Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DHHC palmitoyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9AWG4_LEIMU

TriTrypDb:

LmxM.23.1670

Length:

637

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AWG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWG4

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016409	palmitoyltransferase activity	5	7
GO:0016417	S-acyltransferase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	7
GO:0019707	protein-cysteine S-acyltransferase activity	3	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.675
CLV_NRD_NRD_1	130	132	PF00675	0.404
CLV_NRD_NRD_1	363	365	PF00675	0.483
CLV_NRD_NRD_1	565	567	PF00675	0.441
CLV_NRD_NRD_1	597	599	PF00675	0.440
CLV_PCSK_KEX2_1	130	132	PF00082	0.401
CLV_PCSK_KEX2_1	363	365	PF00082	0.483
CLV_PCSK_KEX2_1	565	567	PF00082	0.441
CLV_PCSK_KEX2_1	597	599	PF00082	0.433
CLV_PCSK_SKI1_1	106	110	PF00082	0.317
CLV_PCSK_SKI1_1	412	416	PF00082	0.255
CLV_PCSK_SKI1_1	434	438	PF00082	0.276
CLV_PCSK_SKI1_1	74	78	PF00082	0.536
DEG_APCC_DBOX_1	609	617	PF00400	0.708
DEG_SCF_FBW7_1	242	249	PF00400	0.608
DEG_SPOP_SBC_1	306	310	PF00917	0.638
DOC_CKS1_1	121	126	PF01111	0.561
DOC_MAPK_gen_1	130	136	PF00069	0.640
DOC_MAPK_gen_1	363	371	PF00069	0.577
DOC_MAPK_gen_1	597	606	PF00069	0.602
DOC_MAPK_MEF2A_6	26	33	PF00069	0.390
DOC_MAPK_MEF2A_6	373	382	PF00069	0.628
DOC_PP1_RVXF_1	104	110	PF00149	0.570
DOC_PP1_RVXF_1	133	139	PF00149	0.640
DOC_PP2B_LxvP_1	619	622	PF13499	0.666
DOC_PP4_FxxP_1	109	112	PF00568	0.634
DOC_PP4_FxxP_1	206	209	PF00568	0.711
DOC_PP4_FxxP_1	606	609	PF00568	0.617
DOC_SPAK_OSR1_1	601	605	PF12202	0.508
DOC_USP7_MATH_1	196	200	PF00917	0.723
DOC_USP7_MATH_1	212	216	PF00917	0.670
DOC_USP7_MATH_1	236	240	PF00917	0.774
DOC_USP7_MATH_1	289	293	PF00917	0.645
DOC_USP7_MATH_1	313	317	PF00917	0.701
DOC_USP7_MATH_1	324	328	PF00917	0.679
DOC_USP7_MATH_1	330	334	PF00917	0.628
DOC_USP7_MATH_1	386	390	PF00917	0.569
DOC_USP7_MATH_1	401	405	PF00917	0.476
DOC_USP7_MATH_1	448	452	PF00917	0.351
DOC_USP7_MATH_1	622	626	PF00917	0.721
DOC_USP7_MATH_2	63	69	PF00917	0.425
DOC_WW_Pin1_4	120	125	PF00397	0.660
DOC_WW_Pin1_4	192	197	PF00397	0.779
DOC_WW_Pin1_4	199	204	PF00397	0.710
DOC_WW_Pin1_4	221	226	PF00397	0.759
DOC_WW_Pin1_4	227	232	PF00397	0.741
DOC_WW_Pin1_4	242	247	PF00397	0.692
DOC_WW_Pin1_4	292	297	PF00397	0.780
DOC_WW_Pin1_4	326	331	PF00397	0.832
DOC_WW_Pin1_4	617	622	PF00397	0.721
LIG_14-3-3_CanoR_1	106	112	PF00244	0.516
LIG_14-3-3_CanoR_1	11	16	PF00244	0.646
LIG_14-3-3_CanoR_1	363	372	PF00244	0.622
LIG_14-3-3_CanoR_1	498	504	PF00244	0.491
LIG_14-3-3_CanoR_1	566	575	PF00244	0.652
