Myotubularin phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWI2_LEIMU

TriTrypDb:

LmxM.23.1500

Length:

468

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWI2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.466
CLV_NRD_NRD_1	222	224	PF00675	0.721
CLV_PCSK_KEX2_1	10	12	PF00082	0.514
CLV_PCSK_KEX2_1	222	224	PF00082	0.721
CLV_PCSK_SKI1_1	170	174	PF00082	0.502
CLV_PCSK_SKI1_1	307	311	PF00082	0.594
CLV_PCSK_SKI1_1	39	43	PF00082	0.397
DEG_SPOP_SBC_1	333	337	PF00917	0.661
DOC_ANK_TNKS_1	18	25	PF00023	0.559
DOC_CDC14_PxL_1	413	421	PF14671	0.534
DOC_CKS1_1	71	76	PF01111	0.582
DOC_CYCLIN_RxL_1	36	45	PF00134	0.354
DOC_MAPK_DCC_7	404	413	PF00069	0.676
DOC_MAPK_gen_1	10	16	PF00069	0.498
DOC_MAPK_gen_1	219	228	PF00069	0.706
DOC_MAPK_MEF2A_6	219	228	PF00069	0.706
DOC_MAPK_MEF2A_6	404	413	PF00069	0.676
DOC_MAPK_MEF2A_6	51	60	PF00069	0.339
DOC_MAPK_NFAT4_5	223	231	PF00069	0.708
DOC_PP4_FxxP_1	213	216	PF00568	0.581
DOC_PP4_FxxP_1	71	74	PF00568	0.574
DOC_USP7_MATH_1	103	107	PF00917	0.587
DOC_USP7_MATH_1	152	156	PF00917	0.461
DOC_USP7_MATH_1	267	271	PF00917	0.484
DOC_USP7_MATH_1	334	338	PF00917	0.605
DOC_USP7_MATH_1	447	451	PF00917	0.661
DOC_USP7_MATH_1	83	87	PF00917	0.694
DOC_WW_Pin1_4	161	166	PF00397	0.619
DOC_WW_Pin1_4	344	349	PF00397	0.529
DOC_WW_Pin1_4	70	75	PF00397	0.572
LIG_14-3-3_CanoR_1	194	202	PF00244	0.590
LIG_14-3-3_CanoR_1	260	268	PF00244	0.685
LIG_14-3-3_CanoR_1	286	293	PF00244	0.673
LIG_14-3-3_CanoR_1	31	35	PF00244	0.511
LIG_14-3-3_CanoR_1	39	45	PF00244	0.465
LIG_14-3-3_CanoR_1	51	57	PF00244	0.333
LIG_AP2alpha_2	299	301	PF02296	0.649
LIG_APCC_ABBA_1	12	17	PF00400	0.381
LIG_APCC_ABBAyCdc20_2	11	17	PF00400	0.495
LIG_BIR_II_1	1	5	PF00653	0.646
LIG_BRCT_BRCA1_1	447	451	PF00533	0.582
LIG_CtBP_PxDLS_1	408	412	PF00389	0.690
LIG_FHA_1	151	157	PF00498	0.465
LIG_FHA_1	185	191	PF00498	0.403
LIG_FHA_1	301	307	PF00498	0.710
LIG_FHA_1	322	328	PF00498	0.563
LIG_FHA_1	334	340	PF00498	0.617
LIG_FHA_1	351	357	PF00498	0.340
LIG_FHA_1	398	404	PF00498	0.513
LIG_FHA_1	53	59	PF00498	0.510
LIG_FHA_2	180	186	PF00498	0.603
LIG_FHA_2	370	376	PF00498	0.686
LIG_FHA_2	4	10	PF00498	0.557
LIG_FHA_2	64	70	PF00498	0.483
LIG_LIR_Apic_2	211	216	PF02991	0.588
LIG_LIR_Apic_2	69	74	PF02991	0.565
LIG_LIR_Gen_1	175	183	PF02991	0.485
LIG_LIR_Gen_1	299	309	PF02991	0.651
LIG_LIR_Nem_3	175	179	PF02991	0.480
LIG_LIR_Nem_3	299	304	PF02991	0.650
LIG_LIR_Nem_3	410	416	PF02991	0.531
LIG_NRBOX	452	458	PF00104	0.519
LIG_PCNA_PIPBox_1	206	215	PF02747	0.506
LIG_Pex14_2	360	364	PF04695	0.456
LIG_Pex14_2	391	395	PF04695	0.622
LIG_REV1ctd_RIR_1	13	23	PF16727	0.415
LIG_SH2_CRK	162	166	PF00017	0.362
LIG_SH2_STAT5	146	149	PF00017	0.429
LIG_SH2_STAT5	394	397	PF00017	0.538
LIG_SH3_2	417	422	PF14604	0.611
LIG_SH3_3	342	348	PF00018	0.661
LIG_SH3_3	411	417	PF00018	0.568
LIG_SH3_3	462	468	PF00018	0.461
LIG_SUMO_SIM_par_1	308	314	PF11976	0.525
LIG_SUMO_SIM_par_1	40	45	PF11976	0.579
LIG_SUMO_SIM_par_1	54	59	PF11976	0.343
LIG_TRAF2_1	372	375	PF00917	0.648
LIG_WRC_WIRS_1	68	73	PF05994	0.544
