Adenylate kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Adenylate kinase

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AWG6_LEIMU

TriTrypDb:

LmxM.23.1690

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWG6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	1
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	1
GO:0005524	ATP binding	5	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0017076	purine nucleotide binding	4	1
GO:0019205	nucleobase-containing compound kinase activity	5	1
GO:0030554	adenyl nucleotide binding	5	1
GO:0032553	ribonucleotide binding	3	1
GO:0032555	purine ribonucleotide binding	4	1
GO:0032559	adenyl ribonucleotide binding	5	1
GO:0035639	purine ribonucleoside triphosphate binding	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	140	142	PF00675	0.359
CLV_NRD_NRD_1	236	238	PF00675	0.551
CLV_PCSK_KEX2_1	236	238	PF00082	0.569
CLV_PCSK_SKI1_1	108	112	PF00082	0.433
CLV_PCSK_SKI1_1	133	137	PF00082	0.490
CLV_PCSK_SKI1_1	276	280	PF00082	0.466
CLV_PCSK_SKI1_1	42	46	PF00082	0.583
DEG_APCC_DBOX_1	275	283	PF00400	0.467
DEG_APCC_DBOX_1	37	45	PF00400	0.584
DEG_ODPH_VHL_1	65	77	PF01847	0.450
DOC_CKS1_1	69	74	PF01111	0.481
DOC_CYCLIN_RxL_1	36	49	PF00134	0.454
DOC_MAPK_gen_1	8	16	PF00069	0.490
DOC_MAPK_RevD_3	222	237	PF00069	0.472
DOC_USP7_MATH_1	102	106	PF00917	0.428
DOC_WW_Pin1_4	140	145	PF00397	0.362
DOC_WW_Pin1_4	36	41	PF00397	0.617
DOC_WW_Pin1_4	68	73	PF00397	0.546
LIG_14-3-3_CanoR_1	227	233	PF00244	0.404
LIG_14-3-3_CanoR_1	245	250	PF00244	0.494
LIG_BIR_II_1	1	5	PF00653	0.505
LIG_BIR_III_3	1	5	PF00653	0.543
LIG_BRCT_BRCA1_1	192	196	PF00533	0.520
LIG_CtBP_PxDLS_1	157	161	PF00389	0.439
LIG_FHA_1	148	154	PF00498	0.347
LIG_FHA_1	190	196	PF00498	0.432
LIG_FHA_1	273	279	PF00498	0.443
LIG_FHA_1	69	75	PF00498	0.436
LIG_FHA_2	203	209	PF00498	0.437
LIG_FHA_2	214	220	PF00498	0.415
LIG_GBD_Chelix_1	165	173	PF00786	0.299
LIG_LIR_Nem_3	193	199	PF02991	0.441
LIG_LIR_Nem_3	250	255	PF02991	0.451
LIG_LYPXL_SIV_4	254	262	PF13949	0.406
LIG_PCNA_yPIPBox_3	18	29	PF02747	0.485
LIG_Pex14_2	252	256	PF04695	0.449
LIG_SH2_STAT3	7	10	PF00017	0.541
LIG_SH2_STAT5	123	126	PF00017	0.486
LIG_SH3_2	37	42	PF14604	0.592
LIG_SH3_3	119	125	PF00018	0.515
LIG_SH3_3	180	186	PF00018	0.601
LIG_SH3_3	34	40	PF00018	0.508
LIG_SUMO_SIM_par_1	73	78	PF11976	0.385
LIG_TRAF2_1	216	219	PF00917	0.472
LIG_TRAF2_1	281	284	PF00917	0.401
LIG_WRC_WIRS_1	249	254	PF05994	0.423
MOD_CDC14_SPxK_1	39	42	PF00782	0.578
MOD_CDK_SPK_2	68	73	PF00069	0.449
MOD_CDK_SPxK_1	36	42	PF00069	0.580
MOD_CK1_1	151	157	PF00069	0.437
MOD_CK1_1	248	254	PF00069	0.528
MOD_CK2_1	202	208	PF00069	0.435
MOD_CK2_1	213	219	PF00069	0.364
MOD_DYRK1A_RPxSP_1	36	40	PF00069	0.579
MOD_GlcNHglycan	2	5	PF01048	0.548
MOD_GlcNHglycan	228	231	PF01048	0.341
MOD_GlcNHglycan	256	259	PF01048	0.500
MOD_GlcNHglycan	57	60	PF01048	0.702
MOD_GSK3_1	147	154	PF00069	0.461
MOD_GSK3_1	218	225	PF00069	0.454
MOD_GSK3_1	32	39	PF00069	0.587
MOD_GSK3_1	83	90	PF00069	0.514
MOD_NEK2_1	152	157	PF00069	0.378
MOD_NEK2_2	191	196	PF00069	0.458
MOD_PKA_1	236	242	PF00069	0.401
MOD_PKA_2	226	232	PF00069	0.413
MOD_PKA_2	236	242	PF00069	0.512
MOD_Plk_1	218	224	PF00069	0.368
MOD_Plk_4	102	108	PF00069	0.409
MOD_Plk_4	148	154	PF00069	0.460
MOD_Plk_4	191	197	PF00069	0.443
MOD_ProDKin_1	140	146	PF00069	0.366
MOD_ProDKin_1	36	42	PF00069	0.617
MOD_ProDKin_1	68	74	PF00069	0.536
MOD_SUMO_for_1	17	20	PF00179	0.500
TRG_DiLeu_BaLyEn_6	160	165	PF01217	0.293
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.354
TRG_ER_diArg_1	173	176	PF00400	0.433
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4ILX8	Bodo saltans	26%	100%
A0A3Q8ICN4	Leishmania donovani	87%	100%
A4HD19	Leishmania braziliensis	74%	96%
A4I0K5	Leishmania infantum	87%	100%
Q4QB05	Leishmania major	89%	100%