Cilia- and flagella-associated protein 53

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tumour suppressor, Mitostatin, putative

Species:

Leishmania mexicana

UniProt:

E9AWH7_LEIMU

TriTrypDb:

LmxM.23.1450

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AWH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWH7

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	12
GO:0006996	organelle organization	4	12
GO:0007017	microtubule-based process	2	12
GO:0007018	microtubule-based movement	3	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0030030	cell projection organization	4	12
GO:0030031	cell projection assembly	5	12
GO:0044782	cilium organization	5	12
GO:0060271	cilium assembly	6	12
GO:0070925	organelle assembly	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0120031	plasma membrane bounded cell projection assembly	6	12
GO:0120036	plasma membrane bounded cell projection organization	5	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.562
CLV_C14_Caspase3-7	286	290	PF00656	0.524
CLV_NRD_NRD_1	100	102	PF00675	0.484
CLV_NRD_NRD_1	105	107	PF00675	0.472
CLV_NRD_NRD_1	16	18	PF00675	0.541
CLV_NRD_NRD_1	165	167	PF00675	0.286
CLV_NRD_NRD_1	217	219	PF00675	0.211
CLV_NRD_NRD_1	227	229	PF00675	0.275
CLV_NRD_NRD_1	245	247	PF00675	0.253
CLV_NRD_NRD_1	251	253	PF00675	0.285
CLV_NRD_NRD_1	308	310	PF00675	0.315
CLV_NRD_NRD_1	345	347	PF00675	0.361
CLV_NRD_NRD_1	370	372	PF00675	0.299
CLV_NRD_NRD_1	387	389	PF00675	0.279
CLV_NRD_NRD_1	412	414	PF00675	0.309
CLV_NRD_NRD_1	47	49	PF00675	0.419
CLV_NRD_NRD_1	73	75	PF00675	0.466
CLV_PCSK_FUR_1	112	116	PF00082	0.583
CLV_PCSK_FUR_1	14	18	PF00082	0.559
CLV_PCSK_FUR_1	200	204	PF00082	0.374
CLV_PCSK_FUR_1	410	414	PF00082	0.301
CLV_PCSK_FUR_1	71	75	PF00082	0.519
CLV_PCSK_KEX2_1	100	102	PF00082	0.484
CLV_PCSK_KEX2_1	114	116	PF00082	0.468
CLV_PCSK_KEX2_1	119	121	PF00082	0.473
CLV_PCSK_KEX2_1	16	18	PF00082	0.541
CLV_PCSK_KEX2_1	164	166	PF00082	0.296
CLV_PCSK_KEX2_1	202	204	PF00082	0.366
CLV_PCSK_KEX2_1	227	229	PF00082	0.312
CLV_PCSK_KEX2_1	247	249	PF00082	0.234
CLV_PCSK_KEX2_1	251	253	PF00082	0.293
CLV_PCSK_KEX2_1	270	272	PF00082	0.274
CLV_PCSK_KEX2_1	308	310	PF00082	0.306
CLV_PCSK_KEX2_1	347	349	PF00082	0.278
CLV_PCSK_KEX2_1	358	360	PF00082	0.282
CLV_PCSK_KEX2_1	370	372	PF00082	0.270
CLV_PCSK_KEX2_1	377	379	PF00082	0.239
CLV_PCSK_KEX2_1	412	414	PF00082	0.297
CLV_PCSK_KEX2_1	442	444	PF00082	0.307
CLV_PCSK_KEX2_1	47	49	PF00082	0.537
CLV_PCSK_KEX2_1	71	73	PF00082	0.466
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.537
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.519
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.341
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.381
CLV_PCSK_PC1ET2_1	270	272	PF00082	0.362
CLV_PCSK_PC1ET2_1	347	349	PF00082	0.287
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.287
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.201
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.352
CLV_PCSK_PC7_1	115	121	PF00082	0.591
CLV_PCSK_PC7_1	43	49	PF00082	0.320
CLV_PCSK_SKI1_1	184	188	PF00082	0.362
CLV_PCSK_SKI1_1	285	289	PF00082	0.287
CLV_PCSK_SKI1_1	330	334	PF00082	0.325
CLV_PCSK_SKI1_1	364	368	PF00082	0.300
CLV_PCSK_SKI1_1	413	417	PF00082	0.340
CLV_PCSK_SKI1_1	439	443	PF00082	0.335
CLV_PCSK_SKI1_1	51	55	PF00082	0.553
DEG_APCC_DBOX_1	71	79	PF00400	0.455
DEG_APCC_KENBOX_2	222	226	PF00400	0.546
DOC_CDC14_PxL_1	475	483	PF14671	0.485
