665	669	PF02991	0.524
LIG_LIR_Nem_3	814	820	PF02991	0.448
LIG_LIR_Nem_3	867	872	PF02991	0.510
LIG_MYND_1	428	432	PF01753	0.388
LIG_PCNA_yPIPBox_3	564	575	PF02747	0.480
LIG_Pex14_1	117	121	PF04695	0.482
LIG_Pex14_2	185	189	PF04695	0.367
LIG_Pex14_2	418	422	PF04695	0.312
LIG_Pex14_2	816	820	PF04695	0.352
LIG_PTB_Apo_2	274	281	PF02174	0.205
LIG_PTB_Apo_2	416	423	PF02174	0.327
LIG_PTB_Phospho_1	274	280	PF10480	0.205
LIG_REV1ctd_RIR_1	415	424	PF16727	0.207
LIG_SH2_NCK_1	360	364	PF00017	0.312
LIG_SH2_SRC	354	357	PF00017	0.312
LIG_SH2_STAP1	278	282	PF00017	0.510
LIG_SH2_STAP1	356	360	PF00017	0.312
LIG_SH2_STAP1	523	527	PF00017	0.312
LIG_SH2_STAP1	791	795	PF00017	0.284
LIG_SH2_STAT5	177	180	PF00017	0.460
LIG_SH2_STAT5	222	225	PF00017	0.387
LIG_SH2_STAT5	280	283	PF00017	0.317
LIG_SH2_STAT5	308	311	PF00017	0.334
LIG_SH2_STAT5	354	357	PF00017	0.350
LIG_SH2_STAT5	369	372	PF00017	0.345
LIG_SH2_STAT5	517	520	PF00017	0.207
LIG_SH2_STAT5	693	696	PF00017	0.380
LIG_SH3_3	181	187	PF00018	0.504
LIG_SH3_3	23	29	PF00018	0.428
LIG_SH3_3	296	302	PF00018	0.312
LIG_SH3_3	426	432	PF00018	0.391
LIG_SH3_3	443	449	PF00018	0.219
LIG_SH3_3	58	64	PF00018	0.488
LIG_SH3_3	842	848	PF00018	0.357
LIG_SH3_3	91	97	PF00018	0.550
LIG_SUMO_SIM_anti_2	334	341	PF11976	0.312
LIG_SUMO_SIM_anti_2	608	616	PF11976	0.415
LIG_SUMO_SIM_anti_2	639	645	PF11976	0.486
LIG_SUMO_SIM_anti_2	721	729	PF11976	0.443
LIG_SUMO_SIM_par_1	384	390	PF11976	0.313
LIG_SUMO_SIM_par_1	40	49	PF11976	0.479
LIG_SUMO_SIM_par_1	641	648	PF11976	0.453
LIG_SUMO_SIM_par_1	693	699	PF11976	0.411
LIG_SUMO_SIM_par_1	721	729	PF11976	0.443
LIG_TRFH_1	852	856	PF08558	0.502
LIG_TYR_ITIM	366	371	PF00017	0.312
LIG_UBA3_1	281	286	PF00899	0.388
LIG_WRC_WIRS_1	158	163	PF05994	0.427
LIG_WW_3	539	543	PF00397	0.388
MOD_CDC14_SPxK_1	332	335	PF00782	0.388
MOD_CDK_SPxK_1	329	335	PF00069	0.388
MOD_CK1_1	131	137	PF00069	0.508
MOD_CK1_1	154	160	PF00069	0.455
MOD_CK1_1	224	230	PF00069	0.408
MOD_CK1_1	316	322	PF00069	0.312
MOD_CK1_1	402	408	PF00069	0.312
MOD_CK1_1	45	51	PF00069	0.517
MOD_CK1_1	6	12	PF00069	0.473
MOD_CK1_1	613	619	PF00069	0.572
MOD_CK1_1	696	702	PF00069	0.459
MOD_CK1_1	749	755	PF00069	0.498
MOD_CK1_1	843	849	PF00069	0.531
MOD_CK2_1	143	149	PF00069	0.456
MOD_CK2_1	306	312	PF00069	0.244
MOD_CK2_1	35	41	PF00069	0.623
MOD_CK2_1	516	522	PF00069	0.312
MOD_CK2_1	786	792	PF00069	0.490
MOD_Cter_Amidation	659	662	PF01082	0.512
MOD_GlcNHglycan	153	156	PF01048	0.478
MOD_GlcNHglycan	29	32	PF01048	0.512
MOD_GlcNHglycan	361	364	PF01048	0.312
MOD_GlcNHglycan	471	474	PF01048	0.437
MOD_GlcNHglycan	564	567	PF01048	0.545
MOD_GlcNHglycan	590	593	PF01048	0.640
MOD_GlcNHglycan	620	623	PF01048	0.479
MOD_GlcNHglycan	733	736	PF01048	0.434
MOD_GlcNHglycan	766	769	PF01048	0.461
MOD_GlcNHglycan	892	895	PF01048	0.389
MOD_GSK3_1	153	160	PF00069	0.497
MOD_GSK3_1	220	227	PF00069	0.537
MOD_GSK3_1	27	34	PF00069	0.585
MOD_GSK3_1	313	320	PF00069	0.310
MOD_GSK3_1	354	361	PF00069	0.328
MOD_GSK3_1	401	408	PF00069	0.312
MOD_GSK3_1	465	472	PF00069	0.308
MOD_GSK3_1	545	552	PF00069	0.541
MOD_GSK3_1	584	591	PF00069	0.748
