Fibronectin type-III domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWI6_LEIMU

TriTrypDb:

LmxM.23.1540

Length:

960

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWI6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.608
CLV_C14_Caspase3-7	530	534	PF00656	0.585
CLV_MEL_PAP_1	344	350	PF00089	0.405
CLV_MEL_PAP_1	890	896	PF00089	0.465
CLV_NRD_NRD_1	756	758	PF00675	0.408
CLV_NRD_NRD_1	796	798	PF00675	0.555
CLV_NRD_NRD_1	877	879	PF00675	0.491
CLV_PCSK_KEX2_1	204	206	PF00082	0.573
CLV_PCSK_KEX2_1	756	758	PF00082	0.408
CLV_PCSK_KEX2_1	795	797	PF00082	0.572
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.456
CLV_PCSK_PC7_1	792	798	PF00082	0.531
CLV_PCSK_SKI1_1	100	104	PF00082	0.461
CLV_PCSK_SKI1_1	232	236	PF00082	0.453
CLV_PCSK_SKI1_1	265	269	PF00082	0.481
CLV_PCSK_SKI1_1	328	332	PF00082	0.632
CLV_PCSK_SKI1_1	616	620	PF00082	0.432
CLV_PCSK_SKI1_1	862	866	PF00082	0.453
DEG_APCC_DBOX_1	656	664	PF00400	0.362
DEG_SCF_FBW7_1	28	34	PF00400	0.512
DEG_SCF_FBW7_2	31	38	PF00400	0.387
DEG_SPOP_SBC_1	144	148	PF00917	0.481
DEG_SPOP_SBC_1	729	733	PF00917	0.464
DEG_SPOP_SBC_1	914	918	PF00917	0.483
DOC_ANK_TNKS_1	452	459	PF00023	0.312
DOC_CKS1_1	261	266	PF01111	0.484
DOC_CKS1_1	28	33	PF01111	0.563
DOC_CKS1_1	315	320	PF01111	0.697
DOC_CKS1_1	424	429	PF01111	0.339
DOC_CKS1_1	70	75	PF01111	0.552
DOC_CYCLIN_RxL_1	262	270	PF00134	0.537
DOC_CYCLIN_RxL_1	916	927	PF00134	0.573
DOC_MAPK_MEF2A_6	114	123	PF00069	0.568
DOC_MAPK_MEF2A_6	395	403	PF00069	0.378
DOC_PP1_RVXF_1	98	104	PF00149	0.306
DOC_PP2B_LxvP_1	605	608	PF13499	0.523
DOC_PP2B_PxIxI_1	607	613	PF00149	0.290
DOC_PP4_FxxP_1	348	351	PF00568	0.422
DOC_PP4_FxxP_1	424	427	PF00568	0.317
DOC_PP4_FxxP_1	8	11	PF00568	0.521
DOC_USP7_MATH_1	143	147	PF00917	0.502
DOC_USP7_MATH_1	414	418	PF00917	0.429
DOC_USP7_MATH_1	696	700	PF00917	0.414
DOC_USP7_MATH_1	915	919	PF00917	0.425
DOC_USP7_UBL2_3	616	620	PF12436	0.458
DOC_WW_Pin1_4	260	265	PF00397	0.388
DOC_WW_Pin1_4	27	32	PF00397	0.548
DOC_WW_Pin1_4	314	319	PF00397	0.671
DOC_WW_Pin1_4	347	352	PF00397	0.673
DOC_WW_Pin1_4	378	383	PF00397	0.570
DOC_WW_Pin1_4	416	421	PF00397	0.487
DOC_WW_Pin1_4	423	428	PF00397	0.497
DOC_WW_Pin1_4	433	438	PF00397	0.407
DOC_WW_Pin1_4	69	74	PF00397	0.526
DOC_WW_Pin1_4	697	702	PF00397	0.445
DOC_WW_Pin1_4	732	737	PF00397	0.583
DOC_WW_Pin1_4	924	929	PF00397	0.545
LIG_14-3-3_CanoR_1	114	121	PF00244	0.595
LIG_14-3-3_CanoR_1	205	215	PF00244	0.279
