Palmitoyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWG2_LEIMU

TriTrypDb:

LmxM.23.1420

Length:

321

Annotations

LeishMANIAdb annotations

Related to other eukaryotic ZDHHC palmitoyltransferases, especially animal ZDHHC2.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AWG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWG2

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006897	endocytosis	5	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016409	palmitoyltransferase activity	5	12
GO:0016417	S-acyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	12
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	12
GO:0019707	protein-cysteine S-acyltransferase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.541
CLV_NRD_NRD_1	263	265	PF00675	0.425
CLV_NRD_NRD_1	299	301	PF00675	0.389
CLV_NRD_NRD_1	307	309	PF00675	0.377
CLV_PCSK_KEX2_1	265	267	PF00082	0.358
CLV_PCSK_KEX2_1	299	301	PF00082	0.389
CLV_PCSK_KEX2_1	307	309	PF00082	0.377
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.397
CLV_PCSK_SKI1_1	131	135	PF00082	0.275
CLV_PCSK_SKI1_1	168	172	PF00082	0.250
CLV_PCSK_SKI1_1	249	253	PF00082	0.256
CLV_PCSK_SKI1_1	287	291	PF00082	0.327
DEG_Nend_UBRbox_4	1	3	PF02207	0.587
DOC_MAPK_FxFP_2	194	197	PF00069	0.254
DOC_MAPK_gen_1	284	292	PF00069	0.508
DOC_MAPK_MEF2A_6	284	292	PF00069	0.529
DOC_PP4_FxxP_1	194	197	PF00568	0.254
DOC_PP4_FxxP_1	317	320	PF00568	0.589
DOC_PP4_FxxP_1	86	89	PF00568	0.550
DOC_USP7_UBL2_3	198	202	PF12436	0.222
DOC_WW_Pin1_4	316	321	PF00397	0.626
LIG_14-3-3_CanoR_1	10	15	PF00244	0.586
LIG_14-3-3_CanoR_1	106	115	PF00244	0.551
LIG_14-3-3_CanoR_1	125	130	PF00244	0.475
LIG_14-3-3_CanoR_1	242	248	PF00244	0.466
LIG_14-3-3_CanoR_1	249	254	PF00244	0.515
LIG_Actin_WH2_2	36	52	PF00022	0.428
LIG_BRCT_BRCA1_1	166	170	PF00533	0.454
LIG_BRCT_BRCA1_1	190	194	PF00533	0.307
LIG_BRCT_BRCA1_1	217	221	PF00533	0.301
LIG_deltaCOP1_diTrp_1	282	292	PF00928	0.508
LIG_EH1_1	64	72	PF00400	0.369
LIG_FHA_2	85	91	PF00498	0.370
LIG_GBD_Chelix_1	68	76	PF00786	0.357
LIG_IBAR_NPY_1	111	113	PF08397	0.562
LIG_LIR_Apic_2	191	197	PF02991	0.336
LIG_LIR_Apic_2	314	320	PF02991	0.582
LIG_LIR_Gen_1	110	121	PF02991	0.567
LIG_LIR_Gen_1	167	178	PF02991	0.454
LIG_LIR_Gen_1	187	197	PF02991	0.317
LIG_LIR_Gen_1	218	229	PF02991	0.330
LIG_LIR_Nem_3	110	116	PF02991	0.564
LIG_LIR_Nem_3	167	173	PF02991	0.497
LIG_LIR_Nem_3	187	193	PF02991	0.295
LIG_LIR_Nem_3	218	224	PF02991	0.330
LIG_LIR_Nem_3	270	276	PF02991	0.535
LIG_LIR_Nem_3	59	65	PF02991	0.258
LIG_MLH1_MIPbox_1	166	170	PF16413	0.454
LIG_PCNA_yPIPBox_3	242	251	PF02747	0.511
LIG_PDZ_Class_1	316	321	PF00595	0.731
LIG_Pex14_2	129	133	PF04695	0.454
LIG_Pex14_2	169	173	PF04695	0.387
LIG_Pex14_2	182	186	PF04695	0.310
LIG_Pex14_2	190	194	PF04695	0.361
LIG_Pex14_2	196	200	PF04695	0.248
LIG_Pex14_2	232	236	PF04695	0.277
LIG_PTB_Apo_2	54	61	PF02174	0.307
LIG_REV1ctd_RIR_1	197	206	PF16727	0.168
LIG_SH2_CRK	286	290	PF00017	0.460
LIG_SH2_CRK	65	69	PF00017	0.336
