RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RING-H2 zinc finger, putative

Species:

Leishmania mexicana

UniProt:

E9AWH1_LEIMU

TriTrypDb:

LmxM.23.1730

Length:

401

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AWH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWH1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004842	ubiquitin-protein transferase activity	4	8
GO:0005488	binding	1	8
GO:0008270	zinc ion binding	6	7
GO:0016740	transferase activity	2	8
GO:0019787	ubiquitin-like protein transferase activity	3	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0046914	transition metal ion binding	5	7
GO:0061630	ubiquitin protein ligase activity	5	8
GO:0061659	ubiquitin-like protein ligase activity	4	8
GO:0140096	catalytic activity, acting on a protein	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	22	26	PF00656	0.648
CLV_C14_Caspase3-7	315	319	PF00656	0.616
CLV_C14_Caspase3-7	8	12	PF00656	0.500
CLV_NRD_NRD_1	73	75	PF00675	0.598
CLV_PCSK_KEX2_1	3	5	PF00082	0.613
CLV_PCSK_KEX2_1	73	75	PF00082	0.598
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.610
CLV_PCSK_SKI1_1	246	250	PF00082	0.604
CLV_PCSK_SKI1_1	66	70	PF00082	0.554
CLV_PCSK_SKI1_1	74	78	PF00082	0.579
DEG_APCC_DBOX_1	73	81	PF00400	0.490
DEG_SPOP_SBC_1	393	397	PF00917	0.615
DOC_CYCLIN_yClb5_NLxxxL_5	254	263	PF00134	0.516
DOC_PP4_FxxP_1	366	369	PF00568	0.472
DOC_USP7_MATH_1	184	188	PF00917	0.600
DOC_USP7_MATH_1	221	225	PF00917	0.739
DOC_USP7_MATH_1	311	315	PF00917	0.478
DOC_USP7_MATH_1	338	342	PF00917	0.471
DOC_USP7_MATH_1	392	396	PF00917	0.609
DOC_USP7_UBL2_3	354	358	PF12436	0.566
DOC_WW_Pin1_4	200	205	PF00397	0.746
DOC_WW_Pin1_4	222	227	PF00397	0.623
DOC_WW_Pin1_4	25	30	PF00397	0.633
DOC_WW_Pin1_4	345	350	PF00397	0.504
DOC_WW_Pin1_4	66	71	PF00397	0.465
LIG_14-3-3_CanoR_1	4	14	PF00244	0.663
LIG_Clathr_ClatBox_1	286	290	PF01394	0.438
LIG_FHA_1	29	35	PF00498	0.611
LIG_FHA_1	319	325	PF00498	0.351
LIG_FHA_1	378	384	PF00498	0.465
LIG_FHA_2	130	136	PF00498	0.616
LIG_FHA_2	245	251	PF00498	0.612
LIG_FHA_2	280	286	PF00498	0.506
LIG_FHA_2	313	319	PF00498	0.476
LIG_FHA_2	6	12	PF00498	0.504
LIG_FHA_2	70	76	PF00498	0.460
LIG_FHA_2	85	91	PF00498	0.503
LIG_LIR_Gen_1	135	144	PF02991	0.666
LIG_LIR_Gen_1	280	289	PF02991	0.443
LIG_LIR_Nem_3	280	286	PF02991	0.445
LIG_SH2_STAP1	137	141	PF00017	0.621
LIG_SH2_STAP1	283	287	PF00017	0.440
LIG_SH3_3	170	176	PF00018	0.666
LIG_SUMO_SIM_anti_2	212	218	PF11976	0.574
LIG_SUMO_SIM_par_1	19	25	PF11976	0.604
LIG_SUMO_SIM_par_1	284	291	PF11976	0.441