LIG_14-3-3_CanoR_1	29	35	PF00244	0.561
LIG_14-3-3_CanoR_1	337	344	PF00244	0.511
LIG_14-3-3_CanoR_1	347	351	PF00244	0.441
LIG_14-3-3_CanoR_1	371	379	PF00244	0.584
LIG_14-3-3_CanoR_1	415	419	PF00244	0.502
LIG_14-3-3_CanoR_1	431	437	PF00244	0.384
LIG_14-3-3_CanoR_1	636	641	PF00244	0.397
LIG_14-3-3_CanoR_1	657	661	PF00244	0.433
LIG_14-3-3_CanoR_1	761	765	PF00244	0.391
LIG_14-3-3_CanoR_1	937	942	PF00244	0.414
LIG_Actin_RPEL_3	446	465	PF02755	0.299
LIG_BRCT_BRCA1_1	220	224	PF00533	0.399
LIG_BRCT_BRCA1_1	373	377	PF00533	0.645
LIG_BRCT_BRCA1_1	4	8	PF00533	0.573
LIG_BRCT_BRCA1_1	420	424	PF00533	0.456
LIG_BRCT_BRCA1_1	63	67	PF00533	0.455
LIG_deltaCOP1_diTrp_1	621	627	PF00928	0.599
LIG_deltaCOP1_diTrp_1	631	640	PF00928	0.453
LIG_DLG_GKlike_1	937	945	PF00625	0.455
LIG_eIF4E_1	261	267	PF01652	0.523
LIG_eIF4E_1	855	861	PF01652	0.302
LIG_eIF4E_1	941	947	PF01652	0.436
LIG_FHA_1	178	184	PF00498	0.540
LIG_FHA_1	195	201	PF00498	0.391
LIG_FHA_1	207	213	PF00498	0.330
LIG_FHA_1	261	267	PF00498	0.523
LIG_FHA_1	276	282	PF00498	0.401
LIG_FHA_1	295	301	PF00498	0.418
LIG_FHA_1	315	321	PF00498	0.719
LIG_FHA_1	441	447	PF00498	0.363
LIG_FHA_1	485	491	PF00498	0.421
LIG_FHA_1	530	536	PF00498	0.496
LIG_FHA_1	597	603	PF00498	0.579
LIG_FHA_1	64	70	PF00498	0.539
LIG_FHA_1	76	82	PF00498	0.404
LIG_FHA_1	91	97	PF00498	0.426
LIG_FHA_1	915	921	PF00498	0.484
LIG_FHA_2	354	360	PF00498	0.555
LIG_FHA_2	528	534	PF00498	0.322
LIG_FHA_2	626	632	PF00498	0.596
LIG_FHA_2	70	76	PF00498	0.487
LIG_FHA_2	836	842	PF00498	0.571
LIG_FHA_2	863	869	PF00498	0.527
LIG_FHA_2	925	931	PF00498	0.445
LIG_HP1_1	414	418	PF01393	0.260
LIG_Integrin_RGD_1	956	958	PF01839	0.550
LIG_LIR_Apic_2	24	28	PF02991	0.545
LIG_LIR_Apic_2	260	264	PF02991	0.514
LIG_LIR_Apic_2	381	387	PF02991	0.577
LIG_LIR_Apic_2	421	427	PF02991	0.317
LIG_LIR_Apic_2	5	11	PF02991	0.547
LIG_LIR_Gen_1	240	248	PF02991	0.464
LIG_LIR_Gen_1	468	477	PF02991	0.436
LIG_LIR_Gen_1	64	73	PF02991	0.528
LIG_LIR_Gen_1	77	87	PF02991	0.424
LIG_LIR_Gen_1	841	849	PF02991	0.404
LIG_LIR_Gen_1	873	881	PF02991	0.351
LIG_LIR_LC3C_4	906	911	PF02991	0.514
LIG_LIR_Nem_3	172	176	PF02991	0.491
LIG_LIR_Nem_3	190	195	PF02991	0.221
LIG_LIR_Nem_3	221	227	PF02991	0.417
LIG_LIR_Nem_3	240	244	PF02991	0.441
LIG_LIR_Nem_3	426	432	PF02991	0.550
LIG_LIR_Nem_3	468	473	PF02991	0.418
LIG_LIR_Nem_3	64	70	PF02991	0.539
LIG_LIR_Nem_3	715	721	PF02991	0.384
LIG_LIR_Nem_3	77	83	PF02991	0.429
