LeishMANIAdb
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V-SNARE domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
V-SNARE domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AWH3_LEIMU
TriTrypDb:
LmxM.23.1750
Length:
282

Annotations

LeishMANIAdb annotations

Similar to other Eukaryotic vesicle-associated V-SNARE proteins, especially VTI1.. Localization: Vesicular (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 19
NetGPI no yes: 0, no: 20
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 16
GO:0016020 membrane 2 21
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043231 intracellular membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 21
GO:0005794 Golgi apparatus 5 5
GO:0005789 endoplasmic reticulum membrane 4 2
GO:0010008 endosome membrane 5 2
GO:0012506 vesicle membrane 4 2
GO:0012507 ER to Golgi transport vesicle membrane 6 2
GO:0030658 transport vesicle membrane 5 2
GO:0030659 cytoplasmic vesicle membrane 5 2
GO:0030662 coated vesicle membrane 5 2
GO:0031090 organelle membrane 3 2
GO:0031201 SNARE complex 3 2
GO:0031902 late endosome membrane 6 2
GO:0032991 protein-containing complex 1 2
GO:0098588 bounding membrane of organelle 4 2
GO:0098796 membrane protein complex 2 2

Expansion

Sequence features

E9AWH3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWH3

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 20
GO:0006886 intracellular protein transport 4 15
GO:0008104 protein localization 4 20
GO:0009987 cellular process 1 20
GO:0015031 protein transport 4 20
GO:0016192 vesicle-mediated transport 4 12
GO:0033036 macromolecule localization 2 20
GO:0045184 establishment of protein localization 3 20
GO:0046907 intracellular transport 3 15
GO:0051179 localization 1 20
GO:0051234 establishment of localization 2 20
GO:0051641 cellular localization 2 20
GO:0051649 establishment of localization in cell 3 15
GO:0070727 cellular macromolecule localization 3 20
GO:0071702 organic substance transport 4 20
GO:0071705 nitrogen compound transport 4 20
GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum 6 2
GO:0048193 Golgi vesicle transport 5 2
GO:0006906 vesicle fusion 6 2
GO:0006996 organelle organization 4 2
GO:0016043 cellular component organization 3 2
GO:0016050 vesicle organization 5 2
GO:0048284 organelle fusion 5 2
GO:0061024 membrane organization 4 2
GO:0061025 membrane fusion 5 2
GO:0071840 cellular component organization or biogenesis 2 2
GO:0090174 organelle membrane fusion 6 2
Molecular functions
Term Name Level Count
GO:0005484 SNAP receptor activity 3 7
GO:0030674 protein-macromolecule adaptor activity 2 7
GO:0060090 molecular adaptor activity 1 7
GO:0000149 SNARE binding 3 2
GO:0005488 binding 1 2
GO:0005515 protein binding 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 11 15 PF00656 0.642
CLV_C14_Caspase3-7 206 210 PF00656 0.522
CLV_NRD_NRD_1 123 125 PF00675 0.493
CLV_NRD_NRD_1 210 212 PF00675 0.213
CLV_NRD_NRD_1 31 33 PF00675 0.314
CLV_PCSK_KEX2_1 123 125 PF00082 0.461
CLV_PCSK_SKI1_1 225 229 PF00082 0.332
CLV_PCSK_SKI1_1 32 36 PF00082 0.152
DEG_APCC_DBOX_1 91 99 PF00400 0.487
DOC_MAPK_gen_1 223 231 PF00069 0.404
DOC_MAPK_MEF2A_6 223 231 PF00069 0.407
DOC_USP7_MATH_1 107 111 PF00917 0.609
DOC_USP7_MATH_1 126 130 PF00917 0.529
DOC_USP7_MATH_1 134 138 PF00917 0.648
DOC_USP7_MATH_1 182 186 PF00917 0.425
DOC_USP7_MATH_1 265 269 PF00917 0.516
DOC_USP7_UBL2_3 219 223 PF12436 0.582
LIG_14-3-3_CanoR_1 187 196 PF00244 0.449
LIG_14-3-3_CanoR_1 252 261 PF00244 0.319
LIG_14-3-3_CanoR_1 81 88 PF00244 0.518
LIG_Actin_WH2_2 12 29 PF00022 0.534
LIG_BIR_III_4 160 164 PF00653 0.396
LIG_FHA_1 173 179 PF00498 0.465
LIG_FHA_1 198 204 PF00498 0.474
LIG_FHA_1 54 60 PF00498 0.481
LIG_FHA_2 16 22 PF00498 0.618
LIG_FHA_2 255 261 PF00498 0.444
LIG_FHA_2 5 11 PF00498 0.495
LIG_FHA_2 81 87 PF00498 0.488
LIG_LIR_Apic_2 35 40 PF02991 0.347
LIG_LIR_Nem_3 2 8 PF02991 0.536
LIG_Pex14_2 236 240 PF04695 0.420
LIG_SH2_CRK 37 41 PF00017 0.457
LIG_SH2_PTP2 244 247 PF00017 0.426
LIG_SH2_STAP1 8 12 PF00017 0.519
LIG_SH2_STAT5 244 247 PF00017 0.398
LIG_SUMO_SIM_anti_2 113 120 PF11976 0.559
LIG_SUMO_SIM_anti_2 230 236 PF11976 0.434
LIG_SUMO_SIM_par_1 148 153 PF11976 0.645
LIG_SUMO_SIM_par_1 198 204 PF11976 0.465
LIG_SUMO_SIM_par_1 225 230 PF11976 0.325
LIG_TRAF2_1 7 10 PF00917 0.544
LIG_TRAF2_1 97 100 PF00917 0.522
LIG_UBA3_1 117 125 PF00899 0.677
LIG_UBA3_1 213 219 PF00899 0.522
MOD_CK1_1 254 260 PF00069 0.525
MOD_CK2_1 254 260 PF00069 0.519
MOD_CK2_1 4 10 PF00069 0.508
MOD_CK2_1 80 86 PF00069 0.454
MOD_GlcNHglycan 108 112 PF01048 0.381
MOD_GlcNHglycan 128 131 PF01048 0.377
MOD_GlcNHglycan 136 139 PF01048 0.410
MOD_GlcNHglycan 160 164 PF01048 0.301
MOD_GlcNHglycan 214 217 PF01048 0.217
MOD_GSK3_1 251 258 PF00069 0.464
MOD_GSK3_1 265 272 PF00069 0.338
MOD_GSK3_1 40 47 PF00069 0.458
MOD_N-GLC_1 172 177 PF02516 0.237
MOD_N-GLC_1 252 257 PF02516 0.720
MOD_NEK2_1 152 157 PF00069 0.545
MOD_NEK2_1 98 103 PF00069 0.533
MOD_NEK2_2 15 20 PF00069 0.469
MOD_NEK2_2 182 187 PF00069 0.562
MOD_PKA_1 32 38 PF00069 0.337
MOD_PKA_2 251 257 PF00069 0.361
MOD_PKA_2 26 32 PF00069 0.424
MOD_PKA_2 80 86 PF00069 0.491
MOD_Plk_1 197 203 PF00069 0.489
MOD_Plk_1 98 104 PF00069 0.392
MOD_Plk_4 271 277 PF00069 0.483
MOD_Plk_4 54 60 PF00069 0.516
MOD_SUMO_rev_2 129 137 PF00179 0.695
MOD_SUMO_rev_2 139 146 PF00179 0.480
MOD_SUMO_rev_2 29 35 PF00179 0.396
TRG_DiLeu_BaLyEn_6 167 172 PF01217 0.463
TRG_ENDOCYTIC_2 244 247 PF00928 0.380
TRG_Pf-PMV_PEXEL_1 17 21 PF00026 0.438
TRG_Pf-PMV_PEXEL_1 170 174 PF00026 0.228
TRG_Pf-PMV_PEXEL_1 96 100 PF00026 0.245

