V-SNARE domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWH3_LEIMU

TriTrypDb:

LmxM.23.1750

Length:

282

Annotations

LeishMANIAdb annotations

Similar to other Eukaryotic vesicle-associated V-SNARE proteins, especially VTI1.. Localization: Vesicular (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 19
NetGPI	no	yes: 0, no: 20

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	16
GO:0005789	endoplasmic reticulum membrane	4	2
GO:0005794	Golgi apparatus	5	5
GO:0010008	endosome membrane	5	2
GO:0012506	vesicle membrane	4	2
GO:0012507	ER to Golgi transport vesicle membrane	6	2
GO:0016020	membrane	2	21
GO:0030658	transport vesicle membrane	5	2
GO:0030659	cytoplasmic vesicle membrane	5	2
GO:0030662	coated vesicle membrane	5	2

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Expansion

Sequence features

E9AWH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWH3

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	20
GO:0006886	intracellular protein transport	4	15
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	2
GO:0006906	vesicle fusion	6	2
GO:0006996	organelle organization	4	2
GO:0008104	protein localization	4	20
GO:0009987	cellular process	1	20
GO:0015031	protein transport	4	20
GO:0016043	cellular component organization	3	2
GO:0016050	vesicle organization	5	2

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Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	2
GO:0005484	SNAP receptor activity	3	7
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030674	protein-macromolecule adaptor activity	2	7
GO:0060090	molecular adaptor activity	1	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.642
CLV_C14_Caspase3-7	206	210	PF00656	0.522
CLV_NRD_NRD_1	123	125	PF00675	0.493
CLV_NRD_NRD_1	210	212	PF00675	0.213
CLV_NRD_NRD_1	31	33	PF00675	0.314
CLV_PCSK_KEX2_1	123	125	PF00082	0.461
CLV_PCSK_SKI1_1	225	229	PF00082	0.332
CLV_PCSK_SKI1_1	32	36	PF00082	0.152
DEG_APCC_DBOX_1	91	99	PF00400	0.487
DOC_MAPK_gen_1	223	231	PF00069	0.404

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G6	Leptomonas seymouri	74%	100%
A0A0N1HXG1	Leptomonas seymouri	32%	100%
A0A0S4IRD2	Bodo saltans	35%	97%
A0A1X0NWY4	Trypanosomatidae	31%	91%
A0A1X0NY79	Trypanosomatidae	49%	97%
A0A3Q8IEP1	Leishmania donovani	35%	100%
A0A3S5IRB0	Trypanosoma rangeli	49%	100%
A0A3S7WY13	Leishmania donovani	91%	81%
A0A422NJV1	Trypanosoma rangeli	34%	100%
A4HD24	Leishmania braziliensis	35%	100%

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