Myotubularin phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Meckel syndrome type 1 protein, putative

Species:

Leishmania mexicana

UniProt:

E9AWG8_LEIMU

TriTrypDb:

LmxM.23.1710

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	6
GO:0032991	protein-containing complex	1	1
GO:0036038	MKS complex	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AWG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWG8

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0030030	cell projection organization	4	7
GO:0071840	cellular component organization or biogenesis	2	7
GO:0006996	organelle organization	4	1
GO:0022607	cellular component assembly	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	175	177	PF00675	0.631
CLV_NRD_NRD_1	323	325	PF00675	0.507
CLV_NRD_NRD_1	370	372	PF00675	0.571
CLV_NRD_NRD_1	410	412	PF00675	0.653
CLV_NRD_NRD_1	70	72	PF00675	0.700
CLV_PCSK_FUR_1	408	412	PF00082	0.655
CLV_PCSK_KEX2_1	175	177	PF00082	0.631
CLV_PCSK_KEX2_1	323	325	PF00082	0.507
CLV_PCSK_KEX2_1	370	372	PF00082	0.571
CLV_PCSK_KEX2_1	408	410	PF00082	0.665
CLV_PCSK_KEX2_1	461	463	PF00082	0.740
CLV_PCSK_KEX2_1	70	72	PF00082	0.700
CLV_PCSK_PC1ET2_1	461	463	PF00082	0.740
CLV_PCSK_SKI1_1	182	186	PF00082	0.573
CLV_PCSK_SKI1_1	19	23	PF00082	0.580
CLV_PCSK_SKI1_1	370	374	PF00082	0.576
CLV_PCSK_SKI1_1	63	67	PF00082	0.604
DEG_APCC_DBOX_1	14	22	PF00400	0.507
DEG_APCC_DBOX_1	369	377	PF00400	0.637
DEG_Nend_UBRbox_3	1	3	PF02207	0.649
DEG_SPOP_SBC_1	400	404	PF00917	0.774
DEG_SPOP_SBC_1	512	516	PF00917	0.598
DOC_CDC14_PxL_1	115	123	PF14671	0.692
DOC_CYCLIN_RxL_1	13	24	PF00134	0.450
DOC_CYCLIN_yCln2_LP_2	165	171	PF00134	0.656
DOC_CYCLIN_yCln2_LP_2	418	424	PF00134	0.486
DOC_CYCLIN_yCln2_LP_2	581	587	PF00134	0.598
DOC_MAPK_gen_1	11	18	PF00069	0.532
DOC_MAPK_gen_1	408	418	PF00069	0.495
DOC_MAPK_MEF2A_6	411	420	PF00069	0.492
DOC_PP1_RVXF_1	131	137	PF00149	0.421
DOC_PP1_RVXF_1	17	24	PF00149	0.434
DOC_PP2B_LxvP_1	165	168	PF13499	0.656
DOC_PP2B_LxvP_1	418	421	PF13499	0.478
DOC_PP2B_LxvP_1	581	584	PF13499	0.598
DOC_PP4_FxxP_1	139	142	PF00568	0.426
DOC_PP4_FxxP_1	547	550	PF00568	0.512
DOC_USP7_MATH_1	161	165	PF00917	0.745
DOC_USP7_MATH_1	226	230	PF00917	0.791
DOC_USP7_MATH_1	280	284	PF00917	0.565
DOC_USP7_MATH_1	307	311	PF00917	0.519
DOC_USP7_MATH_1	396	400	PF00917	0.710
DOC_USP7_MATH_1	468	472	PF00917	0.627
DOC_USP7_MATH_1	512	516	PF00917	0.560
DOC_USP7_MATH_1	529	533	PF00917	0.486
DOC_USP7_MATH_1	559	563	PF00917	0.598
DOC_USP7_MATH_1	588	592	PF00917	0.598
DOC_USP7_MATH_2	55	61	PF00917	0.569
DOC_WW_Pin1_4	157	162	PF00397	0.665
DOC_WW_Pin1_4	201	206	PF00397	0.749
DOC_WW_Pin1_4	501	506	PF00397	0.545
DOC_WW_Pin1_4	51	56	PF00397	0.402
DOC_WW_Pin1_4	560	565	PF00397	0.550
DOC_WW_Pin1_4	593	598	PF00397	0.550
DOC_WW_Pin1_4	99	104	PF00397	0.655
LIG_14-3-3_CanoR_1	19	24	PF00244	0.556
LIG_14-3-3_CanoR_1	264	270	PF00244	0.477
LIG_14-3-3_CanoR_1	301	305	PF00244	0.496
LIG_14-3-3_CanoR_1	306	312	PF00244	0.619