MOD_CDK_SPxxK_3	161	168	PF00069	0.508
MOD_CK1_1	145	151	PF00069	0.552
MOD_CK1_1	2	8	PF00069	0.609
MOD_CK1_1	328	334	PF00069	0.652
MOD_CK1_1	343	349	PF00069	0.531
MOD_CK1_1	52	58	PF00069	0.504
MOD_CK1_1	70	76	PF00069	0.451
MOD_CK2_1	145	151	PF00069	0.552
MOD_CK2_1	179	185	PF00069	0.605
MOD_CK2_1	288	294	PF00069	0.806
MOD_CK2_1	3	9	PF00069	0.410
MOD_CK2_1	369	375	PF00069	0.675
MOD_CK2_1	63	69	PF00069	0.470
MOD_GlcNHglycan	1	4	PF01048	0.671
MOD_GlcNHglycan	156	159	PF01048	0.647
MOD_GlcNHglycan	197	200	PF01048	0.623
MOD_GlcNHglycan	262	265	PF01048	0.626
MOD_GlcNHglycan	269	272	PF01048	0.567
MOD_GlcNHglycan	330	334	PF01048	0.613
MOD_GlcNHglycan	336	339	PF01048	0.599
MOD_GlcNHglycan	342	345	PF01048	0.569
MOD_GlcNHglycan	447	450	PF01048	0.574
MOD_GlcNHglycan	458	461	PF01048	0.606
MOD_GlcNHglycan	51	54	PF01048	0.602
MOD_GlcNHglycan	85	88	PF01048	0.682
MOD_GlcNHglycan	92	95	PF01048	0.639
MOD_GSK3_1	1	8	PF00069	0.618
MOD_GSK3_1	141	148	PF00069	0.402
MOD_GSK3_1	150	157	PF00069	0.483
MOD_GSK3_1	251	258	PF00069	0.644
MOD_GSK3_1	321	328	PF00069	0.560
MOD_GSK3_1	329	336	PF00069	0.624
MOD_GSK3_1	339	346	PF00069	0.529
MOD_GSK3_1	369	376	PF00069	0.715
MOD_GSK3_1	441	448	PF00069	0.508
MOD_GSK3_1	52	59	PF00069	0.503
MOD_GSK3_1	63	70	PF00069	0.431
MOD_N-GLC_1	339	344	PF02516	0.503
MOD_NEK2_1	1	6	PF00069	0.652
MOD_NEK2_1	130	135	PF00069	0.558
MOD_NEK2_1	141	146	PF00069	0.316
MOD_NEK2_1	277	282	PF00069	0.762
MOD_NEK2_1	30	35	PF00069	0.581
MOD_NEK2_1	321	326	PF00069	0.728
MOD_NEK2_1	329	334	PF00069	0.611
MOD_NEK2_1	339	344	PF00069	0.471
MOD_NEK2_1	42	47	PF00069	0.446
MOD_NEK2_1	456	461	PF00069	0.645
MOD_NEK2_1	56	61	PF00069	0.376
MOD_NEK2_2	300	305	PF00069	0.650
MOD_NEK2_2	397	402	PF00069	0.644
MOD_PIKK_1	130	136	PF00454	0.668
MOD_PIKK_1	150	156	PF00454	0.464
MOD_PK_1	118	124	PF00069	0.558
MOD_PKA_2	193	199	PF00069	0.570
MOD_PKA_2	218	224	PF00069	0.703
MOD_PKA_2	248	254	PF00069	0.673
MOD_PKA_2	275	281	PF00069	0.571
MOD_PKA_2	285	291	PF00069	0.673
MOD_PKA_2	30	36	PF00069	0.549
MOD_Plk_1	103	109	PF00069	0.556
MOD_Plk_1	315	321	PF00069	0.611
MOD_Plk_1	397	403	PF00069	0.524
MOD_Plk_4	118	124	PF00069	0.558
MOD_Plk_4	142	148	PF00069	0.410
MOD_Plk_4	208	214	PF00069	0.518
MOD_Plk_4	235	241	PF00069	0.543
MOD_Plk_4	251	257	PF00069	0.689
MOD_Plk_4	288	294	PF00069	0.712
MOD_Plk_4	30	36	PF00069	0.501
MOD_Plk_4	315	321	PF00069	0.733
MOD_ProDKin_1	161	167	PF00069	0.606
MOD_ProDKin_1	344	350	PF00069	0.519
MOD_ProDKin_1	70	76	PF00069	0.578
MOD_SUMO_rev_2	423	430	PF00179	0.593
TRG_ENDOCYTIC_2	242	245	PF00928	0.691
TRG_ENDOCYTIC_2	27	30	PF00928	0.453
TRG_ER_diArg_1	10	12	PF00400	0.466
TRG_ER_diArg_1	222	224	PF00400	0.718
TRG_ER_diArg_1	401	404	PF00400	0.497
TRG_Pf-PMV_PEXEL_1	128	132	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	222	227	PF00026	0.718

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G3	Leptomonas seymouri	38%	100%
A0A3Q8ICP2	Leishmania donovani	89%	100%
A4HD34	Leishmania braziliensis	73%	100%
A4I0M1	Leishmania infantum	89%	100%
Q4QAY8	Leishmania major	89%	100%