MOD_GSK3_1	607	614	PF00069	0.549
MOD_GSK3_1	623	630	PF00069	0.444
MOD_GSK3_1	644	651	PF00069	0.475
MOD_GSK3_1	684	691	PF00069	0.454
MOD_GSK3_1	751	758	PF00069	0.380
MOD_GSK3_1	78	85	PF00069	0.433
MOD_GSK3_1	836	843	PF00069	0.509
MOD_GSK3_1	877	884	PF00069	0.515
MOD_GSK3_1	885	892	PF00069	0.491
MOD_GSK3_1	908	915	PF00069	0.503
MOD_GSK3_1	96	103	PF00069	0.487
MOD_N-GLC_1	100	105	PF02516	0.449
MOD_N-GLC_1	237	242	PF02516	0.303
MOD_N-GLC_1	271	276	PF02516	0.279
MOD_N-GLC_1	405	410	PF02516	0.312
MOD_NEK2_1	3	8	PF00069	0.413
MOD_NEK2_1	313	318	PF00069	0.319
MOD_NEK2_1	35	40	PF00069	0.622
MOD_NEK2_1	355	360	PF00069	0.334
MOD_NEK2_1	377	382	PF00069	0.439
MOD_NEK2_1	399	404	PF00069	0.314
MOD_NEK2_1	516	521	PF00069	0.505
MOD_NEK2_1	545	550	PF00069	0.462
MOD_NEK2_1	627	632	PF00069	0.588
MOD_NEK2_1	686	691	PF00069	0.367
MOD_NEK2_1	695	700	PF00069	0.416
MOD_NEK2_1	726	731	PF00069	0.441
MOD_NEK2_1	881	886	PF00069	0.508
MOD_NEK2_1	889	894	PF00069	0.430
MOD_NEK2_1	900	905	PF00069	0.417
MOD_NEK2_1	912	917	PF00069	0.401
MOD_OFUCOSY	785	790	PF10250	0.475
MOD_PIKK_1	313	319	PF00454	0.388
MOD_PIKK_1	627	633	PF00454	0.497
MOD_PIKK_1	718	724	PF00454	0.460
MOD_PK_1	509	515	PF00069	0.388
MOD_PKA_2	122	128	PF00069	0.434
MOD_PKA_2	204	210	PF00069	0.423
MOD_PKA_2	259	265	PF00069	0.416
MOD_PKA_2	3	9	PF00069	0.510
MOD_PKA_2	346	352	PF00069	0.274
MOD_PKA_2	739	745	PF00069	0.564
MOD_PKA_2	811	817	PF00069	0.443
MOD_PKA_2	881	887	PF00069	0.492
MOD_Plk_1	100	106	PF00069	0.439
MOD_Plk_1	271	277	PF00069	0.310
MOD_Plk_1	607	613	PF00069	0.420
MOD_Plk_4	113	119	PF00069	0.524
MOD_Plk_4	154	160	PF00069	0.544
MOD_Plk_4	231	237	PF00069	0.375
MOD_Plk_4	545	551	PF00069	0.442
MOD_Plk_4	584	590	PF00069	0.558
MOD_Plk_4	6	12	PF00069	0.524
MOD_Plk_4	607	613	PF00069	0.534
MOD_Plk_4	650	656	PF00069	0.399
MOD_Plk_4	769	775	PF00069	0.421
MOD_Plk_4	800	806	PF00069	0.375
MOD_Plk_4	840	846	PF00069	0.423
MOD_Plk_4	881	887	PF00069	0.399
MOD_Plk_4	908	914	PF00069	0.517
MOD_ProDKin_1	227	233	PF00069	0.524
MOD_ProDKin_1	329	335	PF00069	0.388
MOD_ProDKin_1	437	443	PF00069	0.388
MOD_ProDKin_1	634	640	PF00069	0.539
MOD_ProDKin_1	740	746	PF00069	0.516
MOD_ProDKin_1	93	99	PF00069	0.573
TRG_DiLeu_BaEn_1	245	250	PF01217	0.419
TRG_DiLeu_BaEn_1	867	872	PF01217	0.510
TRG_DiLeu_BaEn_2	340	346	PF01217	0.312
TRG_DiLeu_BaEn_2	575	581	PF01217	0.582
TRG_DiLeu_BaEn_4	350	356	PF01217	0.388
TRG_DiLeu_BaLyEn_6	426	431	PF01217	0.388
TRG_DiLeu_BaLyEn_6	741	746	PF01217	0.511
TRG_ENDOCYTIC_2	278	281	PF00928	0.312
TRG_ENDOCYTIC_2	298	301	PF00928	0.303
TRG_ENDOCYTIC_2	368	371	PF00928	0.315
TRG_ENDOCYTIC_2	791	794	PF00928	0.293
TRG_ER_diArg_1	1	4	PF00400	0.642
TRG_ER_diArg_1	138	141	PF00400	0.508
TRG_ER_diArg_1	5	8	PF00400	0.534
TRG_ER_diArg_1	541	544	PF00400	0.449
TRG_ER_diArg_1	834	836	PF00400	0.412
TRG_NES_CRM1_1	811	823	PF08389	0.476
TRG_Pf-PMV_PEXEL_1	411	416	PF00026	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P621	Leptomonas seymouri	54%	99%
A0A3Q8IMF5	Leishmania donovani	90%	100%
A4HD41	Leishmania braziliensis	81%	100%
E9AH19	Leishmania infantum	90%	100%
Q4QAY1	Leishmania major	89%	100%