LIG_LIR_Nem_3	799	804	PF02991	0.494
LIG_LIR_Nem_3	873	877	PF02991	0.578
LIG_PTB_Apo_2	321	328	PF02174	0.553
LIG_PTB_Apo_2	544	551	PF02174	0.417
LIG_PTB_Phospho_1	321	327	PF10480	0.549
LIG_Rb_LxCxE_1	674	690	PF01857	0.364
LIG_Rb_LxCxE_1	705	716	PF01857	0.260
LIG_SH2_CRK	173	177	PF00017	0.438
LIG_SH2_CRK	261	265	PF00017	0.404
LIG_SH2_CRK	718	722	PF00017	0.385
LIG_SH2_GRB2like	322	325	PF00017	0.543
LIG_SH2_PTP2	80	83	PF00017	0.493
LIG_SH2_SRC	322	325	PF00017	0.543
LIG_SH2_STAP1	934	938	PF00017	0.474
LIG_SH2_STAP1	941	945	PF00017	0.363
LIG_SH2_STAT3	855	858	PF00017	0.466
LIG_SH2_STAT5	128	131	PF00017	0.475
LIG_SH2_STAT5	162	165	PF00017	0.565
LIG_SH2_STAT5	412	415	PF00017	0.607
LIG_SH2_STAT5	527	530	PF00017	0.396
LIG_SH2_STAT5	614	617	PF00017	0.447
LIG_SH2_STAT5	739	742	PF00017	0.502
LIG_SH2_STAT5	80	83	PF00017	0.434
LIG_SH2_STAT5	817	820	PF00017	0.350
LIG_SH2_STAT5	842	845	PF00017	0.462
LIG_SH3_3	106	112	PF00018	0.549
LIG_SH3_3	25	31	PF00018	0.570
LIG_SH3_3	312	318	PF00018	0.671
LIG_SH3_3	376	382	PF00018	0.567
LIG_SH3_3	424	430	PF00018	0.525
LIG_SH3_3	485	491	PF00018	0.493
LIG_SUMO_SIM_par_1	301	307	PF11976	0.682
LIG_SUMO_SIM_par_1	486	493	PF11976	0.435
LIG_TYR_ITSM	188	195	PF00017	0.397
LIG_TYR_ITSM	76	83	PF00017	0.460
LIG_UBA3_1	860	866	PF00899	0.258
LIG_WRC_WIRS_1	241	246	PF05994	0.490
LIG_WRC_WIRS_1	714	719	PF05994	0.439
LIG_WRC_WIRS_1	871	876	PF05994	0.426
MOD_CDK_SPK_2	260	265	PF00069	0.388
MOD_CK1_1	243	249	PF00069	0.484
MOD_CK1_1	298	304	PF00069	0.643
MOD_CK1_1	388	394	PF00069	0.553
MOD_CK1_1	476	482	PF00069	0.554
MOD_CK1_1	552	558	PF00069	0.253
MOD_CK1_1	591	597	PF00069	0.551
MOD_CK1_1	649	655	PF00069	0.506
MOD_CK1_1	713	719	PF00069	0.459
MOD_CK1_1	730	736	PF00069	0.498
MOD_CK1_1	776	782	PF00069	0.428
MOD_CK1_1	811	817	PF00069	0.525
MOD_CK2_1	347	353	PF00069	0.553
MOD_CK2_1	555	561	PF00069	0.351
MOD_CK2_1	625	631	PF00069	0.608
MOD_CK2_1	69	75	PF00069	0.469
MOD_CK2_1	835	841	PF00069	0.541
MOD_CK2_1	924	930	PF00069	0.454
MOD_CK2_1	937	943	PF00069	0.319
MOD_Cter_Amidation	202	205	PF01082	0.612
MOD_GlcNHglycan	115	118	PF01048	0.615
MOD_GlcNHglycan	129	132	PF01048	0.434
MOD_GlcNHglycan	141	144	PF01048	0.468
MOD_GlcNHglycan	177	180	PF01048	0.573
MOD_GlcNHglycan	281	284	PF01048	0.479
MOD_GlcNHglycan	310	313	PF01048	0.631
MOD_GlcNHglycan	467	470	PF01048	0.408
MOD_GlcNHglycan	504	507	PF01048	0.516
MOD_GlcNHglycan	508	511	PF01048	0.490
MOD_GlcNHglycan	557	560	PF01048	0.429