LIG_SUMO_SIM_par_1	30	38	PF11976	0.715
LIG_TRAF2_1	160	163	PF00917	0.812
LIG_TRAF2_1	248	251	PF00917	0.597
LIG_TRAF2_1	282	285	PF00917	0.441
LIG_TRAF2_1	35	38	PF00917	0.561
LIG_WRC_WIRS_1	108	113	PF05994	0.745
MOD_CDK_SPxxK_3	222	229	PF00069	0.635
MOD_CDK_SPxxK_3	66	73	PF00069	0.457
MOD_CK1_1	28	34	PF00069	0.652
MOD_CK1_1	330	336	PF00069	0.462
MOD_CK1_1	395	401	PF00069	0.571
MOD_CK2_1	244	250	PF00069	0.616
MOD_CK2_1	279	285	PF00069	0.450
MOD_CK2_1	32	38	PF00069	0.621
MOD_CK2_1	84	90	PF00069	0.659
MOD_DYRK1A_RPxSP_1	66	70	PF00069	0.520
MOD_GlcNHglycan	103	106	PF01048	0.649
MOD_GlcNHglycan	242	245	PF01048	0.610
MOD_GlcNHglycan	315	318	PF01048	0.562
MOD_GlcNHglycan	327	332	PF01048	0.335
MOD_GlcNHglycan	340	343	PF01048	0.257
MOD_GlcNHglycan	349	352	PF01048	0.244
MOD_GlcNHglycan	397	400	PF01048	0.572
MOD_GSK3_1	125	132	PF00069	0.648
MOD_GSK3_1	21	28	PF00069	0.703
MOD_GSK3_1	240	247	PF00069	0.637
MOD_GSK3_1	338	345	PF00069	0.518
MOD_GSK3_1	373	380	PF00069	0.504
MOD_GSK3_1	394	401	PF00069	0.562
MOD_GSK3_1	6	13	PF00069	0.655
MOD_N-GLC_1	294	299	PF02516	0.512
MOD_N-GLC_1	377	382	PF02516	0.286
MOD_NEK2_1	125	130	PF00069	0.609
MOD_NEK2_1	304	309	PF00069	0.471
MOD_NEK2_1	312	317	PF00069	0.465
MOD_NEK2_1	329	334	PF00069	0.397
MOD_NEK2_1	39	44	PF00069	0.620
MOD_NEK2_1	61	66	PF00069	0.440
MOD_PIKK_1	125	131	PF00454	0.650
MOD_PIKK_1	28	34	PF00454	0.649
MOD_PIKK_1	373	379	PF00454	0.535
MOD_PIKK_1	39	45	PF00454	0.568
MOD_PKA_2	240	246	PF00069	0.661
MOD_PKA_2	312	318	PF00069	0.532
MOD_PKA_2	5	11	PF00069	0.487
MOD_PKA_2	61	67	PF00069	0.507
MOD_PKB_1	4	12	PF00069	0.647
MOD_Plk_1	10	16	PF00069	0.654
MOD_Plk_1	279	285	PF00069	0.450
MOD_Plk_2-3	279	285	PF00069	0.450
MOD_Plk_4	209	215	PF00069	0.594
MOD_ProDKin_1	200	206	PF00069	0.744
MOD_ProDKin_1	222	228	PF00069	0.629
MOD_ProDKin_1	25	31	PF00069	0.632
MOD_ProDKin_1	345	351	PF00069	0.504
MOD_ProDKin_1	66	72	PF00069	0.463
TRG_DiLeu_BaEn_2	173	179	PF01217	0.632
TRG_DiLeu_BaEn_4	147	153	PF01217	0.627
TRG_DiLeu_BaEn_4	284	290	PF01217	0.437
TRG_DiLeu_BaLyEn_6	215	220	PF01217	0.571
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.538
TRG_ENDOCYTIC_2	137	140	PF00928	0.669
TRG_ENDOCYTIC_2	283	286	PF00928	0.441
TRG_NES_CRM1_1	88	101	PF08389	0.542
TRG_NLS_MonoExtN_4	2	7	PF00514	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKS7	Leptomonas seymouri	46%	100%
A0A3Q8IBP7	Leishmania donovani	93%	100%
A4HD23	Leishmania braziliensis	78%	100%
A4I0L0	Leishmania infantum	94%	100%
C9ZVI2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
Q4QB00	Leishmania major	91%	100%