DOC_MAPK_gen_1	471	480	PF00069	0.474
DOC_PP1_RVXF_1	34	41	PF00149	0.554
DOC_USP7_UBL2_3	219	223	PF12436	0.581
DOC_USP7_UBL2_3	281	285	PF12436	0.525
DOC_USP7_UBL2_3	343	347	PF12436	0.487
LIG_Actin_WH2_2	255	272	PF00022	0.562
LIG_deltaCOP1_diTrp_1	342	352	PF00928	0.491
LIG_eIF4E_1	475	481	PF01652	0.478
LIG_FHA_1	185	191	PF00498	0.428
LIG_FHA_2	27	33	PF00498	0.609
LIG_LIR_Gen_1	152	162	PF02991	0.562
LIG_LIR_Gen_1	276	284	PF02991	0.477
LIG_LIR_Nem_3	230	236	PF02991	0.518
LIG_LIR_Nem_3	276	280	PF02991	0.477
LIG_NRBOX	74	80	PF00104	0.507
LIG_PCNA_yPIPBox_3	43	57	PF02747	0.587
LIG_Pex14_2	20	24	PF04695	0.647
LIG_RPA_C_Plants	303	314	PF08784	0.511
LIG_SH2_CRK	234	238	PF00017	0.562
LIG_SH2_STAP1	175	179	PF00017	0.581
LIG_SH2_STAP1	456	460	PF00017	0.517
LIG_SH2_STAT3	175	178	PF00017	0.562
LIG_SH2_STAT5	423	426	PF00017	0.487
LIG_SH3_1	476	482	PF00018	0.453
LIG_SH3_2	479	484	PF14604	0.503
LIG_SH3_3	476	482	PF00018	0.453
LIG_TRAF2_1	29	32	PF00917	0.549
LIG_TYR_ITIM	54	59	PF00017	0.611
LIG_UBA3_1	262	270	PF00899	0.449
LIG_UBA3_1	317	322	PF00899	0.398
LIG_UBA3_1	386	394	PF00899	0.398
MOD_CK1_1	88	94	PF00069	0.677
MOD_CK2_1	16	22	PF00069	0.656
MOD_CK2_1	26	32	PF00069	0.617
MOD_CK2_1	6	12	PF00069	0.696
MOD_CK2_1	89	95	PF00069	0.671
MOD_GSK3_1	84	91	PF00069	0.649
MOD_NEK2_1	395	400	PF00069	0.413
MOD_NEK2_1	417	422	PF00069	0.423
MOD_NEK2_1	85	90	PF00069	0.620
MOD_PIKK_1	417	423	PF00454	0.392
MOD_PKA_1	16	22	PF00069	0.656
MOD_PKA_1	227	233	PF00069	0.398
MOD_PKA_1	358	364	PF00069	0.437
MOD_PKA_2	16	22	PF00069	0.603
MOD_PKA_2	227	233	PF00069	0.475
MOD_PKA_2	358	364	PF00069	0.417
MOD_PKB_1	14	22	PF00069	0.660
MOD_Plk_1	26	32	PF00069	0.514
MOD_Plk_1	34	40	PF00069	0.431
MOD_Plk_4	16	22	PF00069	0.656
MOD_Plk_4	358	364	PF00069	0.437
MOD_Plk_4	85	91	PF00069	0.591
MOD_SUMO_for_1	113	116	PF00179	0.510
MOD_SUMO_for_1	280	283	PF00179	0.466
MOD_SUMO_rev_2	116	121	PF00179	0.595
MOD_SUMO_rev_2	267	272	PF00179	0.430
MOD_SUMO_rev_2	278	287	PF00179	0.361
MOD_SUMO_rev_2	326	332	PF00179	0.455
MOD_SUMO_rev_2	391	396	PF00179	0.472
MOD_SUMO_rev_2	46	53	PF00179	0.528
TRG_DiLeu_BaEn_1	232	237	PF01217	0.449
TRG_DiLeu_BaEn_2	390	396	PF01217	0.364
TRG_DiLeu_BaEn_4	116	122	PF01217	0.534
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.494
TRG_DiLeu_BaLyEn_6	476	481	PF01217	0.482
TRG_DiLeu_LyEn_5	232	237	PF01217	0.449
TRG_ENDOCYTIC_2	155	158	PF00928	0.475
TRG_ENDOCYTIC_2	234	237	PF00928	0.449
TRG_ENDOCYTIC_2	277	280	PF00928	0.328
TRG_ENDOCYTIC_2	475	478	PF00928	0.495
TRG_ENDOCYTIC_2	56	59	PF00928	0.585
TRG_ER_diArg_1	14	17	PF00400	0.545
TRG_ER_diArg_1	164	166	PF00400	0.367
TRG_ER_diArg_1	246	249	PF00400	0.417
TRG_ER_diArg_1	308	310	PF00400	0.434
TRG_ER_diArg_1	345	348	PF00400	0.428
TRG_ER_diArg_1	412	414	PF00400	0.363
TRG_ER_diArg_1	71	74	PF00400	0.465
TRG_NLS_MonoExtN_4	482	487	PF00514	0.633
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	256	260	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	388	392	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCD5	Leptomonas seymouri	72%	100%
A0A0S4IRE4	Bodo saltans	37%	99%
A0A1X0NWN4	Trypanosomatidae	48%	100%
A0A3Q8IMD7	Leishmania donovani	95%	100%
A0A422NJE4	Trypanosoma rangeli	49%	100%
A4HD29	Leishmania braziliensis	85%	100%
A4I0L6	Leishmania infantum	95%	100%
C9ZNQ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
Q4QAZ3	Leishmania major	94%	100%
V5D760	Trypanosoma cruzi	50%	100%