Protoheme IX farnesyltransferase, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protoheme IX farnesyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9AWI4_LEIMU

TriTrypDb:

LmxM.23.1520

Length:

433

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	8
GO:0031966	mitochondrial membrane	4	8
GO:0110165	cellular anatomical entity	1	12
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AWI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWI4

Function

Biological processes
Term	Name	Level	Count
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006778	porphyrin-containing compound metabolic process	5	12
GO:0006779	porphyrin-containing compound biosynthetic process	6	12
GO:0006783	heme biosynthetic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009987	cellular process	1	12
GO:0018130	heterocycle biosynthetic process	4	12
GO:0019438	aromatic compound biosynthetic process	4	12
GO:0033013	tetrapyrrole metabolic process	4	12
GO:0033014	tetrapyrrole biosynthetic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0042168	heme metabolic process	3	12
GO:0042440	pigment metabolic process	2	12
GO:0044237	cellular metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0046148	pigment biosynthetic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004311	farnesyltranstransferase activity	5	12
GO:0004659	prenyltransferase activity	4	12
GO:0008495	protoheme IX farnesyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.492
CLV_NRD_NRD_1	19	21	PF00675	0.398
CLV_NRD_NRD_1	191	193	PF00675	0.251
CLV_NRD_NRD_1	301	303	PF00675	0.251
CLV_NRD_NRD_1	66	68	PF00675	0.483
CLV_PCSK_KEX2_1	117	119	PF00082	0.492
CLV_PCSK_KEX2_1	187	189	PF00082	0.251
CLV_PCSK_KEX2_1	19	21	PF00082	0.398
CLV_PCSK_KEX2_1	191	193	PF00082	0.251
CLV_PCSK_KEX2_1	245	247	PF00082	0.241
CLV_PCSK_KEX2_1	301	303	PF00082	0.251
CLV_PCSK_KEX2_1	66	68	PF00082	0.483
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.251
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.251
CLV_PCSK_PC7_1	62	68	PF00082	0.452
CLV_PCSK_SKI1_1	184	188	PF00082	0.245
CLV_PCSK_SKI1_1	19	23	PF00082	0.400
CLV_PCSK_SKI1_1	365	369	PF00082	0.388
CLV_PCSK_SKI1_1	47	51	PF00082	0.405
CLV_Separin_Metazoa	372	376	PF03568	0.556
DEG_APCC_DBOX_1	18	26	PF00400	0.600
DEG_Nend_Nbox_1	1	3	PF02207	0.673
DEG_SPOP_SBC_1	426	430	PF00917	0.251
DOC_CKS1_1	240	245	PF01111	0.475
DOC_CKS1_1	273	278	PF01111	0.300
DOC_CYCLIN_RxL_1	362	372	PF00134	0.388
DOC_MAPK_gen_1	187	198	PF00069	0.511
DOC_PP1_RVXF_1	308	315	PF00149	0.451
DOC_PP1_RVXF_1	363	370	PF00149	0.360
DOC_PP4_FxxP_1	314	317	PF00568	0.451
DOC_PP4_FxxP_1	33	36	PF00568	0.730
DOC_USP7_MATH_1	120	124	PF00917	0.636
DOC_USP7_MATH_1	21	25	PF00917	0.681
DOC_USP7_MATH_1	426	430	PF00917	0.467
DOC_WW_Pin1_4	100	105	PF00397	0.658
DOC_WW_Pin1_4	197	202	PF00397	0.511
DOC_WW_Pin1_4	220	225	PF00397	0.251
DOC_WW_Pin1_4	239	244	PF00397	0.303
DOC_WW_Pin1_4	272	277	PF00397	0.337
LIG_14-3-3_CanoR_1	246	254	PF00244	0.445
LIG_14-3-3_CanoR_1	319	323	PF00244	0.451
LIG_14-3-3_CanoR_1	34	42	PF00244	0.733
