Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWH4_LEIMU

TriTrypDb:

LmxM.23.1760

Length:

849

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWH4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWH4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.732
CLV_C14_Caspase3-7	351	355	PF00656	0.656
CLV_C14_Caspase3-7	358	362	PF00656	0.522
CLV_C14_Caspase3-7	835	839	PF00656	0.635
CLV_NRD_NRD_1	171	173	PF00675	0.645
CLV_NRD_NRD_1	291	293	PF00675	0.708
CLV_NRD_NRD_1	447	449	PF00675	0.769
CLV_NRD_NRD_1	665	667	PF00675	0.507
CLV_NRD_NRD_1	97	99	PF00675	0.605
CLV_PCSK_KEX2_1	171	173	PF00082	0.647
CLV_PCSK_KEX2_1	291	293	PF00082	0.710
CLV_PCSK_KEX2_1	449	451	PF00082	0.791
CLV_PCSK_KEX2_1	665	667	PF00082	0.511
CLV_PCSK_KEX2_1	97	99	PF00082	0.605
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.791
CLV_PCSK_SKI1_1	14	18	PF00082	0.631
CLV_PCSK_SKI1_1	172	176	PF00082	0.623
CLV_PCSK_SKI1_1	183	187	PF00082	0.647
CLV_PCSK_SKI1_1	343	347	PF00082	0.553
CLV_PCSK_SKI1_1	434	438	PF00082	0.717
CLV_PCSK_SKI1_1	551	555	PF00082	0.638
CLV_PCSK_SKI1_1	601	605	PF00082	0.532
CLV_PCSK_SKI1_1	658	662	PF00082	0.442
CLV_PCSK_SKI1_1	699	703	PF00082	0.431
CLV_PCSK_SKI1_1	711	715	PF00082	0.449
CLV_PCSK_SKI1_1	809	813	PF00082	0.439
DEG_APCC_DBOX_1	260	268	PF00400	0.737
DEG_APCC_DBOX_1	342	350	PF00400	0.588
DEG_APCC_DBOX_1	710	718	PF00400	0.544
DEG_SCF_FBW7_1	139	145	PF00400	0.629
DEG_SPOP_SBC_1	266	270	PF00917	0.421
DEG_SPOP_SBC_1	461	465	PF00917	0.650
DOC_CKS1_1	139	144	PF01111	0.631
DOC_CKS1_1	209	214	PF01111	0.538
DOC_CYCLIN_yCln2_LP_2	181	187	PF00134	0.673
DOC_MAPK_MEF2A_6	18	27	PF00069	0.706
DOC_MAPK_MEF2A_6	256	264	PF00069	0.767
DOC_MAPK_MEF2A_6	315	323	PF00069	0.526
DOC_PP2B_LxvP_1	321	324	PF13499	0.469
DOC_PP4_FxxP_1	213	216	PF00568	0.762
DOC_PP4_FxxP_1	791	794	PF00568	0.455
DOC_SPAK_OSR1_1	292	296	PF12202	0.572
DOC_USP7_MATH_1	158	162	PF00917	0.639
DOC_USP7_MATH_1	187	191	PF00917	0.731
DOC_USP7_MATH_1	266	270	PF00917	0.659
DOC_USP7_MATH_1	360	364	PF00917	0.509
DOC_USP7_MATH_1	41	45	PF00917	0.669
DOC_USP7_MATH_1	476	480	PF00917	0.590
DOC_USP7_MATH_1	534	538	PF00917	0.803
DOC_USP7_MATH_1	553	557	PF00917	0.493
DOC_USP7_MATH_1	57	61	PF00917	0.601
DOC_USP7_MATH_1	584	588	PF00917	0.609
DOC_USP7_MATH_1	763	767	PF00917	0.495
DOC_WW_Pin1_4	138	143	PF00397	0.689
DOC_WW_Pin1_4	208	213	PF00397	0.745
DOC_WW_Pin1_4	236	241	PF00397	0.707
DOC_WW_Pin1_4	302	307	PF00397	0.564
DOC_WW_Pin1_4	410	415	PF00397	0.682
DOC_WW_Pin1_4	511	516	PF00397	0.482
DOC_WW_Pin1_4	526	531	PF00397	0.485
DOC_WW_Pin1_4	551	556	PF00397	0.742
DOC_WW_Pin1_4	559	564	PF00397	0.654
DOC_WW_Pin1_4	677	682	PF00397	0.508
DOC_WW_Pin1_4	76	81	PF00397	0.674
DOC_WW_Pin1_4	838	843	PF00397	0.501
LIG_14-3-3_CanoR_1	171	181	PF00244	0.646
LIG_14-3-3_CanoR_1	238	246	PF00244	0.508
LIG_14-3-3_CanoR_1	505	513	PF00244	0.564
LIG_14-3-3_CanoR_1	809	814	PF00244	0.436
LIG_Actin_WH2_2	105	122	PF00022	0.384
LIG_APCC_ABBA_1	322	327	PF00400	0.603
LIG_APCC_ABBA_1	744	749	PF00400	0.319
LIG_APCC_ABBAyCdc20_2	434	440	PF00400	0.830
LIG_APCC_ABBAyCdc20_2	743	749	PF00400	0.445
LIG_BIR_III_2	406	410	PF00653	0.492
LIG_BIR_III_4	423	427	PF00653	0.804
LIG_BIR_III_4	829	833	PF00653	0.539
LIG_BRCT_BRCA1_1	267	271	PF00533	0.594
LIG_BRCT_BRCA1_1	411	415	PF00533	0.581
LIG_BRCT_BRCA1_2	267	273	PF00533	0.622
LIG_CtBP_PxDLS_1	80	84	PF00389	0.581
LIG_deltaCOP1_diTrp_1	408	415	PF00928	0.677
LIG_eIF4E_1	602	608	PF01652	0.470
LIG_FHA_1	195	201	PF00498	0.627
LIG_FHA_1	20	26	PF00498	0.706
LIG_FHA_1	385	391	PF00498	0.618
LIG_FHA_1	483	489	PF00498	0.520
LIG_FHA_1	504	510	PF00498	0.707
LIG_FHA_1	560	566	PF00498	0.657
LIG_FHA_1	581	587	PF00498	0.450
LIG_FHA_1	724	730	PF00498	0.443
LIG_FHA_1	76	82	PF00498	0.723
LIG_FHA_1	774	780	PF00498	0.496
LIG_FHA_1	810	816	PF00498	0.435
LIG_FHA_1	91	97	PF00498	0.515
LIG_FHA_2	143	149	PF00498	0.706
LIG_FHA_2	193	199	PF00498	0.736
LIG_FHA_2	3	9	PF00498	0.693
LIG_FHA_2	403	409	PF00498	0.773
LIG_FHA_2	41	47	PF00498	0.588
LIG_FHA_2	552	558	PF00498	0.740
LIG_Integrin_RGD_1	352	354	PF01839	0.557
LIG_LIR_Apic_2	210	216	PF02991	0.826
LIG_LIR_Apic_2	408	414	PF02991	0.675
LIG_LIR_Gen_1	391	401	PF02991	0.597
LIG_LIR_LC3C_4	427	432	PF02991	0.727
LIG_LIR_Nem_3	391	397	PF02991	0.589
LIG_LIR_Nem_3	696	701	PF02991	0.474
LIG_LIR_Nem_3	814	820	PF02991	0.558
LIG_MYND_1	563	567	PF01753	0.714
LIG_NRBOX	713	719	PF00104	0.425
LIG_PCNA_yPIPBox_3	273	286	PF02747	0.609
LIG_PDZ_Class_3	844	849	PF00595	0.591
LIG_Pex14_1	411	415	PF04695	0.621
LIG_SH2_NCK_1	519	523	PF00017	0.716
LIG_SH2_PTP2	653	656	PF00017	0.442
LIG_SH2_STAP1	519	523	PF00017	0.716
LIG_SH2_STAT3	111	114	PF00017	0.574
LIG_SH2_STAT3	287	290	PF00017	0.667
LIG_SH2_STAT5	111	114	PF00017	0.574
LIG_SH2_STAT5	602	605	PF00017	0.478
LIG_SH2_STAT5	630	633	PF00017	0.465
LIG_SH2_STAT5	644	647	PF00017	0.311
LIG_SH2_STAT5	653	656	PF00017	0.442
LIG_SH2_STAT5	817	820	PF00017	0.451
LIG_SH3_3	329	335	PF00018	0.472
LIG_SH3_3	509	515	PF00018	0.687
LIG_SH3_3	561	567	PF00018	0.722
LIG_SH3_3	583	589	PF00018	0.559
LIG_SH3_3	734	740	PF00018	0.617
LIG_SH3_3	798	804	PF00018	0.504
LIG_SUMO_SIM_anti_2	373	381	PF11976	0.710
LIG_SUMO_SIM_anti_2	812	817	PF11976	0.445
LIG_SUMO_SIM_par_1	699	704	PF11976	0.429
LIG_SUMO_SIM_par_1	728	733	PF11976	0.462
LIG_SUMO_SIM_par_1	78	84	PF11976	0.584
LIG_TRAF2_1	389	392	PF00917	0.627
LIG_TYR_ITIM	815	820	PF00017	0.444
LIG_WW_3	655	659	PF00397	0.434
MOD_CDC14_SPxK_1	680	683	PF00782	0.516
MOD_CDK_SPK_2	236	241	PF00069	0.570
MOD_CDK_SPxK_1	677	683	PF00069	0.515
MOD_CDK_SPxxK_3	838	845	PF00069	0.490
MOD_CK1_1	134	140	PF00069	0.663
MOD_CK1_1	194	200	PF00069	0.739
MOD_CK1_1	223	229	PF00069	0.637
MOD_CK1_1	239	245	PF00069	0.765
MOD_CK1_1	402	408	PF00069	0.563
MOD_CK1_1	413	419	PF00069	0.710
MOD_CK1_1	453	459	PF00069	0.711
MOD_CK1_1	460	466	PF00069	0.724
MOD_CK1_1	490	496	PF00069	0.759
MOD_CK1_1	549	555	PF00069	0.726
MOD_CK1_1	622	628	PF00069	0.579
MOD_CK1_1	75	81	PF00069	0.688
MOD_CK1_1	783	789	PF00069	0.607
MOD_CK1_1	84	90	PF00069	0.672
MOD_CK2_1	402	408	PF00069	0.756
MOD_CK2_1	464	470	PF00069	0.761
MOD_CK2_1	472	478	PF00069	0.637
MOD_CK2_1	511	517	PF00069	0.731
MOD_DYRK1A_RPxSP_1	551	555	PF00069	0.735
MOD_GlcNHglycan	133	136	PF01048	0.627
MOD_GlcNHglycan	189	192	PF01048	0.728
MOD_GlcNHglycan	201	204	PF01048	0.660
MOD_GlcNHglycan	222	225	PF01048	0.736
MOD_GlcNHglycan	226	229	PF01048	0.744
MOD_GlcNHglycan	433	437	PF01048	0.831
MOD_GlcNHglycan	452	455	PF01048	0.545
MOD_GlcNHglycan	459	462	PF01048	0.693
MOD_GlcNHglycan	464	467	PF01048	0.675
MOD_GlcNHglycan	474	477	PF01048	0.711
MOD_GlcNHglycan	506	509	PF01048	0.570
MOD_GlcNHglycan	551	554	PF01048	0.700
MOD_GlcNHglycan	557	560	PF01048	0.676
MOD_GlcNHglycan	59	62	PF01048	0.637
MOD_GlcNHglycan	621	624	PF01048	0.579
MOD_GlcNHglycan	66	69	PF01048	0.639
MOD_GlcNHglycan	74	77	PF01048	0.580
MOD_GlcNHglycan	773	776	PF01048	0.481
MOD_GSK3_1	131	138	PF00069	0.669
MOD_GSK3_1	187	194	PF00069	0.743
MOD_GSK3_1	19	26	PF00069	0.707
MOD_GSK3_1	207	214	PF00069	0.819
MOD_GSK3_1	220	227	PF00069	0.532
MOD_GSK3_1	356	363	PF00069	0.727
MOD_GSK3_1	409	416	PF00069	0.782
MOD_GSK3_1	453	460	PF00069	0.728
MOD_GSK3_1	472	479	PF00069	0.805
MOD_GSK3_1	48	55	PF00069	0.572
MOD_GSK3_1	487	494	PF00069	0.622
MOD_GSK3_1	540	547	PF00069	0.812
MOD_GSK3_1	549	556	PF00069	0.669
MOD_GSK3_1	580	587	PF00069	0.481
MOD_GSK3_1	618	625	PF00069	0.577
MOD_GSK3_1	71	78	PF00069	0.630
MOD_GSK3_1	81	88	PF00069	0.603
MOD_N-GLC_1	131	136	PF02516	0.487
MOD_N-GLC_1	457	462	PF02516	0.529