LIG_14-3-3_CanoR_1	629	637	PF00244	0.639
LIG_BIR_III_2	353	357	PF00653	0.714
LIG_BRCT_BRCA1_1	388	392	PF00533	0.476
LIG_BRCT_BRCA1_1	450	454	PF00533	0.297
LIG_BRCT_BRCA1_1	510	514	PF00533	0.575
LIG_Clathr_ClatBox_1	254	258	PF01394	0.603
LIG_CSL_BTD_1	472	475	PF09270	0.276
LIG_deltaCOP1_diTrp_1	118	126	PF00928	0.606
LIG_deltaCOP1_diTrp_1	466	473	PF00928	0.276
LIG_eIF4E_1	25	31	PF01652	0.237
LIG_FHA_1	243	249	PF00498	0.681
LIG_FHA_1	326	332	PF00498	0.671
LIG_FHA_1	338	344	PF00498	0.628
LIG_FHA_1	34	40	PF00498	0.426
LIG_FHA_1	450	456	PF00498	0.341
LIG_FHA_1	56	62	PF00498	0.423
LIG_FHA_1	85	91	PF00498	0.378
LIG_FHA_2	348	354	PF00498	0.808
LIG_Integrin_RGD_1	580	582	PF01839	0.531
LIG_LIR_Apic_2	5	10	PF02991	0.557
LIG_LIR_Gen_1	103	112	PF02991	0.563
LIG_LIR_Gen_1	451	462	PF02991	0.351
LIG_LIR_Nem_3	103	107	PF02991	0.556
LIG_LIR_Nem_3	14	18	PF02991	0.628
LIG_LIR_Nem_3	389	395	PF02991	0.476
LIG_LIR_Nem_3	451	457	PF02991	0.351
LIG_NRBOX	553	559	PF00104	0.539
LIG_Pex14_2	437	441	PF04695	0.313
LIG_Pex14_2	602	606	PF04695	0.617
LIG_PTAP_UEV_1	587	592	PF05743	0.725
LIG_REV1ctd_RIR_1	43	52	PF16727	0.318
LIG_SH2_CRK	180	184	PF00017	0.596
LIG_SH2_CRK	25	29	PF00017	0.417
LIG_SH2_CRK	442	446	PF00017	0.340
LIG_SH2_CRK	614	618	PF00017	0.792
LIG_SH2_CRK	7	11	PF00017	0.555
LIG_SH2_SRC	114	117	PF00017	0.543
LIG_SH2_SRC	180	183	PF00017	0.596
LIG_SH2_SRC	479	482	PF00017	0.209
LIG_SH2_STAT5	101	104	PF00017	0.372
LIG_SH2_STAT5	114	117	PF00017	0.539
LIG_SH2_STAT5	122	125	PF00017	0.638
LIG_SH2_STAT5	435	438	PF00017	0.390
LIG_SH2_STAT5	487	490	PF00017	0.351
LIG_SH2_STAT5	75	78	PF00017	0.415
LIG_SH2_STAT5	79	82	PF00017	0.373
LIG_SH3_3	113	119	PF00018	0.687
LIG_SH3_3	222	228	PF00018	0.712
LIG_SH3_3	523	529	PF00018	0.663
LIG_SH3_3	585	591	PF00018	0.756
LIG_SH3_3	615	621	PF00018	0.667
LIG_SUMO_SIM_anti_2	367	375	PF11976	0.568
LIG_TRAF2_1	159	162	PF00917	0.609
LIG_TRFH_1	614	618	PF08558	0.717
LIG_TYR_ITIM	440	445	PF00017	0.340
LIG_TYR_ITIM	485	490	PF00017	0.351
LIG_WRC_WIRS_1	101	106	PF05994	0.335
LIG_WW_1	177	180	PF00397	0.561
MOD_CDK_SPK_2	120	125	PF00069	0.659
MOD_CDK_SPxK_1	331	337	PF00069	0.741
MOD_CK1_1	199	205	PF00069	0.710
MOD_CK1_1	253	259	PF00069	0.603
MOD_CK1_1	292	298	PF00069	0.712
MOD_CK1_1	315	321	PF00069	0.698
MOD_CK1_1	325	331	PF00069	0.674
MOD_CK1_1	521	527	PF00069	0.671
MOD_CK1_1	531	537	PF00069	0.665
MOD_CK1_1	573	579	PF00069	0.738
MOD_CK1_1	589	595	PF00069	0.752
MOD_CK2_1	498	504	PF00069	0.495
MOD_CK2_1	514	520	PF00069	0.631
MOD_GlcNHglycan	138	141	PF01048	0.442
MOD_GlcNHglycan	186	189	PF01048	0.481
MOD_GlcNHglycan	198	201	PF01048	0.462
MOD_GlcNHglycan	242	245	PF01048	0.414
MOD_GlcNHglycan	273	276	PF01048	0.561