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6G6 Leptomonas seymouri 74% 100%
A0A0N1HXG1 Leptomonas seymouri 32% 100%
A0A0S4IRD2 Bodo saltans 35% 97%
A0A1X0NWY4 Trypanosomatidae 31% 91%
A0A1X0NY79 Trypanosomatidae 49% 97%
A0A3Q8IEP1 Leishmania donovani 35% 100%
A0A3S5IRB0 Trypanosoma rangeli 49% 100%
A0A3S7WY13 Leishmania donovani 91% 81%
A0A422NJV1 Trypanosoma rangeli 34% 100%
A4HD24 Leishmania braziliensis 35% 100%
A4HD25 Leishmania braziliensis 82% 100%
A4I0L1 Leishmania infantum 35% 100%
A4I0L2 Leishmania infantum 91% 100%
C9ZVI1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
E9AWH2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
O89116 Mus musculus 26% 100%
P58200 Rattus norvegicus 23% 100%
P78768 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 27% 100%
Q04338 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 100%
Q4QAZ8 Leishmania major 89% 100%
Q4QAZ9 Leishmania major 38% 99%
Q96AJ9 Homo sapiens 25% 100%
Q9JI51 Rattus norvegicus 27% 100%
Q9LVP9 Arabidopsis thaliana 24% 100%
Q9SEL5 Arabidopsis thaliana 23% 100%
V5ARB2 Trypanosoma cruzi 49% 100%
V5BFR7 Trypanosoma cruzi 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS