Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWI5_LEIMU

TriTrypDb:

LmxM.23.1530

Length:

651

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWI5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWI5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.448
CLV_C14_Caspase3-7	343	347	PF00656	0.425
CLV_C14_Caspase3-7	421	425	PF00656	0.489
CLV_NRD_NRD_1	193	195	PF00675	0.430
CLV_NRD_NRD_1	319	321	PF00675	0.418
CLV_PCSK_KEX2_1	193	195	PF00082	0.430
CLV_PCSK_KEX2_1	319	321	PF00082	0.424
CLV_PCSK_KEX2_1	369	371	PF00082	0.496
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.496
CLV_PCSK_SKI1_1	131	135	PF00082	0.556
CLV_PCSK_SKI1_1	181	185	PF00082	0.464
CLV_PCSK_SKI1_1	567	571	PF00082	0.421
DEG_APCC_DBOX_1	180	188	PF00400	0.456
DEG_APCC_DBOX_1	307	315	PF00400	0.358
DEG_APCC_DBOX_1	32	40	PF00400	0.455
DEG_Nend_UBRbox_2	1	3	PF02207	0.573
DOC_CDC14_PxL_1	613	621	PF14671	0.371
DOC_CKS1_1	499	504	PF01111	0.463
DOC_CYCLIN_RxL_1	573	585	PF00134	0.452
DOC_CYCLIN_RxL_1	628	639	PF00134	0.393
DOC_MAPK_MEF2A_6	308	315	PF00069	0.445
DOC_MAPK_MEF2A_6	40	47	PF00069	0.434
DOC_MAPK_NFAT4_5	308	316	PF00069	0.465
DOC_PP2B_LxvP_1	302	305	PF13499	0.405
DOC_PP4_FxxP_1	286	289	PF00568	0.510
DOC_PP4_FxxP_1	499	502	PF00568	0.489
DOC_USP7_MATH_1	112	116	PF00917	0.592
DOC_USP7_MATH_1	243	247	PF00917	0.482
DOC_USP7_MATH_1	348	352	PF00917	0.551
DOC_USP7_MATH_1	502	506	PF00917	0.341
DOC_USP7_MATH_1	541	545	PF00917	0.525
DOC_WW_Pin1_4	125	130	PF00397	0.311
DOC_WW_Pin1_4	204	209	PF00397	0.365
DOC_WW_Pin1_4	341	346	PF00397	0.551
DOC_WW_Pin1_4	408	413	PF00397	0.480
DOC_WW_Pin1_4	482	487	PF00397	0.552
DOC_WW_Pin1_4	498	503	PF00397	0.494
DOC_WW_Pin1_4	504	509	PF00397	0.456
LIG_14-3-3_CanoR_1	111	117	PF00244	0.513
LIG_14-3-3_CanoR_1	308	314	PF00244	0.524
LIG_14-3-3_CanoR_1	33	43	PF00244	0.534
LIG_14-3-3_CanoR_1	391	396	PF00244	0.455
LIG_14-3-3_CanoR_1	51	56	PF00244	0.515
LIG_14-3-3_CanoR_1	567	572	PF00244	0.412
LIG_14-3-3_CanoR_1	578	583	PF00244	0.267
LIG_APCC_ABBA_1	43	48	PF00400	0.500
LIG_APCC_ABBA_1	580	585	PF00400	0.387
LIG_APCC_ABBA_1	610	615	PF00400	0.454
LIG_BIR_III_2	538	542	PF00653	0.368
LIG_eIF4E_1	359	365	PF01652	0.505
LIG_eIF4E_1	613	619	PF01652	0.407
LIG_FHA_1	128	134	PF00498	0.394
LIG_FHA_1	156	162	PF00498	0.621
LIG_FHA_1	319	325	PF00498	0.428
LIG_FHA_1	449	455	PF00498	0.439
LIG_FHA_1	65	71	PF00498	0.452
LIG_FHA_2	405	411	PF00498	0.538
LIG_GBD_Chelix_1	225	233	PF00786	0.288
LIG_GBD_Chelix_1	95	103	PF00786	0.510
LIG_LIR_Apic_2	497	502	PF02991	0.408
LIG_LIR_Gen_1	142	148	PF02991	0.410
LIG_LIR_Gen_1	356	366	PF02991	0.536