LIG_14-3-3_CanoR_1	62	68	PF00244	0.684
LIG_14-3-3_CanoR_1	8	13	PF00244	0.593
LIG_Actin_WH2_2	229	247	PF00022	0.305
LIG_BRCT_BRCA1_1	365	369	PF00533	0.360
LIG_BRCT_BRCA1_1	69	73	PF00533	0.699
LIG_FHA_1	13	19	PF00498	0.673
LIG_FHA_1	150	156	PF00498	0.330
LIG_FHA_1	214	220	PF00498	0.398
LIG_FHA_1	273	279	PF00498	0.262
LIG_FHA_2	8	14	PF00498	0.709
LIG_LIR_Gen_1	179	186	PF02991	0.511
LIG_LIR_Gen_1	283	291	PF02991	0.450
LIG_LIR_Gen_1	384	395	PF02991	0.303
LIG_LIR_Nem_3	179	185	PF02991	0.537
LIG_LIR_Nem_3	252	257	PF02991	0.371
LIG_LIR_Nem_3	283	287	PF02991	0.450
LIG_LIR_Nem_3	321	325	PF02991	0.461
LIG_LIR_Nem_3	384	390	PF02991	0.301
LIG_Pex14_1	318	322	PF04695	0.451
LIG_Pex14_2	284	288	PF04695	0.388
LIG_Pex14_2	314	318	PF04695	0.451
LIG_REV1ctd_RIR_1	3	12	PF16727	0.596
LIG_SH2_CRK	182	186	PF00017	0.537
LIG_SH2_CRK	241	245	PF00017	0.446
LIG_SH2_CRK	309	313	PF00017	0.444
LIG_SH2_CRK	364	368	PF00017	0.351
LIG_SH2_NCK_1	304	308	PF00017	0.462
LIG_SH2_PTP2	237	240	PF00017	0.388
LIG_SH2_PTP2	385	388	PF00017	0.338
LIG_SH2_SRC	146	149	PF00017	0.424
LIG_SH2_STAP1	182	186	PF00017	0.511
LIG_SH2_STAP1	323	327	PF00017	0.303
LIG_SH2_STAP1	352	356	PF00017	0.449
LIG_SH2_STAT5	137	140	PF00017	0.354
LIG_SH2_STAT5	146	149	PF00017	0.243
LIG_SH2_STAT5	220	223	PF00017	0.275
LIG_SH2_STAT5	237	240	PF00017	0.289
LIG_SH2_STAT5	241	244	PF00017	0.441
LIG_SH2_STAT5	385	388	PF00017	0.306
LIG_SH2_STAT5	412	415	PF00017	0.330
LIG_SH3_3	219	225	PF00018	0.300
LIG_TYR_ITIM	349	354	PF00017	0.365
LIG_WRC_WIRS_1	281	286	PF05994	0.450
MOD_CDK_SPxK_1	239	245	PF00069	0.303
MOD_CDK_SPxxK_3	239	246	PF00069	0.303
MOD_CK1_1	11	17	PF00069	0.605
MOD_CK1_1	132	138	PF00069	0.405
MOD_CK1_1	170	176	PF00069	0.314
MOD_CK1_1	425	431	PF00069	0.539
MOD_CK2_1	205	211	PF00069	0.360
MOD_CK2_1	426	432	PF00069	0.555
MOD_CK2_1	7	13	PF00069	0.668
MOD_GlcNHglycan	134	137	PF01048	0.324
MOD_GlcNHglycan	169	172	PF01048	0.314
MOD_GlcNHglycan	207	210	PF01048	0.266
MOD_GlcNHglycan	247	250	PF01048	0.303
MOD_GlcNHglycan	25	28	PF01048	0.522
MOD_GlcNHglycan	419	423	PF01048	0.538
MOD_GlcNHglycan	424	427	PF01048	0.560
MOD_GlcNHglycan	69	72	PF01048	0.613
MOD_GlcNHglycan	83	87	PF01048	0.600
MOD_GSK3_1	120	127	PF00069	0.448
MOD_GSK3_1	161	168	PF00069	0.338
MOD_GSK3_1	245	252	PF00069	0.303
MOD_GSK3_1	411	418	PF00069	0.450
MOD_GSK3_1	422	429	PF00069	0.456
MOD_GSK3_1	45	52	PF00069	0.389
MOD_GSK3_1	67	74	PF00069	0.510
MOD_GSK3_1	7	14	PF00069	0.595
MOD_NEK2_1	129	134	PF00069	0.425
MOD_NEK2_1	165	170	PF00069	0.330
MOD_NEK2_1	186	191	PF00069	0.303
MOD_NEK2_1	280	285	PF00069	0.424
MOD_NEK2_1	381	386	PF00069	0.301
MOD_NEK2_1	45	50	PF00069	0.649
MOD_NEK2_1	6	11	PF00069	0.691
MOD_NEK2_1	61	66	PF00069	0.510
MOD_NEK2_2	318	323	PF00069	0.292
MOD_PIKK_1	124	130	PF00454	0.466
MOD_PIKK_1	61	67	PF00454	0.638
MOD_PKA_1	245	251	PF00069	0.289
MOD_PKA_2	245	251	PF00069	0.300
MOD_PKA_2	318	324	PF00069	0.303
MOD_PKA_2	61	67	PF00069	0.615
MOD_PKA_2	7	13	PF00069	0.504
MOD_Plk_1	12	18	PF00069	0.612
MOD_Plk_4	121	127	PF00069	0.459
MOD_Plk_4	13	19	PF00069	0.666
MOD_Plk_4	161	167	PF00069	0.313
