Putative Csl4p homologue

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exosome component CSL4, putative

Species:

Leishmania mexicana

UniProt:

E9AWH5_LEIMU

TriTrypDb:

LmxM.23.1770

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000178	exosome (RNase complex)	4	11
GO:0005737	cytoplasm	2	10
GO:0032991	protein-containing complex	1	11
GO:0110165	cellular anatomical entity	1	10
GO:1902494	catalytic complex	2	11
GO:1905354	exoribonuclease complex	3	11
GO:0000176	nuclear exosome (RNase complex)	3	1
GO:0000177	cytoplasmic exosome (RNase complex)	5	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9AWH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWH5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0000460	maturation of 5.8S rRNA	9	1
GO:0006364	rRNA processing	8	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.563
CLV_NRD_NRD_1	264	266	PF00675	0.463
CLV_PCSK_KEX2_1	264	266	PF00082	0.451
CLV_PCSK_SKI1_1	164	168	PF00082	0.707
CLV_PCSK_SKI1_1	181	185	PF00082	0.304
CLV_PCSK_SKI1_1	190	194	PF00082	0.452
DEG_SPOP_SBC_1	23	27	PF00917	0.577
DOC_CYCLIN_yCln2_LP_2	199	202	PF00134	0.592
DOC_MAPK_gen_1	264	270	PF00069	0.499
DOC_MAPK_MEF2A_6	132	141	PF00069	0.437
DOC_PP2B_LxvP_1	199	202	PF13499	0.486
DOC_PP4_FxxP_1	18	21	PF00568	0.538
DOC_USP7_MATH_1	113	117	PF00917	0.667
DOC_USP7_MATH_1	61	65	PF00917	0.615
DOC_USP7_MATH_1	93	97	PF00917	0.603
DOC_USP7_MATH_1	98	102	PF00917	0.662
DOC_WW_Pin1_4	120	125	PF00397	0.675
DOC_WW_Pin1_4	17	22	PF00397	0.523
LIG_14-3-3_CanoR_1	87	92	PF00244	0.429
LIG_BRCT_BRCA1_1	176	180	PF00533	0.591
LIG_BRCT_BRCA1_1	204	208	PF00533	0.501
LIG_CtBP_PxDLS_1	203	207	PF00389	0.517
LIG_EVH1_1	200	204	PF00568	0.371
LIG_FHA_1	134	140	PF00498	0.461
LIG_FHA_1	271	277	PF00498	0.523
LIG_FHA_2	229	235	PF00498	0.383
LIG_FHA_2	24	30	PF00498	0.537
LIG_FHA_2	242	248	PF00498	0.437
LIG_LIR_Apic_2	15	21	PF02991	0.528
LIG_LIR_Apic_2	53	58	PF02991	0.568
LIG_LIR_Nem_3	177	183	PF02991	0.463
LIG_PTAP_UEV_1	57	62	PF05743	0.557
LIG_SH2_PTP2	55	58	PF00017	0.578
LIG_SH2_STAT3	250	253	PF00017	0.608
LIG_SH2_STAT5	107	110	PF00017	0.443
LIG_SH2_STAT5	51	54	PF00017	0.558
LIG_SH2_STAT5	55	58	PF00017	0.602
LIG_SH3_1	279	285	PF00018	0.497
LIG_SH3_1	55	61	PF00018	0.546
LIG_SH3_2	191	196	PF14604	0.502
LIG_SH3_3	118	124	PF00018	0.638
LIG_SH3_3	125	131	PF00018	0.509
LIG_SH3_3	188	194	PF00018	0.452
LIG_SH3_3	198	204	PF00018	0.449
LIG_SH3_3	279	285	PF00018	0.497
LIG_SH3_3	55	61	PF00018	0.577
LIG_SUMO_SIM_par_1	1	7	PF11976	0.516
LIG_TRAF2_1	35	38	PF00917	0.686
LIG_WRC_WIRS_1	239	244	PF05994	0.507
MOD_CDK_SPK_2	120	125	PF00069	0.624
MOD_CK1_1	116	122	PF00069	0.662
MOD_CK1_1	159	165	PF00069	0.543
MOD_CK1_1	241	247	PF00069	0.544
MOD_CK1_1	64	70	PF00069	0.622
MOD_CK2_1	228	234	PF00069	0.379
MOD_CK2_1	241	247	PF00069	0.416
MOD_CK2_1	269	275	PF00069	0.548
MOD_Cter_Amidation	262	265	PF01082	0.486
MOD_GlcNHglycan	100	103	PF01048	0.612
MOD_GlcNHglycan	117	121	PF01048	0.648
MOD_GlcNHglycan	167	170	PF01048	0.651
MOD_GlcNHglycan	176	179	PF01048	0.493
MOD_GlcNHglycan	58	61	PF01048	0.665
MOD_GlcNHglycan	63	66	PF01048	0.642
MOD_GSK3_1	116	123	PF00069	0.750
MOD_GSK3_1	56	63	PF00069	0.592
MOD_GSK3_1	70	77	PF00069	0.478
MOD_N-GLC_1	156	161	PF02516	0.414
MOD_NEK2_1	139	144	PF00069	0.436
MOD_NEK2_1	269	274	PF00069	0.548
MOD_NEK2_2	133	138	PF00069	0.511
MOD_PIKK_1	217	223	PF00454	0.392
MOD_PK_1	87	93	PF00069	0.490
MOD_PKA_2	139	145	PF00069	0.385
MOD_PKA_2	270	276	PF00069	0.547
MOD_Plk_1	156	162	PF00069	0.495
MOD_Plk_1	70	76	PF00069	0.519
MOD_Plk_4	238	244	PF00069	0.462
MOD_Plk_4	87	93	PF00069	0.450
MOD_ProDKin_1	120	126	PF00069	0.672
MOD_ProDKin_1	17	23	PF00069	0.539
MOD_SUMO_for_1	256	259	PF00179	0.529
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.403
TRG_ER_FFAT_2	240	247	PF00635	0.292

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEJ0	Leptomonas seymouri	58%	97%
A0A0S4IM15	Bodo saltans	36%	98%
A0A3Q8IBW8	Leishmania donovani	93%	100%
A0A422NJG6	Trypanosoma rangeli	46%	100%
A4HD27	Leishmania braziliensis	81%	98%
A4I0L4	Leishmania infantum	93%	100%
C9ZNQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	92%
Q4QAZ6	Leishmania major	93%	100%
V5AR97	Trypanosoma cruzi	45%	100%