Putative Ran-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ran-binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9AWG0_LEIMU

TriTrypDb:

LmxM.23.1400

Length:

213

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AWG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWG0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0045184	establishment of protein localization	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0006606	protein import into nucleus	5	1
GO:0006886	intracellular protein transport	4	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0033365	protein localization to organelle	5	1
GO:0034504	protein localization to nucleus	6	1
GO:0046907	intracellular transport	3	1
GO:0051169	nuclear transport	4	1
GO:0051170	import into nucleus	6	1
GO:0051649	establishment of localization in cell	3	1
GO:0072594	establishment of protein localization to organelle	4	1

Molecular functions
Term	Name	Level	Count
GO:0005085	guanyl-nucleotide exchange factor activity	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0030234	enzyme regulator activity	2	1
GO:0030695	GTPase regulator activity	4	1
GO:0031267	small GTPase binding	5	1
GO:0051020	GTPase binding	4	1
GO:0060589	nucleoside-triphosphatase regulator activity	3	1
GO:0098772	molecular function regulator activity	1	1
GO:0140677	molecular function activator activity	2	1
GO:0140678	molecular function inhibitor activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.231
CLV_NRD_NRD_1	181	183	PF00675	0.357
CLV_PCSK_KEX2_1	181	183	PF00082	0.524
CLV_PCSK_SKI1_1	181	185	PF00082	0.465
DEG_APCC_KENBOX_2	138	142	PF00400	0.464
DEG_SCF_FBW7_1	150	157	PF00400	0.509
DOC_CYCLIN_RxL_1	178	188	PF00134	0.520
DOC_MAPK_gen_1	137	145	PF00069	0.430
DOC_MAPK_MEF2A_6	139	147	PF00069	0.415
DOC_PP2B_LxvP_1	207	210	PF13499	0.386
DOC_PP4_FxxP_1	152	155	PF00568	0.429
DOC_USP7_MATH_1	104	108	PF00917	0.416
DOC_USP7_MATH_1	196	200	PF00917	0.355
DOC_WW_Pin1_4	150	155	PF00397	0.472
LIG_14-3-3_CanoR_1	15	19	PF00244	0.461
LIG_14-3-3_CanoR_1	181	190	PF00244	0.399
LIG_Actin_WH2_2	138	153	PF00022	0.339
LIG_BIR_II_1	1	5	PF00653	0.449
LIG_BRCT_BRCA1_1	116	120	PF00533	0.469
LIG_CaM_IQ_9	124	139	PF13499	0.471
LIG_deltaCOP1_diTrp_1	204	208	PF00928	0.324
LIG_FHA_1	122	128	PF00498	0.504
LIG_FHA_1	151	157	PF00498	0.447
LIG_FHA_1	2	8	PF00498	0.454
LIG_FHA_1	85	91	PF00498	0.477
LIG_FHA_2	183	189	PF00498	0.444
LIG_FHA_2	37	43	PF00498	0.489
LIG_LIR_Gen_1	117	127	PF02991	0.479
LIG_LIR_Gen_1	204	210	PF02991	0.263
LIG_LIR_Nem_3	117	123	PF02991	0.502
LIG_LIR_Nem_3	204	208	PF02991	0.324
LIG_LIR_Nem_3	26	31	PF02991	0.425
LIG_LIR_Nem_3	93	98	PF02991	0.429
LIG_LYPXL_yS_3	95	98	PF13949	0.403
LIG_SH2_GRB2like	133	136	PF00017	0.429
LIG_SH2_NCK_1	38	42	PF00017	0.471
LIG_SH2_STAT5	133	136	PF00017	0.465
LIG_SH2_STAT5	38	41	PF00017	0.429
LIG_SH3_3	161	167	PF00018	0.509
LIG_SUMO_SIM_anti_2	199	204	PF11976	0.394
LIG_SUMO_SIM_par_1	157	165	PF11976	0.441
LIG_SUMO_SIM_par_1	21	27	PF11976	0.472
LIG_SUMO_SIM_par_1	46	53	PF11976	0.359
LIG_TRAF2_1	185	188	PF00917	0.484
LIG_TRAF2_1	83	86	PF00917	0.426
MOD_CK1_1	131	137	PF00069	0.428
MOD_CK1_1	53	59	PF00069	0.355
MOD_CK2_1	182	188	PF00069	0.381
MOD_CK2_1	80	86	PF00069	0.516
MOD_GlcNHglycan	100	103	PF01048	0.257
MOD_GlcNHglycan	106	109	PF01048	0.228
MOD_GlcNHglycan	92	95	PF01048	0.288
MOD_GSK3_1	150	157	PF00069	0.472
MOD_GSK3_1	192	199	PF00069	0.402
MOD_GSK3_1	36	43	PF00069	0.424
MOD_GSK3_1	80	87	PF00069	0.511
MOD_N-GLC_2	75	77	PF02516	0.228
MOD_NEK2_1	1	6	PF00069	0.535
MOD_NEK2_1	14	19	PF00069	0.339
MOD_NEK2_1	192	197	PF00069	0.455
MOD_NEK2_1	203	208	PF00069	0.459
MOD_NEK2_1	98	103	PF00069	0.464
MOD_PIKK_1	80	86	PF00454	0.519
MOD_PKA_2	128	134	PF00069	0.471
MOD_PKA_2	14	20	PF00069	0.434
MOD_PKA_2	53	59	PF00069	0.469
MOD_Plk_1	203	209	PF00069	0.299
MOD_Plk_2-3	36	42	PF00069	0.454
MOD_Plk_4	43	49	PF00069	0.480
MOD_ProDKin_1	150	156	PF00069	0.472
TRG_DiLeu_BaEn_1	188	193	PF01217	0.374
TRG_DiLeu_BaEn_2	139	145	PF01217	0.491
TRG_DiLeu_BaEn_2	203	209	PF01217	0.467
TRG_DiLeu_BaEn_4	85	91	PF01217	0.426
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.514
TRG_ENDOCYTIC_2	68	71	PF00928	0.474
TRG_ENDOCYTIC_2	95	98	PF00928	0.403
TRG_ER_diArg_1	180	182	PF00400	0.298
TRG_NES_CRM1_1	191	204	PF08389	0.351
TRG_Pf-PMV_PEXEL_1	181	186	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBA3	Leptomonas seymouri	68%	100%
A0A0S4JIB8	Bodo saltans	46%	100%
A0A1X0NWS3	Trypanosomatidae	47%	96%
A0A3S7WY05	Leishmania donovani	91%	100%
A0A422NXZ5	Trypanosoma rangeli	51%	100%
A3KPP3	Danio rerio	31%	100%
A4HD13	Leishmania braziliensis	84%	100%
A4I0J9	Leishmania infantum	90%	100%
C9ZVC7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
O75002	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
P47123	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	98%
Q32PE2	Bos taurus	33%	100%
Q4QB12	Leishmania major	91%	100%
Q54ML6	Dictyostelium discoideum	29%	100%
Q9HD47	Homo sapiens	32%	100%