LIG_LIR_Gen_1	531	542	PF02991	0.419
LIG_LIR_Gen_1	590	598	PF02991	0.330
LIG_LIR_Nem_3	142	147	PF02991	0.368
LIG_LIR_Nem_3	327	332	PF02991	0.496
LIG_LIR_Nem_3	356	362	PF02991	0.540
LIG_LIR_Nem_3	590	594	PF02991	0.349
LIG_LIR_Nem_3	627	633	PF02991	0.342
LIG_NRBOX	451	457	PF00104	0.452
LIG_PCNA_PIPBox_1	53	62	PF02747	0.395
LIG_PCNA_yPIPBox_3	51	60	PF02747	0.374
LIG_PDZ_Class_2	646	651	PF00595	0.249
LIG_Pex14_1	512	516	PF04695	0.432
LIG_Pex14_2	286	290	PF04695	0.229
LIG_SH2_CRK	359	363	PF00017	0.463
LIG_SH2_GRB2like	326	329	PF00017	0.407
LIG_SH2_SRC	422	425	PF00017	0.465
LIG_SH2_SRC	613	616	PF00017	0.426
LIG_SH2_STAP1	256	260	PF00017	0.409
LIG_SH2_STAP1	326	330	PF00017	0.451
LIG_SH2_STAP1	419	423	PF00017	0.412
LIG_SH2_STAP1	516	520	PF00017	0.330
LIG_SH2_STAT5	214	217	PF00017	0.346
LIG_SH2_STAT5	266	269	PF00017	0.326
LIG_SH2_STAT5	326	329	PF00017	0.593
LIG_SH2_STAT5	399	402	PF00017	0.504
LIG_SH2_STAT5	422	425	PF00017	0.336
LIG_SH2_STAT5	59	62	PF00017	0.400
LIG_SH2_STAT5	607	610	PF00017	0.438
LIG_SH3_1	406	412	PF00018	0.473
LIG_SH3_3	199	205	PF00018	0.357
LIG_SH3_3	406	412	PF00018	0.473
LIG_SH3_3	640	646	PF00018	0.322
LIG_Sin3_3	300	307	PF02671	0.467
LIG_Sin3_3	434	441	PF02671	0.378
LIG_SUMO_SIM_anti_2	451	456	PF11976	0.392
LIG_SUMO_SIM_anti_2	78	84	PF11976	0.492
LIG_SUMO_SIM_par_1	214	221	PF11976	0.342
LIG_SUMO_SIM_par_1	633	640	PF11976	0.312
LIG_SUMO_SIM_par_1	645	650	PF11976	0.354
LIG_TRAF2_1	137	140	PF00917	0.393
LIG_TRFH_1	171	175	PF08558	0.444
LIG_WRC_WIRS_1	390	395	PF05994	0.490
MOD_CDC14_SPxK_1	128	131	PF00782	0.294
MOD_CDK_SPxK_1	125	131	PF00069	0.307
MOD_CK1_1	115	121	PF00069	0.553
MOD_CK1_1	12	18	PF00069	0.591
MOD_CK1_1	155	161	PF00069	0.609
MOD_CK1_1	176	182	PF00069	0.413
MOD_CK1_1	221	227	PF00069	0.362
MOD_CK1_1	235	241	PF00069	0.348
MOD_CK1_1	411	417	PF00069	0.489
MOD_CK1_1	466	472	PF00069	0.452
MOD_CK1_1	5	11	PF00069	0.618
MOD_CK1_1	504	510	PF00069	0.405
MOD_CK2_1	134	140	PF00069	0.450
MOD_CK2_1	142	148	PF00069	0.429
MOD_CK2_1	203	209	PF00069	0.489
MOD_CK2_1	221	227	PF00069	0.262
MOD_CK2_1	290	296	PF00069	0.610
MOD_CK2_1	404	410	PF00069	0.501
MOD_CK2_1	482	488	PF00069	0.450
MOD_CK2_1	589	595	PF00069	0.542
MOD_GlcNHglycan	114	117	PF01048	0.507
MOD_GlcNHglycan	13	17	PF01048	0.635
MOD_GlcNHglycan	136	139	PF01048	0.513
MOD_GlcNHglycan	144	147	PF01048	0.419
MOD_GlcNHglycan	220	223	PF01048	0.409
MOD_GlcNHglycan	239	242	PF01048	0.244
MOD_GlcNHglycan	352	355	PF01048	0.649
MOD_GlcNHglycan	475	478	PF01048	0.450
MOD_GlcNHglycan	562	565	PF01048	0.443
MOD_GlcNHglycan	567	570	PF01048	0.487
MOD_GlcNHglycan	591	594	PF01048	0.443
MOD_GlcNHglycan	595	599	PF01048	0.513
