LRRcap domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWH9_LEIMU

TriTrypDb:

LmxM.23.1470

Length:

219

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AWH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWH9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.469
CLV_C14_Caspase3-7	164	168	PF00656	0.756
CLV_C14_Caspase3-7	200	204	PF00656	0.744
CLV_C14_Caspase3-7	215	219	PF00656	0.613
CLV_C14_Caspase3-7	75	79	PF00656	0.387
CLV_PCSK_KEX2_1	209	211	PF00082	0.735
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.735
DEG_Nend_UBRbox_2	1	3	PF02207	0.491
DOC_CDC14_PxL_1	29	37	PF14671	0.424
DOC_CKS1_1	129	134	PF01111	0.567
DOC_CYCLIN_yCln2_LP_2	38	44	PF00134	0.539
DOC_MAPK_gen_1	151	160	PF00069	0.545
DOC_MAPK_gen_1	54	62	PF00069	0.398
DOC_MAPK_MEF2A_6	54	62	PF00069	0.483
DOC_PP2B_LxvP_1	96	99	PF13499	0.538
DOC_USP7_MATH_1	147	151	PF00917	0.442
DOC_USP7_MATH_1	204	208	PF00917	0.573
DOC_USP7_MATH_1	89	93	PF00917	0.557
DOC_WW_Pin1_4	128	133	PF00397	0.576
DOC_WW_Pin1_4	37	42	PF00397	0.539
DOC_WW_Pin1_4	82	87	PF00397	0.579
LIG_14-3-3_CanoR_1	111	117	PF00244	0.490
LIG_BIR_III_2	203	207	PF00653	0.690
LIG_Clathr_ClatBox_1	57	61	PF01394	0.528
LIG_CSL_BTD_1	38	41	PF09270	0.534
LIG_FHA_1	154	160	PF00498	0.673
LIG_FHA_1	44	50	PF00498	0.506
LIG_FHA_2	164	170	PF00498	0.691
LIG_FHA_2	190	196	PF00498	0.741
LIG_FHA_2	209	215	PF00498	0.652
LIG_LIR_Gen_1	40	50	PF02991	0.412
LIG_LIR_Nem_3	115	119	PF02991	0.437
LIG_LIR_Nem_3	137	142	PF02991	0.414
LIG_LIR_Nem_3	37	42	PF02991	0.422
LIG_NRBOX	44	50	PF00104	0.510
LIG_NRBOX	92	98	PF00104	0.545
LIG_Pex14_2	135	139	PF04695	0.437
LIG_SH2_SRC	171	174	PF00017	0.570
LIG_SH2_STAT5	42	45	PF00017	0.506
LIG_SH3_3	126	132	PF00018	0.570
LIG_SH3_3	30	36	PF00018	0.372
LIG_SH3_3	80	86	PF00018	0.458
LIG_SUMO_SIM_anti_2	46	52	PF11976	0.383
LIG_SUMO_SIM_anti_2	59	64	PF11976	0.400
LIG_SUMO_SIM_par_1	120	126	PF11976	0.489
LIG_SUMO_SIM_par_1	56	61	PF11976	0.478
LIG_SUMO_SIM_par_1	72	78	PF11976	0.280
LIG_TRAF2_1	105	108	PF00917	0.584
LIG_TRAF2_1	175	178	PF00917	0.674
LIG_TRAF2_1	196	199	PF00917	0.675
LIG_TRAF2_1	20	23	PF00917	0.542
LIG_UBA3_1	48	56	PF00899	0.528
LIG_UBA3_1	62	67	PF00899	0.314
MOD_CK1_1	163	169	PF00069	0.650
MOD_CK1_1	188	194	PF00069	0.723
MOD_CK1_1	40	46	PF00069	0.400
MOD_CK2_1	101	107	PF00069	0.524
MOD_CK2_1	171	177	PF00069	0.654
MOD_CK2_1	189	195	PF00069	0.521
MOD_CK2_1	199	205	PF00069	0.668
MOD_CK2_1	208	214	PF00069	0.564
MOD_GlcNHglycan	188	191	PF01048	0.775
MOD_GlcNHglycan	205	209	PF01048	0.691
MOD_GlcNHglycan	29	32	PF01048	0.506
MOD_GSK3_1	149	156	PF00069	0.568
MOD_GSK3_1	172	179	PF00069	0.712
MOD_GSK3_1	185	192	PF00069	0.749
MOD_GSK3_1	193	200	PF00069	0.759
MOD_GSK3_1	204	211	PF00069	0.657
MOD_NEK2_1	112	117	PF00069	0.486
MOD_NEK2_1	27	32	PF00069	0.511
MOD_NEK2_1	4	9	PF00069	0.426
MOD_PIKK_1	22	28	PF00454	0.540
MOD_PKA_2	183	189	PF00069	0.547
MOD_PKB_1	151	159	PF00069	0.628
MOD_Plk_1	107	113	PF00069	0.533
MOD_Plk_1	22	28	PF00069	0.466
MOD_Plk_2-3	165	171	PF00069	0.647
MOD_Plk_2-3	172	178	PF00069	0.609
MOD_Plk_2-3	197	203	PF00069	0.722
MOD_Plk_4	134	140	PF00069	0.580
MOD_ProDKin_1	128	134	PF00069	0.572
MOD_ProDKin_1	37	43	PF00069	0.543
MOD_ProDKin_1	82	88	PF00069	0.578
TRG_DiLeu_BaEn_4	107	113	PF01217	0.542
TRG_DiLeu_BaEn_4	22	28	PF01217	0.579
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.505
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.549
TRG_ENDOCYTIC_2	42	45	PF00928	0.506
TRG_NLS_MonoExtC_3	208	214	PF00514	0.761
TRG_NLS_MonoExtN_4	206	213	PF00514	0.727

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7B1	Leptomonas seymouri	71%	100%
A0A0S4JGB7	Bodo saltans	32%	90%
A0A1X0NX37	Trypanosomatidae	46%	100%
A0A3S5H7C5	Leishmania donovani	93%	100%
A0A422NJD9	Trypanosoma rangeli	47%	72%
A4HD31	Leishmania braziliensis	86%	100%
A4I0L8	Leishmania infantum	92%	100%
C9ZNR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
Q4QAZ1	Leishmania major	90%	100%
V5BFS2	Trypanosoma cruzi	52%	81%