MOD_Plk_4	249	255	PF00069	0.298
MOD_Plk_4	280	286	PF00069	0.371
MOD_Plk_4	318	324	PF00069	0.303
MOD_Plk_4	325	331	PF00069	0.303
MOD_Plk_4	332	338	PF00069	0.303
MOD_Plk_4	363	369	PF00069	0.410
MOD_Plk_4	386	392	PF00069	0.309
MOD_Plk_4	84	90	PF00069	0.681
MOD_ProDKin_1	100	106	PF00069	0.580
MOD_ProDKin_1	197	203	PF00069	0.388
MOD_ProDKin_1	220	226	PF00069	0.303
MOD_ProDKin_1	239	245	PF00069	0.303
MOD_ProDKin_1	272	278	PF00069	0.424
TRG_ENDOCYTIC_2	182	185	PF00928	0.388
TRG_ENDOCYTIC_2	237	240	PF00928	0.303
TRG_ENDOCYTIC_2	241	244	PF00928	0.268
TRG_ENDOCYTIC_2	309	312	PF00928	0.293
TRG_ENDOCYTIC_2	351	354	PF00928	0.317
TRG_ENDOCYTIC_2	364	367	PF00928	0.226
TRG_ENDOCYTIC_2	385	388	PF00928	0.300
TRG_ER_diArg_1	117	119	PF00400	0.581
TRG_ER_diArg_1	18	20	PF00400	0.518
TRG_ER_diArg_1	191	193	PF00400	0.319
TRG_ER_diArg_1	66	68	PF00400	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDJ6	Leptomonas seymouri	79%	100%
A0A0S4JPE1	Bodo saltans	56%	100%
A0A1X0NWM0	Trypanosomatidae	60%	100%
A0A3Q8IFZ4	Leishmania donovani	94%	100%
A0A3R7KFR3	Trypanosoma rangeli	59%	100%
A0KAR0	Burkholderia cenocepacia (strain HI2424)	29%	100%
A1AV76	Ruthia magnifica subsp. Calyptogena magnifica	27%	100%
A1KIP0	Mycobacterium bovis (strain BCG / Pasteur 1173P2)	30%	100%
A1QRH1	Mycobacterium tuberculosis (strain F11)	30%	100%
A1SY55	Psychromonas ingrahamii (strain 37)	29%	100%
A1TU04	Acidovorax citrulli (strain AAC00-1)	27%	100%
A1TWQ8	Marinobacter nauticus (strain ATCC 700491 / DSM 11845 / VT8)	26%	100%
A1UZV8	Burkholderia mallei (strain SAVP1)	30%	100%
A1VKM6	Polaromonas naphthalenivorans (strain CJ2)	29%	100%
A2S646	Burkholderia mallei (strain NCTC 10229)	30%	100%
A3MQ44	Burkholderia mallei (strain NCTC 10247)	30%	100%
A3N5D1	Burkholderia pseudomallei (strain 668)	30%	100%
A3NR29	Burkholderia pseudomallei (strain 1106a)	30%	100%
A3PGX5	Cereibacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)	29%	100%
A4FBP2	Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)	30%	100%
A4HD36	Leishmania braziliensis	88%	100%
A4I0M3	Leishmania infantum	94%	100%
A4JI25	Burkholderia vietnamiensis (strain G4 / LMG 22486)	29%	100%
A4WQ57	Cereibacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)	28%	100%
A5CXZ0	Vesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA)	27%	100%
A5U2F4	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)	30%	100%
A5UPV7	Roseiflexus sp. (strain RS-1)	28%	81%
A6UXP9	Pseudomonas aeruginosa (strain PA7)	26%	100%
B0T0X6	Caulobacter sp. (strain K31)	26%	100%
B1JZ41	Burkholderia cenocepacia (strain MC0-3)	29%	100%
B1MC66	Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543)	30%	100%
B1YIW5	Exiguobacterium sibiricum (strain DSM 17290 / CIP 109462 / JCM 13490 / 255-15)	28%	100%
B1YN86	Burkholderia ambifaria (strain MC40-6)	29%	100%
B4EA84	Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)	29%	100%
B4SHI1	Stenotrophomonas maltophilia (strain R551-3)	29%	100%
B5ZSV2	Rhizobium leguminosarum bv. trifolii (strain WSM2304)	29%	100%
B9KGP6	Anaplasma marginale (strain Florida)	28%	100%