LIG_14-3-3_CanoR_1	446	451	PF00244	0.763
LIG_14-3-3_CanoR_1	462	468	PF00244	0.458
LIG_14-3-3_CanoR_1	618	622	PF00244	0.598
LIG_14-3-3_CanoR_1	659	663	PF00244	0.441
LIG_Actin_WH2_2	359	376	PF00022	0.660
LIG_Actin_WH2_2	553	568	PF00022	0.441
LIG_Actin_WH2_2	643	661	PF00022	0.402
LIG_APCC_ABBA_1	59	64	PF00400	0.510
LIG_APCC_ABBAyCdc20_2	647	653	PF00400	0.550
LIG_BRCT_BRCA1_1	418	422	PF00533	0.566
LIG_Clathr_ClatBox_1	540	544	PF01394	0.598
LIG_deltaCOP1_diTrp_1	488	492	PF00928	0.598
LIG_DLG_GKlike_1	446	454	PF00625	0.763
LIG_FHA_1	20	26	PF00498	0.479
LIG_FHA_1	260	266	PF00498	0.590
LIG_FHA_1	287	293	PF00498	0.555
LIG_FHA_1	297	303	PF00498	0.440
LIG_FHA_1	413	419	PF00498	0.489
LIG_FHA_1	488	494	PF00498	0.523
LIG_FHA_1	56	62	PF00498	0.574
LIG_FHA_1	650	656	PF00498	0.566
LIG_FHA_1	659	665	PF00498	0.515
LIG_FHA_2	531	537	PF00498	0.531
LIG_FHA_2	610	616	PF00498	0.512
LIG_LIR_Apic_2	544	550	PF02991	0.515
LIG_LIR_Gen_1	356	366	PF02991	0.690
LIG_LIR_Gen_1	471	480	PF02991	0.491
LIG_LIR_Gen_1	488	497	PF02991	0.401
LIG_LIR_Gen_1	552	561	PF02991	0.441
LIG_LIR_Nem_3	356	361	PF02991	0.701
LIG_LIR_Nem_3	471	477	PF02991	0.491
LIG_LIR_Nem_3	488	492	PF02991	0.401
LIG_LIR_Nem_3	552	556	PF02991	0.441
LIG_LIR_Nem_3	60	65	PF02991	0.514
LIG_NBox_RRM_1	23	33	PF00076	0.568
LIG_NRBOX	286	292	PF00104	0.382
LIG_PCNA_TLS_4	141	148	PF02747	0.562
LIG_Pex14_2	547	551	PF04695	0.512
LIG_PTB_Apo_2	545	552	PF02174	0.532
LIG_REV1ctd_RIR_1	135	141	PF16727	0.447
LIG_REV1ctd_RIR_1	275	281	PF16727	0.583
LIG_SH2_CRK	28	32	PF00017	0.516
LIG_SH2_CRK	553	557	PF00017	0.441
LIG_SH2_CRK	587	591	PF00017	0.550
LIG_SH2_NCK_1	587	591	PF00017	0.521
LIG_SH2_SRC	508	511	PF00017	0.402
LIG_SH2_STAP1	298	302	PF00017	0.438
LIG_SH2_STAP1	651	655	PF00017	0.550
LIG_SH2_STAT5	276	279	PF00017	0.576
LIG_SH2_STAT5	296	299	PF00017	0.245
LIG_SH2_STAT5	651	654	PF00017	0.402
LIG_SH3_2	561	566	PF14604	0.550
LIG_SH3_3	110	116	PF00018	0.588
LIG_SH3_3	153	159	PF00018	0.648
LIG_SH3_3	237	243	PF00018	0.492
LIG_SH3_3	49	55	PF00018	0.488
LIG_SH3_3	558	564	PF00018	0.513
LIG_SH3_3	587	593	PF00018	0.550
LIG_SH3_3	599	605	PF00018	0.550
LIG_SH3_3	97	103	PF00018	0.587
LIG_SUMO_SIM_par_1	288	293	PF11976	0.420
LIG_SUMO_SIM_par_1	538	544	PF11976	0.550
LIG_TYR_ITIM	585	590	PF00017	0.550
LIG_ULM_U2AF65_1	408	413	PF00076	0.499
LIG_WRC_WIRS_1	297	302	PF05994	0.438
MOD_CDC14_SPxK_1	563	566	PF00782	0.550
MOD_CDK_SPxK_1	560	566	PF00069	0.550
MOD_CK1_1	399	405	PF00069	0.773
MOD_CK1_1	441	447	PF00069	0.774
MOD_CK1_1	463	469	PF00069	0.588
MOD_CK1_1	514	520	PF00069	0.525
MOD_CK1_1	654	660	PF00069	0.539
MOD_CK2_1	350	356	PF00069	0.663
MOD_CK2_1	399	405	PF00069	0.716
MOD_CK2_1	51	57	PF00069	0.412
MOD_CK2_1	530	536	PF00069	0.531
MOD_CK2_1	609	615	PF00069	0.512
MOD_CK2_1	66	72	PF00069	0.651
MOD_GlcNHglycan	218	221	PF01048	0.686
MOD_GlcNHglycan	243	246	PF01048	0.692
MOD_GlcNHglycan	422	425	PF01048	0.708
MOD_GlcNHglycan	462	465	PF01048	0.662
MOD_GlcNHglycan	518	521	PF01048	0.316