MOD_GlcNHglycan	285	288	PF01048	0.456
MOD_GlcNHglycan	291	294	PF01048	0.416
MOD_GlcNHglycan	322	325	PF01048	0.528
MOD_GlcNHglycan	33	36	PF01048	0.313
MOD_GlcNHglycan	481	484	PF01048	0.286
MOD_GlcNHglycan	520	523	PF01048	0.458
MOD_GlcNHglycan	577	580	PF01048	0.500
MOD_GlcNHglycan	588	591	PF01048	0.481
MOD_GlcNHglycan	7	10	PF01048	0.348
MOD_GSK3_1	184	191	PF00069	0.725
MOD_GSK3_1	192	199	PF00069	0.690
MOD_GSK3_1	210	217	PF00069	0.688
MOD_GSK3_1	236	243	PF00069	0.778
MOD_GSK3_1	246	253	PF00069	0.647
MOD_GSK3_1	279	286	PF00069	0.688
MOD_GSK3_1	288	295	PF00069	0.690
MOD_GSK3_1	301	308	PF00069	0.791
MOD_GSK3_1	309	316	PF00069	0.802
MOD_GSK3_1	318	325	PF00069	0.636
MOD_GSK3_1	326	333	PF00069	0.659
MOD_GSK3_1	449	456	PF00069	0.395
MOD_GSK3_1	504	511	PF00069	0.639
MOD_GSK3_1	514	521	PF00069	0.641
MOD_GSK3_1	567	574	PF00069	0.706
MOD_GSK3_1	77	84	PF00069	0.317
MOD_LATS_1	362	368	PF00433	0.682
MOD_N-GLC_1	449	454	PF02516	0.325
MOD_NEK2_1	100	105	PF00069	0.380
MOD_NEK2_1	134	139	PF00069	0.667
MOD_NEK2_1	322	327	PF00069	0.640
MOD_NEK2_1	441	446	PF00069	0.350
MOD_NEK2_1	453	458	PF00069	0.349
MOD_NEK2_1	514	519	PF00069	0.604
MOD_NEK2_1	567	572	PF00069	0.655
MOD_NEK2_1	575	580	PF00069	0.806
MOD_NEK2_1	77	82	PF00069	0.342
MOD_NEK2_2	357	362	PF00069	0.632
MOD_NEK2_2	386	391	PF00069	0.568
MOD_PIKK_1	521	527	PF00454	0.671
MOD_PKA_2	336	342	PF00069	0.723
MOD_PKA_2	504	510	PF00069	0.579
MOD_PKB_1	627	635	PF00069	0.639
MOD_Plk_1	449	455	PF00069	0.325
MOD_Plk_4	2	8	PF00069	0.568
MOD_Plk_4	214	220	PF00069	0.806
MOD_Plk_4	250	256	PF00069	0.608
MOD_Plk_4	449	455	PF00069	0.474
MOD_ProDKin_1	120	126	PF00069	0.658
MOD_ProDKin_1	192	198	PF00069	0.775
MOD_ProDKin_1	199	205	PF00069	0.712
MOD_ProDKin_1	221	227	PF00069	0.759
MOD_ProDKin_1	242	248	PF00069	0.727
MOD_ProDKin_1	292	298	PF00069	0.781
MOD_ProDKin_1	326	332	PF00069	0.831
MOD_ProDKin_1	617	623	PF00069	0.724
TRG_DiLeu_BaLyEn_6	25	30	PF01217	0.390
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.295
TRG_ENDOCYTIC_2	101	104	PF00928	0.530
TRG_ENDOCYTIC_2	42	45	PF00928	0.273
TRG_ENDOCYTIC_2	433	436	PF00928	0.503
TRG_ENDOCYTIC_2	442	445	PF00928	0.351
TRG_ENDOCYTIC_2	487	490	PF00928	0.351
TRG_ENDOCYTIC_2	614	617	PF00928	0.793
TRG_ER_diArg_1	10	13	PF00400	0.604
TRG_ER_diArg_1	363	365	PF00400	0.683
TRG_ER_diArg_1	564	566	PF00400	0.688
TRG_ER_diArg_1	608	611	PF00400	0.650
TRG_ER_diArg_1	628	631	PF00400	0.702

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P628	Leptomonas seymouri	36%	98%
A0A3S7WXW1	Leishmania donovani	84%	100%
A4HD17	Leishmania braziliensis	60%	100%
A4I0K3	Leishmania infantum	84%	100%
Q4QB07	Leishmania major	82%	100%