MOD_N-GLC_1	544	549	PF02516	0.821
MOD_NEK2_1	1	6	PF00069	0.505
MOD_NEK2_1	23	28	PF00069	0.635
MOD_NEK2_1	265	270	PF00069	0.671
MOD_NEK2_1	300	305	PF00069	0.478
MOD_NEK2_1	462	467	PF00069	0.524
MOD_NEK2_1	482	487	PF00069	0.759
MOD_NEK2_1	504	509	PF00069	0.573
MOD_NEK2_1	52	57	PF00069	0.514
MOD_NEK2_1	546	551	PF00069	0.751
MOD_NEK2_1	594	599	PF00069	0.451
MOD_OFUCOSY	745	751	PF10250	0.531
MOD_PIKK_1	172	178	PF00454	0.641
MOD_PIKK_1	205	211	PF00454	0.626
MOD_PIKK_1	239	245	PF00454	0.576
MOD_PIKK_1	424	430	PF00454	0.813
MOD_PIKK_1	443	449	PF00454	0.531
MOD_PIKK_1	488	494	PF00454	0.506
MOD_PIKK_1	528	534	PF00454	0.730
MOD_PIKK_1	540	546	PF00454	0.662
MOD_PIKK_1	660	666	PF00454	0.447
MOD_PIKK_1	720	726	PF00454	0.452
MOD_PIKK_1	90	96	PF00454	0.708
MOD_PKA_2	114	120	PF00069	0.676
MOD_PKA_2	441	447	PF00069	0.845
MOD_PKA_2	496	502	PF00069	0.713
MOD_PKA_2	504	510	PF00069	0.653
MOD_PKB_1	448	456	PF00069	0.721
MOD_Plk_1	158	164	PF00069	0.538
MOD_Plk_1	360	366	PF00069	0.675
MOD_Plk_1	399	405	PF00069	0.448
MOD_Plk_1	432	438	PF00069	0.830
MOD_Plk_1	457	463	PF00069	0.527
MOD_Plk_1	584	590	PF00069	0.496
MOD_Plk_1	780	786	PF00069	0.447
MOD_Plk_4	114	120	PF00069	0.676
MOD_Plk_4	142	148	PF00069	0.510
MOD_Plk_4	19	25	PF00069	0.711
MOD_ProDKin_1	138	144	PF00069	0.692
MOD_ProDKin_1	208	214	PF00069	0.747
MOD_ProDKin_1	236	242	PF00069	0.707
MOD_ProDKin_1	302	308	PF00069	0.560
MOD_ProDKin_1	410	416	PF00069	0.685
MOD_ProDKin_1	511	517	PF00069	0.484
MOD_ProDKin_1	526	532	PF00069	0.487
MOD_ProDKin_1	551	557	PF00069	0.743
MOD_ProDKin_1	559	565	PF00069	0.653
MOD_ProDKin_1	677	683	PF00069	0.515
MOD_ProDKin_1	76	82	PF00069	0.675
MOD_ProDKin_1	838	844	PF00069	0.492
TRG_DiLeu_BaEn_1	124	129	PF01217	0.407
TRG_DiLeu_BaEn_1	374	379	PF01217	0.712
TRG_DiLeu_BaEn_4	165	171	PF01217	0.648
TRG_ENDOCYTIC_2	630	633	PF00928	0.541
TRG_ENDOCYTIC_2	817	820	PF00928	0.451
TRG_ER_diArg_1	170	172	PF00400	0.638
TRG_ER_diArg_1	260	263	PF00400	0.759
TRG_ER_diArg_1	291	293	PF00400	0.710
TRG_ER_diArg_1	495	498	PF00400	0.713
TRG_ER_diArg_1	96	98	PF00400	0.608
TRG_NES_CRM1_1	100	116	PF08389	0.574
TRG_NES_CRM1_1	391	406	PF08389	0.427
TRG_NLS_MonoExtC_3	447	452	PF00514	0.671
TRG_NLS_MonoExtN_4	448	453	PF00514	0.713
TRG_Pf-PMV_PEXEL_1	168	173	PF00026	0.637

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P625	Leptomonas seymouri	45%	98%
A0A3S7WXX2	Leishmania donovani	87%	100%
A4HD26	Leishmania braziliensis	72%	98%
A4I0L3	Leishmania infantum	87%	100%
Q4QAZ7	Leishmania major	87%	100%