MOD_GSK3_1	115	122	PF00069	0.488
MOD_GSK3_1	153	160	PF00069	0.588
MOD_GSK3_1	217	224	PF00069	0.448
MOD_GSK3_1	228	235	PF00069	0.401
MOD_GSK3_1	350	357	PF00069	0.394
MOD_GSK3_1	385	392	PF00069	0.412
MOD_GSK3_1	404	411	PF00069	0.326
MOD_GSK3_1	446	453	PF00069	0.404
MOD_GSK3_1	498	505	PF00069	0.590
MOD_GSK3_1	5	12	PF00069	0.626
MOD_GSK3_1	90	97	PF00069	0.542
MOD_N-GLC_1	309	314	PF02516	0.367
MOD_NEK2_1	318	323	PF00069	0.414
MOD_NEK2_1	324	329	PF00069	0.430
MOD_NEK2_1	340	345	PF00069	0.324
MOD_NEK2_1	364	369	PF00069	0.439
MOD_NEK2_1	385	390	PF00069	0.391
MOD_NEK2_1	46	51	PF00069	0.536
MOD_NEK2_1	572	577	PF00069	0.507
MOD_NEK2_1	589	594	PF00069	0.396
MOD_NEK2_1	94	99	PF00069	0.539
MOD_NEK2_2	232	237	PF00069	0.383
MOD_NEK2_2	354	359	PF00069	0.388
MOD_PIKK_1	411	417	PF00454	0.552
MOD_PK_1	51	57	PF00069	0.483
MOD_PKA_2	2	8	PF00069	0.771
MOD_PKA_2	318	324	PF00069	0.463
MOD_PKA_2	354	360	PF00069	0.320
MOD_Plk_1	309	315	PF00069	0.368
MOD_Plk_1	404	410	PF00069	0.580
MOD_Plk_1	624	630	PF00069	0.465
MOD_Plk_4	243	249	PF00069	0.443
MOD_Plk_4	309	315	PF00069	0.403
MOD_Plk_4	354	360	PF00069	0.501
MOD_Plk_4	450	456	PF00069	0.503
MOD_Plk_4	51	57	PF00069	0.519
MOD_Plk_4	541	547	PF00069	0.402
MOD_Plk_4	567	573	PF00069	0.448
MOD_Plk_4	578	584	PF00069	0.480
MOD_Plk_4	90	96	PF00069	0.487
MOD_ProDKin_1	125	131	PF00069	0.307
MOD_ProDKin_1	204	210	PF00069	0.361
MOD_ProDKin_1	341	347	PF00069	0.562
MOD_ProDKin_1	408	414	PF00069	0.473
MOD_ProDKin_1	482	488	PF00069	0.552
MOD_ProDKin_1	498	504	PF00069	0.501
TRG_DiLeu_BaEn_1	615	620	PF01217	0.441
TRG_DiLeu_BaLyEn_6	614	619	PF01217	0.411
TRG_DiLeu_BaLyEn_6	643	648	PF01217	0.444
TRG_DiLeu_BaLyEn_6	99	104	PF01217	0.479
TRG_ENDOCYTIC_2	326	329	PF00928	0.540
TRG_ENDOCYTIC_2	359	362	PF00928	0.512
TRG_ENDOCYTIC_2	607	610	PF00928	0.342
TRG_ENDOCYTIC_2	613	616	PF00928	0.330
TRG_ER_diArg_1	193	195	PF00400	0.430
TRG_ER_diArg_1	318	320	PF00400	0.434
TRG_ER_diArg_1	456	459	PF00400	0.419
TRG_NES_CRM1_1	35	48	PF08389	0.433
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	194	199	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	237	242	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	631	636	PF00026	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKS3	Leptomonas seymouri	53%	78%
A0A1X0NXC2	Trypanosomatidae	26%	83%
A0A3Q8IBR0	Leishmania donovani	92%	100%
A0A3R7RJS0	Trypanosoma rangeli	28%	82%
A4HD37	Leishmania braziliensis	84%	100%
C9ZNR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	80%
E9AH15	Leishmania infantum	92%	100%
Q4QAY5	Leishmania major	92%	100%
V5BFS5	Trypanosoma cruzi	26%	82%