MOD_GlcNHglycan	81	85	PF01048	0.760
MOD_GlcNHglycan	89	92	PF01048	0.748
MOD_GSK3_1	157	164	PF00069	0.738
MOD_GSK3_1	228	235	PF00069	0.752
MOD_GSK3_1	255	262	PF00069	0.471
MOD_GSK3_1	276	283	PF00069	0.490
MOD_GSK3_1	296	303	PF00069	0.240
MOD_GSK3_1	396	403	PF00069	0.718
MOD_GSK3_1	412	419	PF00069	0.491
MOD_GSK3_1	434	441	PF00069	0.798
MOD_GSK3_1	499	506	PF00069	0.505
MOD_GSK3_1	51	58	PF00069	0.560
MOD_GSK3_1	510	517	PF00069	0.515
MOD_GSK3_1	654	661	PF00069	0.539
MOD_N-GLC_2	181	183	PF02516	0.622
MOD_NEK2_1	137	142	PF00069	0.420
MOD_NEK2_1	21	26	PF00069	0.332
MOD_NEK2_1	300	305	PF00069	0.463
MOD_NEK2_1	350	355	PF00069	0.657
MOD_NEK2_1	416	421	PF00069	0.755
MOD_NEK2_1	438	443	PF00069	0.678
MOD_NEK2_1	454	459	PF00069	0.490
MOD_NEK2_1	551	556	PF00069	0.530
MOD_NEK2_1	567	572	PF00069	0.512
MOD_NEK2_1	6	11	PF00069	0.545
MOD_NEK2_1	616	621	PF00069	0.541
MOD_NEK2_1	658	663	PF00069	0.555
MOD_NEK2_2	228	233	PF00069	0.621
MOD_NEK2_2	296	301	PF00069	0.569
MOD_NEK2_2	487	492	PF00069	0.524
MOD_PIKK_1	441	447	PF00454	0.774
MOD_PIKK_1	523	529	PF00454	0.512
MOD_PIKK_1	6	12	PF00454	0.535
MOD_PKA_2	140	146	PF00069	0.478
MOD_PKA_2	300	306	PF00069	0.569
MOD_PKA_2	431	437	PF00069	0.767
MOD_PKA_2	445	451	PF00069	0.558
MOD_PKA_2	617	623	PF00069	0.572
MOD_PKA_2	658	664	PF00069	0.441
MOD_Plk_1	255	261	PF00069	0.598
MOD_Plk_1	42	48	PF00069	0.509
MOD_Plk_1	487	493	PF00069	0.523
MOD_Plk_1	499	505	PF00069	0.544
MOD_Plk_1	551	557	PF00069	0.512
MOD_Plk_1	63	69	PF00069	0.546
MOD_Plk_4	161	167	PF00069	0.654
MOD_Plk_4	286	292	PF00069	0.612
MOD_Plk_4	503	509	PF00069	0.563
MOD_Plk_4	530	536	PF00069	0.549
MOD_Plk_4	551	557	PF00069	0.473
MOD_Plk_4	57	63	PF00069	0.573
MOD_Plk_4	617	623	PF00069	0.539
MOD_ProDKin_1	157	163	PF00069	0.666
MOD_ProDKin_1	201	207	PF00069	0.754
MOD_ProDKin_1	501	507	PF00069	0.545
MOD_ProDKin_1	51	57	PF00069	0.404
MOD_ProDKin_1	560	566	PF00069	0.550
MOD_ProDKin_1	593	599	PF00069	0.550
MOD_ProDKin_1	99	105	PF00069	0.658
MOD_SUMO_rev_2	34	38	PF00179	0.546
MOD_SUMO_rev_2	43	53	PF00179	0.405
TRG_DiLeu_BaEn_1	536	541	PF01217	0.598
TRG_DiLeu_BaEn_2	487	493	PF01217	0.550
TRG_DiLeu_BaLyEn_6	110	115	PF01217	0.608
TRG_DiLeu_BaLyEn_6	237	242	PF01217	0.492
TRG_DiLeu_BaLyEn_6	368	373	PF01217	0.517
TRG_DiLeu_BaLyEn_6	563	568	PF01217	0.598
TRG_ENDOCYTIC_2	28	31	PF00928	0.505
TRG_ENDOCYTIC_2	358	361	PF00928	0.704
TRG_ENDOCYTIC_2	474	477	PF00928	0.550
TRG_ENDOCYTIC_2	553	556	PF00928	0.441
TRG_ENDOCYTIC_2	587	590	PF00928	0.512
TRG_ENDOCYTIC_2	62	65	PF00928	0.519
TRG_ER_diArg_1	12	15	PF00400	0.537
TRG_ER_diArg_1	370	372	PF00400	0.571
TRG_ER_diArg_1	408	411	PF00400	0.653
TRG_ER_diArg_1	493	496	PF00400	0.402
TRG_NES_CRM1_1	538	552	PF08389	0.598
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	370	375	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7B5	Leptomonas seymouri	55%	100%
A0A0S4IRB4	Bodo saltans	28%	84%
A0A3Q8IB52	Leishmania donovani	85%	100%
A4I0K7	Leishmania infantum	86%	100%
Q4QB03	Leishmania major	89%	100%