Palmitoyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DHHC zinc finger domain-like protein

Species:

Leishmania mexicana

UniProt:

E9AWG3_LEIMU

TriTrypDb:

LmxM.23.1430

Length:

452

Annotations

LeishMANIAdb annotations

Related to other eukaryotic ZDHHC palmitoyltransferases, especially animal ZDHHC2.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	14
GO:0005783	endoplasmic reticulum	5	2
GO:0005794	Golgi apparatus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

E9AWG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWG3

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	2
GO:0006605	protein targeting	5	2
GO:0006612	protein targeting to membrane	5	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018198	peptidyl-cysteine modification	6	2
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	2
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	2
GO:0018345	protein palmitoylation	6	2
GO:0019538	protein metabolic process	3	2
GO:0033036	macromolecule localization	2	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	2
GO:0044238	primary metabolic process	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0071705	nitrogen compound transport	4	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:0006897	endocytosis	5	1
GO:0016192	vesicle-mediated transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0016409	palmitoyltransferase activity	5	14
GO:0016417	S-acyltransferase activity	5	14
GO:0016740	transferase activity	2	14
GO:0016746	acyltransferase activity	3	14
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	14
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	14
GO:0019707	protein-cysteine S-acyltransferase activity	3	14
GO:0140096	catalytic activity, acting on a protein	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.691
CLV_NRD_NRD_1	127	129	PF00675	0.455
CLV_NRD_NRD_1	35	37	PF00675	0.511
CLV_NRD_NRD_1	410	412	PF00675	0.487
CLV_NRD_NRD_1	431	433	PF00675	0.375
CLV_PCSK_KEX2_1	35	37	PF00082	0.511
CLV_PCSK_KEX2_1	410	412	PF00082	0.448
CLV_PCSK_KEX2_1	431	433	PF00082	0.375
CLV_PCSK_SKI1_1	366	370	PF00082	0.269
CLV_PCSK_SKI1_1	420	424	PF00082	0.352
DOC_CKS1_1	6	11	PF01111	0.302
DOC_CYCLIN_RxL_1	414	427	PF00134	0.523
DOC_MAPK_gen_1	35	43	PF00069	0.202
DOC_MAPK_gen_1	431	438	PF00069	0.590
DOC_MAPK_HePTP_8	33	45	PF00069	0.202
DOC_MAPK_MEF2A_6	302	311	PF00069	0.475
DOC_MAPK_MEF2A_6	36	45	PF00069	0.298
DOC_PP1_RVXF_1	259	265	PF00149	0.459
DOC_PP1_RVXF_1	339	345	PF00149	0.295
DOC_PP2B_LxvP_1	148	151	PF13499	0.631
DOC_PP4_FxxP_1	67	70	PF00568	0.598
DOC_USP7_MATH_1	20	24	PF00917	0.316
DOC_USP7_MATH_1	85	89	PF00917	0.598
DOC_WW_Pin1_4	121	126	PF00397	0.768
DOC_WW_Pin1_4	157	162	PF00397	0.687
DOC_WW_Pin1_4	166	171	PF00397	0.705
DOC_WW_Pin1_4	210	215	PF00397	0.717
DOC_WW_Pin1_4	230	235	PF00397	0.702
DOC_WW_Pin1_4	397	402	PF00397	0.610
DOC_WW_Pin1_4	424	429	PF00397	0.586
DOC_WW_Pin1_4	5	10	PF00397	0.302
DOC_WW_Pin1_4	66	71	PF00397	0.504
LIG_14-3-3_CanoR_1	128	138	PF00244	0.663
LIG_14-3-3_CanoR_1	140	148	PF00244	0.671
LIG_14-3-3_CanoR_1	417	423	PF00244	0.551
LIG_AP2alpha_2	76	78	PF02296	0.547
LIG_APCC_ABBA_1	150	155	PF00400	0.627
LIG_BRCT_BRCA1_1	68	72	PF00533	0.537
LIG_CtBP_PxDLS_1	86	92	PF00389	0.553
LIG_EVH1_1	241	245	PF00568	0.613
LIG_FHA_1	191	197	PF00498	0.658
LIG_FHA_1	6	12	PF00498	0.432
LIG_FHA_2	252	258	PF00498	0.530
LIG_GBD_Chelix_1	11	19	PF00786	0.206
LIG_GBD_Chelix_1	46	54	PF00786	0.379
LIG_IBAR_NPY_1	249	251	PF08397	0.669
LIG_Integrin_isoDGR_2	259	261	PF01839	0.202
LIG_IRF3_LxIS_1	350	357	PF10401	0.206