B9KLZ5	Cereibacter sphaeroides (strain KD131 / KCTC 12085)	29%	100%
C1AN96	Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)	30%	100%
C9ZNR4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	96%
O64886	Arabidopsis thaliana	34%	100%
P9WFR6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	30%	100%
P9WFR7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	30%	100%
Q02UW5	Pseudomonas aeruginosa (strain UCBPP-PA14)	26%	100%
Q0BBM3	Burkholderia ambifaria (strain ATCC BAA-244 / AMMD)	29%	100%
Q0C3D1	Hyphomonas neptunium (strain ATCC 15444)	27%	100%
Q12E37	Polaromonas sp. (strain JS666 / ATCC BAA-500)	29%	100%
Q146A1	Paraburkholderia xenovorans (strain LB400)	28%	100%
Q15N01	Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)	29%	100%
Q1BTD0	Burkholderia cenocepacia (strain AU 1054)	29%	100%
Q1D1K4	Myxococcus xanthus (strain DK1622)	30%	100%
Q1GTA5	Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256)	29%	100%
Q1IGZ4	Pseudomonas entomophila (strain L48)	27%	100%
Q1J1C3	Deinococcus geothermalis (strain DSM 11300 / AG-3a)	28%	100%
Q1MKI5	Rhizobium leguminosarum bv. viciae (strain 3841)	30%	100%
Q28MJ1	Jannaschia sp. (strain CCS1)	28%	100%
Q2JNL3	Synechococcus sp. (strain JA-2-3B'a(2-13))	29%	100%
Q2SQU8	Hahella chejuensis (strain KCTC 2396)	28%	100%
Q2T1F6	Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)	30%	100%
Q39CQ5	Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)	29%	100%
Q3IRC9	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	27%	95%
Q3J5F9	Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.)	29%	100%
Q3JWF7	Burkholderia pseudomallei (strain 1710b)	30%	100%
Q3SUL3	Nitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255)	29%	100%
Q3SW48	Nitrobacter winogradskyi (strain ATCC 25391 / DSM 10237 / CIP 104748 / NCIMB 11846 / Nb-255)	29%	100%
Q3YR13	Ehrlichia canis (strain Jake)	26%	100%
Q4I5G1	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	34%	85%
Q4QAY6	Leishmania major	93%	100%
Q5LNX8	Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)	28%	100%
Q5P9Y8	Anaplasma marginale (strain St. Maries)	28%	100%
Q62F61	Burkholderia mallei (strain ATCC 23344)	30%	100%
Q63XS7	Burkholderia pseudomallei (strain K96243)	30%	100%
Q6AF34	Leifsonia xyli subsp. xyli (strain CTCB07)	29%	100%
Q6KZG0	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	25%	100%
Q72VU2	Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)	28%	100%
Q75F43	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	34%	100%
Q7U021	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	30%	100%
Q8F9F8	Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)	28%	100%
Q985X0	Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)	28%	100%
Q9A301	Caulobacter vibrioides (strain ATCC 19089 / CB15)	26%	100%
Q9CCN4	Mycobacterium leprae (strain TN)	28%	100%
Q9I719	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	26%	100%
Q9PDL9	Xylella fastidiosa (strain 9a5c)	29%	100%
Q9RM98	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	30%	100%
V5BB79	Trypanosoma cruzi	54%	100%