Leucine rich repeat domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AWI1_LEIMU

TriTrypDb:

LmxM.23.1490

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0110165	cellular anatomical entity	1	8
GO:0120025	plasma membrane bounded cell projection	3	8

Expansion

Sequence features

E9AWI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWI1

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0043014	alpha-tubulin binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	145	147	PF00675	0.452
CLV_NRD_NRD_1	230	232	PF00675	0.541
CLV_NRD_NRD_1	244	246	PF00675	0.532
CLV_NRD_NRD_1	281	283	PF00675	0.533
CLV_NRD_NRD_1	286	288	PF00675	0.510
CLV_PCSK_FUR_1	143	147	PF00082	0.503
CLV_PCSK_KEX2_1	145	147	PF00082	0.452
CLV_PCSK_KEX2_1	230	232	PF00082	0.541
CLV_PCSK_KEX2_1	244	246	PF00082	0.532
CLV_PCSK_KEX2_1	294	296	PF00082	0.508
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.429
CLV_PCSK_SKI1_1	12	16	PF00082	0.488
CLV_PCSK_SKI1_1	200	204	PF00082	0.499
CLV_PCSK_SKI1_1	34	38	PF00082	0.469
CLV_PCSK_SKI1_1	43	47	PF00082	0.445
CLV_Separin_Metazoa	241	245	PF03568	0.601
DEG_APCC_DBOX_1	116	124	PF00400	0.515
DOC_CDC14_PxL_1	130	138	PF14671	0.429
DOC_CYCLIN_RxL_1	194	205	PF00134	0.489
DOC_CYCLIN_yCln2_LP_2	156	162	PF00134	0.579
DOC_CYCLIN_yCln2_LP_2	52	58	PF00134	0.500
DOC_MAPK_MEF2A_6	153	162	PF00069	0.522
DOC_PP2B_LxvP_1	156	159	PF13499	0.505
DOC_PP4_MxPP_1	132	135	PF00568	0.549
DOC_USP7_MATH_1	119	123	PF00917	0.452
DOC_USP7_MATH_1	168	172	PF00917	0.501
DOC_USP7_MATH_1	84	88	PF00917	0.586
DOC_USP7_UBL2_3	34	38	PF12436	0.526
LIG_14-3-3_CanoR_1	12	21	PF00244	0.499
LIG_14-3-3_CanoR_1	146	156	PF00244	0.507
LIG_14-3-3_CanoR_1	179	187	PF00244	0.438
LIG_14-3-3_CanoR_1	230	235	PF00244	0.522
LIG_Actin_WH2_2	29	45	PF00022	0.487
LIG_BRCT_BRCA1_1	213	217	PF00533	0.521
LIG_Clathr_ClatBox_1	69	73	PF01394	0.458
LIG_CtBP_PxDLS_1	159	163	PF00389	0.577
LIG_FHA_1	113	119	PF00498	0.560
LIG_FHA_1	13	19	PF00498	0.472
LIG_FHA_1	153	159	PF00498	0.501
LIG_FHA_1	182	188	PF00498	0.573
LIG_FHA_1	21	27	PF00498	0.483
LIG_FHA_1	210	216	PF00498	0.457
LIG_FHA_1	31	37	PF00498	0.438
LIG_FHA_1	80	86	PF00498	0.379
LIG_FHA_2	3	9	PF00498	0.659
LIG_FHA_2	92	98	PF00498	0.446
LIG_IRF3_LxIS_1	119	126	PF10401	0.486
LIG_LIR_Gen_1	269	280	PF02991	0.307
LIG_LIR_Gen_1	28	36	PF02991	0.488
LIG_LIR_Gen_1	64	74	PF02991	0.312
LIG_LIR_Nem_3	138	144	PF02991	0.280
LIG_LIR_Nem_3	193	199	PF02991	0.475
LIG_LIR_Nem_3	269	275	PF02991	0.302
LIG_LIR_Nem_3	28	32	PF02991	0.426
LIG_LIR_Nem_3	64	69	PF02991	0.431
LIG_NRBOX	198	204	PF00104	0.418
LIG_PDZ_Class_3	300	305	PF00595	0.711
LIG_SH2_CRK	272	276	PF00017	0.300
LIG_SH2_NCK_1	10	14	PF00017	0.515
LIG_SH2_STAP1	10	14	PF00017	0.606
LIG_SH2_STAP1	272	276	PF00017	0.300
LIG_SH2_STAP1	58	62	PF00017	0.494
LIG_SUMO_SIM_anti_2	171	176	PF11976	0.483
LIG_SUMO_SIM_par_1	15	23	PF11976	0.510
LIG_SUMO_SIM_par_1	43	48	PF11976	0.483
LIG_SUMO_SIM_par_1	67	73	PF11976	0.479
LIG_TRAF2_1	219	222	PF00917	0.694
LIG_UBA3_1	18	25	PF00899	0.603
LIG_WRC_WIRS_1	182	187	PF05994	0.450
MOD_CK1_1	28	34	PF00069	0.503
MOD_CK1_1	3	9	PF00069	0.377
MOD_CK1_1	64	70	PF00069	0.255
MOD_CK2_1	230	236	PF00069	0.510
MOD_CK2_1	91	97	PF00069	0.537
MOD_GlcNHglycan	125	128	PF01048	0.506
MOD_GlcNHglycan	2	5	PF01048	0.426
MOD_GlcNHglycan	39	42	PF01048	0.391
MOD_GSK3_1	119	126	PF00069	0.413
MOD_GSK3_1	13	20	PF00069	0.525
MOD_GSK3_1	147	154	PF00069	0.563
MOD_GSK3_1	28	35	PF00069	0.420
MOD_GSK3_1	61	68	PF00069	0.509
MOD_N-GLC_1	123	128	PF02516	0.422
MOD_N-GLC_1	151	156	PF02516	0.573
MOD_NEK2_1	123	128	PF00069	0.422
MOD_NEK2_1	209	214	PF00069	0.446
MOD_NEK2_1	32	37	PF00069	0.397
MOD_NEK2_1	65	70	PF00069	0.415
MOD_NEK2_1	72	77	PF00069	0.408
MOD_NEK2_1	79	84	PF00069	0.429
MOD_NEK2_1	91	96	PF00069	0.535
MOD_NMyristoyl	1	7	PF02799	0.590
MOD_PIKK_1	20	26	PF00454	0.529
MOD_PKA_1	230	236	PF00069	0.524
MOD_PKA_2	230	236	PF00069	0.524
MOD_Plk_1	151	157	PF00069	0.578
MOD_Plk_1	188	194	PF00069	0.534
MOD_Plk_4	181	187	PF00069	0.546
MOD_Plk_4	61	67	PF00069	0.496
TRG_DiLeu_BaLyEn_6	132	137	PF01217	0.443
TRG_ENDOCYTIC_2	272	275	PF00928	0.295
TRG_ER_diArg_1	100	103	PF00400	0.560
TRG_ER_diArg_1	142	145	PF00400	0.458
TRG_ER_diArg_1	229	231	PF00400	0.541
TRG_ER_diArg_1	243	245	PF00400	0.529
TRG_Pf-PMV_PEXEL_1	200	205	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL46	Leptomonas seymouri	51%	100%
A0A3Q8ICP4	Leishmania donovani	90%	100%
A0A3R7NP81	Trypanosoma rangeli	35%	100%
A4HD33	Leishmania braziliensis	74%	100%
A4I0M0	Leishmania infantum	91%	100%
Q4QAY9	Leishmania major	90%	100%