LIG_LIR_Apic_2	76	81	PF02991	0.569
LIG_LIR_Gen_1	61	70	PF02991	0.554
LIG_LIR_Nem_3	23	29	PF02991	0.302
LIG_LIR_Nem_3	37	42	PF02991	0.309
LIG_LIR_Nem_3	427	433	PF02991	0.571
LIG_LIR_Nem_3	61	66	PF02991	0.544
LIG_MYND_1	87	91	PF01753	0.610
LIG_SH2_CRK	314	318	PF00017	0.380
LIG_SH2_CRK	433	437	PF00017	0.664
LIG_SH2_CRK	6	10	PF00017	0.362
LIG_SH2_CRK	63	67	PF00017	0.529
LIG_SH2_CRK	84	88	PF00017	0.609
LIG_SH2_NCK_1	314	318	PF00017	0.376
LIG_SH2_NCK_1	63	67	PF00017	0.514
LIG_SH2_STAP1	26	30	PF00017	0.301
LIG_SH2_STAP1	266	270	PF00017	0.402
LIG_SH2_STAP1	63	67	PF00017	0.531
LIG_SH2_STAT3	266	269	PF00017	0.449
LIG_SH2_STAT3	406	409	PF00017	0.515
LIG_SH2_STAT5	225	228	PF00017	0.687
LIG_SH2_STAT5	251	254	PF00017	0.597
LIG_SH2_STAT5	29	32	PF00017	0.274
LIG_SH2_STAT5	362	365	PF00017	0.331
LIG_SH2_STAT5	6	9	PF00017	0.373
LIG_SH3_3	135	141	PF00018	0.855
LIG_SH3_3	155	161	PF00018	0.661
LIG_SH3_3	239	245	PF00018	0.647
LIG_SH3_3	342	348	PF00018	0.243
LIG_SH3_3	71	77	PF00018	0.615
LIG_SUMO_SIM_par_1	17	24	PF11976	0.206
LIG_SUMO_SIM_par_1	55	61	PF11976	0.339
LIG_TYR_ITIM	312	317	PF00017	0.361
LIG_WW_1	81	84	PF00397	0.575
LIG_WW_3	160	164	PF00397	0.632
MOD_CDC14_SPxK_1	160	163	PF00782	0.628
MOD_CDK_SPxK_1	157	163	PF00069	0.635
MOD_CDK_SPxxK_3	121	128	PF00069	0.644
MOD_CDK_SPxxK_3	397	404	PF00069	0.565
MOD_CDK_SPxxK_3	424	431	PF00069	0.549
MOD_CK1_1	124	130	PF00069	0.713
MOD_CK2_1	226	232	PF00069	0.609
MOD_CK2_1	251	257	PF00069	0.510
MOD_CK2_1	371	377	PF00069	0.558
MOD_GlcNHglycan	172	175	PF01048	0.498
MOD_GlcNHglycan	387	390	PF01048	0.433
MOD_GlcNHglycan	448	451	PF01048	0.421
MOD_GSK3_1	123	130	PF00069	0.703
MOD_GSK3_1	153	160	PF00069	0.715
MOD_GSK3_1	166	173	PF00069	0.719
MOD_GSK3_1	181	188	PF00069	0.802
MOD_GSK3_1	20	27	PF00069	0.344
MOD_GSK3_1	226	233	PF00069	0.621
MOD_GSK3_1	313	320	PF00069	0.340
MOD_GSK3_1	371	378	PF00069	0.557
MOD_N-GLC_1	180	185	PF02516	0.436
MOD_N-GLC_2	297	299	PF02516	0.311
MOD_NEK2_1	153	158	PF00069	0.642
MOD_NEK2_1	312	317	PF00069	0.378
MOD_NEK2_1	326	331	PF00069	0.406
MOD_NEK2_1	354	359	PF00069	0.320
MOD_NEK2_1	360	365	PF00069	0.328
MOD_NEK2_1	48	53	PF00069	0.347
MOD_NEK2_2	29	34	PF00069	0.255
MOD_PIKK_1	114	120	PF00454	0.658
MOD_PIKK_1	360	366	PF00454	0.286
MOD_PKA_2	127	133	PF00069	0.694
MOD_Plk_1	444	450	PF00069	0.648
MOD_Plk_4	24	30	PF00069	0.308
MOD_Plk_4	326	332	PF00069	0.450
MOD_Plk_4	375	381	PF00069	0.517
MOD_Plk_4	49	55	PF00069	0.304
MOD_ProDKin_1	121	127	PF00069	0.766
MOD_ProDKin_1	157	163	PF00069	0.689
MOD_ProDKin_1	166	172	PF00069	0.707
MOD_ProDKin_1	210	216	PF00069	0.717
MOD_ProDKin_1	230	236	PF00069	0.703
MOD_ProDKin_1	397	403	PF00069	0.610
MOD_ProDKin_1	424	430	PF00069	0.585
MOD_ProDKin_1	5	11	PF00069	0.302
MOD_ProDKin_1	66	72	PF00069	0.506
TRG_ENDOCYTIC_2	305	308	PF00928	0.538
TRG_ENDOCYTIC_2	314	317	PF00928	0.333
TRG_ENDOCYTIC_2	433	436	PF00928	0.663
TRG_ENDOCYTIC_2	62	65	PF00928	0.541
TRG_ER_diArg_1	261	264	PF00400	0.527
TRG_ER_diArg_1	430	432	PF00400	0.593
TRG_NLS_MonoExtN_4	125	132	PF00514	0.643

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G9	Leptomonas seymouri	42%	91%
A0A3Q8ICN3	Leishmania donovani	77%	100%
A0A3Q8ICT4	Leishmania donovani	30%	100%
A0A3S7WXW1	Leishmania donovani	28%	100%
A4HD15	Leishmania braziliensis	29%	100%
A4HD16	Leishmania braziliensis	53%	97%
A4I0K1	Leishmania infantum	30%	100%
A4I0K2	Leishmania infantum	77%	100%
A4I0K3	Leishmania infantum	28%	100%
E9AWG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
Q4QB08	Leishmania major	75%	100%
Q4QB09	Leishmania major	28%	100%