LIG_SH2_CRK	78	82	PF00017	0.187
LIG_SH2_PTP2	176	179	PF00017	0.257
LIG_SH2_SRC	176	179	PF00017	0.313
LIG_SH2_STAT3	241	244	PF00017	0.511
LIG_SH2_STAT5	126	129	PF00017	0.418
LIG_SH2_STAT5	176	179	PF00017	0.277
LIG_SH2_STAT5	24	27	PF00017	0.314
LIG_SH2_STAT5	305	308	PF00017	0.508
LIG_SH2_STAT5	65	68	PF00017	0.318
LIG_SH3_3	288	294	PF00018	0.491
LIG_SH3_3	90	96	PF00018	0.490
LIG_SUMO_SIM_anti_2	212	218	PF11976	0.283
LIG_SUMO_SIM_par_1	212	218	PF11976	0.253
LIG_SUMO_SIM_par_1	81	87	PF11976	0.397
LIG_TYR_ITIM	174	179	PF00017	0.247
LIG_UBA3_1	250	255	PF00899	0.422
LIG_WRC_WIRS_1	126	131	PF05994	0.454
MOD_CK1_1	188	194	PF00069	0.370
MOD_CK1_1	5	11	PF00069	0.540
MOD_CMANNOS	14	17	PF00535	0.223
MOD_GlcNHglycan	311	314	PF01048	0.351
MOD_GSK3_1	184	191	PF00069	0.279
MOD_GSK3_1	215	222	PF00069	0.333
MOD_GSK3_1	245	252	PF00069	0.379
MOD_N-GLC_1	56	61	PF02516	0.472
MOD_N-GLC_2	159	161	PF02516	0.208
MOD_NEK2_1	20	25	PF00069	0.341
MOD_NEK2_2	2	7	PF00069	0.581
MOD_PKB_1	123	131	PF00069	0.423
MOD_Plk_1	56	62	PF00069	0.304
MOD_Plk_4	185	191	PF00069	0.315
MOD_Plk_4	20	26	PF00069	0.346
MOD_Plk_4	209	215	PF00069	0.312
MOD_Plk_4	220	226	PF00069	0.336
MOD_Plk_4	56	62	PF00069	0.266
TRG_ENDOCYTIC_2	113	116	PF00928	0.551
TRG_ENDOCYTIC_2	126	129	PF00928	0.511
TRG_ENDOCYTIC_2	176	179	PF00928	0.275
TRG_ENDOCYTIC_2	286	289	PF00928	0.461
TRG_ENDOCYTIC_2	64	67	PF00928	0.279
TRG_ENDOCYTIC_2	78	81	PF00928	0.387
TRG_ER_diArg_1	123	126	PF00400	0.524
TRG_ER_diArg_1	298	300	PF00400	0.586
TRG_ER_diArg_1	306	308	PF00400	0.590
TRG_ER_diArg_1	9	12	PF00400	0.624
TRG_NLS_Bipartite_1	254	268	PF00514	0.547
TRG_NLS_MonoExtC_3	263	269	PF00514	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEH3	Leptomonas seymouri	74%	100%
A0A0S4IYT3	Bodo saltans	32%	100%
A0A0S4J1K8	Bodo saltans	30%	70%
A0A0S4KLP7	Bodo saltans	27%	79%
A0A1X0NY23	Trypanosomatidae	45%	100%
A0A3Q8ICT4	Leishmania donovani	92%	100%
A0A3R7MRW9	Trypanosoma rangeli	32%	100%
A0A422NXW5	Trypanosoma rangeli	47%	100%
A4HD15	Leishmania braziliensis	78%	100%
A4I0K1	Leishmania infantum	92%	100%
C9ZVD1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AVW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	81%
E9AWG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	71%
O60069	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	90%
P42836	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	96%
P59267	Mus musculus	31%	88%
Q4QB09	Leishmania major	91%	100%
Q555N7	Dictyostelium discoideum	25%	90%
Q5M757	Arabidopsis thaliana	26%	100%
Q5REH2	Pongo abelii	27%	78%
Q5W0Z9	Homo sapiens	28%	88%
Q6BP97	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	25%	78%
Q6C4W5	Yarrowia lipolytica (strain CLIB 122 / E 150)	24%	80%
Q6FMP5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	24%	91%
Q8VYP5	Arabidopsis thaliana	29%	100%
Q9H6R6	Homo sapiens	27%	78%
Q9JKR5	Rattus norvegicus	31%	88%
Q9NYG2	Homo sapiens	27%	100%
Q9UIJ5	Homo sapiens	32%	87%
V5BJ88	Trypanosoma cruzi	43%	100%
V5DFI9	Trypanosoma cruzi	30%	100%