MOD_GlcNHglycan	576	579	PF01048	0.698
MOD_GlcNHglycan	590	593	PF01048	0.507
MOD_GlcNHglycan	651	654	PF01048	0.505
MOD_GlcNHglycan	732	735	PF01048	0.653
MOD_GlcNHglycan	813	816	PF01048	0.425
MOD_GlcNHglycan	97	100	PF01048	0.425
MOD_GSK3_1	103	110	PF00069	0.390
MOD_GSK3_1	139	146	PF00069	0.504
MOD_GSK3_1	156	163	PF00069	0.540
MOD_GSK3_1	195	202	PF00069	0.544
MOD_GSK3_1	206	213	PF00069	0.518
MOD_GSK3_1	240	247	PF00069	0.432
MOD_GSK3_1	27	34	PF00069	0.538
MOD_GSK3_1	275	282	PF00069	0.444
MOD_GSK3_1	294	301	PF00069	0.606
MOD_GSK3_1	304	311	PF00069	0.617
MOD_GSK3_1	383	390	PF00069	0.536
MOD_GSK3_1	414	421	PF00069	0.508
MOD_GSK3_1	472	479	PF00069	0.478
MOD_GSK3_1	502	509	PF00069	0.433
MOD_GSK3_1	59	66	PF00069	0.498
MOD_GSK3_1	632	639	PF00069	0.467
MOD_GSK3_1	652	659	PF00069	0.563
MOD_GSK3_1	724	731	PF00069	0.543
MOD_GSK3_1	773	780	PF00069	0.386
MOD_GSK3_1	796	803	PF00069	0.538
MOD_LATS_1	794	800	PF00433	0.502
MOD_N-GLC_1	107	112	PF02516	0.362
MOD_N-GLC_1	465	470	PF02516	0.399
MOD_N-GLC_1	48	53	PF02516	0.464
MOD_N-GLC_1	622	627	PF02516	0.327
MOD_NEK2_1	103	108	PF00069	0.475
MOD_NEK2_1	127	132	PF00069	0.387
MOD_NEK2_1	175	180	PF00069	0.433
MOD_NEK2_1	194	199	PF00069	0.374
MOD_NEK2_1	244	249	PF00069	0.452
MOD_NEK2_1	252	257	PF00069	0.424
MOD_NEK2_1	275	280	PF00069	0.464
MOD_NEK2_1	286	291	PF00069	0.463
MOD_NEK2_1	346	351	PF00069	0.620
MOD_NEK2_1	440	445	PF00069	0.456
MOD_NEK2_1	465	470	PF00069	0.402
MOD_NEK2_1	472	477	PF00069	0.409
MOD_NEK2_1	549	554	PF00069	0.465
MOD_NEK2_1	582	587	PF00069	0.649
MOD_NEK2_1	651	656	PF00069	0.328
MOD_NEK2_1	712	717	PF00069	0.542
MOD_NEK2_1	740	745	PF00069	0.466
MOD_NEK2_1	89	94	PF00069	0.595
MOD_NEK2_2	48	53	PF00069	0.513
MOD_PIKK_1	286	292	PF00454	0.585
MOD_PIKK_1	304	310	PF00454	0.454
MOD_PIKK_1	638	644	PF00454	0.250
MOD_PKA_1	796	802	PF00069	0.525
MOD_PKA_2	113	119	PF00069	0.589
MOD_PKA_2	144	150	PF00069	0.569
MOD_PKA_2	206	212	PF00069	0.358
MOD_PKA_2	308	314	PF00069	0.678
MOD_PKA_2	336	342	PF00069	0.611
MOD_PKA_2	346	352	PF00069	0.472
MOD_PKA_2	414	420	PF00069	0.474
MOD_PKA_2	430	436	PF00069	0.425
MOD_PKA_2	588	594	PF00069	0.623
MOD_PKA_2	59	65	PF00069	0.481
MOD_PKA_2	656	662	PF00069	0.417
MOD_PKA_2	740	746	PF00069	0.533
MOD_PKA_2	760	766	PF00069	0.389
MOD_PKA_2	796	802	PF00069	0.476
MOD_PKA_2	901	907	PF00069	0.392
MOD_PKB_1	634	642	PF00069	0.407
MOD_PKB_1	937	945	PF00069	0.455
MOD_Plk_1	107	113	PF00069	0.422
MOD_Plk_1	218	224	PF00069	0.301
MOD_Plk_1	294	300	PF00069	0.477
MOD_Plk_1	465	471	PF00069	0.412
MOD_Plk_1	710	716	PF00069	0.438
MOD_Plk_1	840	846	PF00069	0.494
MOD_Plk_1	883	889	PF00069	0.626
MOD_Plk_2-3	353	359	PF00069	0.586
MOD_Plk_4	210	216	PF00069	0.563
MOD_Plk_4	218	224	PF00069	0.342
MOD_Plk_4	237	243	PF00069	0.499
MOD_Plk_4	252	258	PF00069	0.464
MOD_Plk_4	295	301	PF00069	0.497
MOD_Plk_4	484	490	PF00069	0.503
MOD_Plk_4	63	69	PF00069	0.633
MOD_Plk_4	646	652	PF00069	0.454
MOD_Plk_4	656	662	PF00069	0.304
MOD_Plk_4	713	719	PF00069	0.401
MOD_Plk_4	740	746	PF00069	0.457
MOD_Plk_4	75	81	PF00069	0.479
MOD_Plk_4	781	787	PF00069	0.494
MOD_Plk_4	9	15	PF00069	0.538
MOD_ProDKin_1	260	266	PF00069	0.396
MOD_ProDKin_1	27	33	PF00069	0.558
MOD_ProDKin_1	314	320	PF00069	0.665
MOD_ProDKin_1	347	353	PF00069	0.674
MOD_ProDKin_1	378	384	PF00069	0.568
MOD_ProDKin_1	416	422	PF00069	0.490
MOD_ProDKin_1	423	429	PF00069	0.498
MOD_ProDKin_1	433	439	PF00069	0.400
MOD_ProDKin_1	69	75	PF00069	0.529
MOD_ProDKin_1	697	703	PF00069	0.442
MOD_ProDKin_1	732	738	PF00069	0.578
MOD_ProDKin_1	924	930	PF00069	0.542
MOD_SUMO_for_1	725	728	PF00179	0.539
MOD_SUMO_rev_2	150	160	PF00179	0.460
TRG_DiLeu_BaEn_1	270	275	PF01217	0.588
TRG_DiLeu_BaEn_1	295	300	PF01217	0.425
TRG_DiLeu_BaEn_1	905	910	PF01217	0.516
TRG_DiLeu_BaLyEn_6	262	267	PF01217	0.589
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.594
TRG_DiLeu_BaLyEn_6	396	401	PF01217	0.456
TRG_DiLeu_BaLyEn_6	916	921	PF01217	0.284
TRG_DiLeu_LyEn_5	270	275	PF01217	0.549
TRG_ENDOCYTIC_2	173	176	PF00928	0.540
TRG_ENDOCYTIC_2	192	195	PF00928	0.206
TRG_ENDOCYTIC_2	327	330	PF00928	0.538
TRG_ENDOCYTIC_2	718	721	PF00928	0.318
TRG_ENDOCYTIC_2	80	83	PF00928	0.473
TRG_ENDOCYTIC_2	842	845	PF00928	0.416
TRG_ER_diArg_1	633	636	PF00400	0.547
TRG_ER_diArg_1	755	757	PF00400	0.400
TRG_ER_diArg_1	795	797	PF00400	0.460
TRG_NES_CRM1_1	284	295	PF08389	0.553
TRG_Pf-PMV_PEXEL_1	265	270	PF00026	0.609
TRG_Pf-PMV_PEXEL_1	371	375	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	665	669	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXF5	Leptomonas seymouri	44%	99%
A0A1X0NWP8	Trypanosomatidae	24%	99%
A0A3Q8IEQ1	Leishmania donovani	91%	99%
A0A422NJD5	Trypanosoma rangeli	25%	100%
A4HD38	Leishmania braziliensis	78%	100%
C9ZNR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	97%
E9AH16	Leishmania infantum	92%	99%
Q4QAY4	Leishmania major	89%	100%
V5B6R7	Trypanosoma cruzi	27%	100%